TY  - CONF
AU  - Jovanović, Aleksandra A.
AU  - Dinić, Svetlana
AU  - Uskoković, Aleksandra
AU  - Arambašić Jovanović, Jelena
AU  - Grdović, Nevena
AU  - Vidaković, Melita
AU  - Mihailović, Mirjana
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7077
AB  - The aim of the present study was the characterization of silymarin and silibinin loaded liposomes 
via determination of encapsulation efficiency, particle size, polydispersity index (PDI), zeta 
potential, mobility, and conductivity, as well as storage stability during 28 days at 4ºC and stability 
after UV irradiation. Encapsulation efficiency of silymarin and silibinin were 92.05±1.41% and 
87.86±2.06%, respectively. Particle size and PDI of the liposomes with silymarin were changed 
from 3541.3±62.5 nm to 2677.0±44.2 nm and from 0.346±0.044 to 0.228±0.036, respectively, 
during the 28-days stability study; particle size and PDI of the liposomes with silibinin were 
changed from 2074.7±19.4 nm to 2704.0±35.0 nm and from 0.328±0.030 to 0.456±0.026, 
respectively. Zeta potential of the silymarin-liposomes and silibinin-liposomes was changed from -
27.0±0.7 mV to -26.4±0.4 mV and from -29.4±0.6 mV to -9.0±0.4 mV, respectively. Mobility and 
conductivity of the liposomes with silymarin were changed from -2.120±0.057 µmcm/Vs to -
2.067±0.028 µmcm/Vs and from 0.017±0.005 mS/cm to 0.009±0.004 mS/cm, respectively. 
Mobility and conductivity of the liposomal particles with silibinin were changed from -2.307±0.053 
µmcm/Vs to -0.708±0.033 µmcm/Vs and from 0.018±0.003 mS/cm to 0.060±0.001 mS/cm, 
respectively. UV irradiation did not affect particle size and PDI of all liposomes, but it caused a 
decrease in zeta potential: -23.9±0.8 mV for silymarin and -24.5±0.7 mV for silibinin, in mobility: -
1.874±0.064 µmcm/Vs for silymarin and -1.920±0.057 µmcm/Vs for silibinin, and in conductivity: 
0.014±0.001 mS/cm for silymarin and 0.007±0.003 mS/cm for silibinin. Overall, the obtained 
results qualify liposomes to be used as silymarin and silibinin carriers for application in functional 
foods and pharmaceutical products.
PB  - Banja Luka : University in Banjaluka, Faculty of Technology
C3  - Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022
T1  - The characterisation of silymarin and silibinin loaded liposomes
SP  - 83
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7077
ER  - 

@conference{
author = "Jovanović, Aleksandra A. and Dinić, Svetlana and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Grdović, Nevena and Vidaković, Melita and Mihailović, Mirjana",
year = "2022",
abstract = "The aim of the present study was the characterization of silymarin and silibinin loaded liposomes 
via determination of encapsulation efficiency, particle size, polydispersity index (PDI), zeta 
potential, mobility, and conductivity, as well as storage stability during 28 days at 4ºC and stability 
after UV irradiation. Encapsulation efficiency of silymarin and silibinin were 92.05±1.41% and 
87.86±2.06%, respectively. Particle size and PDI of the liposomes with silymarin were changed 
from 3541.3±62.5 nm to 2677.0±44.2 nm and from 0.346±0.044 to 0.228±0.036, respectively, 
during the 28-days stability study; particle size and PDI of the liposomes with silibinin were 
changed from 2074.7±19.4 nm to 2704.0±35.0 nm and from 0.328±0.030 to 0.456±0.026, 
respectively. Zeta potential of the silymarin-liposomes and silibinin-liposomes was changed from -
27.0±0.7 mV to -26.4±0.4 mV and from -29.4±0.6 mV to -9.0±0.4 mV, respectively. Mobility and 
conductivity of the liposomes with silymarin were changed from -2.120±0.057 µmcm/Vs to -
2.067±0.028 µmcm/Vs and from 0.017±0.005 mS/cm to 0.009±0.004 mS/cm, respectively. 
Mobility and conductivity of the liposomal particles with silibinin were changed from -2.307±0.053 
µmcm/Vs to -0.708±0.033 µmcm/Vs and from 0.018±0.003 mS/cm to 0.060±0.001 mS/cm, 
respectively. UV irradiation did not affect particle size and PDI of all liposomes, but it caused a 
decrease in zeta potential: -23.9±0.8 mV for silymarin and -24.5±0.7 mV for silibinin, in mobility: -
1.874±0.064 µmcm/Vs for silymarin and -1.920±0.057 µmcm/Vs for silibinin, and in conductivity: 
0.014±0.001 mS/cm for silymarin and 0.007±0.003 mS/cm for silibinin. Overall, the obtained 
results qualify liposomes to be used as silymarin and silibinin carriers for application in functional 
foods and pharmaceutical products.",
publisher = "Banja Luka : University in Banjaluka, Faculty of Technology",
journal = "Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022",
title = "The characterisation of silymarin and silibinin loaded liposomes",
pages = "83",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7077"
}

Jovanović, A. A., Dinić, S., Uskoković, A., Arambašić Jovanović, J., Grdović, N., Vidaković, M.,& Mihailović, M.. (2022). The characterisation of silymarin and silibinin loaded liposomes. in Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022
Banja Luka : University in Banjaluka, Faculty of Technology., 83.
https://hdl.handle.net/21.15107/rcub_technorep_7077

Jovanović AA, Dinić S, Uskoković A, Arambašić Jovanović J, Grdović N, Vidaković M, Mihailović M. The characterisation of silymarin and silibinin loaded liposomes. in Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022. 2022;:83.
https://hdl.handle.net/21.15107/rcub_technorep_7077 .

Jovanović, Aleksandra A., Dinić, Svetlana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Grdović, Nevena, Vidaković, Melita, Mihailović, Mirjana, "The characterisation of silymarin and silibinin loaded liposomes" in Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022 (2022):83,
https://hdl.handle.net/21.15107/rcub_technorep_7077 .

TY  - JOUR
AU  - Jovanović, Aleksandra
AU  - Dinić, Svetlana
AU  - Uskoković, Aleksandra
AU  - Arambašić Jovanović, Jelena
AU  - Grdović, Nevena
AU  - Vidaković, Melita
AU  - Mihailović, Mirjana
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6690
AB  - The aim of the present study was the characterization of silymarin and silibinin liposomes via determination of encapsulation efficiency, particle size, polydispersity index (PDI), zeta potential, mobility, and conductivity, as well as storage stability during 28 days at 4ºC and stability after UV irradiation. Encapsulation efficiencies of silymarin and silibinin were 92.05±1.41% and 87.86±2.06%, respectively. Particle size and PDI of the liposomes with silymarin were changed from 3541.3±62.5nm to 2677.0±44.2 nm and from 0.346±0.044 to 0.228±0.036, respectively, during the 28-day stability study; particle size and PDI of the liposomes with silibinin were changed from 2074.7±19.4 nm to 2704.0±35.0 nm and from 0.328±0.030to 0.456±0.026, respectively. The Zeta potential of the silymarin-loaded liposomes and silibinin-loaded liposomes was changed from -27.0±0.7 mV to -26.4±0.4 mV and from -29.4±0.6 mV to -29.0±0.4 mV, respectively. Mobility and conductivity of the liposomes with silymarin were changed from -2.120±0.057 μmcm/Vs to -2.067±0.028 μmcm/Vs and from 0.017±0.005 mS/cm to 0.009±0.004 mS/cm, respectively.  Mobility and conductivity of the liposomal particles with silibinin were changed from -2.307±0.053 μmcm/Vs to -2.110±0.033 μmcm/Vs and from0.018±0.003 mS/cm to 0.060±0.001 mS/cm, respectively. UV irradiation did not affect particle size and PDI of all liposomes, but it caused a decrease in zeta potential: -23.9±0.8 mV for silymarin and -24.5±0.7 mV for silibinin, in mobility: -1.874±0.064 μmcm/Vs for silymarin and -1.920±0.057 μmcm/Vs for silibinin, and in conductivity: 0.014±0.001 mS/cm for silymarin and 0.007±0.003 mS/cm for silibinin. Overall, the obtained results qualify liposomes to be used as silymarin and silibinin carriers for application in functional foods and pharmaceutical products.
PB  - Faculty of Technology, University of East Sarajevo
T2  - Journal of Engineering & Processing Management
T1  - THE CHARACTERIZATION OF SILYMARIN AND SILIBININ LIPOSOMES
EP  - 45
IS  - 2
SP  - 40
VL  - 14
DO  - 10.7251/JEPM2202040j
ER  - 

@article{
author = "Jovanović, Aleksandra and Dinić, Svetlana and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Grdović, Nevena and Vidaković, Melita and Mihailović, Mirjana",
year = "2022",
abstract = "The aim of the present study was the characterization of silymarin and silibinin liposomes via determination of encapsulation efficiency, particle size, polydispersity index (PDI), zeta potential, mobility, and conductivity, as well as storage stability during 28 days at 4ºC and stability after UV irradiation. Encapsulation efficiencies of silymarin and silibinin were 92.05±1.41% and 87.86±2.06%, respectively. Particle size and PDI of the liposomes with silymarin were changed from 3541.3±62.5nm to 2677.0±44.2 nm and from 0.346±0.044 to 0.228±0.036, respectively, during the 28-day stability study; particle size and PDI of the liposomes with silibinin were changed from 2074.7±19.4 nm to 2704.0±35.0 nm and from 0.328±0.030to 0.456±0.026, respectively. The Zeta potential of the silymarin-loaded liposomes and silibinin-loaded liposomes was changed from -27.0±0.7 mV to -26.4±0.4 mV and from -29.4±0.6 mV to -29.0±0.4 mV, respectively. Mobility and conductivity of the liposomes with silymarin were changed from -2.120±0.057 μmcm/Vs to -2.067±0.028 μmcm/Vs and from 0.017±0.005 mS/cm to 0.009±0.004 mS/cm, respectively.  Mobility and conductivity of the liposomal particles with silibinin were changed from -2.307±0.053 μmcm/Vs to -2.110±0.033 μmcm/Vs and from0.018±0.003 mS/cm to 0.060±0.001 mS/cm, respectively. UV irradiation did not affect particle size and PDI of all liposomes, but it caused a decrease in zeta potential: -23.9±0.8 mV for silymarin and -24.5±0.7 mV for silibinin, in mobility: -1.874±0.064 μmcm/Vs for silymarin and -1.920±0.057 μmcm/Vs for silibinin, and in conductivity: 0.014±0.001 mS/cm for silymarin and 0.007±0.003 mS/cm for silibinin. Overall, the obtained results qualify liposomes to be used as silymarin and silibinin carriers for application in functional foods and pharmaceutical products.",
publisher = "Faculty of Technology, University of East Sarajevo",
journal = "Journal of Engineering & Processing Management",
title = "THE CHARACTERIZATION OF SILYMARIN AND SILIBININ LIPOSOMES",
pages = "45-40",
number = "2",
volume = "14",
doi = "10.7251/JEPM2202040j"
}

Jovanović, A., Dinić, S., Uskoković, A., Arambašić Jovanović, J., Grdović, N., Vidaković, M.,& Mihailović, M.. (2022). THE CHARACTERIZATION OF SILYMARIN AND SILIBININ LIPOSOMES. in Journal of Engineering & Processing Management
Faculty of Technology, University of East Sarajevo., 14(2), 40-45.
https://doi.org/10.7251/JEPM2202040j

Jovanović A, Dinić S, Uskoković A, Arambašić Jovanović J, Grdović N, Vidaković M, Mihailović M. THE CHARACTERIZATION OF SILYMARIN AND SILIBININ LIPOSOMES. in Journal of Engineering & Processing Management. 2022;14(2):40-45.
doi:10.7251/JEPM2202040j .

Jovanović, Aleksandra, Dinić, Svetlana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Grdović, Nevena, Vidaković, Melita, Mihailović, Mirjana, "THE CHARACTERIZATION OF SILYMARIN AND SILIBININ LIPOSOMES" in Journal of Engineering & Processing Management, 14, no. 2 (2022):40-45,
https://doi.org/10.7251/JEPM2202040j . .