The characterisation of silymarin and silibinin loaded liposomes
Аутори
Jovanović, Aleksandra A.Dinić, Svetlana
Uskoković, Aleksandra
Arambašić Jovanović, Jelena
Grdović, Nevena
Vidaković, Melita
Mihailović, Mirjana
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of the present study was the characterization of silymarin and silibinin loaded liposomes
via determination of encapsulation efficiency, particle size, polydispersity index (PDI), zeta
potential, mobility, and conductivity, as well as storage stability during 28 days at 4ºC and stability
after UV irradiation. Encapsulation efficiency of silymarin and silibinin were 92.05±1.41% and
87.86±2.06%, respectively. Particle size and PDI of the liposomes with silymarin were changed
from 3541.3±62.5 nm to 2677.0±44.2 nm and from 0.346±0.044 to 0.228±0.036, respectively,
during the 28-days stability study; particle size and PDI of the liposomes with silibinin were
changed from 2074.7±19.4 nm to 2704.0±35.0 nm and from 0.328±0.030 to 0.456±0.026,
respectively. Zeta potential of the silymarin-liposomes and silibinin-liposomes was changed from -
27.0±0.7 mV to -26.4±0.4 mV and from -29.4±0.6 mV to -9.0±0.4 mV, respectively. Mobility and
conductivity of the liposomes with s...ilymarin were changed from -2.120±0.057 µmcm/Vs to -
2.067±0.028 µmcm/Vs and from 0.017±0.005 mS/cm to 0.009±0.004 mS/cm, respectively.
Mobility and conductivity of the liposomal particles with silibinin were changed from -2.307±0.053
µmcm/Vs to -0.708±0.033 µmcm/Vs and from 0.018±0.003 mS/cm to 0.060±0.001 mS/cm,
respectively. UV irradiation did not affect particle size and PDI of all liposomes, but it caused a
decrease in zeta potential: -23.9±0.8 mV for silymarin and -24.5±0.7 mV for silibinin, in mobility: -
1.874±0.064 µmcm/Vs for silymarin and -1.920±0.057 µmcm/Vs for silibinin, and in conductivity:
0.014±0.001 mS/cm for silymarin and 0.007±0.003 mS/cm for silibinin. Overall, the obtained
results qualify liposomes to be used as silymarin and silibinin carriers for application in functional
foods and pharmaceutical products.
Кључне речи:
silymarin / silibinin / liposomes / characterizationИзвор:
Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022, 2022, 83-Издавач:
- Banja Luka : University in Banjaluka, Faculty of Technology
Институција/група
Inovacioni centarTY - CONF AU - Jovanović, Aleksandra A. AU - Dinić, Svetlana AU - Uskoković, Aleksandra AU - Arambašić Jovanović, Jelena AU - Grdović, Nevena AU - Vidaković, Melita AU - Mihailović, Mirjana PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7077 AB - The aim of the present study was the characterization of silymarin and silibinin loaded liposomes via determination of encapsulation efficiency, particle size, polydispersity index (PDI), zeta potential, mobility, and conductivity, as well as storage stability during 28 days at 4ºC and stability after UV irradiation. Encapsulation efficiency of silymarin and silibinin were 92.05±1.41% and 87.86±2.06%, respectively. Particle size and PDI of the liposomes with silymarin were changed from 3541.3±62.5 nm to 2677.0±44.2 nm and from 0.346±0.044 to 0.228±0.036, respectively, during the 28-days stability study; particle size and PDI of the liposomes with silibinin were changed from 2074.7±19.4 nm to 2704.0±35.0 nm and from 0.328±0.030 to 0.456±0.026, respectively. Zeta potential of the silymarin-liposomes and silibinin-liposomes was changed from - 27.0±0.7 mV to -26.4±0.4 mV and from -29.4±0.6 mV to -9.0±0.4 mV, respectively. Mobility and conductivity of the liposomes with silymarin were changed from -2.120±0.057 µmcm/Vs to - 2.067±0.028 µmcm/Vs and from 0.017±0.005 mS/cm to 0.009±0.004 mS/cm, respectively. Mobility and conductivity of the liposomal particles with silibinin were changed from -2.307±0.053 µmcm/Vs to -0.708±0.033 µmcm/Vs and from 0.018±0.003 mS/cm to 0.060±0.001 mS/cm, respectively. UV irradiation did not affect particle size and PDI of all liposomes, but it caused a decrease in zeta potential: -23.9±0.8 mV for silymarin and -24.5±0.7 mV for silibinin, in mobility: - 1.874±0.064 µmcm/Vs for silymarin and -1.920±0.057 µmcm/Vs for silibinin, and in conductivity: 0.014±0.001 mS/cm for silymarin and 0.007±0.003 mS/cm for silibinin. Overall, the obtained results qualify liposomes to be used as silymarin and silibinin carriers for application in functional foods and pharmaceutical products. PB - Banja Luka : University in Banjaluka, Faculty of Technology C3 - Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022 T1 - The characterisation of silymarin and silibinin loaded liposomes SP - 83 UR - https://hdl.handle.net/21.15107/rcub_technorep_7077 ER -
@conference{ author = "Jovanović, Aleksandra A. and Dinić, Svetlana and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Grdović, Nevena and Vidaković, Melita and Mihailović, Mirjana", year = "2022", abstract = "The aim of the present study was the characterization of silymarin and silibinin loaded liposomes via determination of encapsulation efficiency, particle size, polydispersity index (PDI), zeta potential, mobility, and conductivity, as well as storage stability during 28 days at 4ºC and stability after UV irradiation. Encapsulation efficiency of silymarin and silibinin were 92.05±1.41% and 87.86±2.06%, respectively. Particle size and PDI of the liposomes with silymarin were changed from 3541.3±62.5 nm to 2677.0±44.2 nm and from 0.346±0.044 to 0.228±0.036, respectively, during the 28-days stability study; particle size and PDI of the liposomes with silibinin were changed from 2074.7±19.4 nm to 2704.0±35.0 nm and from 0.328±0.030 to 0.456±0.026, respectively. Zeta potential of the silymarin-liposomes and silibinin-liposomes was changed from - 27.0±0.7 mV to -26.4±0.4 mV and from -29.4±0.6 mV to -9.0±0.4 mV, respectively. Mobility and conductivity of the liposomes with silymarin were changed from -2.120±0.057 µmcm/Vs to - 2.067±0.028 µmcm/Vs and from 0.017±0.005 mS/cm to 0.009±0.004 mS/cm, respectively. Mobility and conductivity of the liposomal particles with silibinin were changed from -2.307±0.053 µmcm/Vs to -0.708±0.033 µmcm/Vs and from 0.018±0.003 mS/cm to 0.060±0.001 mS/cm, respectively. UV irradiation did not affect particle size and PDI of all liposomes, but it caused a decrease in zeta potential: -23.9±0.8 mV for silymarin and -24.5±0.7 mV for silibinin, in mobility: - 1.874±0.064 µmcm/Vs for silymarin and -1.920±0.057 µmcm/Vs for silibinin, and in conductivity: 0.014±0.001 mS/cm for silymarin and 0.007±0.003 mS/cm for silibinin. Overall, the obtained results qualify liposomes to be used as silymarin and silibinin carriers for application in functional foods and pharmaceutical products.", publisher = "Banja Luka : University in Banjaluka, Faculty of Technology", journal = "Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022", title = "The characterisation of silymarin and silibinin loaded liposomes", pages = "83", url = "https://hdl.handle.net/21.15107/rcub_technorep_7077" }
Jovanović, A. A., Dinić, S., Uskoković, A., Arambašić Jovanović, J., Grdović, N., Vidaković, M.,& Mihailović, M.. (2022). The characterisation of silymarin and silibinin loaded liposomes. in Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022 Banja Luka : University in Banjaluka, Faculty of Technology., 83. https://hdl.handle.net/21.15107/rcub_technorep_7077
Jovanović AA, Dinić S, Uskoković A, Arambašić Jovanović J, Grdović N, Vidaković M, Mihailović M. The characterisation of silymarin and silibinin loaded liposomes. in Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022. 2022;:83. https://hdl.handle.net/21.15107/rcub_technorep_7077 .
Jovanović, Aleksandra A., Dinić, Svetlana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Grdović, Nevena, Vidaković, Melita, Mihailović, Mirjana, "The characterisation of silymarin and silibinin loaded liposomes" in Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022 (2022):83, https://hdl.handle.net/21.15107/rcub_technorep_7077 .