TY  - JOUR
AU  - Marković, Maja D.
AU  - Svetozarević, Milica M.
AU  - Panić, Vesna V.
AU  - Savić, Sanja I.
AU  - Mašulović, Aleksandra D.
AU  - Spasojević, Pavle M.
AU  - Pjanović, Rada V.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5860
AB  - This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.
PB  - Elsevier B.V.
T2  - Chemical Engineering Journal
T1  - Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds
SP  - 141580
VL  - 459
DO  - 10.1016/j.cej.2023.141580
ER  - 

@article{
author = "Marković, Maja D. and Svetozarević, Milica M. and Panić, Vesna V. and Savić, Sanja I. and Mašulović, Aleksandra D. and Spasojević, Pavle M. and Pjanović, Rada V.",
year = "2023",
abstract = "This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.",
publisher = "Elsevier B.V.",
journal = "Chemical Engineering Journal",
title = "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds",
pages = "141580",
volume = "459",
doi = "10.1016/j.cej.2023.141580"
}

Marković, M. D., Svetozarević, M. M., Panić, V. V., Savić, S. I., Mašulović, A. D., Spasojević, P. M.,& Pjanović, R. V.. (2023). Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal
Elsevier B.V.., 459, 141580.
https://doi.org/10.1016/j.cej.2023.141580

Marković MD, Svetozarević MM, Panić VV, Savić SI, Mašulović AD, Spasojević PM, Pjanović RV. Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal. 2023;459:141580.
doi:10.1016/j.cej.2023.141580 .

Marković, Maja D., Svetozarević, Milica M., Panić, Vesna V., Savić, Sanja I., Mašulović, Aleksandra D., Spasojević, Pavle M., Pjanović, Rada V., "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds" in Chemical Engineering Journal, 459 (2023):141580,
https://doi.org/10.1016/j.cej.2023.141580 . .

TY  - PAT
AU  - Marković, Maja
AU  - Tadić, Julijana
AU  - Šešlija, Sanja
AU  - Mijin, Dušan
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Pjanović, Rada
AU  - Ugrinović, Vukašin
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5950
AB  - Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.
PB  - Zavod za intelektualnu svojinu, Beograd, Srbija
T2  - http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf
T1  - SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5950
ER  - 

@misc{
author = "Marković, Maja and Tadić, Julijana and Šešlija, Sanja and Mijin, Dušan and Panić, Vesna and Spasojević, Pavle and Pjanović, Rada and Ugrinović, Vukašin",
year = "2023",
abstract = "Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.",
publisher = "Zavod za intelektualnu svojinu, Beograd, Srbija",
journal = "http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf",
title = "SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5950"
}

Marković, M., Tadić, J., Šešlija, S., Mijin, D., Panić, V., Spasojević, P., Pjanović, R.,& Ugrinović, V.. (2023). SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA. in http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf
Zavod za intelektualnu svojinu, Beograd, Srbija..
https://hdl.handle.net/21.15107/rcub_technorep_5950

Marković M, Tadić J, Šešlija S, Mijin D, Panić V, Spasojević P, Pjanović R, Ugrinović V. SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA. in http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf. 2023;.
https://hdl.handle.net/21.15107/rcub_technorep_5950 .

Marković, Maja, Tadić, Julijana, Šešlija, Sanja, Mijin, Dušan, Panić, Vesna, Spasojević, Pavle, Pjanović, Rada, Ugrinović, Vukašin, "SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA" in http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf (2023),
https://hdl.handle.net/21.15107/rcub_technorep_5950 .

TY  - JOUR
AU  - Panić, Vesna V.
AU  - Jovanović, Jelena D.
AU  - Popović, Ivanka G.
AU  - Savić, Sanja I.
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Adnađević, Borivoj K.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5966
AB  - High concentrations of hydrophobic MFI zeolite (26.0–51.3 wt%) were successfully embedded in poly(methacrylic acid) (PMAA) network in simple, one-pot synthesis of PMAA-MFI composite hydrogels. The effects of zeolite concentration regarding pure PMAA xerogel, for all of the investigated properties (primary structural parameters, morphological properties, water swelling ability, thermal degradation mechanism and stability, and mechanical properties) were determined and discussed. The PMAA-MFI composite hydrogels had remarkably higher density than PMAA xerogel (1660/1420 kg m−3), higher crosslinking density (29/1.0 × 10−4), improved mechanics in the dry and swollen state (up to 4.9 times higher storage modulus) and lower swelling degree (42/420 g g−1), average molar mass between the network crosslinks (3.6/110 × 104 g mol−1), and distance between the macromolecular chains (64/710 nm). Despite high zeolite concentration, the composites kept porous hydrogel structure with uniformly dispersed zeolite particles. FTIR spectra disclosed the existence of functional groups of PMAA network and MFI zeolite that interacted mutually and led to increased crosslinking density. The effect of zeolite concentration on the thermal degradation mechanism was established. The composition-properties correlations were determined and described by the adequate linear or power law equations revealing the additive nature of the composites and the fractal structure of the networks. These correlations enable the achievement of desired properties by simple adjustment of the initial composition, i.e. zeolite concentration. Therefore, this work presents the base for further development of tailor-made PMAA-MFI composite hydrogels aimed for specific application.
PB  - Elsevier
T2  - Polymer
T1  - The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite
SP  - 125750
VL  - 269
DO  - 10.1016/j.polymer.2023.125750
ER  - 

@article{
author = "Panić, Vesna V. and Jovanović, Jelena D. and Popović, Ivanka G. and Savić, Sanja I. and Marković, Maja D. and Spasojević, Pavle M. and Adnađević, Borivoj K.",
year = "2023",
abstract = "High concentrations of hydrophobic MFI zeolite (26.0–51.3 wt%) were successfully embedded in poly(methacrylic acid) (PMAA) network in simple, one-pot synthesis of PMAA-MFI composite hydrogels. The effects of zeolite concentration regarding pure PMAA xerogel, for all of the investigated properties (primary structural parameters, morphological properties, water swelling ability, thermal degradation mechanism and stability, and mechanical properties) were determined and discussed. The PMAA-MFI composite hydrogels had remarkably higher density than PMAA xerogel (1660/1420 kg m−3), higher crosslinking density (29/1.0 × 10−4), improved mechanics in the dry and swollen state (up to 4.9 times higher storage modulus) and lower swelling degree (42/420 g g−1), average molar mass between the network crosslinks (3.6/110 × 104 g mol−1), and distance between the macromolecular chains (64/710 nm). Despite high zeolite concentration, the composites kept porous hydrogel structure with uniformly dispersed zeolite particles. FTIR spectra disclosed the existence of functional groups of PMAA network and MFI zeolite that interacted mutually and led to increased crosslinking density. The effect of zeolite concentration on the thermal degradation mechanism was established. The composition-properties correlations were determined and described by the adequate linear or power law equations revealing the additive nature of the composites and the fractal structure of the networks. These correlations enable the achievement of desired properties by simple adjustment of the initial composition, i.e. zeolite concentration. Therefore, this work presents the base for further development of tailor-made PMAA-MFI composite hydrogels aimed for specific application.",
publisher = "Elsevier",
journal = "Polymer",
title = "The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite",
pages = "125750",
volume = "269",
doi = "10.1016/j.polymer.2023.125750"
}

Panić, V. V., Jovanović, J. D., Popović, I. G., Savić, S. I., Marković, M. D., Spasojević, P. M.,& Adnađević, B. K.. (2023). The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite. in Polymer
Elsevier., 269, 125750.
https://doi.org/10.1016/j.polymer.2023.125750

Panić VV, Jovanović JD, Popović IG, Savić SI, Marković MD, Spasojević PM, Adnađević BK. The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite. in Polymer. 2023;269:125750.
doi:10.1016/j.polymer.2023.125750 .

Panić, Vesna V., Jovanović, Jelena D., Popović, Ivanka G., Savić, Sanja I., Marković, Maja D., Spasojević, Pavle M., Adnađević, Borivoj K., "The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite" in Polymer, 269 (2023):125750,
https://doi.org/10.1016/j.polymer.2023.125750 . .

TY  - CONF
AU  - Pantić, Olga J.
AU  - Panić, Vesna V.
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Kalagasidis Krušić, Melina T.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6466
AB  - Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz
bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole
su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala.
Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim
količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za
proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska
kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen
dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od
mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je
određivan analizom sadržaja gel faze.
AB  - Development of biobased thermoset polymers encourages the strategic use of biobased
resources and migrating to greener technologies. Unsaturated polyester resins have an
extensive array of properties which makes them the most used thermoset resins in the
production of polymer composite materials. Waste materials, such as eggshells left over
from the usage of chicken eggs, are abundant and non-hazardous materials which offer
many benefits in potential use as a filler in developing a biobased composite material.
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the
resulting composite materials included assessing mechanical properties (uniaxial tensile
test, three-point bending test), FTIR spectroscopy, and gel content analysis.
PB  - Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija
C3  - 59th Meeting of the Serbian Chemical Society
T1  - Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora
T1  - Composite materials prepared from waste eggshells and biobased unsaturated polyester resin
EP  - 148
SP  - 148
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6466
ER  - 

@conference{
author = "Pantić, Olga J. and Panić, Vesna V. and Marković, Maja D. and Spasojević, Pavle M. and Savić, Sanja I. and Kalagasidis Krušić, Melina T.",
year = "2023",
abstract = "Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz
bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole
su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala.
Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim
količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za
proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska
kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen
dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od
mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je
određivan analizom sadržaja gel faze., Development of biobased thermoset polymers encourages the strategic use of biobased
resources and migrating to greener technologies. Unsaturated polyester resins have an
extensive array of properties which makes them the most used thermoset resins in the
production of polymer composite materials. Waste materials, such as eggshells left over
from the usage of chicken eggs, are abundant and non-hazardous materials which offer
many benefits in potential use as a filler in developing a biobased composite material.
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the
resulting composite materials included assessing mechanical properties (uniaxial tensile
test, three-point bending test), FTIR spectroscopy, and gel content analysis.",
publisher = "Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija",
journal = "59th Meeting of the Serbian Chemical Society",
title = "Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora, Composite materials prepared from waste eggshells and biobased unsaturated polyester resin",
pages = "148-148",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6466"
}

Pantić, O. J., Panić, V. V., Marković, M. D., Spasojević, P. M., Savić, S. I.,& Kalagasidis Krušić, M. T.. (2023). Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora. in 59th Meeting of the Serbian Chemical Society
Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija., 148-148.
https://hdl.handle.net/21.15107/rcub_technorep_6466

Pantić OJ, Panić VV, Marković MD, Spasojević PM, Savić SI, Kalagasidis Krušić MT. Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora. in 59th Meeting of the Serbian Chemical Society. 2023;:148-148.
https://hdl.handle.net/21.15107/rcub_technorep_6466 .

Pantić, Olga J., Panić, Vesna V., Marković, Maja D., Spasojević, Pavle M., Savić, Sanja I., Kalagasidis Krušić, Melina T., "Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora" in 59th Meeting of the Serbian Chemical Society (2023):148-148,
https://hdl.handle.net/21.15107/rcub_technorep_6466 .

TY  - CONF
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Pantić, Olga J.
AU  - Panić, Vesna V.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6737
AB  - Modern society are faced with lot of challenges in the treatment of many diseases, especially
with serious ones such as cancer. Safer and more efficient treatment of the cancer patients are main
goals which researchers are aiming. One of the good approaches can be drug delivery systems.
Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled release
can be quite challenging. Present study is focused to improve drug delivery system based on
hydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-soluble
caffeine, which has been developed through our previous research. The hydrogels with 1.6mol% of
crosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-
4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed in
two environments which simulate human stomach and intestines. It is also investigated how the
change in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine,
affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The results
show that controlled release of caffeine is improved, therefore overall therapy can be enhanced.
AB  - Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.
PB  - Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku
C3  - Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
T1  - Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine
T1  - Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina
EP  - 187
SP  - 181
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6737
ER  - 

@conference{
author = "Marković, Maja D. and Spasojević, Pavle M. and Savić, Sanja I. and Pantić, Olga J. and Panić, Vesna V.",
year = "2023",
abstract = "Modern society are faced with lot of challenges in the treatment of many diseases, especially
with serious ones such as cancer. Safer and more efficient treatment of the cancer patients are main
goals which researchers are aiming. One of the good approaches can be drug delivery systems.
Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled release
can be quite challenging. Present study is focused to improve drug delivery system based on
hydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-soluble
caffeine, which has been developed through our previous research. The hydrogels with 1.6mol% of
crosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-
4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed in
two environments which simulate human stomach and intestines. It is also investigated how the
change in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine,
affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The results
show that controlled release of caffeine is improved, therefore overall therapy can be enhanced., Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.",
publisher = "Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku",
journal = "Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac",
title = "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine, Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina",
pages = "187-181",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6737"
}

Marković, M. D., Spasojević, P. M., Savić, S. I., Pantić, O. J.,& Panić, V. V.. (2023). Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku., 181-187.
https://hdl.handle.net/21.15107/rcub_technorep_6737

Marković MD, Spasojević PM, Savić SI, Pantić OJ, Panić VV. Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac. 2023;:181-187.
https://hdl.handle.net/21.15107/rcub_technorep_6737 .

Marković, Maja D., Spasojević, Pavle M., Savić, Sanja I., Pantić, Olga J., Panić, Vesna V., "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine" in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac (2023):181-187,
https://hdl.handle.net/21.15107/rcub_technorep_6737 .

TY  - CONF
AU  - Pantić, Olga
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6860
AB  - The importance of producing thermoset polymers from natural resources has grown due to environmental concerns. Implementing the biorefinery concept is vital for replacing petroleum-based raw materials and transferring to cleaner technologies. Unsaturated polyester resins (UPRs) are a significant class of thermosetting polymers, with a wide range of properties gained from a considerable number of materials that are used for their synthesis. They can be used as pure resins or resins reinforced with suitable fillers in composite material production, which is the focus of this research. Generally, UPRs consist of two main components, prepolymer and reactive diluents, commercially both of which are commonly derived from petroleum. So, it is important to find an adequate bio-based alternative not only for styrene as a reactive diluent, but also for monomers that are used for prepolymer synthesis. Many bio-based monomers (propylene glycol, isosorbide, neopentyl glycol) and reactive diluents (vinyl levulinate, butanediol dimethacrylate, dimethyl itaconate) were investigated in formulating a bio-based UPR. Alongside this, many different bio-based fillers (hemp fibres, spent coffee grounds, rosehip seed flour) were also examined, to conclusively obtain a fully bio-based composite material. Sole introduction of bio-based raw materials is insufficient for proper implementation of the biorefinery principle. It is equally important that the final formulation of the obtained composite material demonstrates that it is environmentally and economically feasible. The quality and market price of the bio-based composite material must be at least be comparable to or better than those of a product from a conventional process in order to be competitive.
PB  - Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering
C3  - Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023
T1  - Bio-based unsaturated polyester resins – a step towards a biorefinery solution
SP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6860
ER  - 

@conference{
author = "Pantić, Olga and Savić, Sanja and Panić, Vesna and Marković, Maja and Spasojević, Pavle",
year = "2023",
abstract = "The importance of producing thermoset polymers from natural resources has grown due to environmental concerns. Implementing the biorefinery concept is vital for replacing petroleum-based raw materials and transferring to cleaner technologies. Unsaturated polyester resins (UPRs) are a significant class of thermosetting polymers, with a wide range of properties gained from a considerable number of materials that are used for their synthesis. They can be used as pure resins or resins reinforced with suitable fillers in composite material production, which is the focus of this research. Generally, UPRs consist of two main components, prepolymer and reactive diluents, commercially both of which are commonly derived from petroleum. So, it is important to find an adequate bio-based alternative not only for styrene as a reactive diluent, but also for monomers that are used for prepolymer synthesis. Many bio-based monomers (propylene glycol, isosorbide, neopentyl glycol) and reactive diluents (vinyl levulinate, butanediol dimethacrylate, dimethyl itaconate) were investigated in formulating a bio-based UPR. Alongside this, many different bio-based fillers (hemp fibres, spent coffee grounds, rosehip seed flour) were also examined, to conclusively obtain a fully bio-based composite material. Sole introduction of bio-based raw materials is insufficient for proper implementation of the biorefinery principle. It is equally important that the final formulation of the obtained composite material demonstrates that it is environmentally and economically feasible. The quality and market price of the bio-based composite material must be at least be comparable to or better than those of a product from a conventional process in order to be competitive.",
publisher = "Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering",
journal = "Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023",
title = "Bio-based unsaturated polyester resins – a step towards a biorefinery solution",
pages = "14",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6860"
}

Pantić, O., Savić, S., Panić, V., Marković, M.,& Spasojević, P.. (2023). Bio-based unsaturated polyester resins – a step towards a biorefinery solution. in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023
Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering., 14.
https://hdl.handle.net/21.15107/rcub_technorep_6860

Pantić O, Savić S, Panić V, Marković M, Spasojević P. Bio-based unsaturated polyester resins – a step towards a biorefinery solution. in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023. 2023;:14.
https://hdl.handle.net/21.15107/rcub_technorep_6860 .

Pantić, Olga, Savić, Sanja, Panić, Vesna, Marković, Maja, Spasojević, Pavle, "Bio-based unsaturated polyester resins – a step towards a biorefinery solution" in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023 (2023):14,
https://hdl.handle.net/21.15107/rcub_technorep_6860 .

TY  - CONF
AU  - Savić, Sanja
AU  - Pantić, Olga
AU  - Vicente, Filipa A.
AU  - Novak, Uroš
AU  - Likozar, Blaž
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6861
AB  - Fruits are the most utilized commodities among all horticultural crops. They are consumed raw, minimally processed, due to their nutrients and health-promoting compounds. With the growing population and changing diet habits, the production and processing of fruits, have increased very significantly to fulfil the increasing demands. Significant losses and waste in the fresh and processing industries are becoming a serious nutritional, economical, and environmental problem. The fruit waste is composed mainly of seed, skin, rind, and pomace, containing good sources of potentially valuable bioactive compounds. The apple pomace is rich in pectic substances and represents important raw material for pectin production all around the world. For example, the portion of residual apple pomace makes about 13 % of the total waste material and on the basis of dry mass, it contains 10–15% pectin. Currently, it is either used for animal feeding or is disposed of as an industrial waste. The extraction of pectin is usually performed using mineral acids, yielding a reasonable quantity of product while also saving time in the process. Even though pectin has various applications in the food manufacturing industry, consumers have a negative perception upon learning that strong acids are used in pectin extraction. Furthermore, high acidity speeds up corrosion and rust formation of the apparatus, leading to water pollution which contributes to environmental concerns.
The present study reports the lab-scale procedure for extraction of pectin from the waste industrial apple pomace using deep eutectic solvents (DESs) as extraction medium. DESs turned to be an excellent choice for extraction because they are non-volatile at room temperature and non-toxic, while the majority of DESs are water-miscible depending on their components. The process consisted of the processing of apples, employing milling, enzymatic digestion and pressing. The further analysis included temperature and ultrasound assisted extraction and purification of pectin as well as the detailed physicochemical analysis of the obtained product. The applied procedure has resulted in satisfactory yields under mild extraction conditions, optimal extraction time and industrially preferred properties of the isolated pectin.
PB  - Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering
C3  - Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023
T1  - Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies
SP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6861
ER  - 

@conference{
author = "Savić, Sanja and Pantić, Olga and Vicente, Filipa A. and Novak, Uroš and Likozar, Blaž and Panić, Vesna and Marković, Maja and Spasojević, Pavle",
year = "2023",
abstract = "Fruits are the most utilized commodities among all horticultural crops. They are consumed raw, minimally processed, due to their nutrients and health-promoting compounds. With the growing population and changing diet habits, the production and processing of fruits, have increased very significantly to fulfil the increasing demands. Significant losses and waste in the fresh and processing industries are becoming a serious nutritional, economical, and environmental problem. The fruit waste is composed mainly of seed, skin, rind, and pomace, containing good sources of potentially valuable bioactive compounds. The apple pomace is rich in pectic substances and represents important raw material for pectin production all around the world. For example, the portion of residual apple pomace makes about 13 % of the total waste material and on the basis of dry mass, it contains 10–15% pectin. Currently, it is either used for animal feeding or is disposed of as an industrial waste. The extraction of pectin is usually performed using mineral acids, yielding a reasonable quantity of product while also saving time in the process. Even though pectin has various applications in the food manufacturing industry, consumers have a negative perception upon learning that strong acids are used in pectin extraction. Furthermore, high acidity speeds up corrosion and rust formation of the apparatus, leading to water pollution which contributes to environmental concerns.
The present study reports the lab-scale procedure for extraction of pectin from the waste industrial apple pomace using deep eutectic solvents (DESs) as extraction medium. DESs turned to be an excellent choice for extraction because they are non-volatile at room temperature and non-toxic, while the majority of DESs are water-miscible depending on their components. The process consisted of the processing of apples, employing milling, enzymatic digestion and pressing. The further analysis included temperature and ultrasound assisted extraction and purification of pectin as well as the detailed physicochemical analysis of the obtained product. The applied procedure has resulted in satisfactory yields under mild extraction conditions, optimal extraction time and industrially preferred properties of the isolated pectin.",
publisher = "Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering",
journal = "Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023",
title = "Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies",
pages = "25",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6861"
}

Savić, S., Pantić, O., Vicente, F. A., Novak, U., Likozar, B., Panić, V., Marković, M.,& Spasojević, P.. (2023). Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies. in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023
Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering., 25.
https://hdl.handle.net/21.15107/rcub_technorep_6861

Savić S, Pantić O, Vicente FA, Novak U, Likozar B, Panić V, Marković M, Spasojević P. Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies. in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023. 2023;:25.
https://hdl.handle.net/21.15107/rcub_technorep_6861 .

Savić, Sanja, Pantić, Olga, Vicente, Filipa A., Novak, Uroš, Likozar, Blaž, Panić, Vesna, Marković, Maja, Spasojević, Pavle, "Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies" in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023 (2023):25,
https://hdl.handle.net/21.15107/rcub_technorep_6861 .

TY  - CONF
AU  - Pantić, Olga
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević Savković, Milica
AU  - Savić, Sanja
AU  - Kalagasidis Krušić, Melina
AU  - Spasojević, Pavle
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6867
AB  - Biocomposites are materials that are composed of a matrix and fillers both of which derived from
renewable resources. They offer an alternative to traditional petroleum-based composites and
have gained interest due to potential environmental benefits and sustaina
idea, itaconic and succinic acids and propylene glycol were used in the synthesis of a biobased
unsaturated polyester, diluted with biobased reactive diluent, dimethyl itaconate, to cure fully
biobased unsaturated polyester resin (UPR). Despite having a low environmental impact, the
mechanical properties of biobased UPRs are not considered commercially viable compared to
their petroleum-based counterparts. To lessen the discrepancy between the two, nanocellulose
(NC) was incorporated into the biobased UPR in two ways. Firstly, NC was added during synthesis,
while secondly it was added after the synthesis of UPR was completed. Both series implied the
use of three different quan s of NC (1, 2, 3 wt.%). FTIR spectroscopy, gel content analysis,
SEM, dynamic mechanical analysis, and uniaxial tensile test were used to characterize obtained
biocomposites. It was demonstrcted that when NC was added during the synthesis, it had no
effect on UPR viscosity. On the other hand, adding NC after the synthesis significantly increased
viscosity. Overall results showed that higher quantities of NC increased tensile strength, storage
modulus at lower frequencies, and decreased glass transition temperature.
PB  - University of North Texas
C3  - Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
T1  - ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS
SP  - 52
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6867
ER  - 

@conference{
author = "Pantić, Olga and Panić, Vesna and Marković, Maja and Spasojević Savković, Milica and Savić, Sanja and Kalagasidis Krušić, Melina and Spasojević, Pavle",
year = "2023",
abstract = "Biocomposites are materials that are composed of a matrix and fillers both of which derived from
renewable resources. They offer an alternative to traditional petroleum-based composites and
have gained interest due to potential environmental benefits and sustaina
idea, itaconic and succinic acids and propylene glycol were used in the synthesis of a biobased
unsaturated polyester, diluted with biobased reactive diluent, dimethyl itaconate, to cure fully
biobased unsaturated polyester resin (UPR). Despite having a low environmental impact, the
mechanical properties of biobased UPRs are not considered commercially viable compared to
their petroleum-based counterparts. To lessen the discrepancy between the two, nanocellulose
(NC) was incorporated into the biobased UPR in two ways. Firstly, NC was added during synthesis,
while secondly it was added after the synthesis of UPR was completed. Both series implied the
use of three different quan s of NC (1, 2, 3 wt.%). FTIR spectroscopy, gel content analysis,
SEM, dynamic mechanical analysis, and uniaxial tensile test were used to characterize obtained
biocomposites. It was demonstrcted that when NC was added during the synthesis, it had no
effect on UPR viscosity. On the other hand, adding NC after the synthesis significantly increased
viscosity. Overall results showed that higher quantities of NC increased tensile strength, storage
modulus at lower frequencies, and decreased glass transition temperature.",
publisher = "University of North Texas",
journal = "Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France",
title = "ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS",
pages = "52",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6867"
}

Pantić, O., Panić, V., Marković, M., Spasojević Savković, M., Savić, S., Kalagasidis Krušić, M.,& Spasojević, P.. (2023). ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
University of North Texas., 52.
https://hdl.handle.net/21.15107/rcub_technorep_6867

Pantić O, Panić V, Marković M, Spasojević Savković M, Savić S, Kalagasidis Krušić M, Spasojević P. ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France. 2023;:52.
https://hdl.handle.net/21.15107/rcub_technorep_6867 .

Pantić, Olga, Panić, Vesna, Marković, Maja, Spasojević Savković, Milica, Savić, Sanja, Kalagasidis Krušić, Melina, Spasojević, Pavle, "ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS" in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France (2023):52,
https://hdl.handle.net/21.15107/rcub_technorep_6867 .

TY  - CONF
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Pantić, Olga
AU  - Marković, Maja
AU  - Vicente, Filipa A.
AU  - Novak, Uroš
AU  - Likozar, Blaž
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6868
AB  - The present study reports the development of the lab-scale procedure for extraction of pectin
from the waste industrial apple pomace using deep eutectic solvents (DES) as extraction medium.
Compared with conventional extraction solvents, DES have attracted considerable attention due
to the fact that they not only are eco-friendly, non-toxic, and biodegradable organic compounds

but also have a low cost, being easy to produce in the own laboratory. The research included a’

screening study that covered extraction using different DES based on choline chloride ([Ch]Cl) as
hydrogen bond acceptor (HBA), and organic acids as hydrogen bond donors (HBD). The applied
HBA:HBD molar ratio was 1:2. The pectin was extracted by employing solid-liquid (SLE) and
ultrasound assisted extraction (UAE). The DES based on [Ch]Cl and lactic acid turned to be most
promising in terms of obtained extraction yields, that reached 35% when applying UAE. It has
been shown that structure of HBD plays a major role with its hydrophilicity and hydrophobicity
influencing the number of established bonds. The HBD with lower amount of carbon molecules
and higher number of hydroxyl and carboxylic groups formed DES that are more efficient at
extracting pectin. Hidotopy study showed significant influence of water on pectin yield due to
more prominent hydrogen interaction established in the system. Depending on the type of DES,
the highest yields were obtained at 30-50 wt% of water, while an additional increase in water
content resulted in reduced yield. The structural properties of extracted pectin, including
esterification degree, was determined using FTIR spectroscopy.
PB  - University of North Texas
C3  - Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
T1  - PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE
SP  - 54
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6868
ER  - 

@conference{
author = "Savić, Sanja and Panić, Vesna and Spasojević, Pavle and Pantić, Olga and Marković, Maja and Vicente, Filipa A. and Novak, Uroš and Likozar, Blaž",
year = "2023",
abstract = "The present study reports the development of the lab-scale procedure for extraction of pectin
from the waste industrial apple pomace using deep eutectic solvents (DES) as extraction medium.
Compared with conventional extraction solvents, DES have attracted considerable attention due
to the fact that they not only are eco-friendly, non-toxic, and biodegradable organic compounds

but also have a low cost, being easy to produce in the own laboratory. The research included a’

screening study that covered extraction using different DES based on choline chloride ([Ch]Cl) as
hydrogen bond acceptor (HBA), and organic acids as hydrogen bond donors (HBD). The applied
HBA:HBD molar ratio was 1:2. The pectin was extracted by employing solid-liquid (SLE) and
ultrasound assisted extraction (UAE). The DES based on [Ch]Cl and lactic acid turned to be most
promising in terms of obtained extraction yields, that reached 35% when applying UAE. It has
been shown that structure of HBD plays a major role with its hydrophilicity and hydrophobicity
influencing the number of established bonds. The HBD with lower amount of carbon molecules
and higher number of hydroxyl and carboxylic groups formed DES that are more efficient at
extracting pectin. Hidotopy study showed significant influence of water on pectin yield due to
more prominent hydrogen interaction established in the system. Depending on the type of DES,
the highest yields were obtained at 30-50 wt% of water, while an additional increase in water
content resulted in reduced yield. The structural properties of extracted pectin, including
esterification degree, was determined using FTIR spectroscopy.",
publisher = "University of North Texas",
journal = "Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France",
title = "PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE",
pages = "54",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6868"
}

Savić, S., Panić, V., Spasojević, P., Pantić, O., Marković, M., Vicente, F. A., Novak, U.,& Likozar, B.. (2023). PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
University of North Texas., 54.
https://hdl.handle.net/21.15107/rcub_technorep_6868

Savić S, Panić V, Spasojević P, Pantić O, Marković M, Vicente FA, Novak U, Likozar B. PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France. 2023;:54.
https://hdl.handle.net/21.15107/rcub_technorep_6868 .

Savić, Sanja, Panić, Vesna, Spasojević, Pavle, Pantić, Olga, Marković, Maja, Vicente, Filipa A., Novak, Uroš, Likozar, Blaž, "PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE" in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France (2023):54,
https://hdl.handle.net/21.15107/rcub_technorep_6868 .

TY  - CONF
AU  - Spasojević, Pavle
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Spasojević Savković, Milica
AU  - Marković, Maja
AU  - Pantić, Olga
AU  - Popović, Ivanka
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6869
AB  - Emerging efforts in the field of biocomposites established novel combinations of biobased matrix
materials and reinforcements, as well as the optimization of curing conditions, to enhance their
properties and expand their range of applications. The curing conditions of nanocellulose

reinforced biobased unsaturated polyester resin (UPR) based on itaconic acid and it derivatives’

were examined within this work. Since the curing process of biobased UPR requires the presence
of both an initiator and an activator, the optimization was conducted in two phases. The first
phase investigated the effect of different concentrations of an activator, cobalt octoate, (0.5, 1.0
and 1.5 mass%) with a constant concentration of an initiator, a mixture of dibenzoyl peroxide
(DBP) and methyl ethyl ketone peroxide (MEKP) (DBP to MEKP ratio 1.5:1.0; 2.5 mass% total).
The ratios of DBP and MEKP were varied in the second phase of experiments in the following
manner: 2.5:0,1.75:0.75, 0.75:1.75 and 0:2.5 (keeping the total initiator mass% of 2.5). The effect
of the different curing conditions on the UPR properties was monitored via the gel content
analysis and the uniaxial tensile test. It was shown that the increase in activator concentration
led to the decrease in gel content, tensile strength and elongation at the break. On the other
hand, the increase in dibenzoyl peroxide concentration in the initiator mixture revealed
enhanced overall mechanical properties. The optimal curing conditions were found to be 0.5
mass% of activator, and 1.75:0.75 DBP to MEKP ratio in the initiator mixture. Thereby obtained
UPR biocomposite showed a significant increase in elastic attributes suggesting that these
materials can be used where high elasticity is needed.
C3  - Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
T1  - OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN
SP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6869
ER  - 

@conference{
author = "Spasojević, Pavle and Savić, Sanja and Panić, Vesna and Spasojević Savković, Milica and Marković, Maja and Pantić, Olga and Popović, Ivanka",
year = "2023",
abstract = "Emerging efforts in the field of biocomposites established novel combinations of biobased matrix
materials and reinforcements, as well as the optimization of curing conditions, to enhance their
properties and expand their range of applications. The curing conditions of nanocellulose

reinforced biobased unsaturated polyester resin (UPR) based on itaconic acid and it derivatives’

were examined within this work. Since the curing process of biobased UPR requires the presence
of both an initiator and an activator, the optimization was conducted in two phases. The first
phase investigated the effect of different concentrations of an activator, cobalt octoate, (0.5, 1.0
and 1.5 mass%) with a constant concentration of an initiator, a mixture of dibenzoyl peroxide
(DBP) and methyl ethyl ketone peroxide (MEKP) (DBP to MEKP ratio 1.5:1.0; 2.5 mass% total).
The ratios of DBP and MEKP were varied in the second phase of experiments in the following
manner: 2.5:0,1.75:0.75, 0.75:1.75 and 0:2.5 (keeping the total initiator mass% of 2.5). The effect
of the different curing conditions on the UPR properties was monitored via the gel content
analysis and the uniaxial tensile test. It was shown that the increase in activator concentration
led to the decrease in gel content, tensile strength and elongation at the break. On the other
hand, the increase in dibenzoyl peroxide concentration in the initiator mixture revealed
enhanced overall mechanical properties. The optimal curing conditions were found to be 0.5
mass% of activator, and 1.75:0.75 DBP to MEKP ratio in the initiator mixture. Thereby obtained
UPR biocomposite showed a significant increase in elastic attributes suggesting that these
materials can be used where high elasticity is needed.",
journal = "Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France",
title = "OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN",
pages = "56",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6869"
}

Spasojević, P., Savić, S., Panić, V., Spasojević Savković, M., Marković, M., Pantić, O.,& Popović, I.. (2023). OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France, 56.
https://hdl.handle.net/21.15107/rcub_technorep_6869

Spasojević P, Savić S, Panić V, Spasojević Savković M, Marković M, Pantić O, Popović I. OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France. 2023;:56.
https://hdl.handle.net/21.15107/rcub_technorep_6869 .

Spasojević, Pavle, Savić, Sanja, Panić, Vesna, Spasojević Savković, Milica, Marković, Maja, Pantić, Olga, Popović, Ivanka, "OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN" in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France (2023):56,
https://hdl.handle.net/21.15107/rcub_technorep_6869 .

TY  - CONF
AU  - Marković, Maja D.
AU  - Miladinović, Nina N.
AU  - Savić, Sanja I.
AU  - Panić, Vesna V.
AU  - Pantić, Olga J.
AU  - Spasojević, Pavle M.
AU  - Pjanović, Rada V.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7300
AB  - Controlled release of drugs is a promising tool for improvement of therapy for many 
diseases because drug concentration for long period of time is kept constant, whereas
number of drug doses and side effects are reduced. pH sensitive hydrogels, such as 
hydrogels based on poly(methacrylic acid) (PMAA), are extensively employed for 
drug delivery. The synthesis of the hydrogel is one of the most important factors
which affect encapsulation of drug and its bioactivity. In present study, we investigate 
if the encapsulation of poorly water-soluble active substance (caffeine) during the 
synthesis of PMAA hydrogels, and later its controlled release from the PMAA
hydrogels, can be achieved by applying novel ”green” method for the hydrogels 
preparation. The PMAA hydrogels with encapsulated caffeine and various amount of 
crosslinker are prepared by free radical polymerisation in aqueous solution and 
ambient conditions by using novel initiation system based on hydrogen peroxide and 
vitamin C. The swelling behaviour of the PMAA hydrogels and controlled release of 
caffeine are investigated in two media with pH 1 and pH 6.8 as simulation of human 
stomach and intestines, respectively. The SDeq values of the PMAA hydrogels are
eight times higher in the medium with pH 6.8 and as a consequence, three times higher
amount of caffeine is released in that medium. The increase in the crosslinker amount 
leads to the decrease of SDeq values of the PMAA hydrogels and amount of released 
caffeine. The results show that the PMAA hydrogels have great potential for controlled
release of poorly water-soluble drugs.
PB  - Leskovac : Faculty of Technology
C3  - Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023
T1  - POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE
SP  - 97
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7300
ER  - 

@conference{
author = "Marković, Maja D. and Miladinović, Nina N. and Savić, Sanja I. and Panić, Vesna V. and Pantić, Olga J. and Spasojević, Pavle M. and Pjanović, Rada V.",
year = "2023",
abstract = "Controlled release of drugs is a promising tool for improvement of therapy for many 
diseases because drug concentration for long period of time is kept constant, whereas
number of drug doses and side effects are reduced. pH sensitive hydrogels, such as 
hydrogels based on poly(methacrylic acid) (PMAA), are extensively employed for 
drug delivery. The synthesis of the hydrogel is one of the most important factors
which affect encapsulation of drug and its bioactivity. In present study, we investigate 
if the encapsulation of poorly water-soluble active substance (caffeine) during the 
synthesis of PMAA hydrogels, and later its controlled release from the PMAA
hydrogels, can be achieved by applying novel ”green” method for the hydrogels 
preparation. The PMAA hydrogels with encapsulated caffeine and various amount of 
crosslinker are prepared by free radical polymerisation in aqueous solution and 
ambient conditions by using novel initiation system based on hydrogen peroxide and 
vitamin C. The swelling behaviour of the PMAA hydrogels and controlled release of 
caffeine are investigated in two media with pH 1 and pH 6.8 as simulation of human 
stomach and intestines, respectively. The SDeq values of the PMAA hydrogels are
eight times higher in the medium with pH 6.8 and as a consequence, three times higher
amount of caffeine is released in that medium. The increase in the crosslinker amount 
leads to the decrease of SDeq values of the PMAA hydrogels and amount of released 
caffeine. The results show that the PMAA hydrogels have great potential for controlled
release of poorly water-soluble drugs.",
publisher = "Leskovac : Faculty of Technology",
journal = "Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023",
title = "POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE",
pages = "97",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7300"
}

Marković, M. D., Miladinović, N. N., Savić, S. I., Panić, V. V., Pantić, O. J., Spasojević, P. M.,& Pjanović, R. V.. (2023). POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE. in Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023
Leskovac : Faculty of Technology., 97.
https://hdl.handle.net/21.15107/rcub_technorep_7300

Marković MD, Miladinović NN, Savić SI, Panić VV, Pantić OJ, Spasojević PM, Pjanović RV. POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE. in Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023. 2023;:97.
https://hdl.handle.net/21.15107/rcub_technorep_7300 .

Marković, Maja D., Miladinović, Nina N., Savić, Sanja I., Panić, Vesna V., Pantić, Olga J., Spasojević, Pavle M., Pjanović, Rada V., "POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE" in Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023 (2023):97,
https://hdl.handle.net/21.15107/rcub_technorep_7300 .

TY  - CONF
AU  - Jovanović, Jelena D.
AU  - Panić, Vesna V.
AU  - Spasojević, Pavle M.
AU  - Popović, Ivanka G.
AU  - Adnađević, Borivoj K.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6977
AB  - Composite hydrogels are the subject of intensive research due to there specific 3D cross-linked
structure with extraordinary physical and chemical properties which enables variety of applications In
spite of increasing interest for using different external fields in physical-chemical processes, three are
no available literature data about the effects of external fields on swelling and swelling kinetics of
hydrogels. Therefore, the effects of (conventional) thermal (TH), ultrasonic (US) and microwave (MW)
fields, on the swelling degree and swelling kinetics. A sample of poly(methacrylic acid) (PMAA) xerogel
with 10%wt of LTA-zeolite (PMMA-LTA) was synthesized and thoroughly characterized. The
isothermal kinetic swelling curves were determined within a temperature range T= 293-323K in the
TH, US and MW fields. The results were well fitted with the Peppas’ kinetic model. At all applied
fields, with an increase in temperature, there is an increase in the equilibrium swelling degree (SDeq)
and the swelling rate constant (k), while the parameter of Pepass's model (n) decreases. The maximum
value of SDeq and parameter n is achieved at TH, while the US assisted process leads to the maximum
value of k. The minimum value of the activation energy (Ea) and at the same time the maximum value
of the pre-exponential factor (lnA) lnA were achieved by applying the MW field. The influence of US
and MW fields on the diffusion of water molecules through the polymer network, activation of the
polymer network for swelling and relaxation of the polymer network was analysed.
PB  - Yuktan Technologies
C3  - Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain
T1  - The Effects of Different Physical Fields on Swelling Kinetics of PMAA-LTA Zeolite Composite Hydrogel Under Controlled Isothermal Conditions
SP  - 63
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6977
ER  - 

@conference{
author = "Jovanović, Jelena D. and Panić, Vesna V. and Spasojević, Pavle M. and Popović, Ivanka G. and Adnađević, Borivoj K.",
year = "2023",
abstract = "Composite hydrogels are the subject of intensive research due to there specific 3D cross-linked
structure with extraordinary physical and chemical properties which enables variety of applications In
spite of increasing interest for using different external fields in physical-chemical processes, three are
no available literature data about the effects of external fields on swelling and swelling kinetics of
hydrogels. Therefore, the effects of (conventional) thermal (TH), ultrasonic (US) and microwave (MW)
fields, on the swelling degree and swelling kinetics. A sample of poly(methacrylic acid) (PMAA) xerogel
with 10%wt of LTA-zeolite (PMMA-LTA) was synthesized and thoroughly characterized. The
isothermal kinetic swelling curves were determined within a temperature range T= 293-323K in the
TH, US and MW fields. The results were well fitted with the Peppas’ kinetic model. At all applied
fields, with an increase in temperature, there is an increase in the equilibrium swelling degree (SDeq)
and the swelling rate constant (k), while the parameter of Pepass's model (n) decreases. The maximum
value of SDeq and parameter n is achieved at TH, while the US assisted process leads to the maximum
value of k. The minimum value of the activation energy (Ea) and at the same time the maximum value
of the pre-exponential factor (lnA) lnA were achieved by applying the MW field. The influence of US
and MW fields on the diffusion of water molecules through the polymer network, activation of the
polymer network for swelling and relaxation of the polymer network was analysed.",
publisher = "Yuktan Technologies",
journal = "Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain",
title = "The Effects of Different Physical Fields on Swelling Kinetics of PMAA-LTA Zeolite Composite Hydrogel Under Controlled Isothermal Conditions",
pages = "63",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6977"
}

Jovanović, J. D., Panić, V. V., Spasojević, P. M., Popović, I. G.,& Adnađević, B. K.. (2023). The Effects of Different Physical Fields on Swelling Kinetics of PMAA-LTA Zeolite Composite Hydrogel Under Controlled Isothermal Conditions. in Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain
Yuktan Technologies., 63.
https://hdl.handle.net/21.15107/rcub_technorep_6977

Jovanović JD, Panić VV, Spasojević PM, Popović IG, Adnađević BK. The Effects of Different Physical Fields on Swelling Kinetics of PMAA-LTA Zeolite Composite Hydrogel Under Controlled Isothermal Conditions. in Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain. 2023;:63.
https://hdl.handle.net/21.15107/rcub_technorep_6977 .

Jovanović, Jelena D., Panić, Vesna V., Spasojević, Pavle M., Popović, Ivanka G., Adnađević, Borivoj K., "The Effects of Different Physical Fields on Swelling Kinetics of PMAA-LTA Zeolite Composite Hydrogel Under Controlled Isothermal Conditions" in Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain (2023):63,
https://hdl.handle.net/21.15107/rcub_technorep_6977 .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Panić, Vesna V.
AU  - Savić, Sanja I.
AU  - Ugrinović, Vukašin Đ.
AU  - Pjanović, Rada V.
AU  - Spasojević, Milica M.
AU  - Spasojević, Pavle M.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5092
AB  - Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.
PB  - Elsevier
T2  - Microporous and Mesoporous Materials
T1  - Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery
SP  - 111817
VL  - 335
DO  - 10.1016/j.micromeso.2022.111817
ER  - 

@article{
author = "Marković, Maja D. and Panić, Vesna V. and Savić, Sanja I. and Ugrinović, Vukašin Đ. and Pjanović, Rada V. and Spasojević, Milica M. and Spasojević, Pavle M.",
year = "2022",
abstract = "Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.",
publisher = "Elsevier",
journal = "Microporous and Mesoporous Materials",
title = "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery",
pages = "111817",
volume = "335",
doi = "10.1016/j.micromeso.2022.111817"
}

Marković, M. D., Panić, V. V., Savić, S. I., Ugrinović, V. Đ., Pjanović, R. V., Spasojević, M. M.,& Spasojević, P. M.. (2022). Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials
Elsevier., 335, 111817.
https://doi.org/10.1016/j.micromeso.2022.111817

Marković MD, Panić VV, Savić SI, Ugrinović VĐ, Pjanović RV, Spasojević MM, Spasojević PM. Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials. 2022;335:111817.
doi:10.1016/j.micromeso.2022.111817 .

Marković, Maja D., Panić, Vesna V., Savić, Sanja I., Ugrinović, Vukašin Đ., Pjanović, Rada V., Spasojević, Milica M., Spasojević, Pavle M., "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery" in Microporous and Mesoporous Materials, 335 (2022):111817,
https://doi.org/10.1016/j.micromeso.2022.111817 . .

TY  - JOUR
AU  - Pantić, Olga
AU  - Spasojević, Milica
AU  - Džunuzović, Enis
AU  - Nikolić, Marija S.
AU  - Savić, Sanja
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5160
AB  - The scope of the present study was to prepare fully bio-based unsaturated polyester resins (UPRs) with comparable properties to the commercial formulations. The focus was set on the determination of the optimal prepolymer formulation using the same set of diacids (itaconic and succinic acid) and different diols (propylene glycol, isosorbide and neopentyl glycol) or its equimolar mixtures, keeping the fixed molar ratio of 1:1:2.1 in all feed compositions. Instead of commonly used styrene, bio-based dimethyl itaconate was used as a reactive diluent (RD). The rheology of the obtained resins was studied in detail. The effect of the used diol on structural (FTIR), thermal (DSC), thermomechanical (DMA), and mechanical (tensile) properties was explained. The properties of UPRs were found to be highly dependent on the diol used in the prepolymer formulation. The UPR with an equimolar ratio of propylene glycol and neopentyl glycol was shown to be the most promising candidate to compete with the commercial petroleum-based resins.
PB  - MDPI
T2  - Polymers
T1  - The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters
IS  - 15
SP  - 2970
VL  - 14
DO  - https://doi.org/10.3390/polym14152970
ER  - 

@article{
author = "Pantić, Olga and Spasojević, Milica and Džunuzović, Enis and Nikolić, Marija S. and Savić, Sanja and Marković, Maja and Spasojević, Pavle",
year = "2022",
abstract = "The scope of the present study was to prepare fully bio-based unsaturated polyester resins (UPRs) with comparable properties to the commercial formulations. The focus was set on the determination of the optimal prepolymer formulation using the same set of diacids (itaconic and succinic acid) and different diols (propylene glycol, isosorbide and neopentyl glycol) or its equimolar mixtures, keeping the fixed molar ratio of 1:1:2.1 in all feed compositions. Instead of commonly used styrene, bio-based dimethyl itaconate was used as a reactive diluent (RD). The rheology of the obtained resins was studied in detail. The effect of the used diol on structural (FTIR), thermal (DSC), thermomechanical (DMA), and mechanical (tensile) properties was explained. The properties of UPRs were found to be highly dependent on the diol used in the prepolymer formulation. The UPR with an equimolar ratio of propylene glycol and neopentyl glycol was shown to be the most promising candidate to compete with the commercial petroleum-based resins.",
publisher = "MDPI",
journal = "Polymers",
title = "The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters",
number = "15",
pages = "2970",
volume = "14",
doi = "https://doi.org/10.3390/polym14152970"
}

Pantić, O., Spasojević, M., Džunuzović, E., Nikolić, M. S., Savić, S., Marković, M.,& Spasojević, P.. (2022). The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters. in Polymers
MDPI., 14(15), 2970.
https://doi.org/https://doi.org/10.3390/polym14152970

Pantić O, Spasojević M, Džunuzović E, Nikolić MS, Savić S, Marković M, Spasojević P. The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters. in Polymers. 2022;14(15):2970.
doi:https://doi.org/10.3390/polym14152970 .

Pantić, Olga, Spasojević, Milica, Džunuzović, Enis, Nikolić, Marija S., Savić, Sanja, Marković, Maja, Spasojević, Pavle, "The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters" in Polymers, 14, no. 15 (2022):2970,
https://doi.org/https://doi.org/10.3390/polym14152970 . .

TY  - CONF
AU  - Pantić, Olga J.
AU  - Spasojević, Pavle M.
AU  - Panić, Vesna V.
AU  - Marković, Maja D.
AU  - Savić, Sanja I.
AU  - Kalagasidis Krušić, Melina T.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5159
AB  - Pectin and pectin derived oligosaccharides can be obtained from waste apple pomace
(biomass). Traditional method for pectin extraction involves use of diluted mineral acids at
elevated temperatures, with yields of about 10 to 15%. As an alternative to conventional
methods, the use of eutectic solvents is increasing because of their superior properties
when it comes to targeted extraction of certain components from biomass. The aim of this
paper is ultrasound assisted extraction of pectin from waste apple pomace using choline
chloride based eutectic solvents and lactic acid. Properties of extracted products were
examined using FTIR spectroscopy and differential scanning calorimetry.
PB  - Serbian Chemical Society
C3  - 58th Meeting of the Serbian Chemical Society
T1  - Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5159
ER  - 

@conference{
author = "Pantić, Olga J. and Spasojević, Pavle M. and Panić, Vesna V. and Marković, Maja D. and Savić, Sanja I. and Kalagasidis Krušić, Melina T.",
year = "2022",
abstract = "Pectin and pectin derived oligosaccharides can be obtained from waste apple pomace
(biomass). Traditional method for pectin extraction involves use of diluted mineral acids at
elevated temperatures, with yields of about 10 to 15%. As an alternative to conventional
methods, the use of eutectic solvents is increasing because of their superior properties
when it comes to targeted extraction of certain components from biomass. The aim of this
paper is ultrasound assisted extraction of pectin from waste apple pomace using choline
chloride based eutectic solvents and lactic acid. Properties of extracted products were
examined using FTIR spectroscopy and differential scanning calorimetry.",
publisher = "Serbian Chemical Society",
journal = "58th Meeting of the Serbian Chemical Society",
title = "Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5159"
}

Pantić, O. J., Spasojević, P. M., Panić, V. V., Marković, M. D., Savić, S. I.,& Kalagasidis Krušić, M. T.. (2022). Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in 58th Meeting of the Serbian Chemical Society
Serbian Chemical Society..
https://hdl.handle.net/21.15107/rcub_technorep_5159

Pantić OJ, Spasojević PM, Panić VV, Marković MD, Savić SI, Kalagasidis Krušić MT. Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in 58th Meeting of the Serbian Chemical Society. 2022;.
https://hdl.handle.net/21.15107/rcub_technorep_5159 .

Pantić, Olga J., Spasojević, Pavle M., Panić, Vesna V., Marković, Maja D., Savić, Sanja I., Kalagasidis Krušić, Melina T., "Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents" in 58th Meeting of the Serbian Chemical Society (2022),
https://hdl.handle.net/21.15107/rcub_technorep_5159 .

TY  - CONF
AU  - Pantić, Olga J.
AU  - Spasojević, Pavle M.
AU  - Marković, Maja D.
AU  - Savić, Sanja I.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5229
AB  - Processing of waste by-products of agricultural origin generated by different kinds of
industries can entail environmental problems. Waste apple pomace (biomass) could play
an important role in pectin production, offering economic advantages and decreasing the
environmental impact. Pectin and pectin derived oligosaccharides have many
applications in food and pharmaceutical products as gelling agents and stabilizers.
Traditional method for pectin extraction involved the use of diluted mineral acids at
elevated temperatures, with yields of about 10 to 15%. Because of the relatively long
period of exposure to direct heating, thermal degradation of pectin often occurs in this
process. The use of deep eutectic solvents could be the solution to this problem. Deep
eutectic solvents have shown superior properties when it comes to targeted extraction of
certain components from biomass, while providing mild conditions when compared to
conventional methods. The aim of this paper is thermal extraction of pectin from waste
apple pomace using choline chloride based deep eutectic solvents combined with
different acids (oxalic acid, lactic acid and malic acid). Properties of extracted products
were examined using FTIR spectroscopy and differential scanning calorimetry.
PB  - Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia
C3  - 8th Conference of Young Chemists of Serbia Book of Abstract
T1  - Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents
SP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5229
ER  - 

@conference{
author = "Pantić, Olga J. and Spasojević, Pavle M. and Marković, Maja D. and Savić, Sanja I.",
year = "2022",
abstract = "Processing of waste by-products of agricultural origin generated by different kinds of
industries can entail environmental problems. Waste apple pomace (biomass) could play
an important role in pectin production, offering economic advantages and decreasing the
environmental impact. Pectin and pectin derived oligosaccharides have many
applications in food and pharmaceutical products as gelling agents and stabilizers.
Traditional method for pectin extraction involved the use of diluted mineral acids at
elevated temperatures, with yields of about 10 to 15%. Because of the relatively long
period of exposure to direct heating, thermal degradation of pectin often occurs in this
process. The use of deep eutectic solvents could be the solution to this problem. Deep
eutectic solvents have shown superior properties when it comes to targeted extraction of
certain components from biomass, while providing mild conditions when compared to
conventional methods. The aim of this paper is thermal extraction of pectin from waste
apple pomace using choline chloride based deep eutectic solvents combined with
different acids (oxalic acid, lactic acid and malic acid). Properties of extracted products
were examined using FTIR spectroscopy and differential scanning calorimetry.",
publisher = "Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia",
journal = "8th Conference of Young Chemists of Serbia Book of Abstract",
title = "Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents",
pages = "66",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5229"
}

Pantić, O. J., Spasojević, P. M., Marković, M. D.,& Savić, S. I.. (2022). Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in 8th Conference of Young Chemists of Serbia Book of Abstract
Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia., 66.
https://hdl.handle.net/21.15107/rcub_technorep_5229

Pantić OJ, Spasojević PM, Marković MD, Savić SI. Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in 8th Conference of Young Chemists of Serbia Book of Abstract. 2022;:66.
https://hdl.handle.net/21.15107/rcub_technorep_5229 .

Pantić, Olga J., Spasojević, Pavle M., Marković, Maja D., Savić, Sanja I., "Thermal extraction of pectin from waste apple pomace using choline chloride based eutectic solvents" in 8th Conference of Young Chemists of Serbia Book of Abstract (2022):66,
https://hdl.handle.net/21.15107/rcub_technorep_5229 .

TY  - CONF
AU  - Pantić, Olga
AU  - Panić, Vesna
AU  - Savić, Sanja
AU  - Marković, Maja
AU  - Kalagasidis Krušić, Melina
AU  - Spasojević, Pavle
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5234
AB  - Replacing styrene with biobased monomers to produce fully biobased unsaturated polyester
resins (UPRs) turned out to be quite a challenging task. Styrene has been recognized as a hazardous
and a potentially carcinogenic substance for human health. Using dimethyl itaconate as an alternative reactive diluent to styrene, which can be obtained from renewable resources, enables low viscosity for easy manipulation of mentioned UPRs. Fully biobased UPRs in question were based on itaconic acid, succinic acid, and propylene glycol, which were then diluted with dimethyl itaconate.
Having in mind that UPRs can be used as a matrix for composite materials, this paper examines the
effect of different weight ratios of spent coffee grounds as a filler. To determine the application of
thus obtained composite materials, characterization consisted of examining mechanical properties
based on viscosity measurements, uniaxial stretching experiments, FTIR spectroscopy and gel content analysis.
PB  - Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) Društvo za procesnu tehniku, Beograd, Srbija
C3  - The 35rd International Congress on Processing Industry, Belgrade, Serbia
T1  - BIOBASED COMPOSITE MATERIALS OBTAINED FROM UNSATURATED POLYESTER RESINS AND WASTE COFFEE
DO  - 10.24094/ptk.022.041
ER  - 

@conference{
author = "Pantić, Olga and Panić, Vesna and Savić, Sanja and Marković, Maja and Kalagasidis Krušić, Melina and Spasojević, Pavle",
year = "2022",
abstract = "Replacing styrene with biobased monomers to produce fully biobased unsaturated polyester
resins (UPRs) turned out to be quite a challenging task. Styrene has been recognized as a hazardous
and a potentially carcinogenic substance for human health. Using dimethyl itaconate as an alternative reactive diluent to styrene, which can be obtained from renewable resources, enables low viscosity for easy manipulation of mentioned UPRs. Fully biobased UPRs in question were based on itaconic acid, succinic acid, and propylene glycol, which were then diluted with dimethyl itaconate.
Having in mind that UPRs can be used as a matrix for composite materials, this paper examines the
effect of different weight ratios of spent coffee grounds as a filler. To determine the application of
thus obtained composite materials, characterization consisted of examining mechanical properties
based on viscosity measurements, uniaxial stretching experiments, FTIR spectroscopy and gel content analysis.",
publisher = "Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) Društvo za procesnu tehniku, Beograd, Srbija",
journal = "The 35rd International Congress on Processing Industry, Belgrade, Serbia",
title = "BIOBASED COMPOSITE MATERIALS OBTAINED FROM UNSATURATED POLYESTER RESINS AND WASTE COFFEE",
doi = "10.24094/ptk.022.041"
}

Pantić, O., Panić, V., Savić, S., Marković, M., Kalagasidis Krušić, M.,& Spasojević, P.. (2022). BIOBASED COMPOSITE MATERIALS OBTAINED FROM UNSATURATED POLYESTER RESINS AND WASTE COFFEE. in The 35rd International Congress on Processing Industry, Belgrade, Serbia
Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) Društvo za procesnu tehniku, Beograd, Srbija..
https://doi.org/10.24094/ptk.022.041

Pantić O, Panić V, Savić S, Marković M, Kalagasidis Krušić M, Spasojević P. BIOBASED COMPOSITE MATERIALS OBTAINED FROM UNSATURATED POLYESTER RESINS AND WASTE COFFEE. in The 35rd International Congress on Processing Industry, Belgrade, Serbia. 2022;.
doi:10.24094/ptk.022.041 .

Pantić, Olga, Panić, Vesna, Savić, Sanja, Marković, Maja, Kalagasidis Krušić, Melina, Spasojević, Pavle, "BIOBASED COMPOSITE MATERIALS OBTAINED FROM UNSATURATED POLYESTER RESINS AND WASTE COFFEE" in The 35rd International Congress on Processing Industry, Belgrade, Serbia (2022),
https://doi.org/10.24094/ptk.022.041 . .

TY  - CONF
AU  - Marković, Maja D.
AU  - Pjanović, Rada V.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Panić, Vesna V.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5643
AB  - Everyday demands for safer and more efficient therapy for many diseases, especially serious ones such as various types of cancer, put various challenges in front of modern science. One of them lies in the fact that numerous anticancer drugs are poorly-water soluble and therefore their encap-sulation and controlled release are quite demanding processes. In the present study, we deepened our research of carrier based on hydrophilic poly(methacrylic acid) modified with amphiphilic ca-sein, in which poorly water-soluble model drug caffeine was encapsulated (PMAC-Caf hydrogels). It was investigated how neutralization degree of methacrylic acid (MAA) and amount of encapsulated caffeine affected swelling behavior of the PMAC-Caf hydrogels and caffeine release. Easy, one pot, simultaneous synthesis of the carrier and the encapsulation of caffeine is presented, obtaining thereby as prepared PMAC-Caf drug delivery system that could respond to the specific demands of the tar-geted delivery of the poorly water-soluble drug - protecting it in the environment which simulated human stomach and releasing it in the environment which simulated human intestines. Changing the synthesis parameters (neutralization degree of MAA and/or amount of encapsulated caffeine) we achieved controlled release of caffeine, indicating that the number of the required doses of the drug in the treatment and its side effects could be reduced. Results showed that the PMAC-Caf drug deliv-ery systems have huge potential for controlled release of poorly water-soluble drugs.
PB  - Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku
C3  - Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji
T1  - CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS
EP  - 24
IS  - 1
SP  - 19
VL  - 35
DO  - https://doi.org/10.24094/ptk.022.019
ER  - 

@conference{
author = "Marković, Maja D. and Pjanović, Rada V. and Spasojević, Pavle M. and Savić, Sanja I. and Panić, Vesna V.",
year = "2022",
abstract = "Everyday demands for safer and more efficient therapy for many diseases, especially serious ones such as various types of cancer, put various challenges in front of modern science. One of them lies in the fact that numerous anticancer drugs are poorly-water soluble and therefore their encap-sulation and controlled release are quite demanding processes. In the present study, we deepened our research of carrier based on hydrophilic poly(methacrylic acid) modified with amphiphilic ca-sein, in which poorly water-soluble model drug caffeine was encapsulated (PMAC-Caf hydrogels). It was investigated how neutralization degree of methacrylic acid (MAA) and amount of encapsulated caffeine affected swelling behavior of the PMAC-Caf hydrogels and caffeine release. Easy, one pot, simultaneous synthesis of the carrier and the encapsulation of caffeine is presented, obtaining thereby as prepared PMAC-Caf drug delivery system that could respond to the specific demands of the tar-geted delivery of the poorly water-soluble drug - protecting it in the environment which simulated human stomach and releasing it in the environment which simulated human intestines. Changing the synthesis parameters (neutralization degree of MAA and/or amount of encapsulated caffeine) we achieved controlled release of caffeine, indicating that the number of the required doses of the drug in the treatment and its side effects could be reduced. Results showed that the PMAC-Caf drug deliv-ery systems have huge potential for controlled release of poorly water-soluble drugs.",
publisher = "Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku",
journal = "Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji",
title = "CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS",
pages = "24-19",
number = "1",
volume = "35",
doi = "https://doi.org/10.24094/ptk.022.019"
}

Marković, M. D., Pjanović, R. V., Spasojević, P. M., Savić, S. I.,& Panić, V. V.. (2022). CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS. in Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji
Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku., 35(1), 19-24.
https://doi.org/https://doi.org/10.24094/ptk.022.019

Marković MD, Pjanović RV, Spasojević PM, Savić SI, Panić VV. CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS. in Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji. 2022;35(1):19-24.
doi:https://doi.org/10.24094/ptk.022.019 .

Marković, Maja D., Pjanović, Rada V., Spasojević, Pavle M., Savić, Sanja I., Panić, Vesna V., "CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS" in Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji, 35, no. 1 (2022):19-24,
https://doi.org/https://doi.org/10.24094/ptk.022.019 . .

TY  - CONF
AU  - Pantić, Olga
AU  - Panić, Vesna
AU  - Savić, Sanja
AU  - Marković, Maja
AU  - Kalagasidis Krušić, Melina
AU  - Spasojević, Pavle
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6863
AB  - Using natural fillers can provide several benefits as they are abundant, low cost, and non-toxic. In
this paper two different natural fillers were examined, rosehip seed flour and hemp fibres, both of
which were varied in weight ratios. A highly biobased unsaturated polyester resin was synthesized as
a matrix. Characterization of thus obtained composite materials consisted of examining mechanical
properties by uniaxial tensile test, FTIR spectroscopy and gel content analysis.
PB  - Banja Luka : University in Banjaluka, Faculty of Technology
C3  - Book of proceedings / International scientific conference, XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka
T1  - BIOBASED UNSATURATED POLYESTER RESINS REINFORCED WITH NATURAL FILLERS
EP  - 55
SP  - 51
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6863
ER  - 

@conference{
author = "Pantić, Olga and Panić, Vesna and Savić, Sanja and Marković, Maja and Kalagasidis Krušić, Melina and Spasojević, Pavle",
year = "2022",
abstract = "Using natural fillers can provide several benefits as they are abundant, low cost, and non-toxic. In
this paper two different natural fillers were examined, rosehip seed flour and hemp fibres, both of
which were varied in weight ratios. A highly biobased unsaturated polyester resin was synthesized as
a matrix. Characterization of thus obtained composite materials consisted of examining mechanical
properties by uniaxial tensile test, FTIR spectroscopy and gel content analysis.",
publisher = "Banja Luka : University in Banjaluka, Faculty of Technology",
journal = "Book of proceedings / International scientific conference, XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka",
title = "BIOBASED UNSATURATED POLYESTER RESINS REINFORCED WITH NATURAL FILLERS",
pages = "55-51",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6863"
}

Pantić, O., Panić, V., Savić, S., Marković, M., Kalagasidis Krušić, M.,& Spasojević, P.. (2022). BIOBASED UNSATURATED POLYESTER RESINS REINFORCED WITH NATURAL FILLERS. in Book of proceedings / International scientific conference, XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka
Banja Luka : University in Banjaluka, Faculty of Technology., 51-55.
https://hdl.handle.net/21.15107/rcub_technorep_6863

Pantić O, Panić V, Savić S, Marković M, Kalagasidis Krušić M, Spasojević P. BIOBASED UNSATURATED POLYESTER RESINS REINFORCED WITH NATURAL FILLERS. in Book of proceedings / International scientific conference, XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka. 2022;:51-55.
https://hdl.handle.net/21.15107/rcub_technorep_6863 .

Pantić, Olga, Panić, Vesna, Savić, Sanja, Marković, Maja, Kalagasidis Krušić, Melina, Spasojević, Pavle, "BIOBASED UNSATURATED POLYESTER RESINS REINFORCED WITH NATURAL FILLERS" in Book of proceedings / International scientific conference, XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka (2022):51-55,
https://hdl.handle.net/21.15107/rcub_technorep_6863 .

TY  - JOUR
AU  - Ugrinović, Vukašin
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Seslija, Sanja
AU  - Bozic, Bojan
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
AU  - Veljović, Đorđe
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4984
AB  - Hydrogels are promising materials for biomedical applications due to highly hydrated, porous, permeable structure with possibility to accommodate living cells, drugs, or bioactive factors. In this paper, we reported poly(methacrylic acid) (PMAA)/gelatin IPN hydrogels, synthesized by free-radical polymerization, with adjustable mechanical, structural, physicochemical, and biological characteristics. The influence of methacrylic acid (MAA), gelatin, and cross-linker in the precursor solution on hydrogels properties was investigated. The increasing concentration of MAA, gelatin, and cross-linker led to better mechanical properties, lower porosity, and water content. The compressive mechanical properties of hydrogels were significantly better in comparison to a single-network PMAA hydrogel, while the obtained compressive strength values up to 16 MPa were comparable with tough hydrogels. The increasing concentration of MAA and cross-linker reduced fatigue resistance and degradability, while the increase in gelatin content acted in the opposite way. Swelling tests in different pH conditions demonstrated strong pH-sensibility of the hydrogels, which was more pronounced as MAA concentration was higher, and gelatin and cross-linker concentrations were lower. In addition, the hydrogels strongly promoted the proliferation of human periodontal ligament stem cells and MRC-5 cells as assayed by MTT assay.
T2  - Polymer Engineering and Science
T1  - Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)
DO  - 10.1002/pen.25870
ER  - 

@article{
author = "Ugrinović, Vukašin and Panić, Vesna and Spasojević, Pavle and Seslija, Sanja and Bozic, Bojan and Petrović, Rada and Janaćković, Đorđe and Veljović, Đorđe",
year = "2022",
abstract = "Hydrogels are promising materials for biomedical applications due to highly hydrated, porous, permeable structure with possibility to accommodate living cells, drugs, or bioactive factors. In this paper, we reported poly(methacrylic acid) (PMAA)/gelatin IPN hydrogels, synthesized by free-radical polymerization, with adjustable mechanical, structural, physicochemical, and biological characteristics. The influence of methacrylic acid (MAA), gelatin, and cross-linker in the precursor solution on hydrogels properties was investigated. The increasing concentration of MAA, gelatin, and cross-linker led to better mechanical properties, lower porosity, and water content. The compressive mechanical properties of hydrogels were significantly better in comparison to a single-network PMAA hydrogel, while the obtained compressive strength values up to 16 MPa were comparable with tough hydrogels. The increasing concentration of MAA and cross-linker reduced fatigue resistance and degradability, while the increase in gelatin content acted in the opposite way. Swelling tests in different pH conditions demonstrated strong pH-sensibility of the hydrogels, which was more pronounced as MAA concentration was higher, and gelatin and cross-linker concentrations were lower. In addition, the hydrogels strongly promoted the proliferation of human periodontal ligament stem cells and MRC-5 cells as assayed by MTT assay.",
journal = "Polymer Engineering and Science",
title = "Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)",
doi = "10.1002/pen.25870"
}

Ugrinović, V., Panić, V., Spasojević, P., Seslija, S., Bozic, B., Petrović, R., Janaćković, Đ.,& Veljović, Đ.. (2022). Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid). in Polymer Engineering and Science.
https://doi.org/10.1002/pen.25870

Ugrinović V, Panić V, Spasojević P, Seslija S, Bozic B, Petrović R, Janaćković Đ, Veljović Đ. Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid). in Polymer Engineering and Science. 2022;.
doi:10.1002/pen.25870 .

Ugrinović, Vukašin, Panić, Vesna, Spasojević, Pavle, Seslija, Sanja, Bozic, Bojan, Petrović, Rada, Janaćković, Đorđe, Veljović, Đorđe, "Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)" in Polymer Engineering and Science (2022),
https://doi.org/10.1002/pen.25870 . .

TY  - CONF
AU  - Marković, Maja D.
AU  - Seslija, Sanja I.
AU  - Tadic, Julijana D.
AU  - Spasojević, Pavle M.
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5071
AB  - pH sensitive hydrogels, such as hydrogels based on poly(methacrylic acid) (PMAA), are 
tremendous materials with great properties due to which they have application in many fields, 
such as: targeted drug delivery, tissue engineering, as contact lenses etc. Hydrogels based on 
PMAA are non-toxic, biocompatible and able to absorb and retain huge amount of water. These 
hydrogels are widely used for targeted drug delivery due to their specific pH swelling behavior 
which enable drug release in environments with pH values higher than pKa(PMAA). However, 
poor mechanical properties of hydrogels based on PMAA often limit their application. In order 
to overcome this limitation, green approach is used in present study. Namely, nanocellulose 
(NC) extracted from wood waste material is added to PMAA due to NC non-toxicity, 
biocompatibility, biodegradability and great mechanical properties (which is used for 
improvement of hydrogels mechanical characteristics). Further improvement of hydrogels based 
on PMAA and NC is achieved by adding carboxymethyl cellulose (CMC). CMC is non-toxic, 
biocompatible, biodegradable, pH-sensitive derivate of cellulose widely used in drug delivery 
systems. Drug delivery system prepared in that way can enable controlled release of drug (such 
as lidocaine hydrochloride (Lid)) for prolonged period of time and therefore, reduce the number 
of acquired drug dosages which further lead to safe and efficient drug application. Therefore, 
Lid is encapsulated in hydrogels based on PMAA, NC and CMC (PM/NC-Lid). Lid is local 
anesthetic often used in dental treatment and it is usually administrated by injection, which is 
painful, unpleasant and treatment is often required several dosages. These limitations can be 
overcome by applying PM/NC-Lid hydrogels as buccal patches for controlled release of 
lidocaine hydrochloride. Present study describes green synthesis and characterization of 
PM/NC-Lid hydrogels (using the Fourier Transform Infrared spectroscopy (FT-IR), the 
Scanning Electron Microscopy (SEM) and the single compression tests). Also, PM/NC-Lid 
swelling behavior and Lid controlled release from PM/NC-Lid hydrogels is investigated 
depending on the variable synthesis parameter (NC wt%) in simulated buccal environment. 
Results presented in this study show that PM/NC-Lid hydrogels are promising materials for 
controlled release of anesthetic drugs and for potential application as buccal patches in dental 
treatments.
PB  - UNIVERSITY OF EAST SARAJEVO FACULTY OF TECHNOLOGY Karakaj 34a, 75 400 Zvornik Republic of Srpska, B&H
C3  - VII international congress engineering, environment and materials in  process industry
T1  - Hydrogels based on poly(methacrylic acid) and nanocellulose with potential application in dental treatments
EP  - 434
SP  - 424
DO  - 10.7251/EEMEN2101424M
ER  - 

@conference{
author = "Marković, Maja D. and Seslija, Sanja I. and Tadic, Julijana D. and Spasojević, Pavle M.",
year = "2021",
abstract = "pH sensitive hydrogels, such as hydrogels based on poly(methacrylic acid) (PMAA), are 
tremendous materials with great properties due to which they have application in many fields, 
such as: targeted drug delivery, tissue engineering, as contact lenses etc. Hydrogels based on 
PMAA are non-toxic, biocompatible and able to absorb and retain huge amount of water. These 
hydrogels are widely used for targeted drug delivery due to their specific pH swelling behavior 
which enable drug release in environments with pH values higher than pKa(PMAA). However, 
poor mechanical properties of hydrogels based on PMAA often limit their application. In order 
to overcome this limitation, green approach is used in present study. Namely, nanocellulose 
(NC) extracted from wood waste material is added to PMAA due to NC non-toxicity, 
biocompatibility, biodegradability and great mechanical properties (which is used for 
improvement of hydrogels mechanical characteristics). Further improvement of hydrogels based 
on PMAA and NC is achieved by adding carboxymethyl cellulose (CMC). CMC is non-toxic, 
biocompatible, biodegradable, pH-sensitive derivate of cellulose widely used in drug delivery 
systems. Drug delivery system prepared in that way can enable controlled release of drug (such 
as lidocaine hydrochloride (Lid)) for prolonged period of time and therefore, reduce the number 
of acquired drug dosages which further lead to safe and efficient drug application. Therefore, 
Lid is encapsulated in hydrogels based on PMAA, NC and CMC (PM/NC-Lid). Lid is local 
anesthetic often used in dental treatment and it is usually administrated by injection, which is 
painful, unpleasant and treatment is often required several dosages. These limitations can be 
overcome by applying PM/NC-Lid hydrogels as buccal patches for controlled release of 
lidocaine hydrochloride. Present study describes green synthesis and characterization of 
PM/NC-Lid hydrogels (using the Fourier Transform Infrared spectroscopy (FT-IR), the 
Scanning Electron Microscopy (SEM) and the single compression tests). Also, PM/NC-Lid 
swelling behavior and Lid controlled release from PM/NC-Lid hydrogels is investigated 
depending on the variable synthesis parameter (NC wt%) in simulated buccal environment. 
Results presented in this study show that PM/NC-Lid hydrogels are promising materials for 
controlled release of anesthetic drugs and for potential application as buccal patches in dental 
treatments.",
publisher = "UNIVERSITY OF EAST SARAJEVO FACULTY OF TECHNOLOGY Karakaj 34a, 75 400 Zvornik Republic of Srpska, B&H",
journal = "VII international congress engineering, environment and materials in  process industry",
title = "Hydrogels based on poly(methacrylic acid) and nanocellulose with potential application in dental treatments",
pages = "434-424",
doi = "10.7251/EEMEN2101424M"
}

Marković, M. D., Seslija, S. I., Tadic, J. D.,& Spasojević, P. M.. (2021). Hydrogels based on poly(methacrylic acid) and nanocellulose with potential application in dental treatments. in VII international congress engineering, environment and materials in  process industry
UNIVERSITY OF EAST SARAJEVO FACULTY OF TECHNOLOGY Karakaj 34a, 75 400 Zvornik Republic of Srpska, B&H., 424-434.
https://doi.org/10.7251/EEMEN2101424M

Marković MD, Seslija SI, Tadic JD, Spasojević PM. Hydrogels based on poly(methacrylic acid) and nanocellulose with potential application in dental treatments. in VII international congress engineering, environment and materials in  process industry. 2021;:424-434.
doi:10.7251/EEMEN2101424M .

Marković, Maja D., Seslija, Sanja I., Tadic, Julijana D., Spasojević, Pavle M., "Hydrogels based on poly(methacrylic acid) and nanocellulose with potential application in dental treatments" in VII international congress engineering, environment and materials in  process industry (2021):424-434,
https://doi.org/10.7251/EEMEN2101424M . .

TY  - JOUR
AU  - Marković, Maja
AU  - Šešlija, Sanja
AU  - Panić, Vesna
AU  - Spasojević, Pavle
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5073
AB  - Intelligent hydrogels, such as pH sensitive hydrogels based on 
poly(methacrylic acid) (PMAA) are widely used for targeted drug 
delivery. Still, PMAA lack of good mechanical properties often 
limits its application. In order to overcome this limitation nano cellulose (NC) was extracted from wood waste material and then 
added to PMAA because NC is biocompatible, non-toxic and has 
excellent mechanical properties. Further, carboxymethyl cellulose 
(CMC) (cellulose derivate widely used for controlled release of 
drugs) was added. CMC can stabilize magnetite nanoparticles (MN) 
which is then also added. MN can significantly improve mechanical 
properties of hydrogels and also possess magnetic properties due to 
which MN can be used for targeted drug delivery. The as-prepared 
material can protect drug, deliver it to the site of action, control its 
release rate and enable in that way its efficient application with re duced side effects. Local anesthetic - lidocaine hydrochloride (LH) 
is often administrated by injection which can induce severe side ef fects. This problem is solved in present study by encapsulating LH 
into hydrogels based on PMAA, NC, CMC and MN (PMNC/MN L). PMNC/MN-L hydrogels were characterized by FTIR and SEM 
spectroscopies and single compressive tests and then their swelling 
behavior and LH release were analyzed. Present study offers unique 
approach for green synthesis of dual responsive hydrogels with im proves properties and their application for controlled release of local 
anesthetic with reduced side effects.
PB  - Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS)
T2  - Procesne tehnologije
T1  - Dual responsive hybrid hydrogels for controlled  release of local anesthetic
EP  - 24
IS  - 2
SP  - 18
VL  - 33
DO  - 10.24094/ptc.021.33.2.18
ER  - 

@article{
author = "Marković, Maja and Šešlija, Sanja and Panić, Vesna and Spasojević, Pavle",
year = "2021",
abstract = "Intelligent hydrogels, such as pH sensitive hydrogels based on 
poly(methacrylic acid) (PMAA) are widely used for targeted drug 
delivery. Still, PMAA lack of good mechanical properties often 
limits its application. In order to overcome this limitation nano cellulose (NC) was extracted from wood waste material and then 
added to PMAA because NC is biocompatible, non-toxic and has 
excellent mechanical properties. Further, carboxymethyl cellulose 
(CMC) (cellulose derivate widely used for controlled release of 
drugs) was added. CMC can stabilize magnetite nanoparticles (MN) 
which is then also added. MN can significantly improve mechanical 
properties of hydrogels and also possess magnetic properties due to 
which MN can be used for targeted drug delivery. The as-prepared 
material can protect drug, deliver it to the site of action, control its 
release rate and enable in that way its efficient application with re duced side effects. Local anesthetic - lidocaine hydrochloride (LH) 
is often administrated by injection which can induce severe side ef fects. This problem is solved in present study by encapsulating LH 
into hydrogels based on PMAA, NC, CMC and MN (PMNC/MN L). PMNC/MN-L hydrogels were characterized by FTIR and SEM 
spectroscopies and single compressive tests and then their swelling 
behavior and LH release were analyzed. Present study offers unique 
approach for green synthesis of dual responsive hydrogels with im proves properties and their application for controlled release of local 
anesthetic with reduced side effects.",
publisher = "Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS)",
journal = "Procesne tehnologije",
title = "Dual responsive hybrid hydrogels for controlled  release of local anesthetic",
pages = "24-18",
number = "2",
volume = "33",
doi = "10.24094/ptc.021.33.2.18"
}

Marković, M., Šešlija, S., Panić, V.,& Spasojević, P.. (2021). Dual responsive hybrid hydrogels for controlled  release of local anesthetic. in Procesne tehnologije
Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS)., 33(2), 18-24.
https://doi.org/10.24094/ptc.021.33.2.18

Marković M, Šešlija S, Panić V, Spasojević P. Dual responsive hybrid hydrogels for controlled  release of local anesthetic. in Procesne tehnologije. 2021;33(2):18-24.
doi:10.24094/ptc.021.33.2.18 .

Marković, Maja, Šešlija, Sanja, Panić, Vesna, Spasojević, Pavle, "Dual responsive hybrid hydrogels for controlled  release of local anesthetic" in Procesne tehnologije, 33, no. 2 (2021):18-24,
https://doi.org/10.24094/ptc.021.33.2.18 . .

TY  - JOUR
AU  - Spasojević, Pavle
AU  - Seslija, Sanja
AU  - Marković, Maja
AU  - Pantic, Olga
AU  - Antić, Katarina
AU  - Spasojevic, Milica
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4782
AB  - Nowadays, unsaturated polyester resins (UPR) are mainly obtained from non-renewable resources. The ever-increasing regulations and the continuous demand for more sustainability have led to extensive research towards more environmentally suitable alternatives to petroleum-based materials. However, one of the main disadvantages of bio-based UPR is their relatively high viscosity compared to petrochemical ones. In order to overcome this drawback, in this work, we investigated the possibility to lower the resin viscosity utilizing a mixture of dimethyl itaconate (DMI) and methyl methacrylate (MMA) as a reactive diluent. The effect of the DMI and MMA ratio on resin rheological properties was investigated. The optimal curing parameters were determined and all UPRs had a high gel content, which was shown to be dependent on the DMI and MMA ratio in the formulation. Furthermore, thermomechanical and mechanical properties of the resulting network were also found to be affected by the used reactive diluent mixture. A small substitution of DMI by MMA proved to be advantageous since it offers lower resin viscosity and improved mechanical properties.
T2  - Polymers
T1  - Optimization of Reactive Diluent for Bio-Based Unsaturated Polyester Resin: A Rheological and Thermomechanical Study
IS  - 16
VL  - 13
DO  - 10.3390/polym13162667
ER  - 

@article{
author = "Spasojević, Pavle and Seslija, Sanja and Marković, Maja and Pantic, Olga and Antić, Katarina and Spasojevic, Milica",
year = "2021",
abstract = "Nowadays, unsaturated polyester resins (UPR) are mainly obtained from non-renewable resources. The ever-increasing regulations and the continuous demand for more sustainability have led to extensive research towards more environmentally suitable alternatives to petroleum-based materials. However, one of the main disadvantages of bio-based UPR is their relatively high viscosity compared to petrochemical ones. In order to overcome this drawback, in this work, we investigated the possibility to lower the resin viscosity utilizing a mixture of dimethyl itaconate (DMI) and methyl methacrylate (MMA) as a reactive diluent. The effect of the DMI and MMA ratio on resin rheological properties was investigated. The optimal curing parameters were determined and all UPRs had a high gel content, which was shown to be dependent on the DMI and MMA ratio in the formulation. Furthermore, thermomechanical and mechanical properties of the resulting network were also found to be affected by the used reactive diluent mixture. A small substitution of DMI by MMA proved to be advantageous since it offers lower resin viscosity and improved mechanical properties.",
journal = "Polymers",
title = "Optimization of Reactive Diluent for Bio-Based Unsaturated Polyester Resin: A Rheological and Thermomechanical Study",
number = "16",
volume = "13",
doi = "10.3390/polym13162667"
}

Spasojević, P., Seslija, S., Marković, M., Pantic, O., Antić, K.,& Spasojevic, M.. (2021). Optimization of Reactive Diluent for Bio-Based Unsaturated Polyester Resin: A Rheological and Thermomechanical Study. in Polymers, 13(16).
https://doi.org/10.3390/polym13162667

Spasojević P, Seslija S, Marković M, Pantic O, Antić K, Spasojevic M. Optimization of Reactive Diluent for Bio-Based Unsaturated Polyester Resin: A Rheological and Thermomechanical Study. in Polymers. 2021;13(16).
doi:10.3390/polym13162667 .

Spasojević, Pavle, Seslija, Sanja, Marković, Maja, Pantic, Olga, Antić, Katarina, Spasojevic, Milica, "Optimization of Reactive Diluent for Bio-Based Unsaturated Polyester Resin: A Rheological and Thermomechanical Study" in Polymers, 13, no. 16 (2021),
https://doi.org/10.3390/polym13162667 . .

TY  - JOUR
AU  - Marković, Maja
AU  - Seslija, Sanja, I
AU  - Ugrinović, Vukašin
AU  - Kunaver, Matjaz
AU  - Panić, Vesna
AU  - Pjanović, Rada
AU  - Spasojević, Pavle
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4802
AB  - pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer-Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.
T2  - Cellulose
T1  - Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen
EP  - 11132
IS  - 17
SP  - 11109
VL  - 28
DO  - 10.1007/s10570-021-04222-w
ER  - 

@article{
author = "Marković, Maja and Seslija, Sanja, I and Ugrinović, Vukašin and Kunaver, Matjaz and Panić, Vesna and Pjanović, Rada and Spasojević, Pavle",
year = "2021",
abstract = "pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer-Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.",
journal = "Cellulose",
title = "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen",
pages = "11132-11109",
number = "17",
volume = "28",
doi = "10.1007/s10570-021-04222-w"
}

Marković, M., Seslija, S. I., Ugrinović, V., Kunaver, M., Panić, V., Pjanović, R.,& Spasojević, P.. (2021). Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose, 28(17), 11109-11132.
https://doi.org/10.1007/s10570-021-04222-w

Marković M, Seslija SI, Ugrinović V, Kunaver M, Panić V, Pjanović R, Spasojević P. Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose. 2021;28(17):11109-11132.
doi:10.1007/s10570-021-04222-w .

Marković, Maja, Seslija, Sanja, I, Ugrinović, Vukašin, Kunaver, Matjaz, Panić, Vesna, Pjanović, Rada, Spasojević, Pavle, "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen" in Cellulose, 28, no. 17 (2021):11109-11132,
https://doi.org/10.1007/s10570-021-04222-w . .

TY  - JOUR
AU  - Sousa, Andreia F.
AU  - Patricio, Rafael
AU  - Terzopoulou, Zoi
AU  - Bikiaris, Dimitrios N.
AU  - Stern, Tobias
AU  - Wenger, Julia
AU  - Loos, Katja
AU  - Lotti, Nadia
AU  - Siracusa, Valentina
AU  - Szymczyk, Anna
AU  - Paszkiewicz, Sandra
AU  - Triantafyllidis, Konstantinos S.
AU  - Zamboulis, Alexandra
AU  - Nikolić, Marija S.
AU  - Spasojević, Pavle
AU  - Thiyagarajan, Shanmugam
AU  - van Es, Daan S.
AU  - Guigo, Nathanael
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4837
AB  - This review sheds light on urgent questions that arise from the need to replace a polymer resin,-poly(ethylene terephthalate), which represents 7.7% market-share in the global plastic demand (Plastics-the Facts 2019), by renewable alternatives. The main question that this review will address is: what are the most promising PET replacements made from biomass? Currently, under debate is naturally its biobased counterpart bio-PET (or even recycle rPET), as well as other aromatic key-players with comparable thermo-mechanical performance and enhanced barrier properties, such as poly(ethylene 2,5-furandicarboxylate) (PEF) and poly(trimethylene 2,5-furandicarboxylate) (PTF). They are most adequate for packaging, but not restricted to. Additional alternatives are the miscellaneous of lignin-based thermoplastic polymers, although the technology involved in this latter case is still premature. (Bio)degradable aliphatic polyesters, despite their typical inferior thermo-mechanical properties, can also play a role e.g., among PET fiber industry applications. Poly(lactic acid) (PLA) is the most developed renewable polyester, already a commercial reality. All biobased polymers reviewed face a major hindrance for their wider deployment their cost-competitiveness. A pertinent question arises then: Are these alternatives, or will they be, economically feasible? Social, political and legal frameworks together with supportive financial schemes are boosting rapid changes. In the future, most probably more than one polymer will come to the market and will be used in some of the panoply of PET applications. This evaluation overviews sustainability issues, including perspectives on their green synthesis. Moreover, this review does also not neglect the accumulation of plastics waste in the environment and the inherent challenges of polymers' end-of-life. Approximately 8 M tons of polymers waste leaks into the environment each year, a fact not disconnected to PET's non-biodegradability and still insufficient collection and recycling rates.
T2  - Green Chemistry
T1  - Recommendations for replacing PET on packaging, fiber, and film materials with biobased counterparts
EP  - 8820
IS  - 22
SP  - 8795
VL  - 23
DO  - 10.1039/d1gc02082j
ER  - 

@article{
author = "Sousa, Andreia F. and Patricio, Rafael and Terzopoulou, Zoi and Bikiaris, Dimitrios N. and Stern, Tobias and Wenger, Julia and Loos, Katja and Lotti, Nadia and Siracusa, Valentina and Szymczyk, Anna and Paszkiewicz, Sandra and Triantafyllidis, Konstantinos S. and Zamboulis, Alexandra and Nikolić, Marija S. and Spasojević, Pavle and Thiyagarajan, Shanmugam and van Es, Daan S. and Guigo, Nathanael",
year = "2021",
abstract = "This review sheds light on urgent questions that arise from the need to replace a polymer resin,-poly(ethylene terephthalate), which represents 7.7% market-share in the global plastic demand (Plastics-the Facts 2019), by renewable alternatives. The main question that this review will address is: what are the most promising PET replacements made from biomass? Currently, under debate is naturally its biobased counterpart bio-PET (or even recycle rPET), as well as other aromatic key-players with comparable thermo-mechanical performance and enhanced barrier properties, such as poly(ethylene 2,5-furandicarboxylate) (PEF) and poly(trimethylene 2,5-furandicarboxylate) (PTF). They are most adequate for packaging, but not restricted to. Additional alternatives are the miscellaneous of lignin-based thermoplastic polymers, although the technology involved in this latter case is still premature. (Bio)degradable aliphatic polyesters, despite their typical inferior thermo-mechanical properties, can also play a role e.g., among PET fiber industry applications. Poly(lactic acid) (PLA) is the most developed renewable polyester, already a commercial reality. All biobased polymers reviewed face a major hindrance for their wider deployment their cost-competitiveness. A pertinent question arises then: Are these alternatives, or will they be, economically feasible? Social, political and legal frameworks together with supportive financial schemes are boosting rapid changes. In the future, most probably more than one polymer will come to the market and will be used in some of the panoply of PET applications. This evaluation overviews sustainability issues, including perspectives on their green synthesis. Moreover, this review does also not neglect the accumulation of plastics waste in the environment and the inherent challenges of polymers' end-of-life. Approximately 8 M tons of polymers waste leaks into the environment each year, a fact not disconnected to PET's non-biodegradability and still insufficient collection and recycling rates.",
journal = "Green Chemistry",
title = "Recommendations for replacing PET on packaging, fiber, and film materials with biobased counterparts",
pages = "8820-8795",
number = "22",
volume = "23",
doi = "10.1039/d1gc02082j"
}

Sousa, A. F., Patricio, R., Terzopoulou, Z., Bikiaris, D. N., Stern, T., Wenger, J., Loos, K., Lotti, N., Siracusa, V., Szymczyk, A., Paszkiewicz, S., Triantafyllidis, K. S., Zamboulis, A., Nikolić, M. S., Spasojević, P., Thiyagarajan, S., van Es, D. S.,& Guigo, N.. (2021). Recommendations for replacing PET on packaging, fiber, and film materials with biobased counterparts. in Green Chemistry, 23(22), 8795-8820.
https://doi.org/10.1039/d1gc02082j

Sousa AF, Patricio R, Terzopoulou Z, Bikiaris DN, Stern T, Wenger J, Loos K, Lotti N, Siracusa V, Szymczyk A, Paszkiewicz S, Triantafyllidis KS, Zamboulis A, Nikolić MS, Spasojević P, Thiyagarajan S, van Es DS, Guigo N. Recommendations for replacing PET on packaging, fiber, and film materials with biobased counterparts. in Green Chemistry. 2021;23(22):8795-8820.
doi:10.1039/d1gc02082j .

Sousa, Andreia F., Patricio, Rafael, Terzopoulou, Zoi, Bikiaris, Dimitrios N., Stern, Tobias, Wenger, Julia, Loos, Katja, Lotti, Nadia, Siracusa, Valentina, Szymczyk, Anna, Paszkiewicz, Sandra, Triantafyllidis, Konstantinos S., Zamboulis, Alexandra, Nikolić, Marija S., Spasojević, Pavle, Thiyagarajan, Shanmugam, van Es, Daan S., Guigo, Nathanael, "Recommendations for replacing PET on packaging, fiber, and film materials with biobased counterparts" in Green Chemistry, 23, no. 22 (2021):8795-8820,
https://doi.org/10.1039/d1gc02082j . .