TY  - JOUR
AU  - Espina, Jaime A.
AU  - Cordeiro, Marilia H.
AU  - Milivojević, Milan
AU  - Pajić-Lijaković, Ivana
AU  - Barriga, Elias H.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6662
AB  - Shear stress is essential for normal physiology and malignancy. Common physiological processes - such as blood flow, particle flow in the gut, or contact between migratory cell clusters and their substrate - produce shear stress that can have an impact on the behavior of different tissues. In addition, shear stress has roles in processes of biomedical interest, such as wound healing, cancer and fibrosis induced by soft implants. Thus, understanding how cells react and adapt to shear stress is important. In this Review, we discuss in vivo and in vitro data obtained from vascular and epithelial models; highlight the insights these have afforded regarding the general mechanisms through which cells sense, transduce and respond to shear stress at the cellular levels; and outline how the changes cells experience in response to shear stress impact tissue organization. Finally, we discuss the role of shear stress in collective cell migration, which is only starting to be appreciated. We review our current understanding of the effects of shear stress in the context of embryo development, cancer and fibrosis, and invite the scientific community to further investigate the role of shear stress in these scenarios.
PB  - Company of Biologists Ltd.
T2  - Journal of Cell Science
T1  - Response of cells and tissues to shear stress
IS  - 18
SP  - jcs260985
VL  - 136
DO  - 10.1242/jcs.260985
ER  - 

@article{
author = "Espina, Jaime A. and Cordeiro, Marilia H. and Milivojević, Milan and Pajić-Lijaković, Ivana and Barriga, Elias H.",
year = "2023",
abstract = "Shear stress is essential for normal physiology and malignancy. Common physiological processes - such as blood flow, particle flow in the gut, or contact between migratory cell clusters and their substrate - produce shear stress that can have an impact on the behavior of different tissues. In addition, shear stress has roles in processes of biomedical interest, such as wound healing, cancer and fibrosis induced by soft implants. Thus, understanding how cells react and adapt to shear stress is important. In this Review, we discuss in vivo and in vitro data obtained from vascular and epithelial models; highlight the insights these have afforded regarding the general mechanisms through which cells sense, transduce and respond to shear stress at the cellular levels; and outline how the changes cells experience in response to shear stress impact tissue organization. Finally, we discuss the role of shear stress in collective cell migration, which is only starting to be appreciated. We review our current understanding of the effects of shear stress in the context of embryo development, cancer and fibrosis, and invite the scientific community to further investigate the role of shear stress in these scenarios.",
publisher = "Company of Biologists Ltd.",
journal = "Journal of Cell Science",
title = "Response of cells and tissues to shear stress",
number = "18",
pages = "jcs260985",
volume = "136",
doi = "10.1242/jcs.260985"
}

Espina, J. A., Cordeiro, M. H., Milivojević, M., Pajić-Lijaković, I.,& Barriga, E. H.. (2023). Response of cells and tissues to shear stress. in Journal of Cell Science
Company of Biologists Ltd.., 136(18), jcs260985.
https://doi.org/10.1242/jcs.260985

Espina JA, Cordeiro MH, Milivojević M, Pajić-Lijaković I, Barriga EH. Response of cells and tissues to shear stress. in Journal of Cell Science. 2023;136(18):jcs260985.
doi:10.1242/jcs.260985 .

Espina, Jaime A., Cordeiro, Marilia H., Milivojević, Milan, Pajić-Lijaković, Ivana, Barriga, Elias H., "Response of cells and tissues to shear stress" in Journal of Cell Science, 136, no. 18 (2023):jcs260985,
https://doi.org/10.1242/jcs.260985 . .