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Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora

Pantić, Olga J.; Panić, Vesna V.; Marković, Maja D.; Spasojević, Pavle M.; Savić, Sanja I.; Kalagasidis Krušić, Melina T.

(Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija, 2023)

TY  - CONF
AU  - Pantić, Olga J.
AU  - Panić, Vesna V.
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Kalagasidis Krušić, Melina T.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6466
AB  - Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz
bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole
su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala.
Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim
količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za
proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska
kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen
dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od
mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je
određivan analizom sadržaja gel faze.
AB  - Development of biobased thermoset polymers encourages the strategic use of biobased
resources and migrating to greener technologies. Unsaturated polyester resins have an
extensive array of properties which makes them the most used thermoset resins in the
production of polymer composite materials. Waste materials, such as eggshells left over
from the usage of chicken eggs, are abundant and non-hazardous materials which offer
many benefits in potential use as a filler in developing a biobased composite material.
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the
resulting composite materials included assessing mechanical properties (uniaxial tensile
test, three-point bending test), FTIR spectroscopy, and gel content analysis.
PB  - Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija
C3  - 59th Meeting of the Serbian Chemical Society
T1  - Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora
T1  - Composite materials prepared from waste eggshells and biobased unsaturated polyester resin
EP  - 148
SP  - 148
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6466
ER  - 
@conference{
author = "Pantić, Olga J. and Panić, Vesna V. and Marković, Maja D. and Spasojević, Pavle M. and Savić, Sanja I. and Kalagasidis Krušić, Melina T.",
year = "2023",
abstract = "Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz
bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole
su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala.
Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim
količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za
proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska
kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen
dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od
mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je
određivan analizom sadržaja gel faze., Development of biobased thermoset polymers encourages the strategic use of biobased
resources and migrating to greener technologies. Unsaturated polyester resins have an
extensive array of properties which makes them the most used thermoset resins in the
production of polymer composite materials. Waste materials, such as eggshells left over
from the usage of chicken eggs, are abundant and non-hazardous materials which offer
many benefits in potential use as a filler in developing a biobased composite material.
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the
resulting composite materials included assessing mechanical properties (uniaxial tensile
test, three-point bending test), FTIR spectroscopy, and gel content analysis.",
publisher = "Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija",
journal = "59th Meeting of the Serbian Chemical Society",
title = "Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora, Composite materials prepared from waste eggshells and biobased unsaturated polyester resin",
pages = "148-148",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6466"
}
Pantić, O. J., Panić, V. V., Marković, M. D., Spasojević, P. M., Savić, S. I.,& Kalagasidis Krušić, M. T.. (2023). Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora. in 59th Meeting of the Serbian Chemical Society
Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija., 148-148.
https://hdl.handle.net/21.15107/rcub_technorep_6466
Pantić OJ, Panić VV, Marković MD, Spasojević PM, Savić SI, Kalagasidis Krušić MT. Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora. in 59th Meeting of the Serbian Chemical Society. 2023;:148-148.
https://hdl.handle.net/21.15107/rcub_technorep_6466 .
Pantić, Olga J., Panić, Vesna V., Marković, Maja D., Spasojević, Pavle M., Savić, Sanja I., Kalagasidis Krušić, Melina T., "Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora" in 59th Meeting of the Serbian Chemical Society (2023):148-148,
https://hdl.handle.net/21.15107/rcub_technorep_6466 .

Zeolite/Chitosan/Gelatin Films: Preparation, SupercriticalCO2Processing, Characterization, and Bioactivity

Pajnik, Jelena; Dikić, Jelena; Milovanović, Stoja; Milošević, Milena; Jevtić, Sanja; Lukić, Ivana

(Wiley, 2022)

TY  - JOUR
AU  - Pajnik, Jelena
AU  - Dikić, Jelena
AU  - Milovanović, Stoja
AU  - Milošević, Milena
AU  - Jevtić, Sanja
AU  - Lukić, Ivana
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5086
AB  - Chitosan/gelatin and chitosan/gelatin/zeolite films prepared by solvent casting method were impregnated with a mixture of thymol and carvacrol using a green solvent, supercritical carbon dioxide at 35 °C and 30 MPa, during 18 h. Proposed method enabled preparation of biocompatible and biodegradable blends with strong antioxidant and antibacterial activity, whereby amounts of loaded thymol/carvacrol mixture were in the range from 3.3-6%. After initial burst release, both types of films exhibited gradual release of bioactive compounds, with around 72 and 96% of impregnated thymol/carvacrol mixture released in water and PBS (pH 7.4) during tested period of 10 days, respectively. Results of water vapor transmission rate (> 76 gm-2 day-1) confirmed that prepared composites are suitable for wound dressing application. Thermal analysis showed superior properties of prepared thymol/carvacrol loaded films compared to control samples. In addition, mechanical and structural properties, as well as solubility and swelling behavior of the obtained films were investigated in detail.
PB  - Wiley
T2  - Macromolecular Materials and Engineering
T1  - Zeolite/Chitosan/Gelatin Films: Preparation, SupercriticalCO2Processing, Characterization, and Bioactivity
EP  - 13
IS  - 4
SP  - 1
VL  - 307
DO  - 10.1002/mame.202200009
ER  - 
@article{
author = "Pajnik, Jelena and Dikić, Jelena and Milovanović, Stoja and Milošević, Milena and Jevtić, Sanja and Lukić, Ivana",
year = "2022",
abstract = "Chitosan/gelatin and chitosan/gelatin/zeolite films prepared by solvent casting method were impregnated with a mixture of thymol and carvacrol using a green solvent, supercritical carbon dioxide at 35 °C and 30 MPa, during 18 h. Proposed method enabled preparation of biocompatible and biodegradable blends with strong antioxidant and antibacterial activity, whereby amounts of loaded thymol/carvacrol mixture were in the range from 3.3-6%. After initial burst release, both types of films exhibited gradual release of bioactive compounds, with around 72 and 96% of impregnated thymol/carvacrol mixture released in water and PBS (pH 7.4) during tested period of 10 days, respectively. Results of water vapor transmission rate (> 76 gm-2 day-1) confirmed that prepared composites are suitable for wound dressing application. Thermal analysis showed superior properties of prepared thymol/carvacrol loaded films compared to control samples. In addition, mechanical and structural properties, as well as solubility and swelling behavior of the obtained films were investigated in detail.",
publisher = "Wiley",
journal = "Macromolecular Materials and Engineering",
title = "Zeolite/Chitosan/Gelatin Films: Preparation, SupercriticalCO2Processing, Characterization, and Bioactivity",
pages = "13-1",
number = "4",
volume = "307",
doi = "10.1002/mame.202200009"
}
Pajnik, J., Dikić, J., Milovanović, S., Milošević, M., Jevtić, S.,& Lukić, I.. (2022). Zeolite/Chitosan/Gelatin Films: Preparation, SupercriticalCO2Processing, Characterization, and Bioactivity. in Macromolecular Materials and Engineering
Wiley., 307(4), 1-13.
https://doi.org/10.1002/mame.202200009
Pajnik J, Dikić J, Milovanović S, Milošević M, Jevtić S, Lukić I. Zeolite/Chitosan/Gelatin Films: Preparation, SupercriticalCO2Processing, Characterization, and Bioactivity. in Macromolecular Materials and Engineering. 2022;307(4):1-13.
doi:10.1002/mame.202200009 .
Pajnik, Jelena, Dikić, Jelena, Milovanović, Stoja, Milošević, Milena, Jevtić, Sanja, Lukić, Ivana, "Zeolite/Chitosan/Gelatin Films: Preparation, SupercriticalCO2Processing, Characterization, and Bioactivity" in Macromolecular Materials and Engineering, 307, no. 4 (2022):1-13,
https://doi.org/10.1002/mame.202200009 . .
8

The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters

Pantić, Olga; Spasojević, Milica; Džunuzović, Enis; Nikolić, Marija S.; Savić, Sanja; Marković, Maja; Spasojević, Pavle

(MDPI, 2022)

TY  - JOUR
AU  - Pantić, Olga
AU  - Spasojević, Milica
AU  - Džunuzović, Enis
AU  - Nikolić, Marija S.
AU  - Savić, Sanja
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5160
AB  - The scope of the present study was to prepare fully bio-based unsaturated polyester resins (UPRs) with comparable properties to the commercial formulations. The focus was set on the determination of the optimal prepolymer formulation using the same set of diacids (itaconic and succinic acid) and different diols (propylene glycol, isosorbide and neopentyl glycol) or its equimolar mixtures, keeping the fixed molar ratio of 1:1:2.1 in all feed compositions. Instead of commonly used styrene, bio-based dimethyl itaconate was used as a reactive diluent (RD). The rheology of the obtained resins was studied in detail. The effect of the used diol on structural (FTIR), thermal (DSC), thermomechanical (DMA), and mechanical (tensile) properties was explained. The properties of UPRs were found to be highly dependent on the diol used in the prepolymer formulation. The UPR with an equimolar ratio of propylene glycol and neopentyl glycol was shown to be the most promising candidate to compete with the commercial petroleum-based resins.
PB  - MDPI
T2  - Polymers
T1  - The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters
IS  - 15
SP  - 2970
VL  - 14
DO  - https://doi.org/10.3390/polym14152970
ER  - 
@article{
author = "Pantić, Olga and Spasojević, Milica and Džunuzović, Enis and Nikolić, Marija S. and Savić, Sanja and Marković, Maja and Spasojević, Pavle",
year = "2022",
abstract = "The scope of the present study was to prepare fully bio-based unsaturated polyester resins (UPRs) with comparable properties to the commercial formulations. The focus was set on the determination of the optimal prepolymer formulation using the same set of diacids (itaconic and succinic acid) and different diols (propylene glycol, isosorbide and neopentyl glycol) or its equimolar mixtures, keeping the fixed molar ratio of 1:1:2.1 in all feed compositions. Instead of commonly used styrene, bio-based dimethyl itaconate was used as a reactive diluent (RD). The rheology of the obtained resins was studied in detail. The effect of the used diol on structural (FTIR), thermal (DSC), thermomechanical (DMA), and mechanical (tensile) properties was explained. The properties of UPRs were found to be highly dependent on the diol used in the prepolymer formulation. The UPR with an equimolar ratio of propylene glycol and neopentyl glycol was shown to be the most promising candidate to compete with the commercial petroleum-based resins.",
publisher = "MDPI",
journal = "Polymers",
title = "The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters",
number = "15",
pages = "2970",
volume = "14",
doi = "https://doi.org/10.3390/polym14152970"
}
Pantić, O., Spasojević, M., Džunuzović, E., Nikolić, M. S., Savić, S., Marković, M.,& Spasojević, P.. (2022). The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters. in Polymers
MDPI., 14(15), 2970.
https://doi.org/https://doi.org/10.3390/polym14152970
Pantić O, Spasojević M, Džunuzović E, Nikolić MS, Savić S, Marković M, Spasojević P. The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters. in Polymers. 2022;14(15):2970.
doi:https://doi.org/10.3390/polym14152970 .
Pantić, Olga, Spasojević, Milica, Džunuzović, Enis, Nikolić, Marija S., Savić, Sanja, Marković, Maja, Spasojević, Pavle, "The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters" in Polymers, 14, no. 15 (2022):2970,
https://doi.org/https://doi.org/10.3390/polym14152970 . .

Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications

Ugrinović, Vukašin; Hristara, Veroniki; Marković, Maja; Petrović, Predrag; Petrović, Rada; Janaćković, Đorđe; Veljović, Đorđe

(Materials Research Society of Serbia, Belgrade, Serbia, 2022)

TY  - CONF
AU  - Ugrinović, Vukašin
AU  - Hristara, Veroniki
AU  - Marković, Maja
AU  - Petrović, Predrag
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
AU  - Veljović, Đorđe
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5240
AB  - Hydrogels are three-dimensional hydrophilic networks of polymers capable of retaining large
amounts of water or biological fluids, which makes them attractive for biomedical and
pharmaceutical applications. Although various types of polymers have been investigated as
hydrogels for biomedical purposes, those obtained from natural polymers have intrinsic
advantages as they are abundant, cheap, biocompatible and biodegradable. Gelatin is a natural
polymer that has been applied in biomedicine due to its low price, biocompatibility, and
biodegradability. HPMC, a derivative of cellulose, is a hydrophilic, biodegradable, and
biocompatible polymer. However, natural polymer-based hydrogels have low mechanical
properties and are relatively soluble in physiological conditions, which requires creative crosslinking strategies to improve the functionality of the hydrogels. The citric acid (CA) is an
inexpensive and non-toxic compound that has been proven to be an effective crosslinker for
natural polymers. In addition, the incorporation of bioactive calcium phosphate particles could
further improve mechanical properties and add new functionalities to the hydrogels.
In this work, we present novel composite hydrogels for biomedical applications, based on CAcrosslinked gelatin/HPMC (HPMC-G) matrix and Mg-doped biphasic calcium phosphate filler
(BCP). Firstly, the HPMC-G hydrogels crosslinking conditions were optimized. Different CA
concentrations, curing temperatures (140-180°C) and times (3-9 min) were applied. During the
second step, the optimaly crosslinked HPMC-G hydrogel was incorporated with different amounts
of BCP. BCP was obtained by calcination of Mg-doped hydroxyapatite (HA) powder synthesized
by the hydrothermal method. XRD analysis confirmed that powder was constituted only of HA
and beta-tricalcium phosphate. The obtained composite hydrogels were characterized by
mechanical testing, FTIR, SEM, swelling behavior and drug deliverability.
PB  - Materials Research Society of Serbia, Belgrade, Serbia
C3  - TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro
T1  - Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5240
ER  - 
@conference{
author = "Ugrinović, Vukašin and Hristara, Veroniki and Marković, Maja and Petrović, Predrag and Petrović, Rada and Janaćković, Đorđe and Veljović, Đorđe",
year = "2022",
abstract = "Hydrogels are three-dimensional hydrophilic networks of polymers capable of retaining large
amounts of water or biological fluids, which makes them attractive for biomedical and
pharmaceutical applications. Although various types of polymers have been investigated as
hydrogels for biomedical purposes, those obtained from natural polymers have intrinsic
advantages as they are abundant, cheap, biocompatible and biodegradable. Gelatin is a natural
polymer that has been applied in biomedicine due to its low price, biocompatibility, and
biodegradability. HPMC, a derivative of cellulose, is a hydrophilic, biodegradable, and
biocompatible polymer. However, natural polymer-based hydrogels have low mechanical
properties and are relatively soluble in physiological conditions, which requires creative crosslinking strategies to improve the functionality of the hydrogels. The citric acid (CA) is an
inexpensive and non-toxic compound that has been proven to be an effective crosslinker for
natural polymers. In addition, the incorporation of bioactive calcium phosphate particles could
further improve mechanical properties and add new functionalities to the hydrogels.
In this work, we present novel composite hydrogels for biomedical applications, based on CAcrosslinked gelatin/HPMC (HPMC-G) matrix and Mg-doped biphasic calcium phosphate filler
(BCP). Firstly, the HPMC-G hydrogels crosslinking conditions were optimized. Different CA
concentrations, curing temperatures (140-180°C) and times (3-9 min) were applied. During the
second step, the optimaly crosslinked HPMC-G hydrogel was incorporated with different amounts
of BCP. BCP was obtained by calcination of Mg-doped hydroxyapatite (HA) powder synthesized
by the hydrothermal method. XRD analysis confirmed that powder was constituted only of HA
and beta-tricalcium phosphate. The obtained composite hydrogels were characterized by
mechanical testing, FTIR, SEM, swelling behavior and drug deliverability.",
publisher = "Materials Research Society of Serbia, Belgrade, Serbia",
journal = "TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro",
title = "Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5240"
}
Ugrinović, V., Hristara, V., Marković, M., Petrović, P., Petrović, R., Janaćković, Đ.,& Veljović, Đ.. (2022). Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications. in TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro
Materials Research Society of Serbia, Belgrade, Serbia..
https://hdl.handle.net/21.15107/rcub_technorep_5240
Ugrinović V, Hristara V, Marković M, Petrović P, Petrović R, Janaćković Đ, Veljović Đ. Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications. in TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro. 2022;.
https://hdl.handle.net/21.15107/rcub_technorep_5240 .
Ugrinović, Vukašin, Hristara, Veroniki, Marković, Maja, Petrović, Predrag, Petrović, Rada, Janaćković, Đorđe, Veljović, Đorđe, "Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications" in TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro (2022),
https://hdl.handle.net/21.15107/rcub_technorep_5240 .

THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN

Marković, Maja D.; Panić, Vesna V.; Pjanović, Rada V.

(University of Szeged, 2022)

TY  - CONF
AU  - Marković, Maja D.
AU  - Panić, Vesna V.
AU  - Pjanović, Rada V.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5477
AB  - Researchers are making everyday efforts to develop new drugs or improve present ones in order
to enhance therapies of various diseases, especially serious ones like cancer. Drug delivery
systems (DDS) are one of the solutions for safer and more efficient therapy. Hydrogels based
on poly(methacrylic acid) (PMAA) are extensively investigated as DDS due to their nontoxicity, biocompatibility and pH sensitivity. Many chemotherapeutics are poorly watersoluble, so it is quite challenging to encapsulate them into highly hydrophilic PMAA. In our
previous study we overcome this limitation by modifying PMAA with amphiphilic casein and
demonstrated that poorly water-soluble model drug – caffeine can be successfully encapsulated
and released in control manner from these samples (H hydrogels). In present study we go step
forward and investigated how the change in the amount of encapsulated caffeine affect the
mechanism of caffeine release from the H hydrogels in medium with pH of 6.8 (which simulates
the environment in human intestines). Commonly used models for the analysis of kinetics of
drug release from hydrogels: Ritger-Peppas, Higuchi and Kopcha model are employed for the
analysis of the mechanism of caffeine release. Presented results indicate that it is possible to
adjust the manner and mechanism of drug release by changing the amount of encapsulated drug,
due to which the H hydrogels can adapt to the unique requirements of the therapy.
PB  - University of Szeged
C3  - PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems
T1  - THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN
EP  - 226
SP  - 221
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5477
ER  - 
@conference{
author = "Marković, Maja D. and Panić, Vesna V. and Pjanović, Rada V.",
year = "2022",
abstract = "Researchers are making everyday efforts to develop new drugs or improve present ones in order
to enhance therapies of various diseases, especially serious ones like cancer. Drug delivery
systems (DDS) are one of the solutions for safer and more efficient therapy. Hydrogels based
on poly(methacrylic acid) (PMAA) are extensively investigated as DDS due to their nontoxicity, biocompatibility and pH sensitivity. Many chemotherapeutics are poorly watersoluble, so it is quite challenging to encapsulate them into highly hydrophilic PMAA. In our
previous study we overcome this limitation by modifying PMAA with amphiphilic casein and
demonstrated that poorly water-soluble model drug – caffeine can be successfully encapsulated
and released in control manner from these samples (H hydrogels). In present study we go step
forward and investigated how the change in the amount of encapsulated caffeine affect the
mechanism of caffeine release from the H hydrogels in medium with pH of 6.8 (which simulates
the environment in human intestines). Commonly used models for the analysis of kinetics of
drug release from hydrogels: Ritger-Peppas, Higuchi and Kopcha model are employed for the
analysis of the mechanism of caffeine release. Presented results indicate that it is possible to
adjust the manner and mechanism of drug release by changing the amount of encapsulated drug,
due to which the H hydrogels can adapt to the unique requirements of the therapy.",
publisher = "University of Szeged",
journal = "PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems",
title = "THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN",
pages = "226-221",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5477"
}
Marković, M. D., Panić, V. V.,& Pjanović, R. V.. (2022). THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN. in PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems
University of Szeged., 221-226.
https://hdl.handle.net/21.15107/rcub_technorep_5477
Marković MD, Panić VV, Pjanović RV. THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN. in PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems. 2022;:221-226.
https://hdl.handle.net/21.15107/rcub_technorep_5477 .
Marković, Maja D., Panić, Vesna V., Pjanović, Rada V., "THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN" in PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems (2022):221-226,
https://hdl.handle.net/21.15107/rcub_technorep_5477 .