Antimicrobial activity of the essential oil and different fractions of Juniperus communis L. and a comparison with some commercial antibiotics
Antimikrobna aktivnost etarskog ulja i različitih frakcija Juniperus communis L. i poređenje sa nekim komercijalnim antibioticima
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The essential oil of common juniper (Juniperus communis L., from the southern part of Serbia) and its fractions of different composition, as well as commercial antibiotics were used for testing their antimicrobial activity against bacteria, yeast and fungi. The essential oil was produced by hydro-distillation in a pilot plant (130 dm3) and then fractionated by distillation over a column, with 36 theoretical stages, under vacuum (26-66 mbar). The essential oil was also fractionated using pure CO2 or CO2 and methanol as co-solvent under supercritical conditions. The native oil showed weak antimicrobial activity, while the fractions with a high content of α-pinene, and mixture of α-pinene and sabinene showed the highest antimicrobial activity, especially against fungi. In comparison to the commercial antibiotics, the oil fractions showed more extensive spectra of antimicrobial activity, as well as wider inhibition zones. .
Etarsko ulje ploda kleke (Juniperus communis L. iz južnog dela Srbije) dobijeno je hidrodestilacijom u pilot postrojenju (130 dm3) a zatim frakcionisano u destilacionoj koloni, sa 36 teoretskih podova, pod vakuumom (26-66 mbar). Etarsko ulje je takođe frakcionisano korišćenjem čistog CO2 i smeše CO2 i metanola kao kosolventa pod natkritičnim uslovima. Devet različitih uzoraka (etarsko ulje i njegove frakcije različitih sastava) kao i komercijalni antibiotici korišćeni su u testiranju antimikrobne aktivnosti i inhibitornog uticaja na razvoj nekih bakterija, kvasaca i gljivica. Etarsko ulje kleke je pokazalo slabu antimikrobnu aktivnost na svim sojevima a frakcije sa čistim α-pinenom i smešom α-pinena i sabinena naročito na rast gljivica. U poređenju sa komercijalnim antibioticima frakcije etarskog ulja kleke pokazuju širok spektar delovanja kao i veće zone inhibicije. .
Keywords:
Juniperus communis L. / essential oil / distillation / supercritical fractionation / antimicrobial activity / antibioticsSource:
Journal of the Serbian Chemical Society, 2007, 72, 4, 311-320Publisher:
- Serbian Chemical Society, Belgrade
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Glišić, Sandra AU - Milojević, Svetomir AU - Dimitrijević, Suzana AU - Orlović, Aleksandar AU - Skala, Dejan PY - 2007 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1198 AB - The essential oil of common juniper (Juniperus communis L., from the southern part of Serbia) and its fractions of different composition, as well as commercial antibiotics were used for testing their antimicrobial activity against bacteria, yeast and fungi. The essential oil was produced by hydro-distillation in a pilot plant (130 dm3) and then fractionated by distillation over a column, with 36 theoretical stages, under vacuum (26-66 mbar). The essential oil was also fractionated using pure CO2 or CO2 and methanol as co-solvent under supercritical conditions. The native oil showed weak antimicrobial activity, while the fractions with a high content of α-pinene, and mixture of α-pinene and sabinene showed the highest antimicrobial activity, especially against fungi. In comparison to the commercial antibiotics, the oil fractions showed more extensive spectra of antimicrobial activity, as well as wider inhibition zones. . AB - Etarsko ulje ploda kleke (Juniperus communis L. iz južnog dela Srbije) dobijeno je hidrodestilacijom u pilot postrojenju (130 dm3) a zatim frakcionisano u destilacionoj koloni, sa 36 teoretskih podova, pod vakuumom (26-66 mbar). Etarsko ulje je takođe frakcionisano korišćenjem čistog CO2 i smeše CO2 i metanola kao kosolventa pod natkritičnim uslovima. Devet različitih uzoraka (etarsko ulje i njegove frakcije različitih sastava) kao i komercijalni antibiotici korišćeni su u testiranju antimikrobne aktivnosti i inhibitornog uticaja na razvoj nekih bakterija, kvasaca i gljivica. Etarsko ulje kleke je pokazalo slabu antimikrobnu aktivnost na svim sojevima a frakcije sa čistim α-pinenom i smešom α-pinena i sabinena naročito na rast gljivica. U poređenju sa komercijalnim antibioticima frakcije etarskog ulja kleke pokazuju širok spektar delovanja kao i veće zone inhibicije. . PB - Serbian Chemical Society, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Antimicrobial activity of the essential oil and different fractions of Juniperus communis L. and a comparison with some commercial antibiotics T1 - Antimikrobna aktivnost etarskog ulja i različitih frakcija Juniperus communis L. i poređenje sa nekim komercijalnim antibioticima EP - 320 IS - 4 SP - 311 VL - 72 UR - https://hdl.handle.net/21.15107/rcub_technorep_1198 ER -
@article{ author = "Glišić, Sandra and Milojević, Svetomir and Dimitrijević, Suzana and Orlović, Aleksandar and Skala, Dejan", year = "2007", abstract = "The essential oil of common juniper (Juniperus communis L., from the southern part of Serbia) and its fractions of different composition, as well as commercial antibiotics were used for testing their antimicrobial activity against bacteria, yeast and fungi. The essential oil was produced by hydro-distillation in a pilot plant (130 dm3) and then fractionated by distillation over a column, with 36 theoretical stages, under vacuum (26-66 mbar). The essential oil was also fractionated using pure CO2 or CO2 and methanol as co-solvent under supercritical conditions. The native oil showed weak antimicrobial activity, while the fractions with a high content of α-pinene, and mixture of α-pinene and sabinene showed the highest antimicrobial activity, especially against fungi. In comparison to the commercial antibiotics, the oil fractions showed more extensive spectra of antimicrobial activity, as well as wider inhibition zones. ., Etarsko ulje ploda kleke (Juniperus communis L. iz južnog dela Srbije) dobijeno je hidrodestilacijom u pilot postrojenju (130 dm3) a zatim frakcionisano u destilacionoj koloni, sa 36 teoretskih podova, pod vakuumom (26-66 mbar). Etarsko ulje je takođe frakcionisano korišćenjem čistog CO2 i smeše CO2 i metanola kao kosolventa pod natkritičnim uslovima. Devet različitih uzoraka (etarsko ulje i njegove frakcije različitih sastava) kao i komercijalni antibiotici korišćeni su u testiranju antimikrobne aktivnosti i inhibitornog uticaja na razvoj nekih bakterija, kvasaca i gljivica. Etarsko ulje kleke je pokazalo slabu antimikrobnu aktivnost na svim sojevima a frakcije sa čistim α-pinenom i smešom α-pinena i sabinena naročito na rast gljivica. U poređenju sa komercijalnim antibioticima frakcije etarskog ulja kleke pokazuju širok spektar delovanja kao i veće zone inhibicije. .", publisher = "Serbian Chemical Society, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Antimicrobial activity of the essential oil and different fractions of Juniperus communis L. and a comparison with some commercial antibiotics, Antimikrobna aktivnost etarskog ulja i različitih frakcija Juniperus communis L. i poređenje sa nekim komercijalnim antibioticima", pages = "320-311", number = "4", volume = "72", url = "https://hdl.handle.net/21.15107/rcub_technorep_1198" }
Glišić, S., Milojević, S., Dimitrijević, S., Orlović, A.,& Skala, D.. (2007). Antimicrobial activity of the essential oil and different fractions of Juniperus communis L. and a comparison with some commercial antibiotics. in Journal of the Serbian Chemical Society Serbian Chemical Society, Belgrade., 72(4), 311-320. https://hdl.handle.net/21.15107/rcub_technorep_1198
Glišić S, Milojević S, Dimitrijević S, Orlović A, Skala D. Antimicrobial activity of the essential oil and different fractions of Juniperus communis L. and a comparison with some commercial antibiotics. in Journal of the Serbian Chemical Society. 2007;72(4):311-320. https://hdl.handle.net/21.15107/rcub_technorep_1198 .
Glišić, Sandra, Milojević, Svetomir, Dimitrijević, Suzana, Orlović, Aleksandar, Skala, Dejan, "Antimicrobial activity of the essential oil and different fractions of Juniperus communis L. and a comparison with some commercial antibiotics" in Journal of the Serbian Chemical Society, 72, no. 4 (2007):311-320, https://hdl.handle.net/21.15107/rcub_technorep_1198 .