Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels
Samo za registrovane korisnike
2012
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Hydrogels based on 2-hydroxyethyl methacrylate (HEMA), different poly(ethylene glycol) dimethacrylates (PEGDMA) and itaconic acid (IA) were prepared by free radical crosslinking copolymerization. The influence of different PEGDMA content and type, with PEG chain length of 550 and 875, on the structure, morphology, biocompatibility, swelling and release properties of P(HEMA/IA/550PEGDMA) and P(HEMA/IA/875PEGDMA) copolymeric hydrogels have been investigated. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line, indicated satisfactory cytocompatibility. Swelling studies were conducted for all samples in a physiological pH and temperature range, showing a noticeable pH sensitivity and temperature dependent equilibrium swelling. The characterization by Fourier transform infrared (FTIR) spectroscopy confirmed the presence of all monomers used in the gel structure, and morphology study, performed by scanning ele...ctron microscopy (SEM), revealed no significant differences between the samples with respect to pore size. In order to elucidate the release mechanism, drug release study was carried out in vitro using two forms of vitamin 6:3: nicotinamide (NAm) and nicotinic acid (NAc). The dissolution profiles were fitted to various mathematical models and the best fit was obtained for first order kinetics. The favorable swelling and drug release properties of P(HEMA/IA/PEGDMA) hydrogels make them good candidates to be used as biomaterials.
Ključne reči:
Hydrogel / 2-Hydroxyethyl methacrylate / Itaconic acid / Poly(ethylene glycol) dimethacrylate / Cytocompatibility / pH sensitive and temperature dependent swelling / Controlled release / Vitamin B-3Izvor:
Chemical Engineering Journal, 2012, 179, 372-380Izdavač:
- Elsevier Science Sa, Lausanne
Finansiranje / projekti:
- Sinteza i karakterizacija novih funkcionalnih polimera i polimernih nanokompozita (RS-MESTD-Basic Research (BR or ON)-172062)
DOI: 10.1016/j.cej.2011.10.083
ISSN: 1385-8947
WoS: 000300202500042
Scopus: 2-s2.0-84155188900
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Dobić, Sava N. AU - Filipović, Jovanka M. AU - Tomić, Simonida PY - 2012 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2213 AB - Hydrogels based on 2-hydroxyethyl methacrylate (HEMA), different poly(ethylene glycol) dimethacrylates (PEGDMA) and itaconic acid (IA) were prepared by free radical crosslinking copolymerization. The influence of different PEGDMA content and type, with PEG chain length of 550 and 875, on the structure, morphology, biocompatibility, swelling and release properties of P(HEMA/IA/550PEGDMA) and P(HEMA/IA/875PEGDMA) copolymeric hydrogels have been investigated. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line, indicated satisfactory cytocompatibility. Swelling studies were conducted for all samples in a physiological pH and temperature range, showing a noticeable pH sensitivity and temperature dependent equilibrium swelling. The characterization by Fourier transform infrared (FTIR) spectroscopy confirmed the presence of all monomers used in the gel structure, and morphology study, performed by scanning electron microscopy (SEM), revealed no significant differences between the samples with respect to pore size. In order to elucidate the release mechanism, drug release study was carried out in vitro using two forms of vitamin 6:3: nicotinamide (NAm) and nicotinic acid (NAc). The dissolution profiles were fitted to various mathematical models and the best fit was obtained for first order kinetics. The favorable swelling and drug release properties of P(HEMA/IA/PEGDMA) hydrogels make them good candidates to be used as biomaterials. PB - Elsevier Science Sa, Lausanne T2 - Chemical Engineering Journal T1 - Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels EP - 380 SP - 372 VL - 179 DO - 10.1016/j.cej.2011.10.083 ER -
@article{ author = "Dobić, Sava N. and Filipović, Jovanka M. and Tomić, Simonida", year = "2012", abstract = "Hydrogels based on 2-hydroxyethyl methacrylate (HEMA), different poly(ethylene glycol) dimethacrylates (PEGDMA) and itaconic acid (IA) were prepared by free radical crosslinking copolymerization. The influence of different PEGDMA content and type, with PEG chain length of 550 and 875, on the structure, morphology, biocompatibility, swelling and release properties of P(HEMA/IA/550PEGDMA) and P(HEMA/IA/875PEGDMA) copolymeric hydrogels have been investigated. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line, indicated satisfactory cytocompatibility. Swelling studies were conducted for all samples in a physiological pH and temperature range, showing a noticeable pH sensitivity and temperature dependent equilibrium swelling. The characterization by Fourier transform infrared (FTIR) spectroscopy confirmed the presence of all monomers used in the gel structure, and morphology study, performed by scanning electron microscopy (SEM), revealed no significant differences between the samples with respect to pore size. In order to elucidate the release mechanism, drug release study was carried out in vitro using two forms of vitamin 6:3: nicotinamide (NAm) and nicotinic acid (NAc). The dissolution profiles were fitted to various mathematical models and the best fit was obtained for first order kinetics. The favorable swelling and drug release properties of P(HEMA/IA/PEGDMA) hydrogels make them good candidates to be used as biomaterials.", publisher = "Elsevier Science Sa, Lausanne", journal = "Chemical Engineering Journal", title = "Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels", pages = "380-372", volume = "179", doi = "10.1016/j.cej.2011.10.083" }
Dobić, S. N., Filipović, J. M.,& Tomić, S.. (2012). Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels. in Chemical Engineering Journal Elsevier Science Sa, Lausanne., 179, 372-380. https://doi.org/10.1016/j.cej.2011.10.083
Dobić SN, Filipović JM, Tomić S. Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels. in Chemical Engineering Journal. 2012;179:372-380. doi:10.1016/j.cej.2011.10.083 .
Dobić, Sava N., Filipović, Jovanka M., Tomić, Simonida, "Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels" in Chemical Engineering Journal, 179 (2012):372-380, https://doi.org/10.1016/j.cej.2011.10.083 . .