Lipophilicity assessment of some 5,5-disubstituted hydantoins by the means of reversed phase liquid chromatography
Procena lipofilnosti nekih 5,5-disupstituisanih hidantoina primenom tečne hromatografije na obrnutim fazama
Аутори
Despotović, VesnaTrišović, Nemanja
Mandić, Anamarija
Ušćumlić, Gordana
Đaković-Sekulić, Tatjana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The retention of some 5,5-disubstituted hydantoins was investigated by reversed phase high performance thin-layer chromatography (RP HPTLC) and reversed phase high-pressure liquid chromatography (RP HPLC). The mobile phases were mixtures of methanol-water and acetonitrile-water in various volume fractions. In order to explore and visualize similarities and differences among the investigated compounds and chromatographic system, Principal Component Analysis (PCA) was used. Results show that the experimental lipophilicity indices estimated from retention data (Rm,w, log kw) and PC1 are directly correlated with logP values at a high significant statistical level.
Ispitano је retenciono ponašanje derivata 5,5-disupstituisanih hidantoina primenom dve tehnike tečne hromatografje na obrnutim fazama, i to hromatografije na tankom sloju velike moći razdvajanja (HPTLC) i tečne hromatografije pod visokim pritiskom (HPLC). Као pokretne faze Korišćene su smeše metanol-voda i acetonitril-voda u različitim zapreminskim odnosima. Da bi ispitali i vizuelno utvrdili sličnosti i razlike među ispitivanim supstancama u korišćenim hromatografskim sistemima, primenjena je analiza glavnih komponenti (PCA analiza). Rezultati su pokazali da između računskih logP vrednosti i hromatografskih parametara lipofilnosti koji su dobijeni ekstrapolacijom retencionih podataka (Rm,w, log kw), као i PC 1 postoji značajna startistička povezanost.
Кључне речи:
RM,W / log kw / PC1 / log P / lipophilicity / R M,W / log kw / PC1 / log P / lipofilnostИзвор:
Chemical Industry & Chemical Engineering Quarterly, 2013, 19, 1, 1-6Издавач:
- Association of the Chemical Engineers of Serbia
Финансирање / пројекти:
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-MESTD-Basic Research (BR or ON)-172013)
DOI: 10.2298/CICEQ120124037D
ISSN: 1451-9372
WoS: 000319787300001
Scopus: 2-s2.0-84875643884
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Despotović, Vesna AU - Trišović, Nemanja AU - Mandić, Anamarija AU - Ušćumlić, Gordana AU - Đaković-Sekulić, Tatjana PY - 2013 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2312 AB - The retention of some 5,5-disubstituted hydantoins was investigated by reversed phase high performance thin-layer chromatography (RP HPTLC) and reversed phase high-pressure liquid chromatography (RP HPLC). The mobile phases were mixtures of methanol-water and acetonitrile-water in various volume fractions. In order to explore and visualize similarities and differences among the investigated compounds and chromatographic system, Principal Component Analysis (PCA) was used. Results show that the experimental lipophilicity indices estimated from retention data (Rm,w, log kw) and PC1 are directly correlated with logP values at a high significant statistical level. AB - Ispitano је retenciono ponašanje derivata 5,5-disupstituisanih hidantoina primenom dve tehnike tečne hromatografje na obrnutim fazama, i to hromatografije na tankom sloju velike moći razdvajanja (HPTLC) i tečne hromatografije pod visokim pritiskom (HPLC). Као pokretne faze Korišćene su smeše metanol-voda i acetonitril-voda u različitim zapreminskim odnosima. Da bi ispitali i vizuelno utvrdili sličnosti i razlike među ispitivanim supstancama u korišćenim hromatografskim sistemima, primenjena je analiza glavnih komponenti (PCA analiza). Rezultati su pokazali da između računskih logP vrednosti i hromatografskih parametara lipofilnosti koji su dobijeni ekstrapolacijom retencionih podataka (Rm,w, log kw), као i PC 1 postoji značajna startistička povezanost. PB - Association of the Chemical Engineers of Serbia T2 - Chemical Industry & Chemical Engineering Quarterly T1 - Lipophilicity assessment of some 5,5-disubstituted hydantoins by the means of reversed phase liquid chromatography T1 - Procena lipofilnosti nekih 5,5-disupstituisanih hidantoina primenom tečne hromatografije na obrnutim fazama EP - 6 IS - 1 SP - 1 VL - 19 DO - 10.2298/CICEQ120124037D ER -
@article{ author = "Despotović, Vesna and Trišović, Nemanja and Mandić, Anamarija and Ušćumlić, Gordana and Đaković-Sekulić, Tatjana", year = "2013", abstract = "The retention of some 5,5-disubstituted hydantoins was investigated by reversed phase high performance thin-layer chromatography (RP HPTLC) and reversed phase high-pressure liquid chromatography (RP HPLC). The mobile phases were mixtures of methanol-water and acetonitrile-water in various volume fractions. In order to explore and visualize similarities and differences among the investigated compounds and chromatographic system, Principal Component Analysis (PCA) was used. Results show that the experimental lipophilicity indices estimated from retention data (Rm,w, log kw) and PC1 are directly correlated with logP values at a high significant statistical level., Ispitano је retenciono ponašanje derivata 5,5-disupstituisanih hidantoina primenom dve tehnike tečne hromatografje na obrnutim fazama, i to hromatografije na tankom sloju velike moći razdvajanja (HPTLC) i tečne hromatografije pod visokim pritiskom (HPLC). Као pokretne faze Korišćene su smeše metanol-voda i acetonitril-voda u različitim zapreminskim odnosima. Da bi ispitali i vizuelno utvrdili sličnosti i razlike među ispitivanim supstancama u korišćenim hromatografskim sistemima, primenjena je analiza glavnih komponenti (PCA analiza). Rezultati su pokazali da između računskih logP vrednosti i hromatografskih parametara lipofilnosti koji su dobijeni ekstrapolacijom retencionih podataka (Rm,w, log kw), као i PC 1 postoji značajna startistička povezanost.", publisher = "Association of the Chemical Engineers of Serbia", journal = "Chemical Industry & Chemical Engineering Quarterly", title = "Lipophilicity assessment of some 5,5-disubstituted hydantoins by the means of reversed phase liquid chromatography, Procena lipofilnosti nekih 5,5-disupstituisanih hidantoina primenom tečne hromatografije na obrnutim fazama", pages = "6-1", number = "1", volume = "19", doi = "10.2298/CICEQ120124037D" }
Despotović, V., Trišović, N., Mandić, A., Ušćumlić, G.,& Đaković-Sekulić, T.. (2013). Lipophilicity assessment of some 5,5-disubstituted hydantoins by the means of reversed phase liquid chromatography. in Chemical Industry & Chemical Engineering Quarterly Association of the Chemical Engineers of Serbia., 19(1), 1-6. https://doi.org/10.2298/CICEQ120124037D
Despotović V, Trišović N, Mandić A, Ušćumlić G, Đaković-Sekulić T. Lipophilicity assessment of some 5,5-disubstituted hydantoins by the means of reversed phase liquid chromatography. in Chemical Industry & Chemical Engineering Quarterly. 2013;19(1):1-6. doi:10.2298/CICEQ120124037D .
Despotović, Vesna, Trišović, Nemanja, Mandić, Anamarija, Ušćumlić, Gordana, Đaković-Sekulić, Tatjana, "Lipophilicity assessment of some 5,5-disubstituted hydantoins by the means of reversed phase liquid chromatography" in Chemical Industry & Chemical Engineering Quarterly, 19, no. 1 (2013):1-6, https://doi.org/10.2298/CICEQ120124037D . .