Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications
Samo za registrovane korisnike
2014
Autori
Hoppe, AlexanderJokić, Bojan
Janaćković, Đorđe
Fey, Tobias
Greil, Peter
Romeis, Stefan
Schmidt, Jochen
Peukert, Wolfgang
Lao, Jonathan
Jallot, Edouard
Boccaccini, Aldo R.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Loading biomaterials with angiogenic therapeutics has emerged as a promising approach for developing superior biomaterials for engineering bone constructs. In this context, cobalt-releasing materials are of interest as Co is a known angiogenic agent. In this study, we report on cobalt-releasing three-dimensional (3D) scaffolds based on a silicate bioactive glass. Novel melt-derived "1393" glass (53 wt % SiO2, 6 wt % Na2O, 12 wt % K2O, wt % MgO, 20 wt % CaO, and 4 wt % P2O5) with CoO substituted for CaO was fabricated and was used to produce a 3D porous scaffold by the foam replica technique. Glass structural and thermal properties as well as scaffold macrostructure, compressive strength, acellular bioactivity, and Co release in simulated body fluid (SBF) were investigated. In particular, detailed insights into the physicochemical reactions occurring at the scaffold-fluid interface were derived from advanced micro-particle-induced X-ray emission/Rutherford backscattering spectrometry an...alysis. CoO is shown to act in a concentration-dependent manner as both a network former and a network modifier. At a concentration of 5 wt % CoO, the glass transition point (T-g) of the glass was reduced because of the replacement of stronger Si-O bonds with Co-O bonds in the glass network. Compressive strengths of gt 2 MPa were measured for Co-containing 1393-derived scaffolds, which are comparable to values of human spongy bone. SBF studies showed that all glass scaffolds form a calcium phosphate (CaP) layer, and for 1393-1Co and 1393-5Co, CaP layers with incorporated traces of Co were observed. The highest Co concentrations of similar to 12 ppm were released in SBF after reaction for 21 days, which are known to be within therapeutic ranges reported for Co2+ ions.
Ključne reči:
cobalt / hypoxia / bioglass / bioactive / scaffold / bone tissue engineering / angiogenesisIzvor:
ACS Applied Materials & Interfaces, 2014, 6, 4, 2865-2877Izdavač:
- Amer Chemical Soc, Washington
DOI: 10.1021/am405354y
ISSN: 1944-8244
PubMed: 24476347
WoS: 000332144600088
Scopus: 2-s2.0-84896893243
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Hoppe, Alexander AU - Jokić, Bojan AU - Janaćković, Đorđe AU - Fey, Tobias AU - Greil, Peter AU - Romeis, Stefan AU - Schmidt, Jochen AU - Peukert, Wolfgang AU - Lao, Jonathan AU - Jallot, Edouard AU - Boccaccini, Aldo R. PY - 2014 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2770 AB - Loading biomaterials with angiogenic therapeutics has emerged as a promising approach for developing superior biomaterials for engineering bone constructs. In this context, cobalt-releasing materials are of interest as Co is a known angiogenic agent. In this study, we report on cobalt-releasing three-dimensional (3D) scaffolds based on a silicate bioactive glass. Novel melt-derived "1393" glass (53 wt % SiO2, 6 wt % Na2O, 12 wt % K2O, wt % MgO, 20 wt % CaO, and 4 wt % P2O5) with CoO substituted for CaO was fabricated and was used to produce a 3D porous scaffold by the foam replica technique. Glass structural and thermal properties as well as scaffold macrostructure, compressive strength, acellular bioactivity, and Co release in simulated body fluid (SBF) were investigated. In particular, detailed insights into the physicochemical reactions occurring at the scaffold-fluid interface were derived from advanced micro-particle-induced X-ray emission/Rutherford backscattering spectrometry analysis. CoO is shown to act in a concentration-dependent manner as both a network former and a network modifier. At a concentration of 5 wt % CoO, the glass transition point (T-g) of the glass was reduced because of the replacement of stronger Si-O bonds with Co-O bonds in the glass network. Compressive strengths of gt 2 MPa were measured for Co-containing 1393-derived scaffolds, which are comparable to values of human spongy bone. SBF studies showed that all glass scaffolds form a calcium phosphate (CaP) layer, and for 1393-1Co and 1393-5Co, CaP layers with incorporated traces of Co were observed. The highest Co concentrations of similar to 12 ppm were released in SBF after reaction for 21 days, which are known to be within therapeutic ranges reported for Co2+ ions. PB - Amer Chemical Soc, Washington T2 - ACS Applied Materials & Interfaces T1 - Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications EP - 2877 IS - 4 SP - 2865 VL - 6 DO - 10.1021/am405354y ER -
@article{ author = "Hoppe, Alexander and Jokić, Bojan and Janaćković, Đorđe and Fey, Tobias and Greil, Peter and Romeis, Stefan and Schmidt, Jochen and Peukert, Wolfgang and Lao, Jonathan and Jallot, Edouard and Boccaccini, Aldo R.", year = "2014", abstract = "Loading biomaterials with angiogenic therapeutics has emerged as a promising approach for developing superior biomaterials for engineering bone constructs. In this context, cobalt-releasing materials are of interest as Co is a known angiogenic agent. In this study, we report on cobalt-releasing three-dimensional (3D) scaffolds based on a silicate bioactive glass. Novel melt-derived "1393" glass (53 wt % SiO2, 6 wt % Na2O, 12 wt % K2O, wt % MgO, 20 wt % CaO, and 4 wt % P2O5) with CoO substituted for CaO was fabricated and was used to produce a 3D porous scaffold by the foam replica technique. Glass structural and thermal properties as well as scaffold macrostructure, compressive strength, acellular bioactivity, and Co release in simulated body fluid (SBF) were investigated. In particular, detailed insights into the physicochemical reactions occurring at the scaffold-fluid interface were derived from advanced micro-particle-induced X-ray emission/Rutherford backscattering spectrometry analysis. CoO is shown to act in a concentration-dependent manner as both a network former and a network modifier. At a concentration of 5 wt % CoO, the glass transition point (T-g) of the glass was reduced because of the replacement of stronger Si-O bonds with Co-O bonds in the glass network. Compressive strengths of gt 2 MPa were measured for Co-containing 1393-derived scaffolds, which are comparable to values of human spongy bone. SBF studies showed that all glass scaffolds form a calcium phosphate (CaP) layer, and for 1393-1Co and 1393-5Co, CaP layers with incorporated traces of Co were observed. The highest Co concentrations of similar to 12 ppm were released in SBF after reaction for 21 days, which are known to be within therapeutic ranges reported for Co2+ ions.", publisher = "Amer Chemical Soc, Washington", journal = "ACS Applied Materials & Interfaces", title = "Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications", pages = "2877-2865", number = "4", volume = "6", doi = "10.1021/am405354y" }
Hoppe, A., Jokić, B., Janaćković, Đ., Fey, T., Greil, P., Romeis, S., Schmidt, J., Peukert, W., Lao, J., Jallot, E.,& Boccaccini, A. R.. (2014). Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications. in ACS Applied Materials & Interfaces Amer Chemical Soc, Washington., 6(4), 2865-2877. https://doi.org/10.1021/am405354y
Hoppe A, Jokić B, Janaćković Đ, Fey T, Greil P, Romeis S, Schmidt J, Peukert W, Lao J, Jallot E, Boccaccini AR. Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications. in ACS Applied Materials & Interfaces. 2014;6(4):2865-2877. doi:10.1021/am405354y .
Hoppe, Alexander, Jokić, Bojan, Janaćković, Đorđe, Fey, Tobias, Greil, Peter, Romeis, Stefan, Schmidt, Jochen, Peukert, Wolfgang, Lao, Jonathan, Jallot, Edouard, Boccaccini, Aldo R., "Cobalt-Releasing 1393 Bioactive Glass-Derived Scaffolds for Bone Tissue Engineering Applications" in ACS Applied Materials & Interfaces, 6, no. 4 (2014):2865-2877, https://doi.org/10.1021/am405354y . .