Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS
Samo za registrovane korisnike
2017
Autori
Lalović, BojanaĐurkić, Tatjana
Vukčević, Marija
Janković-Častvan, Ivona
Kalijadis, Ana
Laušević, Zoran
Laušević, Mila
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In this paper, pristine and chemically treated multi-walled carbon nanotubes (MWCNTs) were employed as solid-phase extraction sorbents for the isolation and enrichment of multi-class pharmaceuticals from the surface water and groundwater, prior to liquid chromatography-tandem mass spectrometry analysis. Thirteen pharmaceuticals that belong to different therapeutical classes (erythromycin, azithromycin, sulfamethoxazole, diazepam, lorazepam, carbamazepine, metoprolol, bisoprolol, enalapril, cilazapril, simvastatin, clopidogrel, diclofenac) and two metabolites of metamizole (4-acetylaminoantipyrine and 4-formylaminoantipyrine) were selected for this study. The influence of chemical treatment on MWCNT surface characteristics and extraction efficiency was studied, and it was shown that HCl treatment of MWCNT leads to a decrease in the amount of surface oxygen groups and at the same time favorably affects the efficiency toward extraction of selected pharmaceuticals. After the optimization o...f the SPE procedure, the following conditions were chosen: 50 mg of HCl-treated MCWNT as a sorbent, 100 mL of water sample at pH 6, and 15 mL of the methanol-dichloromethane mixture (1:1, v/v) as eluent. Under optimal conditions, high recoveries (79-119%), as well as low detection (0.2 to 103 ng L-1) and quantitation (0.5-345 ng L-1) limits, were obtained. The optimized method was applied to the analysis of five surface water and two groundwater samples, and three pharmaceuticals were detected, the antiepileptic drug carbamazepine and two metabolites of antipyretic metamizole.
Ključne reči:
Pharmaceuticals / Solid-phase extraction / Multi-walled carbon nanotubes / Modification / Surface characteristics / Liquid chromatography-tandem mass spectrometryIzvor:
Environmental Science and Pollution Research, 2017, 24, 25, 20784-20793Izdavač:
- Springer Heidelberg, Heidelberg
Finansiranje / projekti:
- Razvoj i primena metoda i materijala za monitoring novih zagađujućih i toksičnih organskih materija i teških metala (RS-MESTD-Basic Research (BR or ON)-172007)
- Fizika i hemija sa jonskim snopovima (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45006)
DOI: 10.1007/s11356-017-9748-0
ISSN: 0944-1344
PubMed: 28718026
WoS: 000408698700056
Scopus: 2-s2.0-85024482334
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Lalović, Bojana AU - Đurkić, Tatjana AU - Vukčević, Marija AU - Janković-Častvan, Ivona AU - Kalijadis, Ana AU - Laušević, Zoran AU - Laušević, Mila PY - 2017 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3577 AB - In this paper, pristine and chemically treated multi-walled carbon nanotubes (MWCNTs) were employed as solid-phase extraction sorbents for the isolation and enrichment of multi-class pharmaceuticals from the surface water and groundwater, prior to liquid chromatography-tandem mass spectrometry analysis. Thirteen pharmaceuticals that belong to different therapeutical classes (erythromycin, azithromycin, sulfamethoxazole, diazepam, lorazepam, carbamazepine, metoprolol, bisoprolol, enalapril, cilazapril, simvastatin, clopidogrel, diclofenac) and two metabolites of metamizole (4-acetylaminoantipyrine and 4-formylaminoantipyrine) were selected for this study. The influence of chemical treatment on MWCNT surface characteristics and extraction efficiency was studied, and it was shown that HCl treatment of MWCNT leads to a decrease in the amount of surface oxygen groups and at the same time favorably affects the efficiency toward extraction of selected pharmaceuticals. After the optimization of the SPE procedure, the following conditions were chosen: 50 mg of HCl-treated MCWNT as a sorbent, 100 mL of water sample at pH 6, and 15 mL of the methanol-dichloromethane mixture (1:1, v/v) as eluent. Under optimal conditions, high recoveries (79-119%), as well as low detection (0.2 to 103 ng L-1) and quantitation (0.5-345 ng L-1) limits, were obtained. The optimized method was applied to the analysis of five surface water and two groundwater samples, and three pharmaceuticals were detected, the antiepileptic drug carbamazepine and two metabolites of antipyretic metamizole. PB - Springer Heidelberg, Heidelberg T2 - Environmental Science and Pollution Research T1 - Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS EP - 20793 IS - 25 SP - 20784 VL - 24 DO - 10.1007/s11356-017-9748-0 ER -
@article{ author = "Lalović, Bojana and Đurkić, Tatjana and Vukčević, Marija and Janković-Častvan, Ivona and Kalijadis, Ana and Laušević, Zoran and Laušević, Mila", year = "2017", abstract = "In this paper, pristine and chemically treated multi-walled carbon nanotubes (MWCNTs) were employed as solid-phase extraction sorbents for the isolation and enrichment of multi-class pharmaceuticals from the surface water and groundwater, prior to liquid chromatography-tandem mass spectrometry analysis. Thirteen pharmaceuticals that belong to different therapeutical classes (erythromycin, azithromycin, sulfamethoxazole, diazepam, lorazepam, carbamazepine, metoprolol, bisoprolol, enalapril, cilazapril, simvastatin, clopidogrel, diclofenac) and two metabolites of metamizole (4-acetylaminoantipyrine and 4-formylaminoantipyrine) were selected for this study. The influence of chemical treatment on MWCNT surface characteristics and extraction efficiency was studied, and it was shown that HCl treatment of MWCNT leads to a decrease in the amount of surface oxygen groups and at the same time favorably affects the efficiency toward extraction of selected pharmaceuticals. After the optimization of the SPE procedure, the following conditions were chosen: 50 mg of HCl-treated MCWNT as a sorbent, 100 mL of water sample at pH 6, and 15 mL of the methanol-dichloromethane mixture (1:1, v/v) as eluent. Under optimal conditions, high recoveries (79-119%), as well as low detection (0.2 to 103 ng L-1) and quantitation (0.5-345 ng L-1) limits, were obtained. The optimized method was applied to the analysis of five surface water and two groundwater samples, and three pharmaceuticals were detected, the antiepileptic drug carbamazepine and two metabolites of antipyretic metamizole.", publisher = "Springer Heidelberg, Heidelberg", journal = "Environmental Science and Pollution Research", title = "Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS", pages = "20793-20784", number = "25", volume = "24", doi = "10.1007/s11356-017-9748-0" }
Lalović, B., Đurkić, T., Vukčević, M., Janković-Častvan, I., Kalijadis, A., Laušević, Z.,& Laušević, M.. (2017). Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS. in Environmental Science and Pollution Research Springer Heidelberg, Heidelberg., 24(25), 20784-20793. https://doi.org/10.1007/s11356-017-9748-0
Lalović B, Đurkić T, Vukčević M, Janković-Častvan I, Kalijadis A, Laušević Z, Laušević M. Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS. in Environmental Science and Pollution Research. 2017;24(25):20784-20793. doi:10.1007/s11356-017-9748-0 .
Lalović, Bojana, Đurkić, Tatjana, Vukčević, Marija, Janković-Častvan, Ivona, Kalijadis, Ana, Laušević, Zoran, Laušević, Mila, "Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS" in Environmental Science and Pollution Research, 24, no. 25 (2017):20784-20793, https://doi.org/10.1007/s11356-017-9748-0 . .