Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method
2017
Autori
Krstić, MarkoRadojević, Marija
Stojanović, Dušica
Radojević, Vesna
Uskoković, Petar
Ibrić, Svetlana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and d...istribution of carvedilol in the encapsulated fibers.
Ključne reči:
Nanofibers / Oral films / Dissolution rate / Process parameters / Formulation parameters / Poly (ethylene oxide)Izvor:
European Journal of Pharmaceutical Sciences, 2017, 101, 160-166Izdavač:
- Elsevier Science Bv, Amsterdam
Finansiranje / projekti:
- Razvoj proizvoda i tehnologija koje obezbeđuju željeno oslobađanje lekovitih supstanci iz čvrstih farmaceutskih oblika (RS-MESTD-Technological Development (TD or TR)-34007)
- Razvoj opreme i procesa dobijanja polimernih kompozitnih materijala sa unapred definisanim funkcionalnim svojstvima (RS-MESTD-Technological Development (TD or TR)-34011)
DOI: 10.1016/j.ejps.2017.02.006
ISSN: 0928-0987
PubMed: 28185991
WoS: 000397685400017
Scopus: 2-s2.0-85013093685
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Krstić, Marko AU - Radojević, Marija AU - Stojanović, Dušica AU - Radojević, Vesna AU - Uskoković, Petar AU - Ibrić, Svetlana PY - 2017 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3749 AB - The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers. PB - Elsevier Science Bv, Amsterdam T2 - European Journal of Pharmaceutical Sciences T1 - Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method EP - 166 SP - 160 VL - 101 DO - 10.1016/j.ejps.2017.02.006 ER -
@article{ author = "Krstić, Marko and Radojević, Marija and Stojanović, Dušica and Radojević, Vesna and Uskoković, Petar and Ibrić, Svetlana", year = "2017", abstract = "The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers.", publisher = "Elsevier Science Bv, Amsterdam", journal = "European Journal of Pharmaceutical Sciences", title = "Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method", pages = "166-160", volume = "101", doi = "10.1016/j.ejps.2017.02.006" }
Krstić, M., Radojević, M., Stojanović, D., Radojević, V., Uskoković, P.,& Ibrić, S.. (2017). Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method. in European Journal of Pharmaceutical Sciences Elsevier Science Bv, Amsterdam., 101, 160-166. https://doi.org/10.1016/j.ejps.2017.02.006
Krstić M, Radojević M, Stojanović D, Radojević V, Uskoković P, Ibrić S. Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method. in European Journal of Pharmaceutical Sciences. 2017;101:160-166. doi:10.1016/j.ejps.2017.02.006 .
Krstić, Marko, Radojević, Marija, Stojanović, Dušica, Radojević, Vesna, Uskoković, Petar, Ibrić, Svetlana, "Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method" in European Journal of Pharmaceutical Sciences, 101 (2017):160-166, https://doi.org/10.1016/j.ejps.2017.02.006 . .