Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release
Само за регистроване кориснике
2019
Аутори
Milovanović, StojaMarković, Darka
Mraković, Ana
Kuska, Robert
Žižović, Irena
Frerich, Sulamith
Ivanović, Jasna
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Amorphous, medical grade poly(D,L-lactic acid) (PLA) and poly(D,L-lactic-co-glycolic acid) (PLGA) were used to develop systems for controlled release of a natural bioactive substance - thymol. Supercritical carbon dioxide (scCO(2)) was successfully used both as an impregnation medium for thymol incorporation into the polymer matrix and a foaming agent in a single-step batch process. Impregnation of samples using low to moderate scCO(2) densities (273 kg/m(3) and 630 kg/m(3)) and short processing times (2 h and 4 h) enabled thymol loading of 0.920/0-6.62% and formation of microcellular foams upon system depressurization. Thymol effect on structural and thermal properties on foamed samples was proven by FTIR and DSC. The effect of CO2 under elevated pressure on the neat polymers was analysed by high pressure DSC. Foaming of polymers with lower molecular weight by CO2 of higher density yielded foams with smaller pores. All tested foams released thymol in a controlled manner in phosphate b...uffered saline (PBS) at 37 degrees C within 3 to 6 weeks. Higher loading and lower cell density favoured thymol release rate, while its concentration in PBS for the tested period depended on foam interaction with the medium. Representative PLGA foam sample with the highest thymol loading (6.62%) showed controlled thymol release within 72 h in mediums having pH values from 1.1 to 7.4.
Кључне речи:
Foaming / Impregnation / PLA / PLGA / Supercritical CO2 / ThymolИзвор:
Materials Science & Engineering C-Materials for Biological Applications, 2019, 99, 394-404Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
- Функционални физиолошки активни биљни материјали са додатом вредношћу за примену у фармацеутској и прехрамбеној индустрији (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45017)
- German Federal Ministry of Education and Research BMBFFederal Ministry of Education & Research (BMBF) [FKZ 01PL11082B]
- German Academic Exchange Service - DAADDeutscher Akademischer Austausch Dienst (DAAD) [57140416]
DOI: 10.1016/j.msec.2019.01.106
ISSN: 0928-4931
PubMed: 30889714
WoS: 000463121200041
Scopus: 2-s2.0-85060859267
Колекције
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Milovanović, Stoja AU - Marković, Darka AU - Mraković, Ana AU - Kuska, Robert AU - Žižović, Irena AU - Frerich, Sulamith AU - Ivanović, Jasna PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4173 AB - Amorphous, medical grade poly(D,L-lactic acid) (PLA) and poly(D,L-lactic-co-glycolic acid) (PLGA) were used to develop systems for controlled release of a natural bioactive substance - thymol. Supercritical carbon dioxide (scCO(2)) was successfully used both as an impregnation medium for thymol incorporation into the polymer matrix and a foaming agent in a single-step batch process. Impregnation of samples using low to moderate scCO(2) densities (273 kg/m(3) and 630 kg/m(3)) and short processing times (2 h and 4 h) enabled thymol loading of 0.920/0-6.62% and formation of microcellular foams upon system depressurization. Thymol effect on structural and thermal properties on foamed samples was proven by FTIR and DSC. The effect of CO2 under elevated pressure on the neat polymers was analysed by high pressure DSC. Foaming of polymers with lower molecular weight by CO2 of higher density yielded foams with smaller pores. All tested foams released thymol in a controlled manner in phosphate buffered saline (PBS) at 37 degrees C within 3 to 6 weeks. Higher loading and lower cell density favoured thymol release rate, while its concentration in PBS for the tested period depended on foam interaction with the medium. Representative PLGA foam sample with the highest thymol loading (6.62%) showed controlled thymol release within 72 h in mediums having pH values from 1.1 to 7.4. PB - Elsevier Science Bv, Amsterdam T2 - Materials Science & Engineering C-Materials for Biological Applications T1 - Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release EP - 404 SP - 394 VL - 99 DO - 10.1016/j.msec.2019.01.106 ER -
@article{ author = "Milovanović, Stoja and Marković, Darka and Mraković, Ana and Kuska, Robert and Žižović, Irena and Frerich, Sulamith and Ivanović, Jasna", year = "2019", abstract = "Amorphous, medical grade poly(D,L-lactic acid) (PLA) and poly(D,L-lactic-co-glycolic acid) (PLGA) were used to develop systems for controlled release of a natural bioactive substance - thymol. Supercritical carbon dioxide (scCO(2)) was successfully used both as an impregnation medium for thymol incorporation into the polymer matrix and a foaming agent in a single-step batch process. Impregnation of samples using low to moderate scCO(2) densities (273 kg/m(3) and 630 kg/m(3)) and short processing times (2 h and 4 h) enabled thymol loading of 0.920/0-6.62% and formation of microcellular foams upon system depressurization. Thymol effect on structural and thermal properties on foamed samples was proven by FTIR and DSC. The effect of CO2 under elevated pressure on the neat polymers was analysed by high pressure DSC. Foaming of polymers with lower molecular weight by CO2 of higher density yielded foams with smaller pores. All tested foams released thymol in a controlled manner in phosphate buffered saline (PBS) at 37 degrees C within 3 to 6 weeks. Higher loading and lower cell density favoured thymol release rate, while its concentration in PBS for the tested period depended on foam interaction with the medium. Representative PLGA foam sample with the highest thymol loading (6.62%) showed controlled thymol release within 72 h in mediums having pH values from 1.1 to 7.4.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Materials Science & Engineering C-Materials for Biological Applications", title = "Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release", pages = "404-394", volume = "99", doi = "10.1016/j.msec.2019.01.106" }
Milovanović, S., Marković, D., Mraković, A., Kuska, R., Žižović, I., Frerich, S.,& Ivanović, J.. (2019). Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release. in Materials Science & Engineering C-Materials for Biological Applications Elsevier Science Bv, Amsterdam., 99, 394-404. https://doi.org/10.1016/j.msec.2019.01.106
Milovanović S, Marković D, Mraković A, Kuska R, Žižović I, Frerich S, Ivanović J. Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release. in Materials Science & Engineering C-Materials for Biological Applications. 2019;99:394-404. doi:10.1016/j.msec.2019.01.106 .
Milovanović, Stoja, Marković, Darka, Mraković, Ana, Kuska, Robert, Žižović, Irena, Frerich, Sulamith, Ivanović, Jasna, "Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release" in Materials Science & Engineering C-Materials for Biological Applications, 99 (2019):394-404, https://doi.org/10.1016/j.msec.2019.01.106 . .