Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide
Samo za registrovane korisnike
2020
Autori
Babić, MarijaVukomanović, Marija
Stefanić, Martin
Nikodinović-Runić, Jasmina
Tomić, Simonida
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2-hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method-modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH-sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast ...in cell culture judged by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications.
Ključne reči:
2-hydroxyethyl methacrylate / gelatin / alginate / iron(III) oxide based hydrogels / controlled curcumin release / degradable scaffolds / scaffolding biomaterialsIzvor:
Macromolecular Chemistry and Physics, 2020, 221, 20, 2000186-Izdavač:
- Wiley-VCH Verlag Gmbh, Weinheim
Finansiranje / projekti:
- SCOPES program of the Swiss National Science Foundation (SNSF)Swiss National Science Foundation (SNSF)
- Swiss Agency for Development and Cooperation (SDC) [IZ73ZO_152327]
- Sinteza i karakterizacija novih funkcionalnih polimera i polimernih nanokompozita (RS-MESTD-Basic Research (BR or ON)-172062)
- Hemijsko i strukturno dizajniranje nanomaterijala za primenu u medicini i inženjerstvu tkiva (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.1002/macp.202000186
ISSN: 1022-1352
WoS: 000572182800001
Scopus: 2-s2.0-85091348146
Kolekcije
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Babić, Marija AU - Vukomanović, Marija AU - Stefanić, Martin AU - Nikodinović-Runić, Jasmina AU - Tomić, Simonida PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4358 AB - The strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2-hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method-modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH-sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast in cell culture judged by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications. PB - Wiley-VCH Verlag Gmbh, Weinheim T2 - Macromolecular Chemistry and Physics T1 - Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide IS - 20 SP - 2000186 VL - 221 DO - 10.1002/macp.202000186 ER -
@article{ author = "Babić, Marija and Vukomanović, Marija and Stefanić, Martin and Nikodinović-Runić, Jasmina and Tomić, Simonida", year = "2020", abstract = "The strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2-hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method-modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH-sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast in cell culture judged by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications.", publisher = "Wiley-VCH Verlag Gmbh, Weinheim", journal = "Macromolecular Chemistry and Physics", title = "Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide", number = "20", pages = "2000186", volume = "221", doi = "10.1002/macp.202000186" }
Babić, M., Vukomanović, M., Stefanić, M., Nikodinović-Runić, J.,& Tomić, S.. (2020). Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide. in Macromolecular Chemistry and Physics Wiley-VCH Verlag Gmbh, Weinheim., 221(20), 2000186. https://doi.org/10.1002/macp.202000186
Babić M, Vukomanović M, Stefanić M, Nikodinović-Runić J, Tomić S. Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide. in Macromolecular Chemistry and Physics. 2020;221(20):2000186. doi:10.1002/macp.202000186 .
Babić, Marija, Vukomanović, Marija, Stefanić, Martin, Nikodinović-Runić, Jasmina, Tomić, Simonida, "Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide" in Macromolecular Chemistry and Physics, 221, no. 20 (2020):2000186, https://doi.org/10.1002/macp.202000186 . .