Fabrication of bacterial cellulose-based wound dressings with improved performance by impregnation with alginate
Само за регистроване кориснике
2020
Аутори
Sulaeva, IrinaHettegger, Hubert
Bergen, Anna
Rohrer, Christian
Kostić, Mirjana
Konnerth, Johannes
Rosenau, Thomas
Potthast, Antje
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Bacterial cellulose (BC) hydrogels are among the most efficient materials already being used for the treatment of complex wounds. The moist environment provided by the BC dressing is a key feature assuring efficient wound recovery. Improving the dressings' moisture-holding ability facilitates its application and leads to an economically preferable extended wear time. To produce materials with reduced moisture loss, BC dressings were impregnated with a secondary hydrophilic component: alginate. The feasibility of an industrial fabrication of this composite was evaluated on pilot scale equipment. It was shown that the procedure can easily be scaled up without significantly increasing the manufacturing time. The resultant composite possessed improved water-retention properties, providing a smooth dressing exchange as demonstrated by a wound-imitating model. The new materials were moreover shown to be compatible with an antimicrobially active compound, which assures their efficiency in the... treatment of highly colonized wounds.
Кључне речи:
Alginate / Bacterial cellulose / Hydrogel / PHMB / Water-holding capacity (WHC) / Wound dressingИзвор:
Materials Science & Engineering C-Materials for Biological Applications, 2020, 110Издавач:
- Elsevier, Amsterdam
Финансирање / пројекти:
- Christian Doppler Research Society, Austria
- CD-Laboratory for Advanced Cellulose Chemistry and Analytics
- Lohmann Rauscher GmbH
DOI: 10.1016/j.msec.2019.110619
ISSN: 0928-4931
PubMed: 32204063
WoS: 000527395900010
Scopus: 2-s2.0-85078509982
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Sulaeva, Irina AU - Hettegger, Hubert AU - Bergen, Anna AU - Rohrer, Christian AU - Kostić, Mirjana AU - Konnerth, Johannes AU - Rosenau, Thomas AU - Potthast, Antje PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4467 AB - Bacterial cellulose (BC) hydrogels are among the most efficient materials already being used for the treatment of complex wounds. The moist environment provided by the BC dressing is a key feature assuring efficient wound recovery. Improving the dressings' moisture-holding ability facilitates its application and leads to an economically preferable extended wear time. To produce materials with reduced moisture loss, BC dressings were impregnated with a secondary hydrophilic component: alginate. The feasibility of an industrial fabrication of this composite was evaluated on pilot scale equipment. It was shown that the procedure can easily be scaled up without significantly increasing the manufacturing time. The resultant composite possessed improved water-retention properties, providing a smooth dressing exchange as demonstrated by a wound-imitating model. The new materials were moreover shown to be compatible with an antimicrobially active compound, which assures their efficiency in the treatment of highly colonized wounds. PB - Elsevier, Amsterdam T2 - Materials Science & Engineering C-Materials for Biological Applications T1 - Fabrication of bacterial cellulose-based wound dressings with improved performance by impregnation with alginate VL - 110 DO - 10.1016/j.msec.2019.110619 ER -
@article{ author = "Sulaeva, Irina and Hettegger, Hubert and Bergen, Anna and Rohrer, Christian and Kostić, Mirjana and Konnerth, Johannes and Rosenau, Thomas and Potthast, Antje", year = "2020", abstract = "Bacterial cellulose (BC) hydrogels are among the most efficient materials already being used for the treatment of complex wounds. The moist environment provided by the BC dressing is a key feature assuring efficient wound recovery. Improving the dressings' moisture-holding ability facilitates its application and leads to an economically preferable extended wear time. To produce materials with reduced moisture loss, BC dressings were impregnated with a secondary hydrophilic component: alginate. The feasibility of an industrial fabrication of this composite was evaluated on pilot scale equipment. It was shown that the procedure can easily be scaled up without significantly increasing the manufacturing time. The resultant composite possessed improved water-retention properties, providing a smooth dressing exchange as demonstrated by a wound-imitating model. The new materials were moreover shown to be compatible with an antimicrobially active compound, which assures their efficiency in the treatment of highly colonized wounds.", publisher = "Elsevier, Amsterdam", journal = "Materials Science & Engineering C-Materials for Biological Applications", title = "Fabrication of bacterial cellulose-based wound dressings with improved performance by impregnation with alginate", volume = "110", doi = "10.1016/j.msec.2019.110619" }
Sulaeva, I., Hettegger, H., Bergen, A., Rohrer, C., Kostić, M., Konnerth, J., Rosenau, T.,& Potthast, A.. (2020). Fabrication of bacterial cellulose-based wound dressings with improved performance by impregnation with alginate. in Materials Science & Engineering C-Materials for Biological Applications Elsevier, Amsterdam., 110. https://doi.org/10.1016/j.msec.2019.110619
Sulaeva I, Hettegger H, Bergen A, Rohrer C, Kostić M, Konnerth J, Rosenau T, Potthast A. Fabrication of bacterial cellulose-based wound dressings with improved performance by impregnation with alginate. in Materials Science & Engineering C-Materials for Biological Applications. 2020;110. doi:10.1016/j.msec.2019.110619 .
Sulaeva, Irina, Hettegger, Hubert, Bergen, Anna, Rohrer, Christian, Kostić, Mirjana, Konnerth, Johannes, Rosenau, Thomas, Potthast, Antje, "Fabrication of bacterial cellulose-based wound dressings with improved performance by impregnation with alginate" in Materials Science & Engineering C-Materials for Biological Applications, 110 (2020), https://doi.org/10.1016/j.msec.2019.110619 . .