Acetylsalicylic acid: Incoming 150 years of the first synthesis
Acetilsalicilna kiselina - stopedeseta godišnjica prve sinteze
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Acetylsalicylic acid is one of the most fascinating and versatile drugs known to medicine, as well as one of the oldest. Acetylsalicylic acid is a drug which is safe, with analgetic, antirheumatic, anti-inflammatory antiplatelet and antithrombotic action. It may be applied not only in clinical practice, but also as prevention. The first known use of an acetylsalicylic acid-like preparation can be traced to ancient Greece. In 1853 Charles Gerhardt published the first synthesis of acetylsalicylic acid. Felix Hoffmann, a chemist for Friedrich Bayer, a German dye company obtained a patent on acetylsalicylic acid some 40 years later. Bayer coined the name Aspirin for the new product. The 20 in century was the century in which many researchers in many companies tried to improve the synthesis of acetylsalicylic acid not only in terms of yield but also purity. This paper describes the history, use, mechanism of action, synthesis and production as well as the purification and stability of acety...lsalicylic acid.
Upotreba acetilsalicilne kiseline datira još iz 4 veka p.n.e., a prva sinteza izvršena je pre skoro 150 godina. U tom periodu veliki broj istraživača radio je na istraživanju dobijanja acetilsalicilne kiseline zbog njenog izuzetno velikog komercijalnog značaja. U raduje data kratka istorija acetilsalicilne kiseline, njena upotreba, način delovanja kao i neželjena dejstva. Takođe su razmatrane osobine, dobijanje (opšte i komercijalno) prečišćavanje i stabilnost acetilsalicilne kiseline.
Ključne reči:
acetylsalicylic acid / properties / synthesis / purification / stability / mechanism of action / acetilsalicilna kiselina / svojstva / sinteza / prečišćavanje / stabilnost / dejstvoIzvor:
Hemijska industrija, 2002, 56, 10, 401-408Izdavač:
- Association of Chemical Engineers of Serbia
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Mijin, Dušan AU - Stanković, Milena AU - Petrović, Slobodan AU - Blagojević, Milorad PY - 2002 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/463 AB - Acetylsalicylic acid is one of the most fascinating and versatile drugs known to medicine, as well as one of the oldest. Acetylsalicylic acid is a drug which is safe, with analgetic, antirheumatic, anti-inflammatory antiplatelet and antithrombotic action. It may be applied not only in clinical practice, but also as prevention. The first known use of an acetylsalicylic acid-like preparation can be traced to ancient Greece. In 1853 Charles Gerhardt published the first synthesis of acetylsalicylic acid. Felix Hoffmann, a chemist for Friedrich Bayer, a German dye company obtained a patent on acetylsalicylic acid some 40 years later. Bayer coined the name Aspirin for the new product. The 20 in century was the century in which many researchers in many companies tried to improve the synthesis of acetylsalicylic acid not only in terms of yield but also purity. This paper describes the history, use, mechanism of action, synthesis and production as well as the purification and stability of acetylsalicylic acid. AB - Upotreba acetilsalicilne kiseline datira još iz 4 veka p.n.e., a prva sinteza izvršena je pre skoro 150 godina. U tom periodu veliki broj istraživača radio je na istraživanju dobijanja acetilsalicilne kiseline zbog njenog izuzetno velikog komercijalnog značaja. U raduje data kratka istorija acetilsalicilne kiseline, njena upotreba, način delovanja kao i neželjena dejstva. Takođe su razmatrane osobine, dobijanje (opšte i komercijalno) prečišćavanje i stabilnost acetilsalicilne kiseline. PB - Association of Chemical Engineers of Serbia T2 - Hemijska industrija T1 - Acetylsalicylic acid: Incoming 150 years of the first synthesis T1 - Acetilsalicilna kiselina - stopedeseta godišnjica prve sinteze EP - 408 IS - 10 SP - 401 VL - 56 DO - 10.2298/HEMIND0210401M ER -
@article{ author = "Mijin, Dušan and Stanković, Milena and Petrović, Slobodan and Blagojević, Milorad", year = "2002", abstract = "Acetylsalicylic acid is one of the most fascinating and versatile drugs known to medicine, as well as one of the oldest. Acetylsalicylic acid is a drug which is safe, with analgetic, antirheumatic, anti-inflammatory antiplatelet and antithrombotic action. It may be applied not only in clinical practice, but also as prevention. The first known use of an acetylsalicylic acid-like preparation can be traced to ancient Greece. In 1853 Charles Gerhardt published the first synthesis of acetylsalicylic acid. Felix Hoffmann, a chemist for Friedrich Bayer, a German dye company obtained a patent on acetylsalicylic acid some 40 years later. Bayer coined the name Aspirin for the new product. The 20 in century was the century in which many researchers in many companies tried to improve the synthesis of acetylsalicylic acid not only in terms of yield but also purity. This paper describes the history, use, mechanism of action, synthesis and production as well as the purification and stability of acetylsalicylic acid., Upotreba acetilsalicilne kiseline datira još iz 4 veka p.n.e., a prva sinteza izvršena je pre skoro 150 godina. U tom periodu veliki broj istraživača radio je na istraživanju dobijanja acetilsalicilne kiseline zbog njenog izuzetno velikog komercijalnog značaja. U raduje data kratka istorija acetilsalicilne kiseline, njena upotreba, način delovanja kao i neželjena dejstva. Takođe su razmatrane osobine, dobijanje (opšte i komercijalno) prečišćavanje i stabilnost acetilsalicilne kiseline.", publisher = "Association of Chemical Engineers of Serbia", journal = "Hemijska industrija", title = "Acetylsalicylic acid: Incoming 150 years of the first synthesis, Acetilsalicilna kiselina - stopedeseta godišnjica prve sinteze", pages = "408-401", number = "10", volume = "56", doi = "10.2298/HEMIND0210401M" }
Mijin, D., Stanković, M., Petrović, S.,& Blagojević, M.. (2002). Acetylsalicylic acid: Incoming 150 years of the first synthesis. in Hemijska industrija Association of Chemical Engineers of Serbia., 56(10), 401-408. https://doi.org/10.2298/HEMIND0210401M
Mijin D, Stanković M, Petrović S, Blagojević M. Acetylsalicylic acid: Incoming 150 years of the first synthesis. in Hemijska industrija. 2002;56(10):401-408. doi:10.2298/HEMIND0210401M .
Mijin, Dušan, Stanković, Milena, Petrović, Slobodan, Blagojević, Milorad, "Acetylsalicylic acid: Incoming 150 years of the first synthesis" in Hemijska industrija, 56, no. 10 (2002):401-408, https://doi.org/10.2298/HEMIND0210401M . .