Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells
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2021
Authors
Lazić, VesnaPirković, Andrea
Sredojević, Dusan
Marković, Jelena
Papan, Jelena
Ahrenkiel, Phillip S.
Janković-Častvan, Ivona
Dekanski, Dragana
Jovanović-Krivokuća, Milica
Nedeljković, Jovan M.
Article (Published version)
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The toxicity of hybrid nanoparticles, consisting of non-toxic components, zirconium dioxide nanoparticles (ZrO2 NPs), and caffeic acid (CA), was examined against four different cell lines (HTR-8 SV/Neo, JEG-3, JAR, and HeLa). Stable aqueous ZrO2 sol, synthesized by forced hydrolysis, consists of 3-4 nm in size primary particles organized in 30-60 nm in size snowflake-like particles, as determined by transmission electron microscopy and direct light scattering measurements. The surface modification of ZrO2 NPs with CA leads to the formation of an interfacial charge transfer (ICT) complex followed by the appearance of absorption in the visible spectral range. The spectroscopic observations are complemented with the density functional theory calculations using a cluster model. The ZrO2 NPs and CA are non-toxic against four different cell lines in investigated concentration range. Also, ZrO2 NPs promote the proliferation of HTR-8 SV/Neo, JAR, and HeLa cells. On the other hand, hybrid ZrO2/...CA NPs induced a significant reduction of the viability of the JEG-3 cells (39 %) for the high concentration of components (1.6 mM ZrO2 and 0.4 mM CA).
Keywords:
Toxicity / Caffeic acid / Interfacial charge transfer complex / DFT calculations / ZrO2 nanoparticlesSource:
Chemico-Biological Interactions, 2021, 347Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (RS-MESTD-inst-2020-200017)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200019 (University of Belgrade, Institute for the Application of Nuclear Energy - INEP) (RS-MESTD-inst-2020-200019)
DOI: 10.1016/j.cbi.2021.109618
ISSN: 0009-2797
PubMed: 34364836
WoS: 000692106800003
Scopus: 2-s2.0-85111979228
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Lazić, Vesna AU - Pirković, Andrea AU - Sredojević, Dusan AU - Marković, Jelena AU - Papan, Jelena AU - Ahrenkiel, Phillip S. AU - Janković-Častvan, Ivona AU - Dekanski, Dragana AU - Jovanović-Krivokuća, Milica AU - Nedeljković, Jovan M. PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4772 AB - The toxicity of hybrid nanoparticles, consisting of non-toxic components, zirconium dioxide nanoparticles (ZrO2 NPs), and caffeic acid (CA), was examined against four different cell lines (HTR-8 SV/Neo, JEG-3, JAR, and HeLa). Stable aqueous ZrO2 sol, synthesized by forced hydrolysis, consists of 3-4 nm in size primary particles organized in 30-60 nm in size snowflake-like particles, as determined by transmission electron microscopy and direct light scattering measurements. The surface modification of ZrO2 NPs with CA leads to the formation of an interfacial charge transfer (ICT) complex followed by the appearance of absorption in the visible spectral range. The spectroscopic observations are complemented with the density functional theory calculations using a cluster model. The ZrO2 NPs and CA are non-toxic against four different cell lines in investigated concentration range. Also, ZrO2 NPs promote the proliferation of HTR-8 SV/Neo, JAR, and HeLa cells. On the other hand, hybrid ZrO2/CA NPs induced a significant reduction of the viability of the JEG-3 cells (39 %) for the high concentration of components (1.6 mM ZrO2 and 0.4 mM CA). T2 - Chemico-Biological Interactions T1 - Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells VL - 347 DO - 10.1016/j.cbi.2021.109618 ER -
@article{ author = "Lazić, Vesna and Pirković, Andrea and Sredojević, Dusan and Marković, Jelena and Papan, Jelena and Ahrenkiel, Phillip S. and Janković-Častvan, Ivona and Dekanski, Dragana and Jovanović-Krivokuća, Milica and Nedeljković, Jovan M.", year = "2021", abstract = "The toxicity of hybrid nanoparticles, consisting of non-toxic components, zirconium dioxide nanoparticles (ZrO2 NPs), and caffeic acid (CA), was examined against four different cell lines (HTR-8 SV/Neo, JEG-3, JAR, and HeLa). Stable aqueous ZrO2 sol, synthesized by forced hydrolysis, consists of 3-4 nm in size primary particles organized in 30-60 nm in size snowflake-like particles, as determined by transmission electron microscopy and direct light scattering measurements. The surface modification of ZrO2 NPs with CA leads to the formation of an interfacial charge transfer (ICT) complex followed by the appearance of absorption in the visible spectral range. The spectroscopic observations are complemented with the density functional theory calculations using a cluster model. The ZrO2 NPs and CA are non-toxic against four different cell lines in investigated concentration range. Also, ZrO2 NPs promote the proliferation of HTR-8 SV/Neo, JAR, and HeLa cells. On the other hand, hybrid ZrO2/CA NPs induced a significant reduction of the viability of the JEG-3 cells (39 %) for the high concentration of components (1.6 mM ZrO2 and 0.4 mM CA).", journal = "Chemico-Biological Interactions", title = "Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells", volume = "347", doi = "10.1016/j.cbi.2021.109618" }
Lazić, V., Pirković, A., Sredojević, D., Marković, J., Papan, J., Ahrenkiel, P. S., Janković-Častvan, I., Dekanski, D., Jovanović-Krivokuća, M.,& Nedeljković, J. M.. (2021). Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells. in Chemico-Biological Interactions, 347. https://doi.org/10.1016/j.cbi.2021.109618
Lazić V, Pirković A, Sredojević D, Marković J, Papan J, Ahrenkiel PS, Janković-Častvan I, Dekanski D, Jovanović-Krivokuća M, Nedeljković JM. Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells. in Chemico-Biological Interactions. 2021;347. doi:10.1016/j.cbi.2021.109618 .
Lazić, Vesna, Pirković, Andrea, Sredojević, Dusan, Marković, Jelena, Papan, Jelena, Ahrenkiel, Phillip S., Janković-Častvan, Ivona, Dekanski, Dragana, Jovanović-Krivokuća, Milica, Nedeljković, Jovan M., "Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells" in Chemico-Biological Interactions, 347 (2021), https://doi.org/10.1016/j.cbi.2021.109618 . .