Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution
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2021
Authors
Lović, JelenaLađarević, Jelena
Trišović, Nemanja
Andrić, Filip
Mladenović, Aleksandar
Mijin, Dušan
Vuković, Dragan
Petrović, Slobodan
Ivić, Milka Avramov
Article (Published version)
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The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD) and beta-cyclodextrin (beta CD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1-0.5 mu M with a limit of detection (LOD) of 2.0 x 10(-8) M and a limit of quantification (LOQ) of 6.7 x 10(-8) M. In the case of inclusion complex of the sertraline with HP beta CD, a good linearity range of 0.1-0.9 mu M was obtained with a LOD of 2.6 x 10(-8) M and a LOQ of 8.8 x 10(-8) M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with beta CD with a LOD and a LOQ being 2.6 x 10(-8) and 8.6 x 10(...-8) M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed. [GRAPHICS] .
Keywords:
Cyclodextrines / Electrochemistry / Human serum / Pharmaceutical formulation / VoltammetrySource:
Monatshefte Fur Chemie, 2021, 152, 2, 185-192Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-MESTD-inst-2020-200026)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-MESTD-inst-2020-200168)
DOI: 10.1007/s00706-021-02745-3
ISSN: 0026-9247
WoS: 000619396100001
Scopus: 2-s2.0-85101260441
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Lović, Jelena AU - Lađarević, Jelena AU - Trišović, Nemanja AU - Andrić, Filip AU - Mladenović, Aleksandar AU - Mijin, Dušan AU - Vuković, Dragan AU - Petrović, Slobodan AU - Ivić, Milka Avramov PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4896 AB - The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD) and beta-cyclodextrin (beta CD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1-0.5 mu M with a limit of detection (LOD) of 2.0 x 10(-8) M and a limit of quantification (LOQ) of 6.7 x 10(-8) M. In the case of inclusion complex of the sertraline with HP beta CD, a good linearity range of 0.1-0.9 mu M was obtained with a LOD of 2.6 x 10(-8) M and a LOQ of 8.8 x 10(-8) M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with beta CD with a LOD and a LOQ being 2.6 x 10(-8) and 8.6 x 10(-8) M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed. [GRAPHICS] . T2 - Monatshefte Fur Chemie T1 - Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution EP - 192 IS - 2 SP - 185 VL - 152 DO - 10.1007/s00706-021-02745-3 ER -
@article{ author = "Lović, Jelena and Lađarević, Jelena and Trišović, Nemanja and Andrić, Filip and Mladenović, Aleksandar and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan and Ivić, Milka Avramov", year = "2021", abstract = "The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD) and beta-cyclodextrin (beta CD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1-0.5 mu M with a limit of detection (LOD) of 2.0 x 10(-8) M and a limit of quantification (LOQ) of 6.7 x 10(-8) M. In the case of inclusion complex of the sertraline with HP beta CD, a good linearity range of 0.1-0.9 mu M was obtained with a LOD of 2.6 x 10(-8) M and a LOQ of 8.8 x 10(-8) M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with beta CD with a LOD and a LOQ being 2.6 x 10(-8) and 8.6 x 10(-8) M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed. [GRAPHICS] .", journal = "Monatshefte Fur Chemie", title = "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution", pages = "192-185", number = "2", volume = "152", doi = "10.1007/s00706-021-02745-3" }
Lović, J., Lađarević, J., Trišović, N., Andrić, F., Mladenović, A., Mijin, D., Vuković, D., Petrović, S.,& Ivić, M. A.. (2021). Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte Fur Chemie, 152(2), 185-192. https://doi.org/10.1007/s00706-021-02745-3
Lović J, Lađarević J, Trišović N, Andrić F, Mladenović A, Mijin D, Vuković D, Petrović S, Ivić MA. Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte Fur Chemie. 2021;152(2):185-192. doi:10.1007/s00706-021-02745-3 .
Lović, Jelena, Lađarević, Jelena, Trišović, Nemanja, Andrić, Filip, Mladenović, Aleksandar, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan, Ivić, Milka Avramov, "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution" in Monatshefte Fur Chemie, 152, no. 2 (2021):185-192, https://doi.org/10.1007/s00706-021-02745-3 . .