Mechanical waves caused by collective cell migration: generation
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2022
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Long-timescale viscoelasticity caused by collective cell migration (CCM) significantly influences cell rearrangement and induces generation of mechanical waves. The phenomenon represents a product of the active turbulence occurring at low Reynolds number. The generation of mechanical waves has been a subject of intensive research primarily in 2D multicellular systems, while 3D systems have not been considered in this context. The aim of this contribution is to discuss the generation of mechanical waves during 3D CCM in two model systems: (1) the fusion of two-cell aggregates and (2) cell aggregate rounding after uni-axial compression, pointing out that mechanical waves represent a characteristic of CCM in general. Such perturbations are also involved in various biological processes, such as embryogenesis, wound healing and cancer invasion. The inter-relation between the viscoelasticity and the appearance of active turbulence remains poorly understood even in 2D. The phenomenon represen...ts a consequence of the competition between the viscoelastic force and the surface tension force which induces successive stiffening and softening of parts of multicellular systems. The viscoelastic force is a product of the residual cell stress accumulation and its inhomogeneous distribution caused by CCM. This modeling consideration represents a powerful tool to address the generation of mechanical waves in CCM towards an understanding of this important but still controversial topic.
Ključne reči:
Collective cell migration / Cell mobility / The state of viscoelasticity / Cell residual stress accumulation / Effective inertia / The active turbulenceIzvor:
European Biophysics Journal With Biophysics Letters, 2022, 51, 1, 1-13Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200135 (Univerzitet u Beogradu, Tehnološko-metalurški fakultet) (RS-MESTD-inst-2020-200135)
DOI: 10.1007/s00249-021-01581-x
ISSN: 0175-7571
PubMed: 35072747
WoS: 000746298200002
Scopus: 2-s2.0-85123468339
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Pajić-Lijaković, Ivana AU - Milivojević, Milan PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5012 AB - Long-timescale viscoelasticity caused by collective cell migration (CCM) significantly influences cell rearrangement and induces generation of mechanical waves. The phenomenon represents a product of the active turbulence occurring at low Reynolds number. The generation of mechanical waves has been a subject of intensive research primarily in 2D multicellular systems, while 3D systems have not been considered in this context. The aim of this contribution is to discuss the generation of mechanical waves during 3D CCM in two model systems: (1) the fusion of two-cell aggregates and (2) cell aggregate rounding after uni-axial compression, pointing out that mechanical waves represent a characteristic of CCM in general. Such perturbations are also involved in various biological processes, such as embryogenesis, wound healing and cancer invasion. The inter-relation between the viscoelasticity and the appearance of active turbulence remains poorly understood even in 2D. The phenomenon represents a consequence of the competition between the viscoelastic force and the surface tension force which induces successive stiffening and softening of parts of multicellular systems. The viscoelastic force is a product of the residual cell stress accumulation and its inhomogeneous distribution caused by CCM. This modeling consideration represents a powerful tool to address the generation of mechanical waves in CCM towards an understanding of this important but still controversial topic. T2 - European Biophysics Journal With Biophysics Letters T1 - Mechanical waves caused by collective cell migration: generation EP - 13 IS - 1 SP - 1 VL - 51 DO - 10.1007/s00249-021-01581-x ER -
@article{ author = "Pajić-Lijaković, Ivana and Milivojević, Milan", year = "2022", abstract = "Long-timescale viscoelasticity caused by collective cell migration (CCM) significantly influences cell rearrangement and induces generation of mechanical waves. The phenomenon represents a product of the active turbulence occurring at low Reynolds number. The generation of mechanical waves has been a subject of intensive research primarily in 2D multicellular systems, while 3D systems have not been considered in this context. The aim of this contribution is to discuss the generation of mechanical waves during 3D CCM in two model systems: (1) the fusion of two-cell aggregates and (2) cell aggregate rounding after uni-axial compression, pointing out that mechanical waves represent a characteristic of CCM in general. Such perturbations are also involved in various biological processes, such as embryogenesis, wound healing and cancer invasion. The inter-relation between the viscoelasticity and the appearance of active turbulence remains poorly understood even in 2D. The phenomenon represents a consequence of the competition between the viscoelastic force and the surface tension force which induces successive stiffening and softening of parts of multicellular systems. The viscoelastic force is a product of the residual cell stress accumulation and its inhomogeneous distribution caused by CCM. This modeling consideration represents a powerful tool to address the generation of mechanical waves in CCM towards an understanding of this important but still controversial topic.", journal = "European Biophysics Journal With Biophysics Letters", title = "Mechanical waves caused by collective cell migration: generation", pages = "13-1", number = "1", volume = "51", doi = "10.1007/s00249-021-01581-x" }
Pajić-Lijaković, I.,& Milivojević, M.. (2022). Mechanical waves caused by collective cell migration: generation. in European Biophysics Journal With Biophysics Letters, 51(1), 1-13. https://doi.org/10.1007/s00249-021-01581-x
Pajić-Lijaković I, Milivojević M. Mechanical waves caused by collective cell migration: generation. in European Biophysics Journal With Biophysics Letters. 2022;51(1):1-13. doi:10.1007/s00249-021-01581-x .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Mechanical waves caused by collective cell migration: generation" in European Biophysics Journal With Biophysics Letters, 51, no. 1 (2022):1-13, https://doi.org/10.1007/s00249-021-01581-x . .