Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery
3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has shown good thermal stability, mechanical properties, and prolonged release of IBU following the Fickian diffusion process.
Ključne reči:
gelatin-based bone scaffold / hardness / in vitro ibuprofen release and kinetics / microindentation / semi-solid extrusion 3D printingIzvor:
Arhiv za Farmaciju, 2022, 72, 6, 661-673Izdavač:
- Savez farmaceutskih udruženja Srbije
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200135 (Univerzitet u Beogradu, Tehnološko-metalurški fakultet) (RS-MESTD-inst-2020-200135)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200161 (Univerzitet u Beogradu, Farmaceutski fakultet) (RS-MESTD-inst-2020-200161)
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Jovanović, Marija AU - Petrović, Miloš AU - Stojanović, Dušica AU - Ibrić, Svetlana AU - Uskoković, Petar PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5961 AB - In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has shown good thermal stability, mechanical properties, and prolonged release of IBU following the Fickian diffusion process. PB - Savez farmaceutskih udruženja Srbije T2 - Arhiv za Farmaciju T1 - Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery T1 - 3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu EP - 673 IS - 6 SP - 661 VL - 72 DO - 10.5937/ARHFARM72-40262 ER -
@article{ author = "Jovanović, Marija and Petrović, Miloš and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar", year = "2022", abstract = "In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has shown good thermal stability, mechanical properties, and prolonged release of IBU following the Fickian diffusion process.", publisher = "Savez farmaceutskih udruženja Srbije", journal = "Arhiv za Farmaciju", title = "Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery, 3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu", pages = "673-661", number = "6", volume = "72", doi = "10.5937/ARHFARM72-40262" }
Jovanović, M., Petrović, M., Stojanović, D., Ibrić, S.,& Uskoković, P.. (2022). Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery. in Arhiv za Farmaciju Savez farmaceutskih udruženja Srbije., 72(6), 661-673. https://doi.org/10.5937/ARHFARM72-40262
Jovanović M, Petrović M, Stojanović D, Ibrić S, Uskoković P. Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery. in Arhiv za Farmaciju. 2022;72(6):661-673. doi:10.5937/ARHFARM72-40262 .
Jovanović, Marija, Petrović, Miloš, Stojanović, Dušica, Ibrić, Svetlana, Uskoković, Petar, "Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery" in Arhiv za Farmaciju, 72, no. 6 (2022):661-673, https://doi.org/10.5937/ARHFARM72-40262 . .