The kinetic study of oleylcinnamate synthesis
Само за регистроване кориснике
2013
Аутори
Jakovetić, SonjaLuković, Nevena
Grbavčić, Sanja
Jovanović, Jelena
Stefanović, Andrea
Carević, Milica
Knežević-Jugović, Zorica
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Increased interest in phenolic acids stems from their physiological benefits, which make them very interesting for various applications in food and pharmaceutical industries [1]. The main advantage of phenolic compounds application as natural antioxidants instead of traditionally used synthetic ones, butylated hydroxytoluen (BHT) and butylated hydroxyanisole (BHA), is found in the fact that both BHT and BHA are potential carcinogens, hence their application continuously decreases [2]. On the other hand, one of the main obstacles for their utilization in foods and cosmetics is their low solubility in emulsions and oil-based formulas as repercussion of their hydrophilic nature. Introduction of aliphatic side chain groups via enzyme-catalyzed esterification, causing solubility alternations of phenolic acids, is an adequate way for increasing their industrial application potential [3]. The aim of this research was to enable efficient enzyme-catalyzed synthesis of liposoluble phenolic ester...s using synthesis oleyl cinnamate as model reaction and to determine kinetic constants which are very important for process scale up. Enzyme used for all esterifications is commercial preparation of lipase B from Candida antarctica, Novozyme 435. Initial kinetic study was performed in capped vessels where different concentrations of cinnamic acid (0.1-0.7 mol dm-3), oleyl alcohol (0.1-0.7 mol dm-3) and immobilized lipase (40 mg) were mixed in isooctane and put on orbital shaker set at 55°C and 150 rpm for 6 hours. Several different models were used to fit experimentally obtained data, but the best fit was obtained when ping-pong bi-bi model was used.
Извор:
ICOSECS8, 2013Издавач:
- Serbian Chemical Society
Колекције
Институција/група
Tehnološko-metalurški fakultetTY - CONF AU - Jakovetić, Sonja AU - Luković, Nevena AU - Grbavčić, Sanja AU - Jovanović, Jelena AU - Stefanović, Andrea AU - Carević, Milica AU - Knežević-Jugović, Zorica PY - 2013 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6212 AB - Increased interest in phenolic acids stems from their physiological benefits, which make them very interesting for various applications in food and pharmaceutical industries [1]. The main advantage of phenolic compounds application as natural antioxidants instead of traditionally used synthetic ones, butylated hydroxytoluen (BHT) and butylated hydroxyanisole (BHA), is found in the fact that both BHT and BHA are potential carcinogens, hence their application continuously decreases [2]. On the other hand, one of the main obstacles for their utilization in foods and cosmetics is their low solubility in emulsions and oil-based formulas as repercussion of their hydrophilic nature. Introduction of aliphatic side chain groups via enzyme-catalyzed esterification, causing solubility alternations of phenolic acids, is an adequate way for increasing their industrial application potential [3]. The aim of this research was to enable efficient enzyme-catalyzed synthesis of liposoluble phenolic esters using synthesis oleyl cinnamate as model reaction and to determine kinetic constants which are very important for process scale up. Enzyme used for all esterifications is commercial preparation of lipase B from Candida antarctica, Novozyme 435. Initial kinetic study was performed in capped vessels where different concentrations of cinnamic acid (0.1-0.7 mol dm-3), oleyl alcohol (0.1-0.7 mol dm-3) and immobilized lipase (40 mg) were mixed in isooctane and put on orbital shaker set at 55°C and 150 rpm for 6 hours. Several different models were used to fit experimentally obtained data, but the best fit was obtained when ping-pong bi-bi model was used. PB - Serbian Chemical Society C3 - ICOSECS8 T1 - The kinetic study of oleylcinnamate synthesis UR - https://hdl.handle.net/21.15107/rcub_technorep_6212 ER -
@conference{ author = "Jakovetić, Sonja and Luković, Nevena and Grbavčić, Sanja and Jovanović, Jelena and Stefanović, Andrea and Carević, Milica and Knežević-Jugović, Zorica", year = "2013", abstract = "Increased interest in phenolic acids stems from their physiological benefits, which make them very interesting for various applications in food and pharmaceutical industries [1]. The main advantage of phenolic compounds application as natural antioxidants instead of traditionally used synthetic ones, butylated hydroxytoluen (BHT) and butylated hydroxyanisole (BHA), is found in the fact that both BHT and BHA are potential carcinogens, hence their application continuously decreases [2]. On the other hand, one of the main obstacles for their utilization in foods and cosmetics is their low solubility in emulsions and oil-based formulas as repercussion of their hydrophilic nature. Introduction of aliphatic side chain groups via enzyme-catalyzed esterification, causing solubility alternations of phenolic acids, is an adequate way for increasing their industrial application potential [3]. The aim of this research was to enable efficient enzyme-catalyzed synthesis of liposoluble phenolic esters using synthesis oleyl cinnamate as model reaction and to determine kinetic constants which are very important for process scale up. Enzyme used for all esterifications is commercial preparation of lipase B from Candida antarctica, Novozyme 435. Initial kinetic study was performed in capped vessels where different concentrations of cinnamic acid (0.1-0.7 mol dm-3), oleyl alcohol (0.1-0.7 mol dm-3) and immobilized lipase (40 mg) were mixed in isooctane and put on orbital shaker set at 55°C and 150 rpm for 6 hours. Several different models were used to fit experimentally obtained data, but the best fit was obtained when ping-pong bi-bi model was used.", publisher = "Serbian Chemical Society", journal = "ICOSECS8", title = "The kinetic study of oleylcinnamate synthesis", url = "https://hdl.handle.net/21.15107/rcub_technorep_6212" }
Jakovetić, S., Luković, N., Grbavčić, S., Jovanović, J., Stefanović, A., Carević, M.,& Knežević-Jugović, Z.. (2013). The kinetic study of oleylcinnamate synthesis. in ICOSECS8 Serbian Chemical Society.. https://hdl.handle.net/21.15107/rcub_technorep_6212
Jakovetić S, Luković N, Grbavčić S, Jovanović J, Stefanović A, Carević M, Knežević-Jugović Z. The kinetic study of oleylcinnamate synthesis. in ICOSECS8. 2013;. https://hdl.handle.net/21.15107/rcub_technorep_6212 .
Jakovetić, Sonja, Luković, Nevena, Grbavčić, Sanja, Jovanović, Jelena, Stefanović, Andrea, Carević, Milica, Knežević-Jugović, Zorica, "The kinetic study of oleylcinnamate synthesis" in ICOSECS8 (2013), https://hdl.handle.net/21.15107/rcub_technorep_6212 .