In vitro antioxidant activity evaluation of selected xanthene derivatives
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Xanthendiones (1,8-dioxooctahydroxanthenes) are a special class of oxygenincorporating tricyclic compounds bearing as a basic feature a pyran nucleus fused on either side with cyclohex-2-enone rings. They are often found as a structural motif in natural products with a wide range of biological activities, such as: antioxidant, antimicrobial, trypanocidal, antiinflammatory, antiproliferative
and anticancer. A convenient and efficient approach toward the synthesis of seven aromatically substituted xanthendiones 1‒7 and one structurally-related xanthenone 8 through condensation of dimedone and the appropriate aromatic aldehyde is reported. The relationship between the chemical structure and pharmacological activity was determined empirically using appropriate software packages and in vitro using the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method. The results of the ABTS assay indicate that five compounds possess the ability to scavenge the ABTS•+ radical cation. Base...d on the comparison of the IC50 values, the activity of the compounds was found to be as follows: 6 > 1 > 7 > 2 > 8.
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Book of abstracts / 9th Conference of the Young Chemists of Serbia, 4th November 2023, Novi Sad, 2023, 70-Publisher:
- Belgrade : Serbian Chemical Society
- Belgrade : Serbian Young Chemists Club
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200287)
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Inovacioni centarTY - CONF AU - Lazić, Anita M. AU - Mašulović, Aleksandra D. AU - Lađarević, Jelena M. AU - Valentić, Nataša V. PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6775 AB - Xanthendiones (1,8-dioxooctahydroxanthenes) are a special class of oxygenincorporating tricyclic compounds bearing as a basic feature a pyran nucleus fused on either side with cyclohex-2-enone rings. They are often found as a structural motif in natural products with a wide range of biological activities, such as: antioxidant, antimicrobial, trypanocidal, antiinflammatory, antiproliferative and anticancer. A convenient and efficient approach toward the synthesis of seven aromatically substituted xanthendiones 1‒7 and one structurally-related xanthenone 8 through condensation of dimedone and the appropriate aromatic aldehyde is reported. The relationship between the chemical structure and pharmacological activity was determined empirically using appropriate software packages and in vitro using the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method. The results of the ABTS assay indicate that five compounds possess the ability to scavenge the ABTS•+ radical cation. Based on the comparison of the IC50 values, the activity of the compounds was found to be as follows: 6 > 1 > 7 > 2 > 8. PB - Belgrade : Serbian Chemical Society PB - Belgrade : Serbian Young Chemists Club C3 - Book of abstracts / 9th Conference of the Young Chemists of Serbia, 4th November 2023, Novi Sad T1 - In vitro antioxidant activity evaluation of selected xanthene derivatives SP - 70 UR - https://hdl.handle.net/21.15107/rcub_technorep_6775 ER -
@conference{ author = "Lazić, Anita M. and Mašulović, Aleksandra D. and Lađarević, Jelena M. and Valentić, Nataša V.", year = "2023", abstract = "Xanthendiones (1,8-dioxooctahydroxanthenes) are a special class of oxygenincorporating tricyclic compounds bearing as a basic feature a pyran nucleus fused on either side with cyclohex-2-enone rings. They are often found as a structural motif in natural products with a wide range of biological activities, such as: antioxidant, antimicrobial, trypanocidal, antiinflammatory, antiproliferative and anticancer. A convenient and efficient approach toward the synthesis of seven aromatically substituted xanthendiones 1‒7 and one structurally-related xanthenone 8 through condensation of dimedone and the appropriate aromatic aldehyde is reported. The relationship between the chemical structure and pharmacological activity was determined empirically using appropriate software packages and in vitro using the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method. The results of the ABTS assay indicate that five compounds possess the ability to scavenge the ABTS•+ radical cation. Based on the comparison of the IC50 values, the activity of the compounds was found to be as follows: 6 > 1 > 7 > 2 > 8.", publisher = "Belgrade : Serbian Chemical Society, Belgrade : Serbian Young Chemists Club", journal = "Book of abstracts / 9th Conference of the Young Chemists of Serbia, 4th November 2023, Novi Sad", title = "In vitro antioxidant activity evaluation of selected xanthene derivatives", pages = "70", url = "https://hdl.handle.net/21.15107/rcub_technorep_6775" }
Lazić, A. M., Mašulović, A. D., Lađarević, J. M.,& Valentić, N. V.. (2023). In vitro antioxidant activity evaluation of selected xanthene derivatives. in Book of abstracts / 9th Conference of the Young Chemists of Serbia, 4th November 2023, Novi Sad Belgrade : Serbian Chemical Society., 70. https://hdl.handle.net/21.15107/rcub_technorep_6775
Lazić AM, Mašulović AD, Lađarević JM, Valentić NV. In vitro antioxidant activity evaluation of selected xanthene derivatives. in Book of abstracts / 9th Conference of the Young Chemists of Serbia, 4th November 2023, Novi Sad. 2023;:70. https://hdl.handle.net/21.15107/rcub_technorep_6775 .
Lazić, Anita M., Mašulović, Aleksandra D., Lađarević, Jelena M., Valentić, Nataša V., "In vitro antioxidant activity evaluation of selected xanthene derivatives" in Book of abstracts / 9th Conference of the Young Chemists of Serbia, 4th November 2023, Novi Sad (2023):70, https://hdl.handle.net/21.15107/rcub_technorep_6775 .