Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents
Sinteza i karakterizacija 1-(4-supstituisanih benzil)-3’,4’-dihidro-2’H-spiro[imidazolidin-4,1’-naftalen]-2,5-diona potencijalnih antikonvulzivnih agenasa
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Among the diverse pharmacological activity reported for spirohydantoin and the closely related spirosuccinimides, their anticonvulsant and antiproliferative activities are commonly encountered. Of all cyclic ureide derivatives, Phenytoin (5,5-diphenylhydantoin) is one of the well-known commercially available anticonvulsants, which is also widely used as an antiarrhythmic agent. However, the clinical use of 5,5-diphenylhydantoin is limited by its central nervous adverse effects in addition to a wide variety of drug interactions [1]. With the aim of developing new analogs with a more efficient therapeutic effect, a series of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-diones, have been synthesized, characterized by melting points, FT-IR, 1H and 13C NMR spectroscopic techniques, and evaluated for anticonvulsant activity. The objective of the present investigation is to identify the pharmacological impact of the spirocyclic attachment of a semi-rigid ...tetralin residue at C-5 of the imidazolidine-2,4-dione ring and to explore the effect of substitution at N-3 on anticonvulsant activity.
Извор:
Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018, 2018, 56-Издавач:
- Beograd : Serbian Chemical Society
Финансирање / пројекти:
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-MESTD-Basic Research (BR or ON)-172013)
Колекције
Институција/група
Inovacioni centarTY - CONF AU - Lazić, Anita M. AU - Mandić, Željko AU - Trišović, Nemanja P. AU - Ušćumlić, Gordana S. PY - 2018 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6789 AB - Among the diverse pharmacological activity reported for spirohydantoin and the closely related spirosuccinimides, their anticonvulsant and antiproliferative activities are commonly encountered. Of all cyclic ureide derivatives, Phenytoin (5,5-diphenylhydantoin) is one of the well-known commercially available anticonvulsants, which is also widely used as an antiarrhythmic agent. However, the clinical use of 5,5-diphenylhydantoin is limited by its central nervous adverse effects in addition to a wide variety of drug interactions [1]. With the aim of developing new analogs with a more efficient therapeutic effect, a series of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-diones, have been synthesized, characterized by melting points, FT-IR, 1H and 13C NMR spectroscopic techniques, and evaluated for anticonvulsant activity. The objective of the present investigation is to identify the pharmacological impact of the spirocyclic attachment of a semi-rigid tetralin residue at C-5 of the imidazolidine-2,4-dione ring and to explore the effect of substitution at N-3 on anticonvulsant activity. PB - Beograd : Serbian Chemical Society C3 - Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018 T1 - Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents T1 - Sinteza i karakterizacija 1-(4-supstituisanih benzil)-3’,4’-dihidro-2’H-spiro[imidazolidin-4,1’-naftalen]-2,5-diona potencijalnih antikonvulzivnih agenasa SP - 56 UR - https://hdl.handle.net/21.15107/rcub_technorep_6789 ER -
@conference{ author = "Lazić, Anita M. and Mandić, Željko and Trišović, Nemanja P. and Ušćumlić, Gordana S.", year = "2018", abstract = "Among the diverse pharmacological activity reported for spirohydantoin and the closely related spirosuccinimides, their anticonvulsant and antiproliferative activities are commonly encountered. Of all cyclic ureide derivatives, Phenytoin (5,5-diphenylhydantoin) is one of the well-known commercially available anticonvulsants, which is also widely used as an antiarrhythmic agent. However, the clinical use of 5,5-diphenylhydantoin is limited by its central nervous adverse effects in addition to a wide variety of drug interactions [1]. With the aim of developing new analogs with a more efficient therapeutic effect, a series of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-diones, have been synthesized, characterized by melting points, FT-IR, 1H and 13C NMR spectroscopic techniques, and evaluated for anticonvulsant activity. The objective of the present investigation is to identify the pharmacological impact of the spirocyclic attachment of a semi-rigid tetralin residue at C-5 of the imidazolidine-2,4-dione ring and to explore the effect of substitution at N-3 on anticonvulsant activity.", publisher = "Beograd : Serbian Chemical Society", journal = "Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018", title = "Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents, Sinteza i karakterizacija 1-(4-supstituisanih benzil)-3’,4’-dihidro-2’H-spiro[imidazolidin-4,1’-naftalen]-2,5-diona potencijalnih antikonvulzivnih agenasa", pages = "56", url = "https://hdl.handle.net/21.15107/rcub_technorep_6789" }
Lazić, A. M., Mandić, Ž., Trišović, N. P.,& Ušćumlić, G. S.. (2018). Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents. in Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018 Beograd : Serbian Chemical Society., 56. https://hdl.handle.net/21.15107/rcub_technorep_6789
Lazić AM, Mandić Ž, Trišović NP, Ušćumlić GS. Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents. in Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018. 2018;:56. https://hdl.handle.net/21.15107/rcub_technorep_6789 .
Lazić, Anita M., Mandić, Željko, Trišović, Nemanja P., Ušćumlić, Gordana S., "Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents" in Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018 (2018):56, https://hdl.handle.net/21.15107/rcub_technorep_6789 .