Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects
Само за регистроване кориснике
2023
Аутори
Milivojević, MarijaChen, Ke
Radovanović, Željko
Petrović, Rada
Dimitrijević-Branković, Suzana
Kojić, Vesna
Marković, Danica
Janaćković, Đorđe
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The restoration of large bone defects caused by trauma, tumor resection, or infection is a major clinical problem in orthopedics and dentistry because postoperative infections, corrosion, and limited osteointegration of metal implants can lead to loosening of the implant. The aim of this study was to improve the surface properties of a 3D-printed (electron beam melting) Ti6Al4V-based macroporous scaffold by multilayer coating with bioactive silicate glasses (BAGs) and hydroxyapatite doped with a silver (AgHAP) or AgHAP additionally sonochemically modified with ZnO (ZnO-AgHAP). The coated scaffolds AgHAP_BAGs_Ti and ZnO-AgHAP_BAGs_Ti enhanced cytocompatibility in L929 and MRC5 cell lines and expressed bioactivity in simulated body fluid. A lower release of vanadium ions in coated samples compared to bare Ti scaffold indicates decreased dissolution of Ti alloy in coated samples. The coated samples reduced growth ofEscherichia coliandStaphylococcus aureusfor 4-6 orders of magnitude. There...fore, the 3D-printed Ti-based scaffolds coated with BAGs and (ZnO-)AgHAP have great potential for application as a multifunctional implant with antibacterial properties for the restoration of defects in load-bearing bones.
Кључне речи:
antibacterial coatings / electron beam melting fabrication / graded bioactive glasses / hydroxyapatite / large bone defect / sonochemical synthesisИзвор:
Biomedical Materials, 2023, 18, 6, 065020-Издавач:
- IOP Publishing
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200135 (Универзитет у Београду, Технолошко-металуршки факултет) (RS-MESTD-inst-2020-200135)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
- National Natural Science Foundation of China (grant number 51675337)
- Foundation of National Facility for Translational Medicine (Shanghai) (grant number TMSK-2020-107)
DOI: 10.1088/1748-605X/ad02d2
ISSN: 1748-6041
PubMed: 37827161
Scopus: 2-s2.0-85175270915
Колекције
Институција/група
Inovacioni centarTY - JOUR AU - Milivojević, Marija AU - Chen, Ke AU - Radovanović, Željko AU - Petrović, Rada AU - Dimitrijević-Branković, Suzana AU - Kojić, Vesna AU - Marković, Danica AU - Janaćković, Đorđe PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6803 AB - The restoration of large bone defects caused by trauma, tumor resection, or infection is a major clinical problem in orthopedics and dentistry because postoperative infections, corrosion, and limited osteointegration of metal implants can lead to loosening of the implant. The aim of this study was to improve the surface properties of a 3D-printed (electron beam melting) Ti6Al4V-based macroporous scaffold by multilayer coating with bioactive silicate glasses (BAGs) and hydroxyapatite doped with a silver (AgHAP) or AgHAP additionally sonochemically modified with ZnO (ZnO-AgHAP). The coated scaffolds AgHAP_BAGs_Ti and ZnO-AgHAP_BAGs_Ti enhanced cytocompatibility in L929 and MRC5 cell lines and expressed bioactivity in simulated body fluid. A lower release of vanadium ions in coated samples compared to bare Ti scaffold indicates decreased dissolution of Ti alloy in coated samples. The coated samples reduced growth ofEscherichia coliandStaphylococcus aureusfor 4-6 orders of magnitude. Therefore, the 3D-printed Ti-based scaffolds coated with BAGs and (ZnO-)AgHAP have great potential for application as a multifunctional implant with antibacterial properties for the restoration of defects in load-bearing bones. PB - IOP Publishing T2 - Biomedical Materials T1 - Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects IS - 6 SP - 065020 VL - 18 DO - 10.1088/1748-605X/ad02d2 ER -
@article{ author = "Milivojević, Marija and Chen, Ke and Radovanović, Željko and Petrović, Rada and Dimitrijević-Branković, Suzana and Kojić, Vesna and Marković, Danica and Janaćković, Đorđe", year = "2023", abstract = "The restoration of large bone defects caused by trauma, tumor resection, or infection is a major clinical problem in orthopedics and dentistry because postoperative infections, corrosion, and limited osteointegration of metal implants can lead to loosening of the implant. The aim of this study was to improve the surface properties of a 3D-printed (electron beam melting) Ti6Al4V-based macroporous scaffold by multilayer coating with bioactive silicate glasses (BAGs) and hydroxyapatite doped with a silver (AgHAP) or AgHAP additionally sonochemically modified with ZnO (ZnO-AgHAP). The coated scaffolds AgHAP_BAGs_Ti and ZnO-AgHAP_BAGs_Ti enhanced cytocompatibility in L929 and MRC5 cell lines and expressed bioactivity in simulated body fluid. A lower release of vanadium ions in coated samples compared to bare Ti scaffold indicates decreased dissolution of Ti alloy in coated samples. The coated samples reduced growth ofEscherichia coliandStaphylococcus aureusfor 4-6 orders of magnitude. Therefore, the 3D-printed Ti-based scaffolds coated with BAGs and (ZnO-)AgHAP have great potential for application as a multifunctional implant with antibacterial properties for the restoration of defects in load-bearing bones.", publisher = "IOP Publishing", journal = "Biomedical Materials", title = "Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects", number = "6", pages = "065020", volume = "18", doi = "10.1088/1748-605X/ad02d2" }
Milivojević, M., Chen, K., Radovanović, Ž., Petrović, R., Dimitrijević-Branković, S., Kojić, V., Marković, D.,& Janaćković, Đ.. (2023). Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects. in Biomedical Materials IOP Publishing., 18(6), 065020. https://doi.org/10.1088/1748-605X/ad02d2
Milivojević M, Chen K, Radovanović Ž, Petrović R, Dimitrijević-Branković S, Kojić V, Marković D, Janaćković Đ. Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects. in Biomedical Materials. 2023;18(6):065020. doi:10.1088/1748-605X/ad02d2 .
Milivojević, Marija, Chen, Ke, Radovanović, Željko, Petrović, Rada, Dimitrijević-Branković, Suzana, Kojić, Vesna, Marković, Danica, Janaćković, Đorđe, "Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects" in Biomedical Materials, 18, no. 6 (2023):065020, https://doi.org/10.1088/1748-605X/ad02d2 . .