QSRR study of β-tetralino-spiro-5-hydantoin derivatives
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In recent years spiro compounds have attracted significant interest due to their unique
conformational features and their structural implications on biological systems. Since spiro
compounds contain two rings with only one shared atom have a good balance between
conformational restriction and flexibility, makes them adaptable to many biological targets.
Therefore, knowledge of their interactions in aqueous systems is of crucial importance for
the understanding of biological response and hence the initial step for the selection of the
compound for the drug candidate.
In this poster presentation the retention data for two series of spiro compounds
derivatives of β-tetralino-spiro-5-hydantoins with a 4-substituted benzyl group or a 2-(4-
substituted phenyl)-2-oxoethyl group in the position 3 (structures presented in Figure 1)
were investigated.
The attention of this work will be focused on the evaluation of chromatographic
lipophilicity parameters determined by means of revers...ed-phase thin layer chromatography
(RP-TLC) and reversed phase high-performance liquid chromatography (RP-HPLC).
Principal Component Analysis (PCA) will be used in order to find similarities and
differences among the investigated compounds, their retention data and structural
parameters relevant for the activity.
Извор:
Book of Abstracts / Conferentia Chemometrica 2023, An international conference on chemometrics and cheminformatics, Sopron, September 10-13, 2023, 2023, P07-Издавач:
- Budapest : Research Centre for Natural Sciences, Institute of Excellence, Hungarian Academy of Sciences
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200125 (Универзитет у Новом Саду, Природно-математички факултет) (RS-MESTD-inst-2020-200125)
Институција/група
Inovacioni centarTY - CONF AU - Đaković-Sekulić, Tatjana AU - Mandić, Anamarija AU - Lazić, Anita PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6858 AB - In recent years spiro compounds have attracted significant interest due to their unique conformational features and their structural implications on biological systems. Since spiro compounds contain two rings with only one shared atom have a good balance between conformational restriction and flexibility, makes them adaptable to many biological targets. Therefore, knowledge of their interactions in aqueous systems is of crucial importance for the understanding of biological response and hence the initial step for the selection of the compound for the drug candidate. In this poster presentation the retention data for two series of spiro compounds derivatives of β-tetralino-spiro-5-hydantoins with a 4-substituted benzyl group or a 2-(4- substituted phenyl)-2-oxoethyl group in the position 3 (structures presented in Figure 1) were investigated. The attention of this work will be focused on the evaluation of chromatographic lipophilicity parameters determined by means of reversed-phase thin layer chromatography (RP-TLC) and reversed phase high-performance liquid chromatography (RP-HPLC). Principal Component Analysis (PCA) will be used in order to find similarities and differences among the investigated compounds, their retention data and structural parameters relevant for the activity. PB - Budapest : Research Centre for Natural Sciences, Institute of Excellence, Hungarian Academy of Sciences C3 - Book of Abstracts / Conferentia Chemometrica 2023, An international conference on chemometrics and cheminformatics, Sopron, September 10-13, 2023 T1 - QSRR study of β-tetralino-spiro-5-hydantoin derivatives SP - P07 UR - https://hdl.handle.net/21.15107/rcub_technorep_6858 ER -
@conference{ author = "Đaković-Sekulić, Tatjana and Mandić, Anamarija and Lazić, Anita", year = "2023", abstract = "In recent years spiro compounds have attracted significant interest due to their unique conformational features and their structural implications on biological systems. Since spiro compounds contain two rings with only one shared atom have a good balance between conformational restriction and flexibility, makes them adaptable to many biological targets. Therefore, knowledge of their interactions in aqueous systems is of crucial importance for the understanding of biological response and hence the initial step for the selection of the compound for the drug candidate. In this poster presentation the retention data for two series of spiro compounds derivatives of β-tetralino-spiro-5-hydantoins with a 4-substituted benzyl group or a 2-(4- substituted phenyl)-2-oxoethyl group in the position 3 (structures presented in Figure 1) were investigated. The attention of this work will be focused on the evaluation of chromatographic lipophilicity parameters determined by means of reversed-phase thin layer chromatography (RP-TLC) and reversed phase high-performance liquid chromatography (RP-HPLC). Principal Component Analysis (PCA) will be used in order to find similarities and differences among the investigated compounds, their retention data and structural parameters relevant for the activity.", publisher = "Budapest : Research Centre for Natural Sciences, Institute of Excellence, Hungarian Academy of Sciences", journal = "Book of Abstracts / Conferentia Chemometrica 2023, An international conference on chemometrics and cheminformatics, Sopron, September 10-13, 2023", title = "QSRR study of β-tetralino-spiro-5-hydantoin derivatives", pages = "P07", url = "https://hdl.handle.net/21.15107/rcub_technorep_6858" }
Đaković-Sekulić, T., Mandić, A.,& Lazić, A.. (2023). QSRR study of β-tetralino-spiro-5-hydantoin derivatives. in Book of Abstracts / Conferentia Chemometrica 2023, An international conference on chemometrics and cheminformatics, Sopron, September 10-13, 2023 Budapest : Research Centre for Natural Sciences, Institute of Excellence, Hungarian Academy of Sciences., P07. https://hdl.handle.net/21.15107/rcub_technorep_6858
Đaković-Sekulić T, Mandić A, Lazić A. QSRR study of β-tetralino-spiro-5-hydantoin derivatives. in Book of Abstracts / Conferentia Chemometrica 2023, An international conference on chemometrics and cheminformatics, Sopron, September 10-13, 2023. 2023;:P07. https://hdl.handle.net/21.15107/rcub_technorep_6858 .
Đaković-Sekulić, Tatjana, Mandić, Anamarija, Lazić, Anita, "QSRR study of β-tetralino-spiro-5-hydantoin derivatives" in Book of Abstracts / Conferentia Chemometrica 2023, An international conference on chemometrics and cheminformatics, Sopron, September 10-13, 2023 (2023):P07, https://hdl.handle.net/21.15107/rcub_technorep_6858 .