IN VITRO RELEASE AND (TRANS)DERMAL DELIVERY STUDY OF BLACKCURRANT ANTHOCYANINS INCORPORATED IN COSMETIC FORMULATION
Само за регистроване кориснике
2023
Аутори
Petrov Ivanković, AnjaĆorović, Marija
Milivojević, Ana
Blagojević, Stevan
Radulović, Aleksandra
Pjanović, Rada
Bezbradica, Dejan
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Blackcurrant is anthocyanin-rich berry with proven antioxidant and photoprotective
activity and emerging prebiotic potential, widely applied in cosmetic products. Although
beneficial effects of its extract are well known, release from skin care products and
(trans)dermal permeation were not previously investigated.
In this study, enzyme-assisted extraction of polyphenols from lyophilized
blackcurrant was performed and obtained extract was incorporated into an Aristoflex® AVC
based hydrogel. Furthermore, Franz diffusion cell experiments were conducted in order to
examine the release of these molecules from the prepared formulation using cellulose acetate
membrane and transdermal and dermal delivery using human skin mimicking membrane
(Strat® M).
Obtained results revealed that all four dominant anthocyanins readily permeated from
hydrogel since 17.5%, 32.8%, 33.8% and 39.2% of delphinidin 3-glucoside, delphinidin 3-
rutinoside, cyanidin 3-glucoside and cyanidin 3-rutinoside, ...respectively, were detected in
receptor fluid after 24 h. Experimental values were successfully fitted with the Peppas and
Sahlin diffusion model. On the other hand, after 72 h long experiment with transdermal skin
diffusion model (Strat® M membrane), no detectable amounts of anthocyanins were present
in receptor fluid and only 0.5% of the initial quantity from donor compartment was extracted
from the membrane itself, indicating weak dermal delivery.
Present study revealed that hydrogel is suitable carrier system for the topical delivery
of bioactive anthocyanins from blackcurrant, while dermal and transdermal delivery of these
molecules is very limited. This implies applicability of blackcurrant extract for treatments
targeting skin surface (i.e. antioxidant, prebiotic, photoprotective).
Кључне речи:
blackcurrant / anthocyanins / hydrogel / diffusionИзвор:
Book of Abstracts / International Conference Biochemical Engineering and Biotechnology for Young Scientists, 7-8 December, 2023, Belgrade, 2023, 30-Издавач:
- Belgrade : University, Faculty of Technology and Metallurgy
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200135 (Универзитет у Београду, Технолошко-металуршки факултет) (RS-MESTD-inst-2020-200135)
- PrIntPrEnzy - Prebiotics for functional food and bioactive cosmetics produced in intensified enzymatic processes (RS-ScienceFundRS-Ideje-7750109)
- Horizon Europe 2021–2027 research and innovation programme (101060130)
Колекције
Институција/група
Inovacioni centarTY - CONF AU - Petrov Ivanković, Anja AU - Ćorović, Marija AU - Milivojević, Ana AU - Blagojević, Stevan AU - Radulović, Aleksandra AU - Pjanović, Rada AU - Bezbradica, Dejan PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6947 AB - Blackcurrant is anthocyanin-rich berry with proven antioxidant and photoprotective activity and emerging prebiotic potential, widely applied in cosmetic products. Although beneficial effects of its extract are well known, release from skin care products and (trans)dermal permeation were not previously investigated. In this study, enzyme-assisted extraction of polyphenols from lyophilized blackcurrant was performed and obtained extract was incorporated into an Aristoflex® AVC based hydrogel. Furthermore, Franz diffusion cell experiments were conducted in order to examine the release of these molecules from the prepared formulation using cellulose acetate membrane and transdermal and dermal delivery using human skin mimicking membrane (Strat® M). Obtained results revealed that all four dominant anthocyanins readily permeated from hydrogel since 17.5%, 32.8%, 33.8% and 39.2% of delphinidin 3-glucoside, delphinidin 3- rutinoside, cyanidin 3-glucoside and cyanidin 3-rutinoside, respectively, were detected in receptor fluid after 24 h. Experimental values were successfully fitted with the Peppas and Sahlin diffusion model. On the other hand, after 72 h long experiment with transdermal skin diffusion model (Strat® M membrane), no detectable amounts of anthocyanins were present in receptor fluid and only 0.5% of the initial quantity from donor compartment was extracted from the membrane itself, indicating weak dermal delivery. Present study revealed that hydrogel is suitable carrier system for the topical delivery of bioactive anthocyanins from blackcurrant, while dermal and transdermal delivery of these molecules is very limited. This implies applicability of blackcurrant extract for treatments targeting skin surface (i.e. antioxidant, prebiotic, photoprotective). PB - Belgrade : University, Faculty of Technology and Metallurgy C3 - Book of Abstracts / International Conference Biochemical Engineering and Biotechnology for Young Scientists, 7-8 December, 2023, Belgrade T1 - IN VITRO RELEASE AND (TRANS)DERMAL DELIVERY STUDY OF BLACKCURRANT ANTHOCYANINS INCORPORATED IN COSMETIC FORMULATION SP - 30 UR - https://hdl.handle.net/21.15107/rcub_technorep_6947 ER -
@conference{ author = "Petrov Ivanković, Anja and Ćorović, Marija and Milivojević, Ana and Blagojević, Stevan and Radulović, Aleksandra and Pjanović, Rada and Bezbradica, Dejan", year = "2023", abstract = "Blackcurrant is anthocyanin-rich berry with proven antioxidant and photoprotective activity and emerging prebiotic potential, widely applied in cosmetic products. Although beneficial effects of its extract are well known, release from skin care products and (trans)dermal permeation were not previously investigated. In this study, enzyme-assisted extraction of polyphenols from lyophilized blackcurrant was performed and obtained extract was incorporated into an Aristoflex® AVC based hydrogel. Furthermore, Franz diffusion cell experiments were conducted in order to examine the release of these molecules from the prepared formulation using cellulose acetate membrane and transdermal and dermal delivery using human skin mimicking membrane (Strat® M). Obtained results revealed that all four dominant anthocyanins readily permeated from hydrogel since 17.5%, 32.8%, 33.8% and 39.2% of delphinidin 3-glucoside, delphinidin 3- rutinoside, cyanidin 3-glucoside and cyanidin 3-rutinoside, respectively, were detected in receptor fluid after 24 h. Experimental values were successfully fitted with the Peppas and Sahlin diffusion model. On the other hand, after 72 h long experiment with transdermal skin diffusion model (Strat® M membrane), no detectable amounts of anthocyanins were present in receptor fluid and only 0.5% of the initial quantity from donor compartment was extracted from the membrane itself, indicating weak dermal delivery. Present study revealed that hydrogel is suitable carrier system for the topical delivery of bioactive anthocyanins from blackcurrant, while dermal and transdermal delivery of these molecules is very limited. This implies applicability of blackcurrant extract for treatments targeting skin surface (i.e. antioxidant, prebiotic, photoprotective).", publisher = "Belgrade : University, Faculty of Technology and Metallurgy", journal = "Book of Abstracts / International Conference Biochemical Engineering and Biotechnology for Young Scientists, 7-8 December, 2023, Belgrade", title = "IN VITRO RELEASE AND (TRANS)DERMAL DELIVERY STUDY OF BLACKCURRANT ANTHOCYANINS INCORPORATED IN COSMETIC FORMULATION", pages = "30", url = "https://hdl.handle.net/21.15107/rcub_technorep_6947" }
Petrov Ivanković, A., Ćorović, M., Milivojević, A., Blagojević, S., Radulović, A., Pjanović, R.,& Bezbradica, D.. (2023). IN VITRO RELEASE AND (TRANS)DERMAL DELIVERY STUDY OF BLACKCURRANT ANTHOCYANINS INCORPORATED IN COSMETIC FORMULATION. in Book of Abstracts / International Conference Biochemical Engineering and Biotechnology for Young Scientists, 7-8 December, 2023, Belgrade Belgrade : University, Faculty of Technology and Metallurgy., 30. https://hdl.handle.net/21.15107/rcub_technorep_6947
Petrov Ivanković A, Ćorović M, Milivojević A, Blagojević S, Radulović A, Pjanović R, Bezbradica D. IN VITRO RELEASE AND (TRANS)DERMAL DELIVERY STUDY OF BLACKCURRANT ANTHOCYANINS INCORPORATED IN COSMETIC FORMULATION. in Book of Abstracts / International Conference Biochemical Engineering and Biotechnology for Young Scientists, 7-8 December, 2023, Belgrade. 2023;:30. https://hdl.handle.net/21.15107/rcub_technorep_6947 .
Petrov Ivanković, Anja, Ćorović, Marija, Milivojević, Ana, Blagojević, Stevan, Radulović, Aleksandra, Pjanović, Rada, Bezbradica, Dejan, "IN VITRO RELEASE AND (TRANS)DERMAL DELIVERY STUDY OF BLACKCURRANT ANTHOCYANINS INCORPORATED IN COSMETIC FORMULATION" in Book of Abstracts / International Conference Biochemical Engineering and Biotechnology for Young Scientists, 7-8 December, 2023, Belgrade (2023):30, https://hdl.handle.net/21.15107/rcub_technorep_6947 .