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Single-step, electrophoretically deposited hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicin coating for biomedical applications
dc.creator | Jaćimović, Nevena | |
dc.creator | Đošić, Marija | |
dc.creator | Janković, Ana | |
dc.creator | Grujić, Svetlana | |
dc.creator | Matić Bujagić, Ivana | |
dc.creator | Stojanović, Jovica | |
dc.creator | Vukašinović-Sekulić, Maja | |
dc.creator | Kojić, Vesna | |
dc.creator | Mišković-Stanković, Vesna | |
dc.date.accessioned | 2024-02-22T14:18:05Z | |
dc.date.available | 2024-02-22T14:18:05Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1857-5552 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7260 | |
dc.description.abstract | Biocomposite hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicin coatings were fabricated on titanium by an electrophoretic deposition process (EPD) from an aqueous suspension using the constant voltage method. Characterization of the deposited coatings was performed by scanning electron micros-copy with field emission (FE-SEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD) after immersion in simulated body fluid (SBF) at 37 °C. The concentration of the released gentamicin was determined using high-performance liquid chromatography (HPLC) coupled with a mass spectrometer (MS). The release profile confirmed an initial “burst-release effect” with ~ 30 % of the gen-tamicin released in the first 48 h, which could be of assistance in the prevention of biofilm formation. An-tibacterial activity was proven by the agar diffusion method on Staphylococcus aureus TL and Escherich-ia coli ATCC 25922 bacterial strains. Cytotoxicity was tested by the dye exclusion test (DET) on MRC-5 and L929 fibroblast cell lines, with both coatings expressing nontoxicity. The results showed the high ap-plicability potential of a poly(vinyl alcohol)-based biocomposite coating for medical purposes. | |
dc.publisher | Society of Chemists and Technologists of Macedonia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200287/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200023/RS// | |
dc.relation | Ministry of Science, Technological Development and Innova-tion, Republic of Serbia (Contract No. 337-00-110/2023-05/13) | |
dc.relation | European Union’s Horizon 2020 research and innovation program under grant agreement No. 952033 | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Macedonian Journal of Chemistry and Chemical Engineering | |
dc.subject | electrophoretic deposition | |
dc.subject | Chitosan | |
dc.subject | poly(vinyl alcohol) | |
dc.subject | gentamicin release | |
dc.subject | antibacterial | |
dc.title | Single-step, electrophoretically deposited hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicin coating for biomedical applications | |
dc.type | article | en |
dc.rights.license | BY-NC | |
dc.citation.epage | 262 | |
dc.citation.issue | 2 | |
dc.citation.spage | 249 | |
dc.citation.volume | 42 | |
dc.identifier.doi | 10.20450/mjcce.2023.2775 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/20012/Single_step_electrophoretically_pub_2023.pdf | |
dc.identifier.scopus | 2-s2.0-85184154996 | |
dc.type.version | publishedVersion |