Collective durotaxis along a self-generated mobile stiffness gradient in vivo
Само за регистроване кориснике
2024
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A crucial aspect of tissue self-organization during morphogenesis, wound healing, and cancer invasion is directed migration of cell collectives. The majority of in vivo directed migration has been guided by chemotaxis, whereby cells follow a chemical gradient. In certain situations, migrating cell collectives can also self-generate the stiffness gradient in the surrounding tissue, which can have a feedback effect on the directionality of the migration. The phenomenon has been observed during collective durotaxis in vivo. Along the biointerface between neighbouring tissues, heterotypic cell-cell interactions are the main cause of this self-generated stiffness gradient. The physical processes in charge of tissue self-organization along the biointerface, which are related to the interplay between cell signalling and the formation of heterotypic cell-cell adhesion contacts, are less well-developed than the biological mechanisms of the cellular interactions. This complex phenomenon is discu...ssed here in the model system, such as collective migration of neural crest cells between ectodermal placode and mesoderm subpopulations within Xenopus embryos by pointing to the role of the dynamics along the biointerface between adjacent cell subpopulations on the subpopulation stiffness.
Кључне речи:
Cell residual stress generation / Collective cell migration / Homotypic and heterotypic cell-cell interactions / Interfacial tension between adjacent cell subpopulations / Surface tension of the subpopulationsИзвор:
Biosystems, 03-2024, 237, 105155-Издавач:
- Elsevier B.V.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200135 (Универзитет у Београду, Технолошко-металуршки факултет) (RS-MESTD-inst-2020-200135)
DOI: 10.1016/j.biosystems.2024.105155
ISSN: 0303-2647
PubMed: 38367761
Scopus: 2-s2.0-85185588446
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Pajić-Lijaković, Ivana AU - Milivojević, Milan PY - 2024-03 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7319 AB - A crucial aspect of tissue self-organization during morphogenesis, wound healing, and cancer invasion is directed migration of cell collectives. The majority of in vivo directed migration has been guided by chemotaxis, whereby cells follow a chemical gradient. In certain situations, migrating cell collectives can also self-generate the stiffness gradient in the surrounding tissue, which can have a feedback effect on the directionality of the migration. The phenomenon has been observed during collective durotaxis in vivo. Along the biointerface between neighbouring tissues, heterotypic cell-cell interactions are the main cause of this self-generated stiffness gradient. The physical processes in charge of tissue self-organization along the biointerface, which are related to the interplay between cell signalling and the formation of heterotypic cell-cell adhesion contacts, are less well-developed than the biological mechanisms of the cellular interactions. This complex phenomenon is discussed here in the model system, such as collective migration of neural crest cells between ectodermal placode and mesoderm subpopulations within Xenopus embryos by pointing to the role of the dynamics along the biointerface between adjacent cell subpopulations on the subpopulation stiffness. PB - Elsevier B.V. T2 - Biosystems T1 - Collective durotaxis along a self-generated mobile stiffness gradient in vivo SP - 105155 VL - 237 DO - 10.1016/j.biosystems.2024.105155 ER -
@article{ author = "Pajić-Lijaković, Ivana and Milivojević, Milan", year = "2024-03", abstract = "A crucial aspect of tissue self-organization during morphogenesis, wound healing, and cancer invasion is directed migration of cell collectives. The majority of in vivo directed migration has been guided by chemotaxis, whereby cells follow a chemical gradient. In certain situations, migrating cell collectives can also self-generate the stiffness gradient in the surrounding tissue, which can have a feedback effect on the directionality of the migration. The phenomenon has been observed during collective durotaxis in vivo. Along the biointerface between neighbouring tissues, heterotypic cell-cell interactions are the main cause of this self-generated stiffness gradient. The physical processes in charge of tissue self-organization along the biointerface, which are related to the interplay between cell signalling and the formation of heterotypic cell-cell adhesion contacts, are less well-developed than the biological mechanisms of the cellular interactions. This complex phenomenon is discussed here in the model system, such as collective migration of neural crest cells between ectodermal placode and mesoderm subpopulations within Xenopus embryos by pointing to the role of the dynamics along the biointerface between adjacent cell subpopulations on the subpopulation stiffness.", publisher = "Elsevier B.V.", journal = "Biosystems", title = "Collective durotaxis along a self-generated mobile stiffness gradient in vivo", pages = "105155", volume = "237", doi = "10.1016/j.biosystems.2024.105155" }
Pajić-Lijaković, I.,& Milivojević, M.. (2024-03). Collective durotaxis along a self-generated mobile stiffness gradient in vivo. in Biosystems Elsevier B.V.., 237, 105155. https://doi.org/10.1016/j.biosystems.2024.105155
Pajić-Lijaković I, Milivojević M. Collective durotaxis along a self-generated mobile stiffness gradient in vivo. in Biosystems. 2024;237:105155. doi:10.1016/j.biosystems.2024.105155 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Collective durotaxis along a self-generated mobile stiffness gradient in vivo" in Biosystems, 237 (2024-03):105155, https://doi.org/10.1016/j.biosystems.2024.105155 . .