Role of Band 3 in the Erythrocyte Membrane Structural Changes Under Isotonic and Hypotonic Conditions
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An attempt was made to discuss and connect various modeling approaches which have been proposed in the literature in order to shed further light on the erythrocyte membrane relaxation under isotonic and hypotonic conditions. Roles of the main membrane constituents: (1) the actin‐spectrin cortex, (2) the lipid bilayer, and (3) the transmembrane protein band 3 and its course‐consequence relations were considered to estimate the membrane relaxation phenomena. Cell response to loading conditions includes the successive sub‐bioprocesses: (1) erythrocyte local or global deformation, (2) the cortex‐bilayer coupling, and (3) the rearrangements of band 3. The results indicate that the membrane structural changes include: (1) the spectrin flexibility distribution and (2) the rate of its changes influenced by the number of band 3 molecules attached to spectrin filaments, and phosphorylation of the actin‐spectrin junctions. Band 3 rearrangement also influences: (1) the effective bending modulus an...d (2) the band 3‐bilayer interaction energy and on that base the bilayer bending state. The erythrocyte swelling under hypotonic conditions influences the bilayer integrity which leads to the hemolytic hole formation. The hemolytic hole represents the excited cluster of band 3 molecules.
Кључне речи:
packing state changes of band 3 clusters / reversible hemolytic hole formation / the lipid bilayer bending state changes / the spectrin inter‐ and intrachain interactions / mathematical modelingИзвор:
Cytoskeleton - Structure, Dynamics, Function and Disease, 2017, 89-103Издавач:
- IntechOpen
Финансирање / пројекти:
- Развој и примена нових и традиционалних технологија у производњи конкурентних прехрамбених производа са додатом вредношћу за европско и светско тржиште - Створимо богатство из богатства Србије (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46001)
Институција/група
Tehnološko-metalurški fakultetTY - CHAP AU - Pajić-Lijaković, Ivana AU - Milivojević, Milan PY - 2017 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7429 AB - An attempt was made to discuss and connect various modeling approaches which have been proposed in the literature in order to shed further light on the erythrocyte membrane relaxation under isotonic and hypotonic conditions. Roles of the main membrane constituents: (1) the actin‐spectrin cortex, (2) the lipid bilayer, and (3) the transmembrane protein band 3 and its course‐consequence relations were considered to estimate the membrane relaxation phenomena. Cell response to loading conditions includes the successive sub‐bioprocesses: (1) erythrocyte local or global deformation, (2) the cortex‐bilayer coupling, and (3) the rearrangements of band 3. The results indicate that the membrane structural changes include: (1) the spectrin flexibility distribution and (2) the rate of its changes influenced by the number of band 3 molecules attached to spectrin filaments, and phosphorylation of the actin‐spectrin junctions. Band 3 rearrangement also influences: (1) the effective bending modulus and (2) the band 3‐bilayer interaction energy and on that base the bilayer bending state. The erythrocyte swelling under hypotonic conditions influences the bilayer integrity which leads to the hemolytic hole formation. The hemolytic hole represents the excited cluster of band 3 molecules. PB - IntechOpen T2 - Cytoskeleton - Structure, Dynamics, Function and Disease T1 - Role of Band 3 in the Erythrocyte Membrane Structural Changes Under Isotonic and Hypotonic Conditions EP - 103 SP - 89 DO - 10.5772/64964 ER -
@inbook{ author = "Pajić-Lijaković, Ivana and Milivojević, Milan", year = "2017", abstract = "An attempt was made to discuss and connect various modeling approaches which have been proposed in the literature in order to shed further light on the erythrocyte membrane relaxation under isotonic and hypotonic conditions. Roles of the main membrane constituents: (1) the actin‐spectrin cortex, (2) the lipid bilayer, and (3) the transmembrane protein band 3 and its course‐consequence relations were considered to estimate the membrane relaxation phenomena. Cell response to loading conditions includes the successive sub‐bioprocesses: (1) erythrocyte local or global deformation, (2) the cortex‐bilayer coupling, and (3) the rearrangements of band 3. The results indicate that the membrane structural changes include: (1) the spectrin flexibility distribution and (2) the rate of its changes influenced by the number of band 3 molecules attached to spectrin filaments, and phosphorylation of the actin‐spectrin junctions. Band 3 rearrangement also influences: (1) the effective bending modulus and (2) the band 3‐bilayer interaction energy and on that base the bilayer bending state. The erythrocyte swelling under hypotonic conditions influences the bilayer integrity which leads to the hemolytic hole formation. The hemolytic hole represents the excited cluster of band 3 molecules.", publisher = "IntechOpen", journal = "Cytoskeleton - Structure, Dynamics, Function and Disease", booktitle = "Role of Band 3 in the Erythrocyte Membrane Structural Changes Under Isotonic and Hypotonic Conditions", pages = "103-89", doi = "10.5772/64964" }
Pajić-Lijaković, I.,& Milivojević, M.. (2017). Role of Band 3 in the Erythrocyte Membrane Structural Changes Under Isotonic and Hypotonic Conditions. in Cytoskeleton - Structure, Dynamics, Function and Disease IntechOpen., 89-103. https://doi.org/10.5772/64964
Pajić-Lijaković I, Milivojević M. Role of Band 3 in the Erythrocyte Membrane Structural Changes Under Isotonic and Hypotonic Conditions. in Cytoskeleton - Structure, Dynamics, Function and Disease. 2017;:89-103. doi:10.5772/64964 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Role of Band 3 in the Erythrocyte Membrane Structural Changes Under Isotonic and Hypotonic Conditions" in Cytoskeleton - Structure, Dynamics, Function and Disease (2017):89-103, https://doi.org/10.5772/64964 . .