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Ordered mesoporous silica to enhance the bioavailability of poorly water-soluble drugs: Proof of concept in man
dc.creator | Bukara, Katarina | |
dc.creator | Schueller, Laurent | |
dc.creator | Rosier, Jan | |
dc.creator | Martens, Mark A. | |
dc.creator | Daems, Tinne | |
dc.creator | Verheyden, Loes | |
dc.creator | Eelen, Siemon | |
dc.creator | Van Speybroeck, Michiel | |
dc.creator | Libanati, Cristian | |
dc.creator | Martens, Johan A. | |
dc.creator | Van Den Mooter, Guy | |
dc.creator | Frerart, Francoise | |
dc.creator | Jolling, Koen | |
dc.creator | De Gieter, Marjan | |
dc.creator | Bugarski, Branko | |
dc.creator | Kiekens, Filip | |
dc.date.accessioned | 2021-03-10T13:06:56Z | |
dc.date.available | 2021-03-10T13:06:56Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0939-6411 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3326 | |
dc.description.abstract | Formulating poorly water soluble drugs using ordered mesoporous silica materials is an emerging approach to tackle solubility-related bioavailability problems. The current study was conducted to assess the bioavailability-enhancing potential of ordered mesoporous silica in man. In this open-label, randomized, two-way cross-over study, 12 overnight fasted healthy volunteers received a single dose of fenofibrate formulated with ordered mesoporous silica-or a marketed product based on micronized fenofibrate. Plasma concentrations of fenofibric acid, the pharmacologically active metabolite of fenofibrate, were monitored up to 96 h post-dose. The rate (C-max/dose increased by 77%; t(max) reduced by 0.75 h) and extent of absorption (AUC(0-24h)/dose increased by 54%) of fenofibrate were significantly enhanced following administration of the ordered mesoporous silica based formulation. The results of this study serve as a proof of concept in man for this novel formulation approach. | en |
dc.publisher | Elsevier Science Bv, Amsterdam | |
dc.relation | Flemish Institute for the Promotion of Innovation through Science and Technology (IWT-Vlaanderen) | |
dc.relation | Flemish Government | |
dc.rights | openAccess | |
dc.source | European Journal of Pharmaceutics and Biopharmaceutics | |
dc.subject | Ordered mesoporous silica | en |
dc.subject | Solubility | en |
dc.subject | Absorption | en |
dc.subject | Bioavailability | en |
dc.subject | Fenofibrate | en |
dc.title | Ordered mesoporous silica to enhance the bioavailability of poorly water-soluble drugs: Proof of concept in man | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 225 | |
dc.citation.other | 108: 220-225 | |
dc.citation.rank | M21 | |
dc.citation.spage | 220 | |
dc.citation.volume | 108 | |
dc.identifier.doi | 10.1016/j.ejpb.2016.08.020 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/1251/3323.pdf | |
dc.identifier.pmid | 27648957 | |
dc.identifier.scopus | 2-s2.0-84988421303 | |
dc.identifier.wos | 000388052600023 | |
dc.type.version | publishedVersion |