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A Kinetic Study of Candida rugosa Lipase-Catalyzed Synthesis of 4,6-Dimethyl-3-cyano-2-pyridone
dc.creator | Prlainović, Nevena | |
dc.creator | Bezbradica, Dejan | |
dc.creator | Knežević-Jugović, Zorica | |
dc.creator | Kozlowska, Roksana T. | |
dc.creator | Mijin, Dušan | |
dc.date.accessioned | 2021-03-10T11:14:01Z | |
dc.date.available | 2021-03-10T11:14:01Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0103-5053 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1563 | |
dc.description.abstract | The synthesis of 4,6-dimethyl-3-cyano-2-pyridone was studied in a reaction catalyzed with Candida rugosa lipase. A response surface methodology (RSM) was applied for the optimization of the experimental conditions. The study showed that temperature and molar ratio cyanoacetamide/acetylacetone have a great influence on the yield of the reaction; the maximum yield was achieved at 44 degrees C with a molar ratio cyanoacetamide/acetylacetone of 36. The kinetics of the enzymatic synthesis of 4,6-dimethyl-3-cyano-2-pyridone was investigated, and it was determined that a ping-pong bi-ter mechanism with cyanoacetamide inhibition fits the obtained results. The mechanism of lipase-catalyzed reaction was proposed. | en |
dc.publisher | Sociedade Brasileira de Química | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142063/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/20064/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Journal of the Brazilian Chemical Society | |
dc.subject | Candida rugosa lipase | en |
dc.subject | ping-pong kinetics | en |
dc.subject | cyanoacetamide inhibition | en |
dc.subject | acetylacetone | en |
dc.subject | pyridone | en |
dc.title | A Kinetic Study of Candida rugosa Lipase-Catalyzed Synthesis of 4,6-Dimethyl-3-cyano-2-pyridone | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.epage | 2293 | |
dc.citation.issue | 12 | |
dc.citation.other | 21(12): 2285-2293 | |
dc.citation.rank | M22 | |
dc.citation.spage | 2285 | |
dc.citation.volume | 21 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/13459/bitstream_13459.pdf | |
dc.identifier.pmid | ||
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_technorep_1563 | |
dc.identifier.scopus | 2-s2.0-78649619961 | |
dc.identifier.wos | 000284787500015 | |
dc.type.version | publishedVersion |