Приказ основних података о документу
Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties
dc.creator | Mijin, Dušan | |
dc.creator | Božić-Nedeljković, Biljana | |
dc.creator | Božić, Bojan | |
dc.creator | Kovrlija, Ilijana | |
dc.creator | Lađarević, Jelena | |
dc.creator | Ušćumlić, Gordana | |
dc.date.accessioned | 2021-03-10T13:51:20Z | |
dc.date.available | 2021-03-10T13:51:20Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1300-0527 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4008 | |
dc.description.abstract | New azo dyes bearing 2-pyridone and benzimidazole moieties were prepared using diazotization of 4-(1H-benzo[d]imidazol-2-yl)aniline and coupling of the obtained diazonium salt with substituted 3-cyano-2-pyridones. Obtained compounds were characterized via UV-Vis, FT-IR, and H-1 and C-13 NMR spectroscopy as well as by elemental analysis data. The UV-Vis spectra of the synthesized dyes were measured in thirteen solvents of different properties at room temperature. Solvatochromism and tautomerism of novel azo dyes were discussed. An MTT (3,4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide) test was performed to prove the biocompatibility of the investigated dyes. The investigated dyes exhibited satisfying antiproliferative activities against both tumor cell lines, MDA-MB-231 and HCT-116, demonstrating the potent capacity for treatment of tumors. | en |
dc.publisher | Scientific Technical Research Council Turkey-Tubitak, Ankara | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173052/RS// | |
dc.rights | openAccess | |
dc.source | Turkish Journal of Chemistry | |
dc.subject | UV-Vis spectroscopy | en |
dc.subject | azo dyes | en |
dc.subject | biocompatibility | en |
dc.subject | antiproliferative activity | en |
dc.subject | tautomerism | en |
dc.title | Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 907 | |
dc.citation.issue | 3 | |
dc.citation.other | 42(3): 896-907 | |
dc.citation.rank | M23 | |
dc.citation.spage | 896 | |
dc.citation.volume | 42 | |
dc.identifier.doi | 10.3906/kim-1711-97 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/1757/4005.pdf | |
dc.identifier.scopus | 2-s2.0-85047941142 | |
dc.identifier.wos | 000433980300023 | |
dc.type.version | publishedVersion |