dc.creator | Pavlović, Marija | |
dc.creator | Dimitrijević, Aleksandra | |
dc.creator | Bezbradica, Dejan | |
dc.creator | Milosavić, Nenad | |
dc.creator | Gavrović-Jankulović, Marija | |
dc.creator | Šegan, Dejan M. | |
dc.creator | Veličković, Dušan | |
dc.date.accessioned | 2021-03-10T12:29:53Z | |
dc.date.available | 2021-03-10T12:29:53Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0008-6215 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2753 | |
dc.description.abstract | Benzyl alcohol, a potent anesthetic and bacteriostatic, can be efficiently glucosylated by alpha-glucosidase from Saccharomyces cerevisiae to produce benzyl alcohol alpha-glucoside with a 75% yield. However, while studying the transglucosylation reaction conditions, it was found out that benzyl alcohol is a non-competitive inhibitor of alpha-glucosidase's hydrolytic activity (K-i = 18 mM, toward maltose). Due to its interesting ability to be glycosylated by the enzyme and to inhibit its hydrolytic activity, we proposed a plausible mechanism for the phenolic alpha-glucosydase inhibitor's binding, since the mechanism of inhibition has not yet been elucidated. | en |
dc.publisher | Elsevier Sci Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/256716/EU// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS// | |
dc.rights | restrictedAccess | |
dc.source | Carbohydrate Research | |
dc.subject | Benzyl alcohol | en |
dc.subject | alpha-Glucosidase inhibition | en |
dc.subject | Transglucosylation | en |
dc.subject | Primary hydrolysis | en |
dc.title | Dual effect of benzyl alcohol on alpha-glucosidase activity: efficient substrate for high yield transglucosylation and non-competitive inhibitor of its hydrolytic activity | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 18 | |
dc.citation.other | 387: 14-18 | |
dc.citation.rank | M22 | |
dc.citation.spage | 14 | |
dc.citation.volume | 387 | |
dc.identifier.doi | 10.1016/j.carres.2013.08.028 | |
dc.identifier.pmid | 24531390 | |
dc.identifier.scopus | 2-s2.0-84894090228 | |
dc.identifier.wos | 000332959100004 | |
dc.type.version | publishedVersion | |