dc.creator | Marković, Maja D. | |
dc.creator | Tadic, Julijana D. | |
dc.creator | Pjanović, Rada V. | |
dc.date.accessioned | 2022-04-20T12:59:46Z | |
dc.date.available | 2022-04-20T12:59:46Z | |
dc.date.issued | 2021 | |
dc.identifier.isbn | 978-963-306-835-9 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5070 | |
dc.description.abstract | Nowadays, humanity are faced with many challenges which affect health of people all around
the globe (such as climate change, new diseases and/or already present ones for which cure has
not been found yet – cancer). The efforts of researchers on the field of drug delivery systems
bring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels based
on poly(methacrylic acid) are recognized as materials with huge potential for controlled release
of drugs. The encapsulation and controlled release of many chemotherapeutics is quite
challenge due to their poorly water-solubility. In our previous research we overcome this
problem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showed
that prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further our
research and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyze
how the change of crosslinker amount affect the mechanism of release kinetics of caffeine in
medium with pH of 6.8 (which simulated the environment in human intestines). Obtained
results showed that only by changing one parameter such as crosslinker amount it is possible to
fine tune the type of drug release mechanism, due to which the PMAC carriers would be able
to respond to the specific demands of therapy. | sr |
dc.language.iso | en | sr |
dc.publisher | University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200287/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | The 27 th International Symposium on Analytical and Environmental Problems | sr |
dc.title | Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount | sr |
dc.type | conferenceObject | sr |
dc.rights.license | BY | sr |
dc.citation.epage | 207 | |
dc.citation.spage | 203 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/8217/bitstream_8217.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_technorep_5070 | |
dc.type.version | publishedVersion | sr |