dc.creator | Miladinović, Nina N. | |
dc.creator | Marković, Maja | |
dc.creator | Pjanović, Rada | |
dc.date.accessioned | 2022-10-31T11:07:45Z | |
dc.date.available | 2022-10-31T11:07:45Z | |
dc.date.issued | 2022 | |
dc.identifier.isbn | 978-86-7132-080-1 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5228 | |
dc.description.abstract | Several million tons of orange peel are generated annually as a result of the industrial
processing of this fruit. Orange peels are rich in polyphenols, that show antioxidant
activity. Hence, converting orange peels into antioxidant extract by using green eutectic
solvents (GES) would be a good solution. GES represent a mixture of organic substances
that are not harmful to human health, environmentally friendly and highly selective
towards the targeted active substance. The aim of this work was the extraction of
polyphenols from orange peel waste using a GES based on urea and glycerol, their
encapsulation into hydrogels based on poly(methacrylic acid) (PMAA), and controlled
release from these hydrogels. PMAA are non-toxic, biocompatible and pH sensitive, so
they are widely used for the targeted delivery of active substances. Swelling of PMAA
and the controlled release of polyphenols from PMAA were monitored in two mediums
with different pH values: 0.1 M hydrochloric acid (pH=1) and phosphate buffer
(pH=6.8) at 37 °C. The influence of the crosslinker amount and neutralization degree of
methacrylic acid (ND) on the PMAA swelling and the release of polyphenols was
examined. The kinetics of PMAA swelling and polyphenol release were analyzed using
the Peppas model. It was concluded that the swelling degree of PMAA increased with
an increase in pH value of medium and ND, and decreased with an increase in crosslinker
amount. As a consequence, the cumulative release of polyphenols was around three
times higher in pH=6.8 than in pH=1 for both series of the samples. Peppas model
showed that diffusion was the primary mechanism of polyphenols release for most
samples. Based on the analysis of the results, it is concluded that the sample with optimal
characteristics for the controlled release of polyphenols is the sample with 0%
neutralized methacrylic acid and 0.4 mol% MBA. | sr |
dc.language.iso | en | sr |
dc.publisher | Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200287/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | 8th Conference of Young Chemists of Serbia Book of Abstract | sr |
dc.title | Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels | sr |
dc.type | conferenceObject | sr |
dc.rights.license | BY | sr |
dc.citation.spage | 88 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/12911/bitstream_12911.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_technorep_5228 | |
dc.type.version | publishedVersion | sr |