TY  - JOUR
AU  - Dimitrijević, Snežana
AU  - Milić, Marija
AU  - Tadić, Vanja
AU  - Maksimović, Svetolik
AU  - Filipović, Vladimir
AU  - Dimitrijević-Branković, Suzana
AU  - Miljković, Miona
AU  - Salamon, Ivan
PY  - 2024-02
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7036
AB  - Within this investigation, the effect of conventional and sophisticated extraction method was evaluated on the chemical composition of black cumin seeds (Nigella sativa L.) essential oils and their bioactive characteristics. Soxhlet extraction at 60 °C by hexane (SEH) and petroleum ether (SEP) was adopted as traditionally used technique, while the supercritical extraction with CO2 (SFE), under the pressure of 10 MPa and temperature of 40 °C, was performed as a modern method, expected to overcome the drawbacks of the conventional solvent extraction. The results showed that SFE enabled up to ten times higher extraction yields, compared to essential oils derived after Soxhlet extraction, however, the bioactive compounds content, such as polyphenols, flavonoids and carotenoids, were extracted in higher quantities in the oil from Soxhlet extraction performance. Thereby, the strongest antioxidant agent was found to be the essential oil obtained from SEP, followed by the oil from SFE and oil obtained from SEH, respectively. The GC-MS analysis revealed that the content of thymoquinone was the highest in the essential oil from SEP (69.58%), and the obtained values are among the highest reported within the available literature data. Also, this oil sample contained about eleven times higher thymoquinone quantities than the essential oil obtained by SFE, which was mostly constituted of a methyl linoleate, a fatty acid methyl ester of linoleic acid. In addition, the essential oil from SEP exerted a value added antimicrobial properties, where it was found to be particularly effective in suppression of the Gram-positive bacteria growth.
PB  - Elsevier B.V.
T2  - Sustainable Chemistry and Pharmacy
T1  - Black cumin essential oil as a valuable source of bioactive compounds: Evaluation of the conventional vs. modern extraction technique
SP  - 101390
VL  - 37
DO  - 10.1016/j.scp.2023.101390
ER  - 

@article{
author = "Dimitrijević, Snežana and Milić, Marija and Tadić, Vanja and Maksimović, Svetolik and Filipović, Vladimir and Dimitrijević-Branković, Suzana and Miljković, Miona and Salamon, Ivan",
year = "2024-02",
abstract = "Within this investigation, the effect of conventional and sophisticated extraction method was evaluated on the chemical composition of black cumin seeds (Nigella sativa L.) essential oils and their bioactive characteristics. Soxhlet extraction at 60 °C by hexane (SEH) and petroleum ether (SEP) was adopted as traditionally used technique, while the supercritical extraction with CO2 (SFE), under the pressure of 10 MPa and temperature of 40 °C, was performed as a modern method, expected to overcome the drawbacks of the conventional solvent extraction. The results showed that SFE enabled up to ten times higher extraction yields, compared to essential oils derived after Soxhlet extraction, however, the bioactive compounds content, such as polyphenols, flavonoids and carotenoids, were extracted in higher quantities in the oil from Soxhlet extraction performance. Thereby, the strongest antioxidant agent was found to be the essential oil obtained from SEP, followed by the oil from SFE and oil obtained from SEH, respectively. The GC-MS analysis revealed that the content of thymoquinone was the highest in the essential oil from SEP (69.58%), and the obtained values are among the highest reported within the available literature data. Also, this oil sample contained about eleven times higher thymoquinone quantities than the essential oil obtained by SFE, which was mostly constituted of a methyl linoleate, a fatty acid methyl ester of linoleic acid. In addition, the essential oil from SEP exerted a value added antimicrobial properties, where it was found to be particularly effective in suppression of the Gram-positive bacteria growth.",
publisher = "Elsevier B.V.",
journal = "Sustainable Chemistry and Pharmacy",
title = "Black cumin essential oil as a valuable source of bioactive compounds: Evaluation of the conventional vs. modern extraction technique",
pages = "101390",
volume = "37",
doi = "10.1016/j.scp.2023.101390"
}

Dimitrijević, S., Milić, M., Tadić, V., Maksimović, S., Filipović, V., Dimitrijević-Branković, S., Miljković, M.,& Salamon, I.. (2024-02). Black cumin essential oil as a valuable source of bioactive compounds: Evaluation of the conventional vs. modern extraction technique. in Sustainable Chemistry and Pharmacy
Elsevier B.V.., 37, 101390.
https://doi.org/10.1016/j.scp.2023.101390

Dimitrijević S, Milić M, Tadić V, Maksimović S, Filipović V, Dimitrijević-Branković S, Miljković M, Salamon I. Black cumin essential oil as a valuable source of bioactive compounds: Evaluation of the conventional vs. modern extraction technique. in Sustainable Chemistry and Pharmacy. 2024;37:101390.
doi:10.1016/j.scp.2023.101390 .

Dimitrijević, Snežana, Milić, Marija, Tadić, Vanja, Maksimović, Svetolik, Filipović, Vladimir, Dimitrijević-Branković, Suzana, Miljković, Miona, Salamon, Ivan, "Black cumin essential oil as a valuable source of bioactive compounds: Evaluation of the conventional vs. modern extraction technique" in Sustainable Chemistry and Pharmacy, 37 (2024-02):101390,
https://doi.org/10.1016/j.scp.2023.101390 . .

TY  - JOUR
AU  - Maksimović, Svetolik
AU  - Stanković, Milica
AU  - Roganović, Sonja
AU  - Nešić, Ivana
AU  - Zvezdanović, Jelena
AU  - Tadić, Vanja
AU  - Žižović, Irena
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5230
AB  - Ethnopharmacological relevance: Helichrysum italicum has been widely used in traditional medicine to treat allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections, and sleeplessness. Furthermore, it possesses considerable wound healing and skin protective properties, documented by several in vivo studies performed on animals. However, there is a lack of experimental evidence supporting its potential as a topical agent tested by human clinical trials. Aim of the study: The study aimed to investigate the skin protective activity of cotton gauze and polypropylene non-woven fabric, impregnated with H. italicum extract by the integrated supercritical CO2 extraction-supercritical solvent impregnation process. Materials and methods: The integrated process of supercritical CO2 extraction of H. italicum and the impregnation of cotton gauze and polypropylene non-woven fabric was performed under 350 bar and 40 °C with and without the addition of ethanol as a cosolvent. Impregnated textile materials were tested in vivo for their bioactivity on irritated human skin. Randomized in vivo studies performed involved assays of both safety and efficacy of the impregnated textiles. The effects were evaluated using the in vivo non-invasive biophysical measurements of the following skin parameters: electrical capacitance, transepidermal water loss, melanin index, erythema index, and skin pH. Results: Both cotton gauze and polypropylene non-woven fabric were impregnated with H. italicum extracts under supercritical conditions with considerable values of the impregnation yield (1.97%–4.25%). The addition of ethanol as a cosolvent during the process caused significant changes in the incorporated extracts’ impregnation yield and chemical profile. Both impregnated textile materials were safe, evaluated by their testing on the human skin with no cause of any irritation and redness. However, efficacy studies revealed that polypropylene non-woven fabric impregnated with H. italicum extract with ethanol as a cosolvent, possessed significantly greater potential for skin protection than the other investigated samples. Conclusions: The present study demonstrated the feasibility of the combined supercritical extraction and impregnation process in developing materials for topical application based on H. italicum extract. The results of in vivo studies performed on human volunteers confirmed the suitability of H. italicum active components to be a part of human skin protective preparations because of their ability to maintain the skin unimpaired. Traditionally claimed applications as a medicinal plant capable of regenerating skin have been scientifically proven, in addition to employing green technology in obtaining the impregnated materials with a broad spectrum of utilization.
PB  - Elsevier Ireland Ltd
T2  - Journal of Ethnopharmacology
T1  - Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin
SP  - 115779
VL  - 301
DO  - 10.1016/j.jep.2022.115779
ER  - 

@article{
author = "Maksimović, Svetolik and Stanković, Milica and Roganović, Sonja and Nešić, Ivana and Zvezdanović, Jelena and Tadić, Vanja and Žižović, Irena",
year = "2023",
abstract = "Ethnopharmacological relevance: Helichrysum italicum has been widely used in traditional medicine to treat allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections, and sleeplessness. Furthermore, it possesses considerable wound healing and skin protective properties, documented by several in vivo studies performed on animals. However, there is a lack of experimental evidence supporting its potential as a topical agent tested by human clinical trials. Aim of the study: The study aimed to investigate the skin protective activity of cotton gauze and polypropylene non-woven fabric, impregnated with H. italicum extract by the integrated supercritical CO2 extraction-supercritical solvent impregnation process. Materials and methods: The integrated process of supercritical CO2 extraction of H. italicum and the impregnation of cotton gauze and polypropylene non-woven fabric was performed under 350 bar and 40 °C with and without the addition of ethanol as a cosolvent. Impregnated textile materials were tested in vivo for their bioactivity on irritated human skin. Randomized in vivo studies performed involved assays of both safety and efficacy of the impregnated textiles. The effects were evaluated using the in vivo non-invasive biophysical measurements of the following skin parameters: electrical capacitance, transepidermal water loss, melanin index, erythema index, and skin pH. Results: Both cotton gauze and polypropylene non-woven fabric were impregnated with H. italicum extracts under supercritical conditions with considerable values of the impregnation yield (1.97%–4.25%). The addition of ethanol as a cosolvent during the process caused significant changes in the incorporated extracts’ impregnation yield and chemical profile. Both impregnated textile materials were safe, evaluated by their testing on the human skin with no cause of any irritation and redness. However, efficacy studies revealed that polypropylene non-woven fabric impregnated with H. italicum extract with ethanol as a cosolvent, possessed significantly greater potential for skin protection than the other investigated samples. Conclusions: The present study demonstrated the feasibility of the combined supercritical extraction and impregnation process in developing materials for topical application based on H. italicum extract. The results of in vivo studies performed on human volunteers confirmed the suitability of H. italicum active components to be a part of human skin protective preparations because of their ability to maintain the skin unimpaired. Traditionally claimed applications as a medicinal plant capable of regenerating skin have been scientifically proven, in addition to employing green technology in obtaining the impregnated materials with a broad spectrum of utilization.",
publisher = "Elsevier Ireland Ltd",
journal = "Journal of Ethnopharmacology",
title = "Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin",
pages = "115779",
volume = "301",
doi = "10.1016/j.jep.2022.115779"
}

Maksimović, S., Stanković, M., Roganović, S., Nešić, I., Zvezdanović, J., Tadić, V.,& Žižović, I.. (2023). Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin. in Journal of Ethnopharmacology
Elsevier Ireland Ltd., 301, 115779.
https://doi.org/10.1016/j.jep.2022.115779

Maksimović S, Stanković M, Roganović S, Nešić I, Zvezdanović J, Tadić V, Žižović I. Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin. in Journal of Ethnopharmacology. 2023;301:115779.
doi:10.1016/j.jep.2022.115779 .

Maksimović, Svetolik, Stanković, Milica, Roganović, Sonja, Nešić, Ivana, Zvezdanović, Jelena, Tadić, Vanja, Žižović, Irena, "Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin" in Journal of Ethnopharmacology, 301 (2023):115779,
https://doi.org/10.1016/j.jep.2022.115779 . .

TY  - PAT
AU  - Tadić, Vanja
AU  - Žugić, Ana
AU  - Nešić, Ivana
AU  - Krgović, Nemanja
AU  - Mudrić, Jelena
AU  - Martinović, Milica
AU  - Stojanović, Sanja
AU  - Maksimović, Svetolik
AU  - Lukić, Ivana
AU  - Petrović, Slobodan
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6924
T2  - Zavod za intelektualnu svojinu republike Srbije
T1  - Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6924
ER  - 

@misc{
author = "Tadić, Vanja and Žugić, Ana and Nešić, Ivana and Krgović, Nemanja and Mudrić, Jelena and Martinović, Milica and Stojanović, Sanja and Maksimović, Svetolik and Lukić, Ivana and Petrović, Slobodan",
year = "2023",
journal = "Zavod za intelektualnu svojinu republike Srbije",
title = "Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6924"
}

Tadić, V., Žugić, A., Nešić, I., Krgović, N., Mudrić, J., Martinović, M., Stojanović, S., Maksimović, S., Lukić, I.,& Petrović, S.. (2023). Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja. in Zavod za intelektualnu svojinu republike Srbije.
https://hdl.handle.net/21.15107/rcub_technorep_6924

Tadić V, Žugić A, Nešić I, Krgović N, Mudrić J, Martinović M, Stojanović S, Maksimović S, Lukić I, Petrović S. Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja. in Zavod za intelektualnu svojinu republike Srbije. 2023;.
https://hdl.handle.net/21.15107/rcub_technorep_6924 .

Tadić, Vanja, Žugić, Ana, Nešić, Ivana, Krgović, Nemanja, Mudrić, Jelena, Martinović, Milica, Stojanović, Sanja, Maksimović, Svetolik, Lukić, Ivana, Petrović, Slobodan, "Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja" in Zavod za intelektualnu svojinu republike Srbije (2023),
https://hdl.handle.net/21.15107/rcub_technorep_6924 .

TY  - PAT
AU  - Tadić, Vanja
AU  - Nešić, Ivana
AU  - Milenković, Marina
AU  - Martinović, Milica
AU  - Žugić, Ana
AU  - Maksimović, Svetolik
AU  - Stojanović, Sanja
AU  - Milovanović, Stoja
AU  - Krgović, Nemanja
AU  - Petrović, Slobodan
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6900
T2  - Zavod za intelektualnu svojinu republike Srbije
T1  - Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6900
ER  - 

@misc{
author = "Tadić, Vanja and Nešić, Ivana and Milenković, Marina and Martinović, Milica and Žugić, Ana and Maksimović, Svetolik and Stojanović, Sanja and Milovanović, Stoja and Krgović, Nemanja and Petrović, Slobodan",
year = "2023",
journal = "Zavod za intelektualnu svojinu republike Srbije",
title = "Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6900"
}

Tadić, V., Nešić, I., Milenković, M., Martinović, M., Žugić, A., Maksimović, S., Stojanović, S., Milovanović, S., Krgović, N.,& Petrović, S.. (2023). Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom. in Zavod za intelektualnu svojinu republike Srbije.
https://hdl.handle.net/21.15107/rcub_technorep_6900

Tadić V, Nešić I, Milenković M, Martinović M, Žugić A, Maksimović S, Stojanović S, Milovanović S, Krgović N, Petrović S. Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom. in Zavod za intelektualnu svojinu republike Srbije. 2023;.
https://hdl.handle.net/21.15107/rcub_technorep_6900 .

Tadić, Vanja, Nešić, Ivana, Milenković, Marina, Martinović, Milica, Žugić, Ana, Maksimović, Svetolik, Stojanović, Sanja, Milovanović, Stoja, Krgović, Nemanja, Petrović, Slobodan, "Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom" in Zavod za intelektualnu svojinu republike Srbije (2023),
https://hdl.handle.net/21.15107/rcub_technorep_6900 .

TY  - JOUR
AU  - Vukmirović, Saša
AU  - Ilić, Vladimirka
AU  - Tadić, Vanja
AU  - Čapo, Ivan
AU  - Pavlović, Nebojša
AU  - Tomas, Ana
AU  - Paut Kusturica, Milica
AU  - Tomić, Nataša
AU  - Maksimović, Svetolik
AU  - Stilinović, Nebojša
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6221
AB  - The framework of this study was a comprehensive investigation of Morus nigra L. extracts, with the aim to establish the correlation between chemical composition and antioxidant/hepatoprotective activity of a series of black mulberry extracts obtained from aerial parts of the plant. Black mulberry leaf (MLEE), bark (MBEE), juice (MJ) and fresh fruit (MFEE) extracts were obtained using the conventional Soxhlet extraction, while the supercritical CO2 extraction procedure was employed for preparation of the seed oil (MSO). Analysis of the chemical composition was performed using spectrophotometric, HPLC and GC methods. For the evaluation of antioxidant activity, in vitro FRAP and DPPH assays were applied. In Haan strain NMRI mice with streptozotocin-induced oxidative stress, in vivo antioxidant activity and liver tissue integrity were examined. The content of polyphenolic compounds was the highest in MBEE (68.3 ± 0.7 mgGAE/g) with the most abundant compounds being polyphenolic acids, followed by MLEE (23.4 ± 0.5 mgGAE/g) with the flavonoids isoquercetin and rutin being present in a significant amount. An analysis of MSO revealed a high content of γ-linoleic acid. The highest antioxidant activity in vitro (FRAP and DPPH) was observed for MLEE, MBEE and MSO. Beneficial effects were confirmed in vivo, with lower values of hepatosomatic index, potentiation of the activity of the enzymes superoxide dismutase and catalase, a lower rate of lipid peroxidation and reduced positivity for the P450 enzyme in animals treated with MLEE, MBEE and MSO. Black mulberry leaf and bark extracts as well as seed oil exhibited significant antioxidant activity. Apart from the confirmed biological properties of the fruit and leaf extracts, the observed activities of black mulberry seed oil and bark extract imply its importance as a sustainable source of phytochemicals.
PB  - MDPI
T2  - Antioxidants
T1  - Comprehensive Analysis of Antioxidant and Hepatoprotective Properties of Morus nigra L.
IS  - 2
SP  - 382
VL  - 12
DO  - 10.3390/antiox12020382
ER  - 

@article{
author = "Vukmirović, Saša and Ilić, Vladimirka and Tadić, Vanja and Čapo, Ivan and Pavlović, Nebojša and Tomas, Ana and Paut Kusturica, Milica and Tomić, Nataša and Maksimović, Svetolik and Stilinović, Nebojša",
year = "2023",
abstract = "The framework of this study was a comprehensive investigation of Morus nigra L. extracts, with the aim to establish the correlation between chemical composition and antioxidant/hepatoprotective activity of a series of black mulberry extracts obtained from aerial parts of the plant. Black mulberry leaf (MLEE), bark (MBEE), juice (MJ) and fresh fruit (MFEE) extracts were obtained using the conventional Soxhlet extraction, while the supercritical CO2 extraction procedure was employed for preparation of the seed oil (MSO). Analysis of the chemical composition was performed using spectrophotometric, HPLC and GC methods. For the evaluation of antioxidant activity, in vitro FRAP and DPPH assays were applied. In Haan strain NMRI mice with streptozotocin-induced oxidative stress, in vivo antioxidant activity and liver tissue integrity were examined. The content of polyphenolic compounds was the highest in MBEE (68.3 ± 0.7 mgGAE/g) with the most abundant compounds being polyphenolic acids, followed by MLEE (23.4 ± 0.5 mgGAE/g) with the flavonoids isoquercetin and rutin being present in a significant amount. An analysis of MSO revealed a high content of γ-linoleic acid. The highest antioxidant activity in vitro (FRAP and DPPH) was observed for MLEE, MBEE and MSO. Beneficial effects were confirmed in vivo, with lower values of hepatosomatic index, potentiation of the activity of the enzymes superoxide dismutase and catalase, a lower rate of lipid peroxidation and reduced positivity for the P450 enzyme in animals treated with MLEE, MBEE and MSO. Black mulberry leaf and bark extracts as well as seed oil exhibited significant antioxidant activity. Apart from the confirmed biological properties of the fruit and leaf extracts, the observed activities of black mulberry seed oil and bark extract imply its importance as a sustainable source of phytochemicals.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Comprehensive Analysis of Antioxidant and Hepatoprotective Properties of Morus nigra L.",
number = "2",
pages = "382",
volume = "12",
doi = "10.3390/antiox12020382"
}

Vukmirović, S., Ilić, V., Tadić, V., Čapo, I., Pavlović, N., Tomas, A., Paut Kusturica, M., Tomić, N., Maksimović, S.,& Stilinović, N.. (2023). Comprehensive Analysis of Antioxidant and Hepatoprotective Properties of Morus nigra L.. in Antioxidants
MDPI., 12(2), 382.
https://doi.org/10.3390/antiox12020382

Vukmirović S, Ilić V, Tadić V, Čapo I, Pavlović N, Tomas A, Paut Kusturica M, Tomić N, Maksimović S, Stilinović N. Comprehensive Analysis of Antioxidant and Hepatoprotective Properties of Morus nigra L.. in Antioxidants. 2023;12(2):382.
doi:10.3390/antiox12020382 .

Vukmirović, Saša, Ilić, Vladimirka, Tadić, Vanja, Čapo, Ivan, Pavlović, Nebojša, Tomas, Ana, Paut Kusturica, Milica, Tomić, Nataša, Maksimović, Svetolik, Stilinović, Nebojša, "Comprehensive Analysis of Antioxidant and Hepatoprotective Properties of Morus nigra L." in Antioxidants, 12, no. 2 (2023):382,
https://doi.org/10.3390/antiox12020382 . .

TY  - BOOK
AU  - Tadić, Vanja
AU  - Maksimović, Svetolik
AU  - Nešić, Ivana
AU  - Žižović, Irena
AU  - Mišić, Dušan
AU  - Milovanović, Stoja
AU  - Žugić, Ana
AU  - Aksentijević, Ksenija
AU  - Stanković, Milica
AU  - Ivanović, Jasna
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6876
PB  - Niš : Galaksijanis
T1  - Smilje od tradicionalne do naučno zasnovane primene
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6876
ER  - 

@book{
author = "Tadić, Vanja and Maksimović, Svetolik and Nešić, Ivana and Žižović, Irena and Mišić, Dušan and Milovanović, Stoja and Žugić, Ana and Aksentijević, Ksenija and Stanković, Milica and Ivanović, Jasna",
year = "2021",
publisher = "Niš : Galaksijanis",
title = "Smilje od tradicionalne do naučno zasnovane primene",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6876"
}

Tadić, V., Maksimović, S., Nešić, I., Žižović, I., Mišić, D., Milovanović, S., Žugić, A., Aksentijević, K., Stanković, M.,& Ivanović, J.. (2021). Smilje od tradicionalne do naučno zasnovane primene. 
Niš : Galaksijanis..
https://hdl.handle.net/21.15107/rcub_technorep_6876

Tadić V, Maksimović S, Nešić I, Žižović I, Mišić D, Milovanović S, Žugić A, Aksentijević K, Stanković M, Ivanović J. Smilje od tradicionalne do naučno zasnovane primene. 2021;.
https://hdl.handle.net/21.15107/rcub_technorep_6876 .

Tadić, Vanja, Maksimović, Svetolik, Nešić, Ivana, Žižović, Irena, Mišić, Dušan, Milovanović, Stoja, Žugić, Ana, Aksentijević, Ksenija, Stanković, Milica, Ivanović, Jasna, "Smilje od tradicionalne do naučno zasnovane primene" (2021),
https://hdl.handle.net/21.15107/rcub_technorep_6876 .

TY  - CONF
AU  - Milovanović, Stoja
AU  - Lukić, Ivana
AU  - Pajnik, Jelena
AU  - Maksimović, Svetolik
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6895
AB  - Starch is an abundant and low-cost polysaccharide obtained from renewable resources. Biocompatibility, biodegradability, and versatility of starch enable its application in several industries including food and pharmaceutical.
In this work, supercritical CO2 drying process was tested for preparation of stable and porous starch-based material. First, a hydrogel was formed from an aqueous solution (cornstarch to water mass ratio 1:10) at 95 °C. Subsequently, water was replaced with acetone during several days to form an acetogel. Finally, acetogels were subjected to supercritical CO2 drying at pressures of 8, 10, 20 MPa and temperatures of 35 and 45 °C up to 3 h to form aerogels. Obtained aerogels were compared with starch xerogels prepared by air drying of acetogels.
The SEM, FTIR, and porosity analysis confirmed significant effect of supercritical CO2 drying process conditions on starch aerogels properties and their suitability to form nanostructured matrices. SEM analysis showed that aerogels were filamentous with filament diameter less than 100 nm. Due to their low density (0.273-0.773 g/cm3) and high porosity (48-82%) obtained starch aerogels present promising candidates as matrices and carriers for bioactive substances.
C3  - 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France
T1  - Effect of supercritical CO2 drying process conditions on starch aerogel properties
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6895
ER  - 

@conference{
author = "Milovanović, Stoja and Lukić, Ivana and Pajnik, Jelena and Maksimović, Svetolik",
year = "2021",
abstract = "Starch is an abundant and low-cost polysaccharide obtained from renewable resources. Biocompatibility, biodegradability, and versatility of starch enable its application in several industries including food and pharmaceutical.
In this work, supercritical CO2 drying process was tested for preparation of stable and porous starch-based material. First, a hydrogel was formed from an aqueous solution (cornstarch to water mass ratio 1:10) at 95 °C. Subsequently, water was replaced with acetone during several days to form an acetogel. Finally, acetogels were subjected to supercritical CO2 drying at pressures of 8, 10, 20 MPa and temperatures of 35 and 45 °C up to 3 h to form aerogels. Obtained aerogels were compared with starch xerogels prepared by air drying of acetogels.
The SEM, FTIR, and porosity analysis confirmed significant effect of supercritical CO2 drying process conditions on starch aerogels properties and their suitability to form nanostructured matrices. SEM analysis showed that aerogels were filamentous with filament diameter less than 100 nm. Due to their low density (0.273-0.773 g/cm3) and high porosity (48-82%) obtained starch aerogels present promising candidates as matrices and carriers for bioactive substances.",
journal = "18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France",
title = "Effect of supercritical CO2 drying process conditions on starch aerogel properties",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6895"
}

Milovanović, S., Lukić, I., Pajnik, J.,& Maksimović, S.. (2021). Effect of supercritical CO2 drying process conditions on starch aerogel properties. in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France.
https://hdl.handle.net/21.15107/rcub_technorep_6895

Milovanović S, Lukić I, Pajnik J, Maksimović S. Effect of supercritical CO2 drying process conditions on starch aerogel properties. in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France. 2021;.
https://hdl.handle.net/21.15107/rcub_technorep_6895 .

Milovanović, Stoja, Lukić, Ivana, Pajnik, Jelena, Maksimović, Svetolik, "Effect of supercritical CO2 drying process conditions on starch aerogel properties" in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France (2021),
https://hdl.handle.net/21.15107/rcub_technorep_6895 .

TY  - CONF
AU  - Maksimović, Svetolik
AU  - Milovanović, Stoja
AU  - Ivanović, Jasna
AU  - Žižović, Irena
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6896
AB  - The coupling of supercritical fluid extraction and supercritical solvent impregnation processes has been proved to be convenient in cases where the active substance, to be incorporated in the solid carrier, is supercritical extract. The integrated process enables minimizing the loss of the extract by directly using the supercritical CO2-extract solution leaving the extractor vessel for the impregnation and avoidance of the intermediate decompression step in the separate processes (decompression after extraction), and consequently leads to energy and time savings.
The objective of this work was to examine the application of the integrated process for impregnation of chitosan/alginate and corn starch xerogels and aerogels with Helichrysum italicum supercritical CO2 extract. For that purpose, first chitosan/alginate and starch hydrogels were prepared by sol-gel method. Thereafter hydrogels were transformed into alcogels by water exchange with ethanol or acetone. Xerogels and aerogels were produced by air and supercritical CO2 drying of the alcogels or acetogels, respectively. Finally, impregnation of the xerogels and aerogels was performed in the laboratory unit for the integrated processes.
Both chitosan/alginate and starch xerogels and aerogels showed significant affinity for the incorporation of active principles from H. italicum which was confirmed by FTIR method. SEM method indicated significant differences in materials’ porosity. One of the reason for this is pore collapse phenomenon associated the formation of the xerogels. Obtained results confirmed that it is possible to impregnate chitosan/alginate and starch xerogels and aerogels with H. italicum extract by the integrated process of supercritical CO2 extraction and impregnation.
C3  - 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France
T1  - The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6896
ER  - 

@conference{
author = "Maksimović, Svetolik and Milovanović, Stoja and Ivanović, Jasna and Žižović, Irena",
year = "2021",
abstract = "The coupling of supercritical fluid extraction and supercritical solvent impregnation processes has been proved to be convenient in cases where the active substance, to be incorporated in the solid carrier, is supercritical extract. The integrated process enables minimizing the loss of the extract by directly using the supercritical CO2-extract solution leaving the extractor vessel for the impregnation and avoidance of the intermediate decompression step in the separate processes (decompression after extraction), and consequently leads to energy and time savings.
The objective of this work was to examine the application of the integrated process for impregnation of chitosan/alginate and corn starch xerogels and aerogels with Helichrysum italicum supercritical CO2 extract. For that purpose, first chitosan/alginate and starch hydrogels were prepared by sol-gel method. Thereafter hydrogels were transformed into alcogels by water exchange with ethanol or acetone. Xerogels and aerogels were produced by air and supercritical CO2 drying of the alcogels or acetogels, respectively. Finally, impregnation of the xerogels and aerogels was performed in the laboratory unit for the integrated processes.
Both chitosan/alginate and starch xerogels and aerogels showed significant affinity for the incorporation of active principles from H. italicum which was confirmed by FTIR method. SEM method indicated significant differences in materials’ porosity. One of the reason for this is pore collapse phenomenon associated the formation of the xerogels. Obtained results confirmed that it is possible to impregnate chitosan/alginate and starch xerogels and aerogels with H. italicum extract by the integrated process of supercritical CO2 extraction and impregnation.",
journal = "18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France",
title = "The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6896"
}

Maksimović, S., Milovanović, S., Ivanović, J.,& Žižović, I.. (2021). The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract. in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France.
https://hdl.handle.net/21.15107/rcub_technorep_6896

Maksimović S, Milovanović S, Ivanović J, Žižović I. The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract. in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France. 2021;.
https://hdl.handle.net/21.15107/rcub_technorep_6896 .

Maksimović, Svetolik, Milovanović, Stoja, Ivanović, Jasna, Žižović, Irena, "The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract" in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France (2021),
https://hdl.handle.net/21.15107/rcub_technorep_6896 .

TY  - JOUR
AU  - Milovanović, Ivan
AU  - Zengin, Gokhan
AU  - Maksimović, Svetolik
AU  - Tadić, Vanja
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/17
AB  - Background This study provides an insight into the impact of ultrasound-assisted extraction with water as solvent (UAEW) and extraction by supercritical carbon dioxide (SC-CO2) with 5% EtOH on antioxidant and enzyme inhibitory activity in regard to the chemical profile of the edible and medicinal mushroom,Pleurotus pulmonarius. Results Extraction efficiency was between 0.36% and 63.32%, depending on the extraction technique. The main compounds in the extracts were fatty acids. Supercritical CO(2)extraction with co-solvent was the most suitable method for obtaining extracts that were rich in ergosterol content, reaching a value of 40.1 mg g(-1). The UAEW of crude mushroom powder ensured the highest yield, as well as the extracts with best antioxidative activity. The measurements of enzyme inhibitory activity revealed that all types of investigated extracts exhibited only tyrosinase and amylase inhibition at a significant level. Conclusion Based on our results, the extraction methods significantly affected the chemical profile and bioactivity ofP. pulmonarius.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food and Agriculture
T1  - Supercritical and ultrasound-assisted extracts fromPleurotus pulmonariusmushroom: chemical profiles, antioxidative, and enzyme-inhibitory properties
EP  - 2293
IS  - 6
SP  - 2284
VL  - 101
DO  - 10.1002/jsfa.10849
ER  - 

@article{
author = "Milovanović, Ivan and Zengin, Gokhan and Maksimović, Svetolik and Tadić, Vanja",
year = "2021",
abstract = "Background This study provides an insight into the impact of ultrasound-assisted extraction with water as solvent (UAEW) and extraction by supercritical carbon dioxide (SC-CO2) with 5% EtOH on antioxidant and enzyme inhibitory activity in regard to the chemical profile of the edible and medicinal mushroom,Pleurotus pulmonarius. Results Extraction efficiency was between 0.36% and 63.32%, depending on the extraction technique. The main compounds in the extracts were fatty acids. Supercritical CO(2)extraction with co-solvent was the most suitable method for obtaining extracts that were rich in ergosterol content, reaching a value of 40.1 mg g(-1). The UAEW of crude mushroom powder ensured the highest yield, as well as the extracts with best antioxidative activity. The measurements of enzyme inhibitory activity revealed that all types of investigated extracts exhibited only tyrosinase and amylase inhibition at a significant level. Conclusion Based on our results, the extraction methods significantly affected the chemical profile and bioactivity ofP. pulmonarius.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food and Agriculture",
title = "Supercritical and ultrasound-assisted extracts fromPleurotus pulmonariusmushroom: chemical profiles, antioxidative, and enzyme-inhibitory properties",
pages = "2293-2284",
number = "6",
volume = "101",
doi = "10.1002/jsfa.10849"
}

Milovanović, I., Zengin, G., Maksimović, S.,& Tadić, V.. (2021). Supercritical and ultrasound-assisted extracts fromPleurotus pulmonariusmushroom: chemical profiles, antioxidative, and enzyme-inhibitory properties. in Journal of the Science of Food and Agriculture
Wiley, Hoboken., 101(6), 2284-2293.
https://doi.org/10.1002/jsfa.10849

Milovanović I, Zengin G, Maksimović S, Tadić V. Supercritical and ultrasound-assisted extracts fromPleurotus pulmonariusmushroom: chemical profiles, antioxidative, and enzyme-inhibitory properties. in Journal of the Science of Food and Agriculture. 2021;101(6):2284-2293.
doi:10.1002/jsfa.10849 .

Milovanović, Ivan, Zengin, Gokhan, Maksimović, Svetolik, Tadić, Vanja, "Supercritical and ultrasound-assisted extracts fromPleurotus pulmonariusmushroom: chemical profiles, antioxidative, and enzyme-inhibitory properties" in Journal of the Science of Food and Agriculture, 101, no. 6 (2021):2284-2293,
https://doi.org/10.1002/jsfa.10849 . .

TY  - JOUR
AU  - Tadic, Vanja M.
AU  - Zugic, Ana
AU  - Martinovic, Milica
AU  - Stankovic, Milica
AU  - Maksimović, Svetolik
AU  - Frank, Almut
AU  - Nesic, Ivana
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4821
AB  - Immortelle, as rich source of chlorogenic acid and the phloroglucinol alpha-pyrone compound arzanol, possesses anti-inflammatory and antioxidant properties, affects cell regeneration, and has positive effect on many skin conditions. Hemp oil, characterized by a favorable omega-6 to omega-3 ratio, as well as an abundance of essential fatty acids and vitamin E, participates in immunoregulation and also act as an anti-inflammatory. In the present study, we examined the effect on the skin of creams and emulgels with immortelle extract and hemp oil, by comparing them to placebo samples and a non-treated control. A long-term in vivo study of biophysical skin characteristics, which lasted for 30 days, was conducted on 25 healthy human volunteers. Measured parameters were electrical capacitance of the stratum corneum, trans-epidermal water loss (TEWL), and skin pH and erythema index. Further, a sensory study was carried out in which the panelists had to choose descriptive terms for sensory attributes in questionnaire. The results showed that application of all preparations led to increase of skin hydration and TEWL reduction, while the skin was not irritated, and its normal pH was not disrupted. This study also showed importance of the carrier. Not only were emulgels described by panelists as preparations with better sensory properties, there was a significant difference between the skin hydration effect of emulgel with immortelle extract and hemp oil compared to the placebo emulgel, which was not the case with creams. Such findings indicated enhanced delivery of herbal active substances from emulgel compared to the cream.
T2  - Pharmaceutics
T1  - Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)
IS  - 11
VL  - 13
DO  - 10.3390/pharmaceutics13111919
ER  - 

@article{
author = "Tadic, Vanja M. and Zugic, Ana and Martinovic, Milica and Stankovic, Milica and Maksimović, Svetolik and Frank, Almut and Nesic, Ivana",
year = "2021",
abstract = "Immortelle, as rich source of chlorogenic acid and the phloroglucinol alpha-pyrone compound arzanol, possesses anti-inflammatory and antioxidant properties, affects cell regeneration, and has positive effect on many skin conditions. Hemp oil, characterized by a favorable omega-6 to omega-3 ratio, as well as an abundance of essential fatty acids and vitamin E, participates in immunoregulation and also act as an anti-inflammatory. In the present study, we examined the effect on the skin of creams and emulgels with immortelle extract and hemp oil, by comparing them to placebo samples and a non-treated control. A long-term in vivo study of biophysical skin characteristics, which lasted for 30 days, was conducted on 25 healthy human volunteers. Measured parameters were electrical capacitance of the stratum corneum, trans-epidermal water loss (TEWL), and skin pH and erythema index. Further, a sensory study was carried out in which the panelists had to choose descriptive terms for sensory attributes in questionnaire. The results showed that application of all preparations led to increase of skin hydration and TEWL reduction, while the skin was not irritated, and its normal pH was not disrupted. This study also showed importance of the carrier. Not only were emulgels described by panelists as preparations with better sensory properties, there was a significant difference between the skin hydration effect of emulgel with immortelle extract and hemp oil compared to the placebo emulgel, which was not the case with creams. Such findings indicated enhanced delivery of herbal active substances from emulgel compared to the cream.",
journal = "Pharmaceutics",
title = "Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)",
number = "11",
volume = "13",
doi = "10.3390/pharmaceutics13111919"
}

Tadic, V. M., Zugic, A., Martinovic, M., Stankovic, M., Maksimović, S., Frank, A.,& Nesic, I.. (2021). Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil). in Pharmaceutics, 13(11).
https://doi.org/10.3390/pharmaceutics13111919

Tadic VM, Zugic A, Martinovic M, Stankovic M, Maksimović S, Frank A, Nesic I. Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil). in Pharmaceutics. 2021;13(11).
doi:10.3390/pharmaceutics13111919 .

Tadic, Vanja M., Zugic, Ana, Martinovic, Milica, Stankovic, Milica, Maksimović, Svetolik, Frank, Almut, Nesic, Ivana, "Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)" in Pharmaceutics, 13, no. 11 (2021),
https://doi.org/10.3390/pharmaceutics13111919 . .

TY  - JOUR
AU  - Maksimović, Svetolik
AU  - Tadic, Vanja
AU  - Zvezdanovic, Jelena
AU  - Zizovic, Irena
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4904
AB  - Helichrysum italicum (Roth) G. Don fil., Asteraceae, possesses numerous secondary plant metabolites with a wide range of biological activities. Yet, data on the potential of supercritical fluid extraction (SFE) in their isolation are scarce. This study provides analyses of the chemical profiles of extracts obtained by SFE with or without ethanol as a cosolvent using GC-FID, GC-MS, HPLC, and UHPLC-MS techniques. Among the compounds with proven biological activity identified, the presence of arzanol was confirmed. In the next step, the integrated process of supercritical fluid extraction and impregnation was applied to deliver active compounds to cotton gauze and polypropylene fabric for possible topical applications. The analytical procedures results showed a considerable affinity of both textile materials for incorporating active components present in the H. italicum. The study indicated the high-pressure techniques applied as very efficient in the isolation of bioactive components from H. italicum and their adsorption on selected carriers.
T2  - Journal of Supercritical Fluids
T1  - Utilization of supercritical CO2 in bioactive principles isolation from Helichrysum italicum and their adsorption on selected fabrics
VL  - 171
DO  - 10.1016/j.supflu.2021.105197
ER  - 

@article{
author = "Maksimović, Svetolik and Tadic, Vanja and Zvezdanovic, Jelena and Zizovic, Irena",
year = "2021",
abstract = "Helichrysum italicum (Roth) G. Don fil., Asteraceae, possesses numerous secondary plant metabolites with a wide range of biological activities. Yet, data on the potential of supercritical fluid extraction (SFE) in their isolation are scarce. This study provides analyses of the chemical profiles of extracts obtained by SFE with or without ethanol as a cosolvent using GC-FID, GC-MS, HPLC, and UHPLC-MS techniques. Among the compounds with proven biological activity identified, the presence of arzanol was confirmed. In the next step, the integrated process of supercritical fluid extraction and impregnation was applied to deliver active compounds to cotton gauze and polypropylene fabric for possible topical applications. The analytical procedures results showed a considerable affinity of both textile materials for incorporating active components present in the H. italicum. The study indicated the high-pressure techniques applied as very efficient in the isolation of bioactive components from H. italicum and their adsorption on selected carriers.",
journal = "Journal of Supercritical Fluids",
title = "Utilization of supercritical CO2 in bioactive principles isolation from Helichrysum italicum and their adsorption on selected fabrics",
volume = "171",
doi = "10.1016/j.supflu.2021.105197"
}

Maksimović, S., Tadic, V., Zvezdanovic, J.,& Zizovic, I.. (2021). Utilization of supercritical CO2 in bioactive principles isolation from Helichrysum italicum and their adsorption on selected fabrics. in Journal of Supercritical Fluids, 171.
https://doi.org/10.1016/j.supflu.2021.105197

Maksimović S, Tadic V, Zvezdanovic J, Zizovic I. Utilization of supercritical CO2 in bioactive principles isolation from Helichrysum italicum and their adsorption on selected fabrics. in Journal of Supercritical Fluids. 2021;171.
doi:10.1016/j.supflu.2021.105197 .

Maksimović, Svetolik, Tadic, Vanja, Zvezdanovic, Jelena, Zizovic, Irena, "Utilization of supercritical CO2 in bioactive principles isolation from Helichrysum italicum and their adsorption on selected fabrics" in Journal of Supercritical Fluids, 171 (2021),
https://doi.org/10.1016/j.supflu.2021.105197 . .

TY  - JOUR
AU  - Tadic, Vanja M.
AU  - Nesic, Ivana
AU  - Martinovic, Milica
AU  - Roj, Edward
AU  - Brasanac-Vukanovic, Snezana
AU  - Maksimović, Svetolik
AU  - Zugic, Ana
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4907
AB  - Bilberry represents a valuable source of antioxidant substances responsible for its application for the treatment of different conditions (such as inflammation, cardiovascular disease, cancer, diabetes, and different age-related diseases) associated with increased oxidative stress. As oxidative stress might cause skin impairments, we aim to evaluate a topical preparation containing bilberry leaves extract and bilberry seeds oil, obtained as a byproduct of the food industry. To obtain the extracts, the conventional maceration technique for leaves, and supercritical carbon dioxide extraction for seeds were employed. The chemical profile of both actives was achieved by HPLC and GC methods, revealing the presence of phenolic acids (chlorogenic being the most abundant), flavonoids (isoquercetin in the highest amount), and resveratrol in leaves extract, while in seeds oil the essential omega-3 and omega-6 fatty acids were determined in favorable ratio, almost being 1. Antioxidant potential of the wild bilberry extract and seed oil was evaluated using in vitro DPPH and FRAP assays. Finally, effects of the oil-in-water creams with mentioned wild bilberry isolates on the skin were investigated in an in vivo study conducted on healthy human volunteers, revealing the significant beneficial effects when topically applied.
T2  - Antioxidants
T1  - Old Plant, New Possibilities: Wild Bilberry (Vaccinium myrtillus L., Ericaceae) in Topical Skin Preparation
IS  - 3
VL  - 10
DO  - 10.3390/antiox10030465
ER  - 

@article{
author = "Tadic, Vanja M. and Nesic, Ivana and Martinovic, Milica and Roj, Edward and Brasanac-Vukanovic, Snezana and Maksimović, Svetolik and Zugic, Ana",
year = "2021",
abstract = "Bilberry represents a valuable source of antioxidant substances responsible for its application for the treatment of different conditions (such as inflammation, cardiovascular disease, cancer, diabetes, and different age-related diseases) associated with increased oxidative stress. As oxidative stress might cause skin impairments, we aim to evaluate a topical preparation containing bilberry leaves extract and bilberry seeds oil, obtained as a byproduct of the food industry. To obtain the extracts, the conventional maceration technique for leaves, and supercritical carbon dioxide extraction for seeds were employed. The chemical profile of both actives was achieved by HPLC and GC methods, revealing the presence of phenolic acids (chlorogenic being the most abundant), flavonoids (isoquercetin in the highest amount), and resveratrol in leaves extract, while in seeds oil the essential omega-3 and omega-6 fatty acids were determined in favorable ratio, almost being 1. Antioxidant potential of the wild bilberry extract and seed oil was evaluated using in vitro DPPH and FRAP assays. Finally, effects of the oil-in-water creams with mentioned wild bilberry isolates on the skin were investigated in an in vivo study conducted on healthy human volunteers, revealing the significant beneficial effects when topically applied.",
journal = "Antioxidants",
title = "Old Plant, New Possibilities: Wild Bilberry (Vaccinium myrtillus L., Ericaceae) in Topical Skin Preparation",
number = "3",
volume = "10",
doi = "10.3390/antiox10030465"
}

Tadic, V. M., Nesic, I., Martinovic, M., Roj, E., Brasanac-Vukanovic, S., Maksimović, S.,& Zugic, A.. (2021). Old Plant, New Possibilities: Wild Bilberry (Vaccinium myrtillus L., Ericaceae) in Topical Skin Preparation. in Antioxidants, 10(3).
https://doi.org/10.3390/antiox10030465

Tadic VM, Nesic I, Martinovic M, Roj E, Brasanac-Vukanovic S, Maksimović S, Zugic A. Old Plant, New Possibilities: Wild Bilberry (Vaccinium myrtillus L., Ericaceae) in Topical Skin Preparation. in Antioxidants. 2021;10(3).
doi:10.3390/antiox10030465 .

Tadic, Vanja M., Nesic, Ivana, Martinovic, Milica, Roj, Edward, Brasanac-Vukanovic, Snezana, Maksimović, Svetolik, Zugic, Ana, "Old Plant, New Possibilities: Wild Bilberry (Vaccinium myrtillus L., Ericaceae) in Topical Skin Preparation" in Antioxidants, 10, no. 3 (2021),
https://doi.org/10.3390/antiox10030465 . .

TY  - JOUR
AU  - Maksimović, Svetolik
AU  - Tadić, Vanja
AU  - Ivanović, Jasna
AU  - Radmanović, Tanja
AU  - Milovanović, Stoja
AU  - Stanković, Milica
AU  - Žižović, Irena
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3867
AB  - Supercritical CO2 extraction of Helichrysum italicum and impregnation of starch xerogels with the extract by using an integrated scCO(2) extraction and impregnation process were performed at 350 bar and 40 degrees C in order to produce biomaterials for possible oral intake of the extract. Xerogels produced by air-drying of acetogels and alcogels were used as carriers in the supercritical impregnation process. The effect of ethanol as a co-solvent, contact time, plant material/carrier mass ratio and xerogel preparation on the impregnation loading was studied. The highest impregnation loading (1.261 +/- 0.22%) was achieved after 5 h impregnation of the xerogel obtained from alcogel using pure scCO(2) and plant material/carrier mass ratio of 10. Chemical analysis of the extracts showed that the addition of ethanol as co-solvent had a positive effect on scCO(2) selectivity to terpene fraction and total flavonoids, while it lowered the total phenolic content. Despite the difference in chemical composition, both extracts expressed similar antioxidant activity according to the DPPH and FRAP methods. The integrated process was shown to be a feasible method for isolation and incorporation of bioactive components of H italicum into starch xerogels.
PB  - Savez hemijskih inženjera, Beograd
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Utilization of the integrated process of supercritical extraction and impregnation for incorporation of helichrysum italicum extract into corn starch xerogel
EP  - 200
IS  - 2
SP  - 191
VL  - 24
DO  - 10.2298/CICEQ170223031M
ER  - 

@article{
author = "Maksimović, Svetolik and Tadić, Vanja and Ivanović, Jasna and Radmanović, Tanja and Milovanović, Stoja and Stanković, Milica and Žižović, Irena",
year = "2018",
abstract = "Supercritical CO2 extraction of Helichrysum italicum and impregnation of starch xerogels with the extract by using an integrated scCO(2) extraction and impregnation process were performed at 350 bar and 40 degrees C in order to produce biomaterials for possible oral intake of the extract. Xerogels produced by air-drying of acetogels and alcogels were used as carriers in the supercritical impregnation process. The effect of ethanol as a co-solvent, contact time, plant material/carrier mass ratio and xerogel preparation on the impregnation loading was studied. The highest impregnation loading (1.261 +/- 0.22%) was achieved after 5 h impregnation of the xerogel obtained from alcogel using pure scCO(2) and plant material/carrier mass ratio of 10. Chemical analysis of the extracts showed that the addition of ethanol as co-solvent had a positive effect on scCO(2) selectivity to terpene fraction and total flavonoids, while it lowered the total phenolic content. Despite the difference in chemical composition, both extracts expressed similar antioxidant activity according to the DPPH and FRAP methods. The integrated process was shown to be a feasible method for isolation and incorporation of bioactive components of H italicum into starch xerogels.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Utilization of the integrated process of supercritical extraction and impregnation for incorporation of helichrysum italicum extract into corn starch xerogel",
pages = "200-191",
number = "2",
volume = "24",
doi = "10.2298/CICEQ170223031M"
}

Maksimović, S., Tadić, V., Ivanović, J., Radmanović, T., Milovanović, S., Stanković, M.,& Žižović, I.. (2018). Utilization of the integrated process of supercritical extraction and impregnation for incorporation of helichrysum italicum extract into corn starch xerogel. in Chemical Industry & Chemical Engineering Quarterly
Savez hemijskih inženjera, Beograd., 24(2), 191-200.
https://doi.org/10.2298/CICEQ170223031M

Maksimović S, Tadić V, Ivanović J, Radmanović T, Milovanović S, Stanković M, Žižović I. Utilization of the integrated process of supercritical extraction and impregnation for incorporation of helichrysum italicum extract into corn starch xerogel. in Chemical Industry & Chemical Engineering Quarterly. 2018;24(2):191-200.
doi:10.2298/CICEQ170223031M .

Maksimović, Svetolik, Tadić, Vanja, Ivanović, Jasna, Radmanović, Tanja, Milovanović, Stoja, Stanković, Milica, Žižović, Irena, "Utilization of the integrated process of supercritical extraction and impregnation for incorporation of helichrysum italicum extract into corn starch xerogel" in Chemical Industry & Chemical Engineering Quarterly, 24, no. 2 (2018):191-200,
https://doi.org/10.2298/CICEQ170223031M . .

TY  - JOUR
AU  - Stanković, Milica
AU  - Maksimović, Svetolik
AU  - Tadić, Vanja
AU  - Arsić, Ivana A.
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3811
AB  - Oils from wild fruits have gained attention due to the presence of the wide variety of natural bioactive lipid components (essential polyunsaturated fatty acids, phytosterols, lipid-soluble vitamins), which have positive effects on human health. The present study describes the extraction of oils from fruits of different plant species, Sambucus nigra, Prunus spinosa, Sorbus aucuparia and Rosa canina, using the conventional Soxhlet extraction technique with petroleum ether. Before the extraction, mechanical processing of fruit samples (exposure to elevated pressure and temperature) was performed. The yield of oil (%) was expressed as mass of obtained oil per mass of dry plant material (w/w). Moisture content of fruit samples was also determined. Wild fruits showed different moisture contents, ranging from 6.53 to 71.52 g/100 g of fresh weight, in R. canina and S. aucuparia fruits, respectively. S. nigra and P. spinosa fruits revealed similar moisture contents, 68.48 g/100 g and 68.89 g/100 g of fresh weight, respectively. Oil yields of the investigated fruit samples showed statistically significant differences (p  lt  0.05) and ranged from 0.38 to 3.22% (w/w) in the R. canina and P. spinosa fruits, respectively. Dry fruits of S. nigra had 2.55% (w/w) of oil, while the oil content in S. aucuparia fruits was 0.68% (w/w). The findings obtained from this study might be useful from the aspect of potential utilization of these wild fruits, in particular fruits of P. spinosa and S. nigra, as raw materials for the extraction of valuable oil for the application in food, cosmetic and pharmaceutical industry.
AB  - Ulja dobijena iz plodova biljaka sve više dobijaju na značaju, upravo zbog prisustva velikog broja prirodnih, bioaktivnih lipidnih komponenata (esencijalnih, polinezasićenih masnih kiselina, fitosterola, liposolubilnih vitamina), koji ispoljavaju pozitivne efekte na ljudsko zdravlje. U ovom radu opisan je postupak ekstrakcije ulja iz plodova različitih biljnih vrsta (Sambucus nigra, Prunus spinosa, Sorbus aucuparia i Rosa canina), primenom konvencionalne Soxhlet ekstrakcione tehnike sa petrol-etrom. Pre ekstrakcije izvršena je mehanička obrada uzoraka plodova, njihovim izlaganjem povišenom pritisku i temperaturi. Prinos ulja (%) je izražen kao masa dobijenog ulja u odnosu na masu suvog biljnog materijala (w/w). Određen je i sadržaj vlage u uzorcima plodova. Divlji plodovi su se razlikovali po sadržaju vlage, čije su vrednosti bile u granicama od 6,53 g/100 g svežih plodova (R. canina) do 71,52 g/100 g svežih plodova (S. aucuparia). Biljne vrste S. nigra i P. spinosa pokazale su sličan sadržaj vlage u plodovima, i to 68,48 g/100 g i 68,89 g/100 g svežih plodova. Prinosi ulja ispitivanih uzoraka plodova razlikovali su se statistički značajno (p  lt  0,05), a vrednosti su bile od 0,38% (kod R. canina plodova) do 3,22% (plodovi P. spinosa). Kod suvih plodova S. nigra dobijeni prinos ulja je iznosio 2,55%, dok je sadržaj ulja u plodovima S. aucuparia iznosio 0,68%. Dobijeni rezultati su korisni zbog mogućnosti upotrebe ispitivanih divljih plodova, naročito plodova P. spinosa i S. nigra (imale su najveći sadržaj ulja), kao polaznih sirovina za ekstrakciju biljnog ulja za primenu u prehrambenoj, kozmetičkoj i farmaceutskoj industriji.
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš
T2  - Acta Facultatis Medicae Naissensis
T1  - The oil content of wild fruits from different plant species obtained by conventional Soxhlet extraction technique
T1  - Sadržaj ulja divljih plodova različitih biljnih vrsta dobijen konvencionalnom Soxhlet tehnikom ekstrakcije
EP  - 200
IS  - 3
SP  - 193
VL  - 35
DO  - 10.2478/afmnai-2018-0021
ER  - 

@article{
author = "Stanković, Milica and Maksimović, Svetolik and Tadić, Vanja and Arsić, Ivana A.",
year = "2018",
abstract = "Oils from wild fruits have gained attention due to the presence of the wide variety of natural bioactive lipid components (essential polyunsaturated fatty acids, phytosterols, lipid-soluble vitamins), which have positive effects on human health. The present study describes the extraction of oils from fruits of different plant species, Sambucus nigra, Prunus spinosa, Sorbus aucuparia and Rosa canina, using the conventional Soxhlet extraction technique with petroleum ether. Before the extraction, mechanical processing of fruit samples (exposure to elevated pressure and temperature) was performed. The yield of oil (%) was expressed as mass of obtained oil per mass of dry plant material (w/w). Moisture content of fruit samples was also determined. Wild fruits showed different moisture contents, ranging from 6.53 to 71.52 g/100 g of fresh weight, in R. canina and S. aucuparia fruits, respectively. S. nigra and P. spinosa fruits revealed similar moisture contents, 68.48 g/100 g and 68.89 g/100 g of fresh weight, respectively. Oil yields of the investigated fruit samples showed statistically significant differences (p  lt  0.05) and ranged from 0.38 to 3.22% (w/w) in the R. canina and P. spinosa fruits, respectively. Dry fruits of S. nigra had 2.55% (w/w) of oil, while the oil content in S. aucuparia fruits was 0.68% (w/w). The findings obtained from this study might be useful from the aspect of potential utilization of these wild fruits, in particular fruits of P. spinosa and S. nigra, as raw materials for the extraction of valuable oil for the application in food, cosmetic and pharmaceutical industry., Ulja dobijena iz plodova biljaka sve više dobijaju na značaju, upravo zbog prisustva velikog broja prirodnih, bioaktivnih lipidnih komponenata (esencijalnih, polinezasićenih masnih kiselina, fitosterola, liposolubilnih vitamina), koji ispoljavaju pozitivne efekte na ljudsko zdravlje. U ovom radu opisan je postupak ekstrakcije ulja iz plodova različitih biljnih vrsta (Sambucus nigra, Prunus spinosa, Sorbus aucuparia i Rosa canina), primenom konvencionalne Soxhlet ekstrakcione tehnike sa petrol-etrom. Pre ekstrakcije izvršena je mehanička obrada uzoraka plodova, njihovim izlaganjem povišenom pritisku i temperaturi. Prinos ulja (%) je izražen kao masa dobijenog ulja u odnosu na masu suvog biljnog materijala (w/w). Određen je i sadržaj vlage u uzorcima plodova. Divlji plodovi su se razlikovali po sadržaju vlage, čije su vrednosti bile u granicama od 6,53 g/100 g svežih plodova (R. canina) do 71,52 g/100 g svežih plodova (S. aucuparia). Biljne vrste S. nigra i P. spinosa pokazale su sličan sadržaj vlage u plodovima, i to 68,48 g/100 g i 68,89 g/100 g svežih plodova. Prinosi ulja ispitivanih uzoraka plodova razlikovali su se statistički značajno (p  lt  0,05), a vrednosti su bile od 0,38% (kod R. canina plodova) do 3,22% (plodovi P. spinosa). Kod suvih plodova S. nigra dobijeni prinos ulja je iznosio 2,55%, dok je sadržaj ulja u plodovima S. aucuparia iznosio 0,68%. Dobijeni rezultati su korisni zbog mogućnosti upotrebe ispitivanih divljih plodova, naročito plodova P. spinosa i S. nigra (imale su najveći sadržaj ulja), kao polaznih sirovina za ekstrakciju biljnog ulja za primenu u prehrambenoj, kozmetičkoj i farmaceutskoj industriji.",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš",
journal = "Acta Facultatis Medicae Naissensis",
title = "The oil content of wild fruits from different plant species obtained by conventional Soxhlet extraction technique, Sadržaj ulja divljih plodova različitih biljnih vrsta dobijen konvencionalnom Soxhlet tehnikom ekstrakcije",
pages = "200-193",
number = "3",
volume = "35",
doi = "10.2478/afmnai-2018-0021"
}

Stanković, M., Maksimović, S., Tadić, V.,& Arsić, I. A.. (2018). The oil content of wild fruits from different plant species obtained by conventional Soxhlet extraction technique. in Acta Facultatis Medicae Naissensis
Univerzitet u Nišu - Medicinski fakultet, Niš., 35(3), 193-200.
https://doi.org/10.2478/afmnai-2018-0021

Stanković M, Maksimović S, Tadić V, Arsić IA. The oil content of wild fruits from different plant species obtained by conventional Soxhlet extraction technique. in Acta Facultatis Medicae Naissensis. 2018;35(3):193-200.
doi:10.2478/afmnai-2018-0021 .

Stanković, Milica, Maksimović, Svetolik, Tadić, Vanja, Arsić, Ivana A., "The oil content of wild fruits from different plant species obtained by conventional Soxhlet extraction technique" in Acta Facultatis Medicae Naissensis, 35, no. 3 (2018):193-200,
https://doi.org/10.2478/afmnai-2018-0021 . .

TY  - JOUR
AU  - Dimitrijević, Snežana
AU  - Pavlović, Marija
AU  - Maksimović, Svetolik
AU  - Ristić, Mihailo S.
AU  - Filipović, Vladimir
AU  - Antonović, Dušan
AU  - Dimitrijević-Branković, Suzana
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3995
AB  - BACKGROUNDIn order to study the influence of plant growth-promoting bacteria (PGPB) belonging to Streptomyces sp., Paenibacillus sp., and Hymenobacter sp. on fixed oil content of flaxseed and black cumin, 2-year field experiments were conducted. PGPB was applied during seedtime of plants. The extraction of oil from seeds was performed using supercritical CO2. RESULTSThe addition of PGPB significantly increases the content of C18:1 (from 16.060.03% to 16.97 +/- 0.03%) and C18:3 (from 42.97 +/- 0.2% to 45.42 +/- 0.5%) in flaxseed oil and C18:2 (from 52.68 +/- 0.50% to 57.11 +/- 0.40%) and C20:2 (from 4.34 +/- 0.02% to 4.54 +/- 0.03%) in black cumin seed oil. The contents of total polyphenols, flavonoids, and carotenoids, as well as antioxidant activity measured by ferric-reducing ability of plasma assay, were found to be greater in the oil from the seeds of plants treated with the PGPB, compared with the respective non-treated samples. CONCLUSIONThe use of PGPB enhances plant nutritive properties; these represent a great source for obtaining valuable functional food ingredients.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food and Agriculture
T1  - Plant growth-promoting bacteria elevate the nutritional and functional properties of black cumin and flaxseed fixed oil
EP  - 1590
IS  - 4
SP  - 1584
VL  - 98
DO  - 10.1002/jsfa.8631
ER  - 

@article{
author = "Dimitrijević, Snežana and Pavlović, Marija and Maksimović, Svetolik and Ristić, Mihailo S. and Filipović, Vladimir and Antonović, Dušan and Dimitrijević-Branković, Suzana",
year = "2018",
abstract = "BACKGROUNDIn order to study the influence of plant growth-promoting bacteria (PGPB) belonging to Streptomyces sp., Paenibacillus sp., and Hymenobacter sp. on fixed oil content of flaxseed and black cumin, 2-year field experiments were conducted. PGPB was applied during seedtime of plants. The extraction of oil from seeds was performed using supercritical CO2. RESULTSThe addition of PGPB significantly increases the content of C18:1 (from 16.060.03% to 16.97 +/- 0.03%) and C18:3 (from 42.97 +/- 0.2% to 45.42 +/- 0.5%) in flaxseed oil and C18:2 (from 52.68 +/- 0.50% to 57.11 +/- 0.40%) and C20:2 (from 4.34 +/- 0.02% to 4.54 +/- 0.03%) in black cumin seed oil. The contents of total polyphenols, flavonoids, and carotenoids, as well as antioxidant activity measured by ferric-reducing ability of plasma assay, were found to be greater in the oil from the seeds of plants treated with the PGPB, compared with the respective non-treated samples. CONCLUSIONThe use of PGPB enhances plant nutritive properties; these represent a great source for obtaining valuable functional food ingredients.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food and Agriculture",
title = "Plant growth-promoting bacteria elevate the nutritional and functional properties of black cumin and flaxseed fixed oil",
pages = "1590-1584",
number = "4",
volume = "98",
doi = "10.1002/jsfa.8631"
}

Dimitrijević, S., Pavlović, M., Maksimović, S., Ristić, M. S., Filipović, V., Antonović, D.,& Dimitrijević-Branković, S.. (2018). Plant growth-promoting bacteria elevate the nutritional and functional properties of black cumin and flaxseed fixed oil. in Journal of the Science of Food and Agriculture
Wiley, Hoboken., 98(4), 1584-1590.
https://doi.org/10.1002/jsfa.8631

Dimitrijević S, Pavlović M, Maksimović S, Ristić MS, Filipović V, Antonović D, Dimitrijević-Branković S. Plant growth-promoting bacteria elevate the nutritional and functional properties of black cumin and flaxseed fixed oil. in Journal of the Science of Food and Agriculture. 2018;98(4):1584-1590.
doi:10.1002/jsfa.8631 .

Dimitrijević, Snežana, Pavlović, Marija, Maksimović, Svetolik, Ristić, Mihailo S., Filipović, Vladimir, Antonović, Dušan, Dimitrijević-Branković, Suzana, "Plant growth-promoting bacteria elevate the nutritional and functional properties of black cumin and flaxseed fixed oil" in Journal of the Science of Food and Agriculture, 98, no. 4 (2018):1584-1590,
https://doi.org/10.1002/jsfa.8631 . .

TY  - THES
AU  - Maksimović, Svetolik
PY  - 2017
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=5694
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:17443/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49968399
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4667
AB  - Curry plant (Helichrysum italicum (Roth) G. Don fil., Asteraceae) is Mediterranean plant, known for its traditional use in treatment of inflammatory processes mostly on skin and in the digestive system. This plant presents a valuable source of bioactive components, among which the most common are terpenes and phenolic compounds. According to available literature data, supercritical extraction with carbon dioxide from curry plant has not been investigated enough regarding chemical composition and possible uses of the supercritical extracts. In this dissertation, supercritical extraction from curry plant was investigated, and for the first time, supercritical extract of curry plant was used as an active component for impregnation of different solid carriers under supercritical conditions...
AB  - Smilje (Helichrysum italicum (Roth) G. Don fil., Asteraceae) je mediteranska biljka, poznata po svojoj tradicionalnoj upotrebi u tretmanu upalnih procesa pretežno na koži i u digestivnom sistemu. Smilje predstavlja vredan izvor biološki aktivnih komponenata, među kojima su najzastupljenije terpeni i fenolna jedinjenja. Na osnovu pregleda literaturnih podataka može se zaključiti da ekstrakcija pomoću natkritičnog ugljenik(IV)-oksida nije dovoljno istražena u pogledu hemijskog sastava i mogućih primena dobijenih natkritičnih ekstrakata. U ovoj disertaciji ispitana je natkritična ekstrakcija iz smilja i, po prvi put je natkritični ekstrakt smilja korišćen kao aktivna supstanca za impregnaciju različitih čvrstih nosača u natkritičnim uslovima...
PB  - Univerzitet u Beogradu, Tehnološko-metalurški fakultet
T1  - Extraction from curry plant (Helichrysum italicum) and impregnation of solid carries with the extract using supercritical carbon dioxide
T1  - Ekstrakcija iz smilja (Helichrysum italicum) i impregnacija čvrstih nosača ekstraktom primenom natkritičnog ugljenik(IV)-oksida
UR  - https://hdl.handle.net/21.15107/rcub_technorep_4667
ER  - 

@phdthesis{
author = "Maksimović, Svetolik",
year = "2017",
abstract = "Curry plant (Helichrysum italicum (Roth) G. Don fil., Asteraceae) is Mediterranean plant, known for its traditional use in treatment of inflammatory processes mostly on skin and in the digestive system. This plant presents a valuable source of bioactive components, among which the most common are terpenes and phenolic compounds. According to available literature data, supercritical extraction with carbon dioxide from curry plant has not been investigated enough regarding chemical composition and possible uses of the supercritical extracts. In this dissertation, supercritical extraction from curry plant was investigated, and for the first time, supercritical extract of curry plant was used as an active component for impregnation of different solid carriers under supercritical conditions..., Smilje (Helichrysum italicum (Roth) G. Don fil., Asteraceae) je mediteranska biljka, poznata po svojoj tradicionalnoj upotrebi u tretmanu upalnih procesa pretežno na koži i u digestivnom sistemu. Smilje predstavlja vredan izvor biološki aktivnih komponenata, među kojima su najzastupljenije terpeni i fenolna jedinjenja. Na osnovu pregleda literaturnih podataka može se zaključiti da ekstrakcija pomoću natkritičnog ugljenik(IV)-oksida nije dovoljno istražena u pogledu hemijskog sastava i mogućih primena dobijenih natkritičnih ekstrakata. U ovoj disertaciji ispitana je natkritična ekstrakcija iz smilja i, po prvi put je natkritični ekstrakt smilja korišćen kao aktivna supstanca za impregnaciju različitih čvrstih nosača u natkritičnim uslovima...",
publisher = "Univerzitet u Beogradu, Tehnološko-metalurški fakultet",
title = "Extraction from curry plant (Helichrysum italicum) and impregnation of solid carries with the extract using supercritical carbon dioxide, Ekstrakcija iz smilja (Helichrysum italicum) i impregnacija čvrstih nosača ekstraktom primenom natkritičnog ugljenik(IV)-oksida",
url = "https://hdl.handle.net/21.15107/rcub_technorep_4667"
}

Maksimović, S.. (2017). Extraction from curry plant (Helichrysum italicum) and impregnation of solid carries with the extract using supercritical carbon dioxide. 
Univerzitet u Beogradu, Tehnološko-metalurški fakultet..
https://hdl.handle.net/21.15107/rcub_technorep_4667

Maksimović S. Extraction from curry plant (Helichrysum italicum) and impregnation of solid carries with the extract using supercritical carbon dioxide. 2017;.
https://hdl.handle.net/21.15107/rcub_technorep_4667 .

Maksimović, Svetolik, "Extraction from curry plant (Helichrysum italicum) and impregnation of solid carries with the extract using supercritical carbon dioxide" (2017),
https://hdl.handle.net/21.15107/rcub_technorep_4667 .

TY  - JOUR
AU  - Maksimović, Svetolik
AU  - Tadić, Vanja
AU  - Skala, Dejan
AU  - Žižović, Irena
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3757
AB  - Helichrysum italicum presents a valuable source of natural bioactive compounds. In this work, a literature review of terpenes, phenolic compounds, and other less common phytochemicals from H. italicum with regard to application of different separation methods is presented. Data including extraction/separation methods and experimental conditions applied, obtained yields, number of identified compounds, content of different compound groups, and analytical techniques applied are shown as corresponding tables. Numerous biological activities of both isolates and individual compounds are emphasized. In addition, the data reported are discussed, and the directions for further investigations are proposed.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Separation of phytochemicals from Helichrysum italicum: An analysis of different isolation techniques and biological activity of prepared extracts
EP  - 28
SP  - 9
VL  - 138
DO  - 10.1016/j.phytochem.2017.01.001
ER  - 

@article{
author = "Maksimović, Svetolik and Tadić, Vanja and Skala, Dejan and Žižović, Irena",
year = "2017",
abstract = "Helichrysum italicum presents a valuable source of natural bioactive compounds. In this work, a literature review of terpenes, phenolic compounds, and other less common phytochemicals from H. italicum with regard to application of different separation methods is presented. Data including extraction/separation methods and experimental conditions applied, obtained yields, number of identified compounds, content of different compound groups, and analytical techniques applied are shown as corresponding tables. Numerous biological activities of both isolates and individual compounds are emphasized. In addition, the data reported are discussed, and the directions for further investigations are proposed.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Separation of phytochemicals from Helichrysum italicum: An analysis of different isolation techniques and biological activity of prepared extracts",
pages = "28-9",
volume = "138",
doi = "10.1016/j.phytochem.2017.01.001"
}

Maksimović, S., Tadić, V., Skala, D.,& Žižović, I.. (2017). Separation of phytochemicals from Helichrysum italicum: An analysis of different isolation techniques and biological activity of prepared extracts. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 138, 9-28.
https://doi.org/10.1016/j.phytochem.2017.01.001

Maksimović S, Tadić V, Skala D, Žižović I. Separation of phytochemicals from Helichrysum italicum: An analysis of different isolation techniques and biological activity of prepared extracts. in Phytochemistry. 2017;138:9-28.
doi:10.1016/j.phytochem.2017.01.001 .

Maksimović, Svetolik, Tadić, Vanja, Skala, Dejan, Žižović, Irena, "Separation of phytochemicals from Helichrysum italicum: An analysis of different isolation techniques and biological activity of prepared extracts" in Phytochemistry, 138 (2017):9-28,
https://doi.org/10.1016/j.phytochem.2017.01.001 . .

TY  - JOUR
AU  - Lukić, Ivana
AU  - Kesić, Željka
AU  - Maksimović, Svetolik
AU  - Zdujić, Miodrag
AU  - Krstić, Jugoslav
AU  - Skala, Dejan
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2608
AB  - The kinetics of heterogeneous methanolysis of sunflower oil was studied at 60 °C using mechanochemically synthesized CaO·ZnO as catalyst. The influence of agitation speed, catalyst amount, and methanol-to-oil molar ratio on the rate of reaction was analyzed. The rate of the process depends on the two resistances - mass transfer of triglycerides to the catalyst surface and chemical reaction on the catalyst surface, which are defined as the values of the overall triglyceride volumetric mass transfer coefficient, kmt,TG, and the effective pseudo first-order reaction rate constant, k, respectively. These kinetic parameters actually determine the value of the apparent reaction rate constant, kapp, the time dependence of which is defined by the change of triglyceride (TG) conversion. A kinetic model is proposed and the model parameters are determined.
AB  - Kinetika heterogene metanolize suncokretovog ulja je ispitivana na 60 °C korišćenjem CaO·ZnO katalizatora koji je sintetizovan mehanohemijskim putem. Analiziran je uticaj intenziteta mešanja, mase korišćenog katalizatora u sintezi i različitog molskog odnosa metanola i ulja na brzinu metanolize. Brzina procesa metanolize zavisi od dva otpora - otpora prenosu mase triglicerida do površine katalizatora i otpora brzini hemijske reakcije na površini katalizatora. Oba otpora određuju vrednost ukupnog zapreminskog koeficijenta prenosa mase triglicerida, kmt,TG, odnosno efektivne vrednosti konstante brzine hemijske reakcije pseudo-prvog reda, k. Ovi kinetički parametri određuju vrednost prividne konstante brzine procesa metanolize, kapp, koja se menja sa vremenom u zavisnosti od ostvareneog stepena konverzije triglicerida (TG). Predložen je odgovarajući model kojim je moguće definisati brzinu metanolize i određeni su odgovarajući parametri ovog modela.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Kinetics of heterogeneous methanolysis of sunflower oil with CaO·ZnO catalyst: Influence of different hydrodynamic conditions
T1  - Kinetika heterogene metanolize suncokretovog ulja sa CaO·ZnO kao katalizatorom - uticaj različitih hidrodinamičkih uslova
EP  - 439
IS  - 3
SP  - 425
VL  - 20
DO  - 10.2298/CICEQ130514025L
ER  - 

@article{
author = "Lukić, Ivana and Kesić, Željka and Maksimović, Svetolik and Zdujić, Miodrag and Krstić, Jugoslav and Skala, Dejan",
year = "2014",
abstract = "The kinetics of heterogeneous methanolysis of sunflower oil was studied at 60 °C using mechanochemically synthesized CaO·ZnO as catalyst. The influence of agitation speed, catalyst amount, and methanol-to-oil molar ratio on the rate of reaction was analyzed. The rate of the process depends on the two resistances - mass transfer of triglycerides to the catalyst surface and chemical reaction on the catalyst surface, which are defined as the values of the overall triglyceride volumetric mass transfer coefficient, kmt,TG, and the effective pseudo first-order reaction rate constant, k, respectively. These kinetic parameters actually determine the value of the apparent reaction rate constant, kapp, the time dependence of which is defined by the change of triglyceride (TG) conversion. A kinetic model is proposed and the model parameters are determined., Kinetika heterogene metanolize suncokretovog ulja je ispitivana na 60 °C korišćenjem CaO·ZnO katalizatora koji je sintetizovan mehanohemijskim putem. Analiziran je uticaj intenziteta mešanja, mase korišćenog katalizatora u sintezi i različitog molskog odnosa metanola i ulja na brzinu metanolize. Brzina procesa metanolize zavisi od dva otpora - otpora prenosu mase triglicerida do površine katalizatora i otpora brzini hemijske reakcije na površini katalizatora. Oba otpora određuju vrednost ukupnog zapreminskog koeficijenta prenosa mase triglicerida, kmt,TG, odnosno efektivne vrednosti konstante brzine hemijske reakcije pseudo-prvog reda, k. Ovi kinetički parametri određuju vrednost prividne konstante brzine procesa metanolize, kapp, koja se menja sa vremenom u zavisnosti od ostvareneog stepena konverzije triglicerida (TG). Predložen je odgovarajući model kojim je moguće definisati brzinu metanolize i određeni su odgovarajući parametri ovog modela.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Kinetics of heterogeneous methanolysis of sunflower oil with CaO·ZnO catalyst: Influence of different hydrodynamic conditions, Kinetika heterogene metanolize suncokretovog ulja sa CaO·ZnO kao katalizatorom - uticaj različitih hidrodinamičkih uslova",
pages = "439-425",
number = "3",
volume = "20",
doi = "10.2298/CICEQ130514025L"
}

Lukić, I., Kesić, Ž., Maksimović, S., Zdujić, M., Krstić, J.,& Skala, D.. (2014). Kinetics of heterogeneous methanolysis of sunflower oil with CaO·ZnO catalyst: Influence of different hydrodynamic conditions. in Chemical Industry & Chemical Engineering Quarterly
Association of the Chemical Engineers of Serbia., 20(3), 425-439.
https://doi.org/10.2298/CICEQ130514025L

Lukić I, Kesić Ž, Maksimović S, Zdujić M, Krstić J, Skala D. Kinetics of heterogeneous methanolysis of sunflower oil with CaO·ZnO catalyst: Influence of different hydrodynamic conditions. in Chemical Industry & Chemical Engineering Quarterly. 2014;20(3):425-439.
doi:10.2298/CICEQ130514025L .

Lukić, Ivana, Kesić, Željka, Maksimović, Svetolik, Zdujić, Miodrag, Krstić, Jugoslav, Skala, Dejan, "Kinetics of heterogeneous methanolysis of sunflower oil with CaO·ZnO catalyst: Influence of different hydrodynamic conditions" in Chemical Industry & Chemical Engineering Quarterly, 20, no. 3 (2014):425-439,
https://doi.org/10.2298/CICEQ130514025L . .

TY  - JOUR
AU  - Lukić, Ivana
AU  - Kesić, Željka
AU  - Maksimović, Svetolik
AU  - Zdujić, Miodrag
AU  - Liu, Hui
AU  - Krstić, Jugoslav
AU  - Skala, Dejan
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2423
AB  - The kinetics of heterogeneous methanolysis of sunflower oil and used vegetable oil were studied at different temperatures, ranging from 60 to 96 degrees C using CaO center dot ZnO as catalyst (2 wt% on the basis of oil) and methanol to oil molar ratio of 10:1. Heterogeneous CaO center dot ZnO catalyst was synthesized by mechanochemical treatment of CaO and ZnO powder mixture with the addition of water necessary for the formation of corresponding mixed hydroxides, and their calcination at 700 degrees C in air. It was shown that kinetics of overall process could be described as pseudo-first order reaction. For the sunflower oil methanolysis at 60 and 70 degrees C, the rate of process at the beginning of biodiesel synthesis was limited by triglycerides mass transfer to the catalyst surface, and after that it is governed by the rate of chemical reaction at catalyst surface. At higher temperatures the influence of mass transfer resistance is almost negligible implying that the rate of chemical reaction determines the overall kinetic of biodiesel synthesis. In the case of used vegetable oil, the influence of mass transfer resistance was not observed either at higher or lower temperature. The kinetic model that describes the whole process well was proposed, and it comprises both the triglycerides mass transfer and chemical reaction controlled regime. The overall volumetric mass transfer coefficient was defined, assuming that it depends on the conversion of triglycerides.
PB  - Elsevier Sci Ltd, Oxford
T2  - Fuel
T1  - Kinetics of sunflower and used vegetable oil methanolysis catalyzed by CaO·ZnO
EP  - 378
SP  - 367
VL  - 113
DO  - 10.1016/j.fuel.2013.05.093
ER  - 

@article{
author = "Lukić, Ivana and Kesić, Željka and Maksimović, Svetolik and Zdujić, Miodrag and Liu, Hui and Krstić, Jugoslav and Skala, Dejan",
year = "2013",
abstract = "The kinetics of heterogeneous methanolysis of sunflower oil and used vegetable oil were studied at different temperatures, ranging from 60 to 96 degrees C using CaO center dot ZnO as catalyst (2 wt% on the basis of oil) and methanol to oil molar ratio of 10:1. Heterogeneous CaO center dot ZnO catalyst was synthesized by mechanochemical treatment of CaO and ZnO powder mixture with the addition of water necessary for the formation of corresponding mixed hydroxides, and their calcination at 700 degrees C in air. It was shown that kinetics of overall process could be described as pseudo-first order reaction. For the sunflower oil methanolysis at 60 and 70 degrees C, the rate of process at the beginning of biodiesel synthesis was limited by triglycerides mass transfer to the catalyst surface, and after that it is governed by the rate of chemical reaction at catalyst surface. At higher temperatures the influence of mass transfer resistance is almost negligible implying that the rate of chemical reaction determines the overall kinetic of biodiesel synthesis. In the case of used vegetable oil, the influence of mass transfer resistance was not observed either at higher or lower temperature. The kinetic model that describes the whole process well was proposed, and it comprises both the triglycerides mass transfer and chemical reaction controlled regime. The overall volumetric mass transfer coefficient was defined, assuming that it depends on the conversion of triglycerides.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Fuel",
title = "Kinetics of sunflower and used vegetable oil methanolysis catalyzed by CaO·ZnO",
pages = "378-367",
volume = "113",
doi = "10.1016/j.fuel.2013.05.093"
}

Lukić, I., Kesić, Ž., Maksimović, S., Zdujić, M., Liu, H., Krstić, J.,& Skala, D.. (2013). Kinetics of sunflower and used vegetable oil methanolysis catalyzed by CaO·ZnO. in Fuel
Elsevier Sci Ltd, Oxford., 113, 367-378.
https://doi.org/10.1016/j.fuel.2013.05.093

Lukić I, Kesić Ž, Maksimović S, Zdujić M, Liu H, Krstić J, Skala D. Kinetics of sunflower and used vegetable oil methanolysis catalyzed by CaO·ZnO. in Fuel. 2013;113:367-378.
doi:10.1016/j.fuel.2013.05.093 .

Lukić, Ivana, Kesić, Željka, Maksimović, Svetolik, Zdujić, Miodrag, Liu, Hui, Krstić, Jugoslav, Skala, Dejan, "Kinetics of sunflower and used vegetable oil methanolysis catalyzed by CaO·ZnO" in Fuel, 113 (2013):367-378,
https://doi.org/10.1016/j.fuel.2013.05.093 . .

TY  - JOUR
AU  - Maksimović, Svetolik
AU  - Kesić, Željka
AU  - Lukić, Ivana
AU  - Milovanović, Stoja
AU  - Ristić, Mihailo S.
AU  - Skala, Dejan
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2498
AB  - Yield and composition of curry flower (Helichrysum italicum) and sage leaves (Salvia officinalis) extract obtained by supercritical CO2 extraction (SFE) at 15 MPa and 40 degrees C were analyzed and compared to composition of curry flowers and sage essential oil isolated by hydrodistillation. Furthermore, the SFE performed using a mixture of curry flowers and sage plant and SFE of mixture of curry flowers and essential oil of sage were analyzed, too. It was shown that the average selectivity of monoterpenes and some individual sesquiterpenes and diterpenes present in pure sage or pure curry extract were significantly changed when mixture of these plants was used for SFE. The goal of SFE realized with mixture of curry flowers and sage essential oil was to explain effect of essential oil used as co-solvent changing the solubility of different compounds or characteristic group of terpenes in supercritical CO2. Increased extraction of heavier compounds from curry flower which is actually not present in pure essential oil of sage was also detected. The pseudo-kinetic model was proposed and corresponding parameters which define the rate of extraction were determined and compared to the parameters obtained according to Sovova's model usually used in literature for predicting yield of SFE from different plants.
PB  - Elsevier, Amsterdam
T2  - Journal of Supercritical Fluids
T1  - Supercritical fluid extraction of curry flowers, sage leaves, and their mixture
EP  - 12
SP  - 1
VL  - 84
DO  - 10.1016/j.supflu.2013.09.003
ER  - 

@article{
author = "Maksimović, Svetolik and Kesić, Željka and Lukić, Ivana and Milovanović, Stoja and Ristić, Mihailo S. and Skala, Dejan",
year = "2013",
abstract = "Yield and composition of curry flower (Helichrysum italicum) and sage leaves (Salvia officinalis) extract obtained by supercritical CO2 extraction (SFE) at 15 MPa and 40 degrees C were analyzed and compared to composition of curry flowers and sage essential oil isolated by hydrodistillation. Furthermore, the SFE performed using a mixture of curry flowers and sage plant and SFE of mixture of curry flowers and essential oil of sage were analyzed, too. It was shown that the average selectivity of monoterpenes and some individual sesquiterpenes and diterpenes present in pure sage or pure curry extract were significantly changed when mixture of these plants was used for SFE. The goal of SFE realized with mixture of curry flowers and sage essential oil was to explain effect of essential oil used as co-solvent changing the solubility of different compounds or characteristic group of terpenes in supercritical CO2. Increased extraction of heavier compounds from curry flower which is actually not present in pure essential oil of sage was also detected. The pseudo-kinetic model was proposed and corresponding parameters which define the rate of extraction were determined and compared to the parameters obtained according to Sovova's model usually used in literature for predicting yield of SFE from different plants.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Supercritical Fluids",
title = "Supercritical fluid extraction of curry flowers, sage leaves, and their mixture",
pages = "12-1",
volume = "84",
doi = "10.1016/j.supflu.2013.09.003"
}

Maksimović, S., Kesić, Ž., Lukić, I., Milovanović, S., Ristić, M. S.,& Skala, D.. (2013). Supercritical fluid extraction of curry flowers, sage leaves, and their mixture. in Journal of Supercritical Fluids
Elsevier, Amsterdam., 84, 1-12.
https://doi.org/10.1016/j.supflu.2013.09.003

Maksimović S, Kesić Ž, Lukić I, Milovanović S, Ristić MS, Skala D. Supercritical fluid extraction of curry flowers, sage leaves, and their mixture. in Journal of Supercritical Fluids. 2013;84:1-12.
doi:10.1016/j.supflu.2013.09.003 .

Maksimović, Svetolik, Kesić, Željka, Lukić, Ivana, Milovanović, Stoja, Ristić, Mihailo S., Skala, Dejan, "Supercritical fluid extraction of curry flowers, sage leaves, and their mixture" in Journal of Supercritical Fluids, 84 (2013):1-12,
https://doi.org/10.1016/j.supflu.2013.09.003 . .

TY  - JOUR
AU  - Maksimović, Svetolik
AU  - Ivanović, Jasna
AU  - Skala, Dejan
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2243
AB  - Supercritical CO2 extraction was studied using dried leaves of Mentha, originated from the northern part of Libya. Leaves were milled and sieved to obtain different average particles (d(p) = 0.25 - 0.80 mm). They were treated with supercritical CO2 at 313 K and 10 MPa in order to isolate essential oil. The new approach of supercritical extraction modelling on the basis of proposed "pseudo kinetic model" (PKM) was investigated and compared to most applied in literature Sovova's model. The main focus of these investigation was to determine the influence of particle size on extractions yield and to determine optimal methodology for determination parameters of PKM. Achieved results showed good agreement between both models and experimental results and good prospects for further usage of PKM.
PB  - Elsevier Science Bv, Amsterdam
T2  - CHISA 2012
T1  - Supercritical extraction of essential oil from Mentha and mathematical modelling- the influence of plant particle size
EP  - 1777
SP  - 1767
VL  - 42
DO  - 10.1016/j.proeng.2012.07.571
ER  - 

@article{
author = "Maksimović, Svetolik and Ivanović, Jasna and Skala, Dejan",
year = "2012",
abstract = "Supercritical CO2 extraction was studied using dried leaves of Mentha, originated from the northern part of Libya. Leaves were milled and sieved to obtain different average particles (d(p) = 0.25 - 0.80 mm). They were treated with supercritical CO2 at 313 K and 10 MPa in order to isolate essential oil. The new approach of supercritical extraction modelling on the basis of proposed "pseudo kinetic model" (PKM) was investigated and compared to most applied in literature Sovova's model. The main focus of these investigation was to determine the influence of particle size on extractions yield and to determine optimal methodology for determination parameters of PKM. Achieved results showed good agreement between both models and experimental results and good prospects for further usage of PKM.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "CHISA 2012",
title = "Supercritical extraction of essential oil from Mentha and mathematical modelling- the influence of plant particle size",
pages = "1777-1767",
volume = "42",
doi = "10.1016/j.proeng.2012.07.571"
}

Maksimović, S., Ivanović, J.,& Skala, D.. (2012). Supercritical extraction of essential oil from Mentha and mathematical modelling- the influence of plant particle size. in CHISA 2012
Elsevier Science Bv, Amsterdam., 42, 1767-1777.
https://doi.org/10.1016/j.proeng.2012.07.571

Maksimović S, Ivanović J, Skala D. Supercritical extraction of essential oil from Mentha and mathematical modelling- the influence of plant particle size. in CHISA 2012. 2012;42:1767-1777.
doi:10.1016/j.proeng.2012.07.571 .

Maksimović, Svetolik, Ivanović, Jasna, Skala, Dejan, "Supercritical extraction of essential oil from Mentha and mathematical modelling- the influence of plant particle size" in CHISA 2012, 42 (2012):1767-1777,
https://doi.org/10.1016/j.proeng.2012.07.571 . .