TY  - JOUR
AU  - Borović, Teona Teodora
AU  - Panić, Jovana
AU  - Radović, Ivona
AU  - Grozdanić, Nikola
AU  - Vraneš, Milan
PY  - 2024-03
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7188
AB  - In this study, a detailed physicochemical characterization of caffeine in 0.1 mol∙kg−1 of 1-butyl-3-methylimidazolium salicylate (abbreviation [Bmim][Sal]) aqueous solutions is performed based on density, speed of sound, refractive index and viscosity measurements in the temperature range from T = (293.15–313.15) K. [Bmim][Sal] slightly increases the solubility of caffeine in water. Data obtained from the volumetric and viscosimetric measurements indicate that [Bmim][Sal] promotes the self-aggregation of caffeine in water. Molecular dynamic simulations provided insight into how [Bmim][Sal] increases caffeine solubility in water. At higher temperatures, the salicylate anion has stronger interactions with caffeine through π–π interactions than at lower temperatures.
PB  - Elsevier B.V.
T2  - Journal of Molecular Liquids
T1  - Interactions of caffeine and 1-butyl-3-methylimidazolium salicylate ionic liquid in water – Solubility, volumetric, acoustic, viscometric and refractometric studies supported by MD simulation
SP  - 124058
VL  - 397
DO  - 10.1016/j.molliq.2024.124058
ER  - 

@article{
author = "Borović, Teona Teodora and Panić, Jovana and Radović, Ivona and Grozdanić, Nikola and Vraneš, Milan",
year = "2024-03",
abstract = "In this study, a detailed physicochemical characterization of caffeine in 0.1 mol∙kg−1 of 1-butyl-3-methylimidazolium salicylate (abbreviation [Bmim][Sal]) aqueous solutions is performed based on density, speed of sound, refractive index and viscosity measurements in the temperature range from T = (293.15–313.15) K. [Bmim][Sal] slightly increases the solubility of caffeine in water. Data obtained from the volumetric and viscosimetric measurements indicate that [Bmim][Sal] promotes the self-aggregation of caffeine in water. Molecular dynamic simulations provided insight into how [Bmim][Sal] increases caffeine solubility in water. At higher temperatures, the salicylate anion has stronger interactions with caffeine through π–π interactions than at lower temperatures.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Liquids",
title = "Interactions of caffeine and 1-butyl-3-methylimidazolium salicylate ionic liquid in water – Solubility, volumetric, acoustic, viscometric and refractometric studies supported by MD simulation",
pages = "124058",
volume = "397",
doi = "10.1016/j.molliq.2024.124058"
}

Borović, T. T., Panić, J., Radović, I., Grozdanić, N.,& Vraneš, M.. (2024-03). Interactions of caffeine and 1-butyl-3-methylimidazolium salicylate ionic liquid in water – Solubility, volumetric, acoustic, viscometric and refractometric studies supported by MD simulation. in Journal of Molecular Liquids
Elsevier B.V.., 397, 124058.
https://doi.org/10.1016/j.molliq.2024.124058

Borović TT, Panić J, Radović I, Grozdanić N, Vraneš M. Interactions of caffeine and 1-butyl-3-methylimidazolium salicylate ionic liquid in water – Solubility, volumetric, acoustic, viscometric and refractometric studies supported by MD simulation. in Journal of Molecular Liquids. 2024;397:124058.
doi:10.1016/j.molliq.2024.124058 .

Borović, Teona Teodora, Panić, Jovana, Radović, Ivona, Grozdanić, Nikola, Vraneš, Milan, "Interactions of caffeine and 1-butyl-3-methylimidazolium salicylate ionic liquid in water – Solubility, volumetric, acoustic, viscometric and refractometric studies supported by MD simulation" in Journal of Molecular Liquids, 397 (2024-03):124058,
https://doi.org/10.1016/j.molliq.2024.124058 . .

TY  - JOUR
AU  - Anojčić, Jasmina
AU  - Mijin, Dušan
AU  - Eraković Pantović, Sanja
AU  - Bogdanović, Aleksandra
AU  - Turuntaš, Nikola
AU  - Mutić, Sanja
AU  - Petrović, Slobodan
AU  - Avramov Ivić, Milka
PY  - 2024-03
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7278
AB  - The anticholinergic drug, solifenacin, is frequently used for the treatment of the urological tract for urinary incontinence, and urinary frequency. The development of reliable and effective solifenacin electrochemical sensors is of great importance for the pharmaceutical industry and clinical practice. In this work, the electrochemical behavior of solifenacin succinate (SOL) was studied using three different working electrodes: gold (Au), glassy carbon (GCE) and boron-doped diamond electrode (BDDE). The cyclic voltammetric (CV) measurements performed in 0.05 M NaHCO3 indicated that the SOL oxidation process is irreversible and diffusion-controlled at all investigated working electrodes. Afterwards, the testing of SOL electrochemical stability and the possibility of its electrochemical degradation was performed at the Au electrode by the cycling of the potential during 3 h and continuously to 6 h. It was shown that the SOL was electrochemically transformed into another electroactive species and its degradation was excluded. For electroanalytical application, the anodically pretreated BDDE (+2.0 V; 30 s) was selected. Various experimental parameters were optimized, including the pH of the aqueous Britton-Robinson (B-R) buffer as a supporting electrolyte (from pH 2.0 to 11.98) and the most intensive peak of the target analyte was at pH 11.0, so this pH value was chosen as the optimum for further measurements. Based on the correlation of the SOL peak intensity and different concentrations, the developed differential pulse voltammetric (DPV) method was characterized by a linear concentration range from 0.041 to 2.50 µM, with a correlation coefficient of 0.999, and a relative standard deviation of 0.3 %. Taking into account the sensitivity of the developed DPV method towards the electrochemical oxidation of SOL, a very low detection limit of 0.012 µM in the model system was achieved. The BDDE showed adequate selectivity for SOL in the presence of the investigated interferents. The obtained results indicate that the BDDE with an optimized DPV method could be applied for the trace-level electroanalytical determination of SOL in human urine sample with excellent recovery and reproducibility.
PB  - Elsevier B.V.
T2  - Journal of Electroanalytical Chemistry
T1  - Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination
SP  - 118113
VL  - 957
DO  - 10.1016/j.jelechem.2024.118113
ER  - 

@article{
author = "Anojčić, Jasmina and Mijin, Dušan and Eraković Pantović, Sanja and Bogdanović, Aleksandra and Turuntaš, Nikola and Mutić, Sanja and Petrović, Slobodan and Avramov Ivić, Milka",
year = "2024-03",
abstract = "The anticholinergic drug, solifenacin, is frequently used for the treatment of the urological tract for urinary incontinence, and urinary frequency. The development of reliable and effective solifenacin electrochemical sensors is of great importance for the pharmaceutical industry and clinical practice. In this work, the electrochemical behavior of solifenacin succinate (SOL) was studied using three different working electrodes: gold (Au), glassy carbon (GCE) and boron-doped diamond electrode (BDDE). The cyclic voltammetric (CV) measurements performed in 0.05 M NaHCO3 indicated that the SOL oxidation process is irreversible and diffusion-controlled at all investigated working electrodes. Afterwards, the testing of SOL electrochemical stability and the possibility of its electrochemical degradation was performed at the Au electrode by the cycling of the potential during 3 h and continuously to 6 h. It was shown that the SOL was electrochemically transformed into another electroactive species and its degradation was excluded. For electroanalytical application, the anodically pretreated BDDE (+2.0 V; 30 s) was selected. Various experimental parameters were optimized, including the pH of the aqueous Britton-Robinson (B-R) buffer as a supporting electrolyte (from pH 2.0 to 11.98) and the most intensive peak of the target analyte was at pH 11.0, so this pH value was chosen as the optimum for further measurements. Based on the correlation of the SOL peak intensity and different concentrations, the developed differential pulse voltammetric (DPV) method was characterized by a linear concentration range from 0.041 to 2.50 µM, with a correlation coefficient of 0.999, and a relative standard deviation of 0.3 %. Taking into account the sensitivity of the developed DPV method towards the electrochemical oxidation of SOL, a very low detection limit of 0.012 µM in the model system was achieved. The BDDE showed adequate selectivity for SOL in the presence of the investigated interferents. The obtained results indicate that the BDDE with an optimized DPV method could be applied for the trace-level electroanalytical determination of SOL in human urine sample with excellent recovery and reproducibility.",
publisher = "Elsevier B.V.",
journal = "Journal of Electroanalytical Chemistry",
title = "Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination",
pages = "118113",
volume = "957",
doi = "10.1016/j.jelechem.2024.118113"
}

Anojčić, J., Mijin, D., Eraković Pantović, S., Bogdanović, A., Turuntaš, N., Mutić, S., Petrović, S.,& Avramov Ivić, M.. (2024-03). Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination. in Journal of Electroanalytical Chemistry
Elsevier B.V.., 957, 118113.
https://doi.org/10.1016/j.jelechem.2024.118113

Anojčić J, Mijin D, Eraković Pantović S, Bogdanović A, Turuntaš N, Mutić S, Petrović S, Avramov Ivić M. Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination. in Journal of Electroanalytical Chemistry. 2024;957:118113.
doi:10.1016/j.jelechem.2024.118113 .

Anojčić, Jasmina, Mijin, Dušan, Eraković Pantović, Sanja, Bogdanović, Aleksandra, Turuntaš, Nikola, Mutić, Sanja, Petrović, Slobodan, Avramov Ivić, Milka, "Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination" in Journal of Electroanalytical Chemistry, 957 (2024-03):118113,
https://doi.org/10.1016/j.jelechem.2024.118113 . .

TY  - JOUR
AU  - Matijević, Borko
AU  - Mrđan, Gorana
AU  - Lađarević, Jelena
AU  - Valentić, Nataša
AU  - Mijin, Dušan
AU  - Apostolov, Suzana
AU  - Vaštag, Đenđi
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6950
AB  - Aryl azo dyes are widely used due to their excellent physicochemical properties (primarily high value of the molar extinction coefficient and great resistance to light and wet processing) and the fact that can be obtained in a simple method of diazotization and coupling. In this paper, three new dyes of 5-(hydroxy substituted phenylazo)-3-cyano-6-hydroxy-4-methyl-2-pyridone were synthesized by a diazo coupling reaction. The obtained dyes were characterized by melting point, IR, NMR, and UV-Vis spectroscopy. Given the fact that the structure of the molecule and interactions obtained with the surrounding medium can affect its activity, the possibility of azo hydrazo tautomerism has been studied, as the influence of the position of the substituent present (orto-, meta- and para position). In addition, the effect of the solvent used was determined by applying a solvatochromic model using the LSER method (linear solvation energy relationship). Obtaining information about the inter- and intramolecular relationships that newly synthesized compounds can achieve may be of great importance for all further investigations and their potential application as biologically active compounds.
AB  - Aril azo boje imaju široku primenu zbog svojih odličnih fizičko-hemijskih svojstava (prvenstveno visoke vrednosti molarnog ekstinkcionog koeficijenta i velike otpornosti na svetlost i vlagu) i činjenice da se mogu dobiti jednostavnom metodom diazotizacije i kuplovanja. U ovom radu susintetisane tri boje 5-(hidroksi supstituisane fenilazo)-3-cijano-6-hidroksi-4-metil-2-piridona reakcijom diazo kuplovanja. Dobijene boje su okarakterisane tačkom topljenja, IR, NMR i UV-Vis spektroskopijom. S obzirom na to da struktura molekula i ostvarene interakcije sa okolnim medijumom mogu uticati na aktivnost ispitivanih jedinjenja, proučavan je solvatohromizam i moguććnost azo-hidrazon tautomerije, kao i uticaj položaja prisutnog supstituenta (orto-, meta- i para pozicija ) u strukturi ispitivanih jedinjenja. Pored toga, kvantitatifikovan je efekat korišććenih rastvarača primenom dva solvatohromna modela koristeći LSER metodu (linear solvation energy relationship). Dobijanje informacija o inter- i intra-molekulskim interakcijama koje sintetizovana jedinjenja mogu da ostvare su od velike važnosti za sva dalja istraživanja i njihovu potencijalnu primenu kao biološki aktivnih jedinjenja.
PB  - Inženjersko društvo za koroziju
T2  - Zaštita materijala
T1  - Synthesis and solvatochromism of some hydroxy substituted phenyl azo pyridone dyes
T1  - Sinteza i solvatohromizam nekih hidroksi supstituisanih fenilazo piridonskih boja
EP  - 451
IS  - 4
SP  - 444
VL  - 64
DO  - 10.5937/zasmat2304444M
ER  - 

@article{
author = "Matijević, Borko and Mrđan, Gorana and Lađarević, Jelena and Valentić, Nataša and Mijin, Dušan and Apostolov, Suzana and Vaštag, Đenđi",
year = "2023",
abstract = "Aryl azo dyes are widely used due to their excellent physicochemical properties (primarily high value of the molar extinction coefficient and great resistance to light and wet processing) and the fact that can be obtained in a simple method of diazotization and coupling. In this paper, three new dyes of 5-(hydroxy substituted phenylazo)-3-cyano-6-hydroxy-4-methyl-2-pyridone were synthesized by a diazo coupling reaction. The obtained dyes were characterized by melting point, IR, NMR, and UV-Vis spectroscopy. Given the fact that the structure of the molecule and interactions obtained with the surrounding medium can affect its activity, the possibility of azo hydrazo tautomerism has been studied, as the influence of the position of the substituent present (orto-, meta- and para position). In addition, the effect of the solvent used was determined by applying a solvatochromic model using the LSER method (linear solvation energy relationship). Obtaining information about the inter- and intramolecular relationships that newly synthesized compounds can achieve may be of great importance for all further investigations and their potential application as biologically active compounds., Aril azo boje imaju široku primenu zbog svojih odličnih fizičko-hemijskih svojstava (prvenstveno visoke vrednosti molarnog ekstinkcionog koeficijenta i velike otpornosti na svetlost i vlagu) i činjenice da se mogu dobiti jednostavnom metodom diazotizacije i kuplovanja. U ovom radu susintetisane tri boje 5-(hidroksi supstituisane fenilazo)-3-cijano-6-hidroksi-4-metil-2-piridona reakcijom diazo kuplovanja. Dobijene boje su okarakterisane tačkom topljenja, IR, NMR i UV-Vis spektroskopijom. S obzirom na to da struktura molekula i ostvarene interakcije sa okolnim medijumom mogu uticati na aktivnost ispitivanih jedinjenja, proučavan je solvatohromizam i moguććnost azo-hidrazon tautomerije, kao i uticaj položaja prisutnog supstituenta (orto-, meta- i para pozicija ) u strukturi ispitivanih jedinjenja. Pored toga, kvantitatifikovan je efekat korišććenih rastvarača primenom dva solvatohromna modela koristeći LSER metodu (linear solvation energy relationship). Dobijanje informacija o inter- i intra-molekulskim interakcijama koje sintetizovana jedinjenja mogu da ostvare su od velike važnosti za sva dalja istraživanja i njihovu potencijalnu primenu kao biološki aktivnih jedinjenja.",
publisher = "Inženjersko društvo za koroziju",
journal = "Zaštita materijala",
title = "Synthesis and solvatochromism of some hydroxy substituted phenyl azo pyridone dyes, Sinteza i solvatohromizam nekih hidroksi supstituisanih fenilazo piridonskih boja",
pages = "451-444",
number = "4",
volume = "64",
doi = "10.5937/zasmat2304444M"
}

Matijević, B., Mrđan, G., Lađarević, J., Valentić, N., Mijin, D., Apostolov, S.,& Vaštag, Đ.. (2023). Synthesis and solvatochromism of some hydroxy substituted phenyl azo pyridone dyes. in Zaštita materijala
Inženjersko društvo za koroziju., 64(4), 444-451.
https://doi.org/10.5937/zasmat2304444M

Matijević B, Mrđan G, Lađarević J, Valentić N, Mijin D, Apostolov S, Vaštag Đ. Synthesis and solvatochromism of some hydroxy substituted phenyl azo pyridone dyes. in Zaštita materijala. 2023;64(4):444-451.
doi:10.5937/zasmat2304444M .

Matijević, Borko, Mrđan, Gorana, Lađarević, Jelena, Valentić, Nataša, Mijin, Dušan, Apostolov, Suzana, Vaštag, Đenđi, "Synthesis and solvatochromism of some hydroxy substituted phenyl azo pyridone dyes" in Zaštita materijala, 64, no. 4 (2023):444-451,
https://doi.org/10.5937/zasmat2304444M . .

TY  - CONF
AU  - Turuntaš, Nikola
AU  - Mutić, Sanja
AU  - Avramov Ivić, Milka
AU  - Eraković Pantović, Sanja
AU  - Mijin, Dušan
AU  - Petrović, Slobodan
AU  - Anojčić, Jasmina
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6951
AB  - The anticholinergic drug, solifenacin (SOL), is frequently used for the treatments in urological
tract for urinary incontinence, and urinary frequency [1]. As an electroactive molecule, SOL can
be an appropriate target analyte for voltammetric measurements. Boron doped diamond
electrode (BDDE) was selected as a working electrode because of its unique electrochemical
properties and emphasis on anodic measurements [2]. Prior to the voltammetric measurements
of SOL, BDDE was electrochemically activated in the supporting electrolyte by anodic
pretreatment (+2.0 V; 30 s) to achieve an oxygen terminated surface [3]. The voltammetric
behavior of SOL was investigated by cyclic voltammetry (CV) and differential pulse voltammetry
(DPV) in a model system. Based on the CV measurements it is proved that the certain electrooxidation process is diffusion controlled. Various experimental parameters were optimized
including the pH of the aqueous Britton-Robinson (B-R) buffer as a supporting electrolyte (from
pH 2.0 to 11.98) in the potential range from -0.3 V to 1.6 V vs saturated calomel electrode.
Depending on the pH value of the B-R buffer one oxidation peak of SOL was obtained at maxima
of peak potential around 1.1 V. The most intensive peak of the target analyte was at pH 11.0 which
was chosen as an optimal pH value for further measurements. Based on the correlation of SOL
peak intensity and different concentrations, the developed DPV method was characterized by a
linear concentration range from 0.015 to 0.907 µg mL-1, coefficient correlation of 0.999, and
relative standard deviation of 0.33%. Taking into account the sensitivity of the developed DPV
method towards the electrochemical oxidation of SOL, a very low detection limit of 0.005 µg mL-1
in the model system is achieved. The BDDE showed adequate selectivity for SOL in the presence
of investigated interferents. The obtained results indicate that BDDE with an optimized DPV
method could be applied for the trace-level electroanalytical determination of SOL in real samples.
PB  - Belgrade : Faculty of Chemistry
C3  - Book of Abstracts / 28th Young Investigators' Seminar on Analytical Chemistry, YISAC 2023, June 25th-28th, 2023, Belgrade
T1  - Electroanalytical performance of boron doped diamond electrode for the determination of solifenacin
SP  - 24
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6951
ER  - 

@conference{
author = "Turuntaš, Nikola and Mutić, Sanja and Avramov Ivić, Milka and Eraković Pantović, Sanja and Mijin, Dušan and Petrović, Slobodan and Anojčić, Jasmina",
year = "2023",
abstract = "The anticholinergic drug, solifenacin (SOL), is frequently used for the treatments in urological
tract for urinary incontinence, and urinary frequency [1]. As an electroactive molecule, SOL can
be an appropriate target analyte for voltammetric measurements. Boron doped diamond
electrode (BDDE) was selected as a working electrode because of its unique electrochemical
properties and emphasis on anodic measurements [2]. Prior to the voltammetric measurements
of SOL, BDDE was electrochemically activated in the supporting electrolyte by anodic
pretreatment (+2.0 V; 30 s) to achieve an oxygen terminated surface [3]. The voltammetric
behavior of SOL was investigated by cyclic voltammetry (CV) and differential pulse voltammetry
(DPV) in a model system. Based on the CV measurements it is proved that the certain electrooxidation process is diffusion controlled. Various experimental parameters were optimized
including the pH of the aqueous Britton-Robinson (B-R) buffer as a supporting electrolyte (from
pH 2.0 to 11.98) in the potential range from -0.3 V to 1.6 V vs saturated calomel electrode.
Depending on the pH value of the B-R buffer one oxidation peak of SOL was obtained at maxima
of peak potential around 1.1 V. The most intensive peak of the target analyte was at pH 11.0 which
was chosen as an optimal pH value for further measurements. Based on the correlation of SOL
peak intensity and different concentrations, the developed DPV method was characterized by a
linear concentration range from 0.015 to 0.907 µg mL-1, coefficient correlation of 0.999, and
relative standard deviation of 0.33%. Taking into account the sensitivity of the developed DPV
method towards the electrochemical oxidation of SOL, a very low detection limit of 0.005 µg mL-1
in the model system is achieved. The BDDE showed adequate selectivity for SOL in the presence
of investigated interferents. The obtained results indicate that BDDE with an optimized DPV
method could be applied for the trace-level electroanalytical determination of SOL in real samples.",
publisher = "Belgrade : Faculty of Chemistry",
journal = "Book of Abstracts / 28th Young Investigators' Seminar on Analytical Chemistry, YISAC 2023, June 25th-28th, 2023, Belgrade",
title = "Electroanalytical performance of boron doped diamond electrode for the determination of solifenacin",
pages = "24",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6951"
}

Turuntaš, N., Mutić, S., Avramov Ivić, M., Eraković Pantović, S., Mijin, D., Petrović, S.,& Anojčić, J.. (2023). Electroanalytical performance of boron doped diamond electrode for the determination of solifenacin. in Book of Abstracts / 28th Young Investigators' Seminar on Analytical Chemistry, YISAC 2023, June 25th-28th, 2023, Belgrade
Belgrade : Faculty of Chemistry., 24.
https://hdl.handle.net/21.15107/rcub_technorep_6951

Turuntaš N, Mutić S, Avramov Ivić M, Eraković Pantović S, Mijin D, Petrović S, Anojčić J. Electroanalytical performance of boron doped diamond electrode for the determination of solifenacin. in Book of Abstracts / 28th Young Investigators' Seminar on Analytical Chemistry, YISAC 2023, June 25th-28th, 2023, Belgrade. 2023;:24.
https://hdl.handle.net/21.15107/rcub_technorep_6951 .

Turuntaš, Nikola, Mutić, Sanja, Avramov Ivić, Milka, Eraković Pantović, Sanja, Mijin, Dušan, Petrović, Slobodan, Anojčić, Jasmina, "Electroanalytical performance of boron doped diamond electrode for the determination of solifenacin" in Book of Abstracts / 28th Young Investigators' Seminar on Analytical Chemistry, YISAC 2023, June 25th-28th, 2023, Belgrade (2023):24,
https://hdl.handle.net/21.15107/rcub_technorep_6951 .

TY  - CONF
AU  - Mrđan, Gorana
AU  - Mijin, Dušan
AU  - Lađarević, Jelena
AU  - Vaštag, Đenđi
AU  - Apostolov, Suzana
AU  - Matijević, Borko
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6736
AB  - Azo boje predstavljaju veoma značajnu grupu jedinjenja budući da više od 50% sintetičkih boja pripada upravo ovim strukturama. Zahvaljujući jednostavnoj i ekonomičnoj sintezi, kao i velikoj otpornosti prema svetlosti i pranju lako su pronašle primenu u raznim granama industrije. Pored uobičajene upotrebe u tekstilnoj, kozmetičkoj i prehrambenoj industriji, azo boje se koriste i za izradu solarnih ćelija, LCD ekrana, fotografskih, itd. Neka jedinjenja iz ove grupe su pokazala i dobru biološku aktivnost, a po najnovijim istraživanjima mogu se primeniti u lečenju tumora. U ovom radu je ispitan uticaj rastvarača na apsorpcione spektre odabranih arilazo piridonskih boja radi dobijanja informacija o solvatohromnim osobinama koje mogu imati veliki uticaj na potencijalnu biološku aktivnost. Spektri sedam derivata 5-(disupstituisanih fenilazo)-3-cijano-6-hidroksi-4-metil-2-piridona snimljeni su u deset rastvarača različitih svojstava u opsegu talasnih dužina 300-600 nm. Kvantitativna analiza interakcija između odabranih azo boja i okolnog medijuma je urađena primenom odgovarajućeg solvatohromnog modela metodom višestruke linerane korelacije solvatohromnih energija (LSER metoda).
AB  - Azo dyes represent a very important group of compounds since
more than 50% of synthetic dyes belong to these structures. Because of their
economic synthesis, as well as great light and washing resistance, they have
easily found applications in industry. In addition to the use in textile, cosmetic, and food industries, azo dyes are also used for making solar cells, LCD
screens, photographic systems, etc. Some derivatives have shown good biological activity, and they can be used in the treatment of tumors. In this paper, the
influence of solvents on the absorption spectra of selected aryl azo pyridone
dyes was investigated to obtain information on solvatochromic properties that
can have a great influence on potential biological activity. Spectra of seven
5-(disubstituted phenyl azo)-3-cyano-6-hydroxy-4-methyl-2-pyridones were
recorded in ten solvents of different properties in the wavelength range 300-
600 nm. Quantitative analysis of interactions between selected azo dyes and
the surrounding medium was performed using the corresponding solvatochromic model by the method of multiple linear correlations of solvatochromic
energies.
PB  - Banja Luka : Akademija nauka i umjetnosti Republike Srpske
C3  - Zbornik radova / 15. Međunarodni naučni skup „Savremeni materijali 2022”, Banja Luka, 8-9. septembar 2022
T1  - PROUČAVANJE SOLVATOHROMNIH SVOJSTAVA ODABRANIH ARILAZO PIRIDONSKIH BOJA
T1  - STUDY OF SOLVATOCHROMIC PROPERTIES OF SELECTED ARYL AZO PYRIDONE DYES
EP  - 89
SP  - 77
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6736
ER  - 

@conference{
author = "Mrđan, Gorana and Mijin, Dušan and Lađarević, Jelena and Vaštag, Đenđi and Apostolov, Suzana and Matijević, Borko",
year = "2023",
abstract = "Azo boje predstavljaju veoma značajnu grupu jedinjenja budući da više od 50% sintetičkih boja pripada upravo ovim strukturama. Zahvaljujući jednostavnoj i ekonomičnoj sintezi, kao i velikoj otpornosti prema svetlosti i pranju lako su pronašle primenu u raznim granama industrije. Pored uobičajene upotrebe u tekstilnoj, kozmetičkoj i prehrambenoj industriji, azo boje se koriste i za izradu solarnih ćelija, LCD ekrana, fotografskih, itd. Neka jedinjenja iz ove grupe su pokazala i dobru biološku aktivnost, a po najnovijim istraživanjima mogu se primeniti u lečenju tumora. U ovom radu je ispitan uticaj rastvarača na apsorpcione spektre odabranih arilazo piridonskih boja radi dobijanja informacija o solvatohromnim osobinama koje mogu imati veliki uticaj na potencijalnu biološku aktivnost. Spektri sedam derivata 5-(disupstituisanih fenilazo)-3-cijano-6-hidroksi-4-metil-2-piridona snimljeni su u deset rastvarača različitih svojstava u opsegu talasnih dužina 300-600 nm. Kvantitativna analiza interakcija između odabranih azo boja i okolnog medijuma je urađena primenom odgovarajućeg solvatohromnog modela metodom višestruke linerane korelacije solvatohromnih energija (LSER metoda)., Azo dyes represent a very important group of compounds since
more than 50% of synthetic dyes belong to these structures. Because of their
economic synthesis, as well as great light and washing resistance, they have
easily found applications in industry. In addition to the use in textile, cosmetic, and food industries, azo dyes are also used for making solar cells, LCD
screens, photographic systems, etc. Some derivatives have shown good biological activity, and they can be used in the treatment of tumors. In this paper, the
influence of solvents on the absorption spectra of selected aryl azo pyridone
dyes was investigated to obtain information on solvatochromic properties that
can have a great influence on potential biological activity. Spectra of seven
5-(disubstituted phenyl azo)-3-cyano-6-hydroxy-4-methyl-2-pyridones were
recorded in ten solvents of different properties in the wavelength range 300-
600 nm. Quantitative analysis of interactions between selected azo dyes and
the surrounding medium was performed using the corresponding solvatochromic model by the method of multiple linear correlations of solvatochromic
energies.",
publisher = "Banja Luka : Akademija nauka i umjetnosti Republike Srpske",
journal = "Zbornik radova / 15. Međunarodni naučni skup „Savremeni materijali 2022”, Banja Luka, 8-9. septembar 2022",
title = "PROUČAVANJE SOLVATOHROMNIH SVOJSTAVA ODABRANIH ARILAZO PIRIDONSKIH BOJA, STUDY OF SOLVATOCHROMIC PROPERTIES OF SELECTED ARYL AZO PYRIDONE DYES",
pages = "89-77",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6736"
}

Mrđan, G., Mijin, D., Lađarević, J., Vaštag, Đ., Apostolov, S.,& Matijević, B.. (2023). PROUČAVANJE SOLVATOHROMNIH SVOJSTAVA ODABRANIH ARILAZO PIRIDONSKIH BOJA. in Zbornik radova / 15. Međunarodni naučni skup „Savremeni materijali 2022”, Banja Luka, 8-9. septembar 2022
Banja Luka : Akademija nauka i umjetnosti Republike Srpske., 77-89.
https://hdl.handle.net/21.15107/rcub_technorep_6736

Mrđan G, Mijin D, Lađarević J, Vaštag Đ, Apostolov S, Matijević B. PROUČAVANJE SOLVATOHROMNIH SVOJSTAVA ODABRANIH ARILAZO PIRIDONSKIH BOJA. in Zbornik radova / 15. Međunarodni naučni skup „Savremeni materijali 2022”, Banja Luka, 8-9. septembar 2022. 2023;:77-89.
https://hdl.handle.net/21.15107/rcub_technorep_6736 .

Mrđan, Gorana, Mijin, Dušan, Lađarević, Jelena, Vaštag, Đenđi, Apostolov, Suzana, Matijević, Borko, "PROUČAVANJE SOLVATOHROMNIH SVOJSTAVA ODABRANIH ARILAZO PIRIDONSKIH BOJA" in Zbornik radova / 15. Međunarodni naučni skup „Savremeni materijali 2022”, Banja Luka, 8-9. septembar 2022 (2023):77-89,
https://hdl.handle.net/21.15107/rcub_technorep_6736 .

TY  - CONF
AU  - Đaković-Sekulić, Tatjana
AU  - Mandić, Anamarija
AU  - Lazić, Anita
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6858
AB  - In recent years spiro compounds have attracted significant interest due to their unique
conformational features and their structural implications on biological systems. Since spiro
compounds contain two rings with only one shared atom have a good balance between
conformational restriction and flexibility, makes them adaptable to many biological targets.
Therefore, knowledge of their interactions in aqueous systems is of crucial importance for
the understanding of biological response and hence the initial step for the selection of the
compound for the drug candidate.
In this poster presentation the retention data for two series of spiro compounds
derivatives of β-tetralino-spiro-5-hydantoins with a 4-substituted benzyl group or a 2-(4-
substituted phenyl)-2-oxoethyl group in the position 3 (structures presented in Figure 1)
were investigated.
The attention of this work will be focused on the evaluation of chromatographic
lipophilicity parameters determined by means of reversed-phase thin layer chromatography
(RP-TLC) and reversed phase high-performance liquid chromatography (RP-HPLC).
Principal Component Analysis (PCA) will be used in order to find similarities and
differences among the investigated compounds, their retention data and structural
parameters relevant for the activity.
PB  - Budapest : Research Centre for Natural Sciences, Institute of Excellence, Hungarian Academy of Sciences
C3  - Book of Abstracts / Conferentia  Chemometrica 2023, An international conference on chemometrics and  cheminformatics, Sopron, September 10-13, 2023
T1  - QSRR study of β-tetralino-spiro-5-hydantoin derivatives
SP  - P07
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6858
ER  - 

@conference{
author = "Đaković-Sekulić, Tatjana and Mandić, Anamarija and Lazić, Anita",
year = "2023",
abstract = "In recent years spiro compounds have attracted significant interest due to their unique
conformational features and their structural implications on biological systems. Since spiro
compounds contain two rings with only one shared atom have a good balance between
conformational restriction and flexibility, makes them adaptable to many biological targets.
Therefore, knowledge of their interactions in aqueous systems is of crucial importance for
the understanding of biological response and hence the initial step for the selection of the
compound for the drug candidate.
In this poster presentation the retention data for two series of spiro compounds
derivatives of β-tetralino-spiro-5-hydantoins with a 4-substituted benzyl group or a 2-(4-
substituted phenyl)-2-oxoethyl group in the position 3 (structures presented in Figure 1)
were investigated.
The attention of this work will be focused on the evaluation of chromatographic
lipophilicity parameters determined by means of reversed-phase thin layer chromatography
(RP-TLC) and reversed phase high-performance liquid chromatography (RP-HPLC).
Principal Component Analysis (PCA) will be used in order to find similarities and
differences among the investigated compounds, their retention data and structural
parameters relevant for the activity.",
publisher = "Budapest : Research Centre for Natural Sciences, Institute of Excellence, Hungarian Academy of Sciences",
journal = "Book of Abstracts / Conferentia  Chemometrica 2023, An international conference on chemometrics and  cheminformatics, Sopron, September 10-13, 2023",
title = "QSRR study of β-tetralino-spiro-5-hydantoin derivatives",
pages = "P07",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6858"
}

Đaković-Sekulić, T., Mandić, A.,& Lazić, A.. (2023). QSRR study of β-tetralino-spiro-5-hydantoin derivatives. in Book of Abstracts / Conferentia  Chemometrica 2023, An international conference on chemometrics and  cheminformatics, Sopron, September 10-13, 2023
Budapest : Research Centre for Natural Sciences, Institute of Excellence, Hungarian Academy of Sciences., P07.
https://hdl.handle.net/21.15107/rcub_technorep_6858

Đaković-Sekulić T, Mandić A, Lazić A. QSRR study of β-tetralino-spiro-5-hydantoin derivatives. in Book of Abstracts / Conferentia  Chemometrica 2023, An international conference on chemometrics and  cheminformatics, Sopron, September 10-13, 2023. 2023;:P07.
https://hdl.handle.net/21.15107/rcub_technorep_6858 .

Đaković-Sekulić, Tatjana, Mandić, Anamarija, Lazić, Anita, "QSRR study of β-tetralino-spiro-5-hydantoin derivatives" in Book of Abstracts / Conferentia  Chemometrica 2023, An international conference on chemometrics and  cheminformatics, Sopron, September 10-13, 2023 (2023):P07,
https://hdl.handle.net/21.15107/rcub_technorep_6858 .

TY  - JOUR
AU  - Zarić, Milana M.
AU  - Vraneš, Milan
AU  - Bikić, Siniša
AU  - Tot, Aleksandar
AU  - Papović, Snežana
AU  - Borović, Teona Teodora
AU  - Kijevčanin, Mirjana Lj.
AU  - Radović, Ivona R.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5246
AB  - Ethylene glycol is recognized as a heat transfer fluid. To improve its performance, caffeine is added to pure ethylene glycol. The experimental measurements of densities at pressures of up to 60 MPa and in the range of temperatures 293.15-413.15 K were performed. Obtained experimental results were fitted by the modified Tammann-Tait equation, and parameters were used to determine some valuable thermodynamic and mechanical properties, the isothermal compressibility, the isobaric thermal expansibility, the internal pressure, and the difference of specific heat capacity at constant pressure and constant volume. The same approach was applied to the equimolar mixture of ethylene glycol and water. The results confirm negligible changes in the investigated thermodynamic properties with the addition of caffeine into pure ethylene glycol and significantly smaller dependence on temperature compared to the mixture of ethylene glycol and water.
PB  - American Chemical Society
T2  - Journal of Chemical and Engineering Data
T1  - Thermodynamic Properties of Caffeine in Ethylene Glycol at High Pressures and High Temperatures
DO  - 10.1021/acs.jced.2c00401
ER  - 

@article{
author = "Zarić, Milana M. and Vraneš, Milan and Bikić, Siniša and Tot, Aleksandar and Papović, Snežana and Borović, Teona Teodora and Kijevčanin, Mirjana Lj. and Radović, Ivona R.",
year = "2022",
abstract = "Ethylene glycol is recognized as a heat transfer fluid. To improve its performance, caffeine is added to pure ethylene glycol. The experimental measurements of densities at pressures of up to 60 MPa and in the range of temperatures 293.15-413.15 K were performed. Obtained experimental results were fitted by the modified Tammann-Tait equation, and parameters were used to determine some valuable thermodynamic and mechanical properties, the isothermal compressibility, the isobaric thermal expansibility, the internal pressure, and the difference of specific heat capacity at constant pressure and constant volume. The same approach was applied to the equimolar mixture of ethylene glycol and water. The results confirm negligible changes in the investigated thermodynamic properties with the addition of caffeine into pure ethylene glycol and significantly smaller dependence on temperature compared to the mixture of ethylene glycol and water.",
publisher = "American Chemical Society",
journal = "Journal of Chemical and Engineering Data",
title = "Thermodynamic Properties of Caffeine in Ethylene Glycol at High Pressures and High Temperatures",
doi = "10.1021/acs.jced.2c00401"
}

Zarić, M. M., Vraneš, M., Bikić, S., Tot, A., Papović, S., Borović, T. T., Kijevčanin, M. Lj.,& Radović, I. R.. (2022). Thermodynamic Properties of Caffeine in Ethylene Glycol at High Pressures and High Temperatures. in Journal of Chemical and Engineering Data
American Chemical Society..
https://doi.org/10.1021/acs.jced.2c00401

Zarić MM, Vraneš M, Bikić S, Tot A, Papović S, Borović TT, Kijevčanin ML, Radović IR. Thermodynamic Properties of Caffeine in Ethylene Glycol at High Pressures and High Temperatures. in Journal of Chemical and Engineering Data. 2022;.
doi:10.1021/acs.jced.2c00401 .

Zarić, Milana M., Vraneš, Milan, Bikić, Siniša, Tot, Aleksandar, Papović, Snežana, Borović, Teona Teodora, Kijevčanin, Mirjana Lj., Radović, Ivona R., "Thermodynamic Properties of Caffeine in Ethylene Glycol at High Pressures and High Temperatures" in Journal of Chemical and Engineering Data (2022),
https://doi.org/10.1021/acs.jced.2c00401 . .

TY  - CONF
AU  - Matijević, Borko
AU  - Mrđan, Gorana
AU  - Mijin, Dušan
AU  - Lađarević, Jelena
AU  - Apostolov, Suzana
AU  - Vaštag, Đenđi
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6735
AB  - Pyridone aryl azo dyes belong to a class of compounds that have wide application, not only as
agents for coloring various materials in many branches of the industry but also in medicine as
biologically active compounds. It has been proven that they have anti-tumor, anti-inflammatory,
and anti-tuberculosis activity and are widely used for therapeutic purposes. Their application can
highly depend on the inter- or intra- molecular interactions that occur between the dissolved
compound and the surrounding medium. Therefore, the study of these interactions is of great
importance for newly synthesized compounds. The spectrophotometric method can be used to
examine intermolecular interactions thoroughly by studying the solvatochromic properties of newly
synthesized compounds in different molecular environments. To this end, absorption spectra of
seven newly synthesized aryl azo pyridone dyes based on 5-((disubstituted phenyl)diazenyl)-6-
hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile were recorded in ten solvents of
different properties. The spectra were recorded in the range from 300 to 600 nm and showed one
absorption maximum. By applying different models based on the principle of multiple linear
correlations of solvatochromic energies (LSER method), information about the effects of certain
interactions that take place between the tested compounds and the surrounding medium were
obtained.
PB  - Banja Luka : University in Banjaluka, Faculty of Technology
C3  - Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022
T1  - SOLVATOCHROMIC PROPERTIES OF NEWLY SYNTHESIZED ARYL AZO PYRIDONE DYES
SP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6735
ER  - 

@conference{
author = "Matijević, Borko and Mrđan, Gorana and Mijin, Dušan and Lađarević, Jelena and Apostolov, Suzana and Vaštag, Đenđi",
year = "2022",
abstract = "Pyridone aryl azo dyes belong to a class of compounds that have wide application, not only as
agents for coloring various materials in many branches of the industry but also in medicine as
biologically active compounds. It has been proven that they have anti-tumor, anti-inflammatory,
and anti-tuberculosis activity and are widely used for therapeutic purposes. Their application can
highly depend on the inter- or intra- molecular interactions that occur between the dissolved
compound and the surrounding medium. Therefore, the study of these interactions is of great
importance for newly synthesized compounds. The spectrophotometric method can be used to
examine intermolecular interactions thoroughly by studying the solvatochromic properties of newly
synthesized compounds in different molecular environments. To this end, absorption spectra of
seven newly synthesized aryl azo pyridone dyes based on 5-((disubstituted phenyl)diazenyl)-6-
hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile were recorded in ten solvents of
different properties. The spectra were recorded in the range from 300 to 600 nm and showed one
absorption maximum. By applying different models based on the principle of multiple linear
correlations of solvatochromic energies (LSER method), information about the effects of certain
interactions that take place between the tested compounds and the surrounding medium were
obtained.",
publisher = "Banja Luka : University in Banjaluka, Faculty of Technology",
journal = "Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022",
title = "SOLVATOCHROMIC PROPERTIES OF NEWLY SYNTHESIZED ARYL AZO PYRIDONE DYES",
pages = "32",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6735"
}

Matijević, B., Mrđan, G., Mijin, D., Lađarević, J., Apostolov, S.,& Vaštag, Đ.. (2022). SOLVATOCHROMIC PROPERTIES OF NEWLY SYNTHESIZED ARYL AZO PYRIDONE DYES. in Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022
Banja Luka : University in Banjaluka, Faculty of Technology., 32.
https://hdl.handle.net/21.15107/rcub_technorep_6735

Matijević B, Mrđan G, Mijin D, Lađarević J, Apostolov S, Vaštag Đ. SOLVATOCHROMIC PROPERTIES OF NEWLY SYNTHESIZED ARYL AZO PYRIDONE DYES. in Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022. 2022;:32.
https://hdl.handle.net/21.15107/rcub_technorep_6735 .

Matijević, Borko, Mrđan, Gorana, Mijin, Dušan, Lađarević, Jelena, Apostolov, Suzana, Vaštag, Đenđi, "SOLVATOCHROMIC PROPERTIES OF NEWLY SYNTHESIZED ARYL AZO PYRIDONE DYES" in Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022 (2022):32,
https://hdl.handle.net/21.15107/rcub_technorep_6735 .

TY  - JOUR
AU  - Lopičić, Srđan
AU  - Svirčev, Zorica
AU  - Palanački Malešević, Tamara
AU  - Kopitović, Aleksandar
AU  - Ivanovska, Aleksandra
AU  - Meriluoto, Jussi
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5294
AB  - In the present review we have discussed the occurrence of β-N-methylamino-L-alanine (BMAA) and its natural isomers, and the organisms and sample types in which the toxin(s) have been detected. Further, the review discusses general pathogenic mechanisms of neurodegenerative diseases, and how modes of action of BMAA fit in those mechanisms. The biogeography of BMAA occurrence presented here contributes to the planning of epidemiological research based on the geographical distribution of BMAA and human exposure. Analysis of BMAA mechanisms in relation to pathogenic processes of neurodegeneration is used to critically assess the potential significance of the amino acid as well as to identify gaps in our understanding. Taken together, these two approaches provide the basis for the discussion on the potential role of BMAA as a secondary factor in neurodegenerative diseases, the rationale for further research and possible directions the research can take, which are outlined in the conclusions.
PB  - MDPI
T2  - Microorganisms
T1  - Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases
IS  - 12
SP  - 2418
VL  - 10
DO  - 10.3390/microorganisms10122418
ER  - 

@article{
author = "Lopičić, Srđan and Svirčev, Zorica and Palanački Malešević, Tamara and Kopitović, Aleksandar and Ivanovska, Aleksandra and Meriluoto, Jussi",
year = "2022",
abstract = "In the present review we have discussed the occurrence of β-N-methylamino-L-alanine (BMAA) and its natural isomers, and the organisms and sample types in which the toxin(s) have been detected. Further, the review discusses general pathogenic mechanisms of neurodegenerative diseases, and how modes of action of BMAA fit in those mechanisms. The biogeography of BMAA occurrence presented here contributes to the planning of epidemiological research based on the geographical distribution of BMAA and human exposure. Analysis of BMAA mechanisms in relation to pathogenic processes of neurodegeneration is used to critically assess the potential significance of the amino acid as well as to identify gaps in our understanding. Taken together, these two approaches provide the basis for the discussion on the potential role of BMAA as a secondary factor in neurodegenerative diseases, the rationale for further research and possible directions the research can take, which are outlined in the conclusions.",
publisher = "MDPI",
journal = "Microorganisms",
title = "Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases",
number = "12",
pages = "2418",
volume = "10",
doi = "10.3390/microorganisms10122418"
}

Lopičić, S., Svirčev, Z., Palanački Malešević, T., Kopitović, A., Ivanovska, A.,& Meriluoto, J.. (2022). Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases. in Microorganisms
MDPI., 10(12), 2418.
https://doi.org/10.3390/microorganisms10122418

Lopičić S, Svirčev Z, Palanački Malešević T, Kopitović A, Ivanovska A, Meriluoto J. Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases. in Microorganisms. 2022;10(12):2418.
doi:10.3390/microorganisms10122418 .

Lopičić, Srđan, Svirčev, Zorica, Palanački Malešević, Tamara, Kopitović, Aleksandar, Ivanovska, Aleksandra, Meriluoto, Jussi, "Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases" in Microorganisms, 10, no. 12 (2022):2418,
https://doi.org/10.3390/microorganisms10122418 . .

TY  - JOUR
AU  - Radovanović, Lidija
AU  - Malenov, Dušan P.
AU  - Rodić, Marko, V
AU  - Kremenović, Aleksandar
AU  - Rogan, Jelena
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4980
AB  - Orange single crystals of new polymeric cobalt(II) complex {[Co(bipy)(H2O)(4)](2)[Co(mu-mell)(H2O)(2)].10H(2)O}(n), 1, were synthesized by slow evaporation method at room temperature (bipy = 2,2 '-bipyridine, mell = hexaanion of mellitic acid) and its crystal structure was determined by single-crystal X-ray diffraction. The complex 1 was characterized based on elemental analysis, FTIR spectroscopy and thermal (TG/DTA) analysis followed by computational analysis of noncovalent interactions and quantum chemical calculations of interaction energies. In 1, two crystallographically different Co(II) atoms adopt a deformed octahedral geometry, while bridging mell acts as a tetrakis monodentate ligand allowing the development of wavy-like anionic chains running along [100] direction. The 3D supramolecular network of 1 is composed of alternating supramolecular and water layers connected by hydrogen bonds. The supramolecular layer is formed of ionic interactions between complex cations and polymeric complex anions, established mainly through O-H...O hydrogen bonds, as well as stacking interactions between bipy ligands, while the water layers are comprised of hydrogen bonded lattice water molecules. Upon heating up to 1200 degrees C in nitrogen and air atmosphere, complex 1 showed multiple-step degradation that resulted in the formation of Co and Co3O4, respectively. Computed Hirshfeld surfaces and 2D fingerprint plots indicated that O-H...O hydrogen bonds are the most dominant in the crystal structure, while the shape index and curvedness mapped on the Hirshfeld surfaces of 1 revealed that stacking interactions have an important role in the stabilization of the crystal packing. Quantum chemical calculations showed that, aside from ionic hydrogen-bonded interaction between cation and anionic polymer, the important role in the stability of supramolecular structure of 1 is played by hydrogen bonds of cation and anionic polymer with lattice water, as well as by stacking interactions between bipy ligands.
PB  - Elsevier B.V.
T2  - Journal of Molecular Structure
T1  - Crystallographic, spectroscopic, thermal and computational studies of polymeric cobalt(II)-mellitate complex with 2,2 '-bipyridine
SP  - 132202
VL  - 1252
DO  - 10.1016/j.molstruc.2021.132202
ER  - 

@article{
author = "Radovanović, Lidija and Malenov, Dušan P. and Rodić, Marko, V and Kremenović, Aleksandar and Rogan, Jelena",
year = "2022",
abstract = "Orange single crystals of new polymeric cobalt(II) complex {[Co(bipy)(H2O)(4)](2)[Co(mu-mell)(H2O)(2)].10H(2)O}(n), 1, were synthesized by slow evaporation method at room temperature (bipy = 2,2 '-bipyridine, mell = hexaanion of mellitic acid) and its crystal structure was determined by single-crystal X-ray diffraction. The complex 1 was characterized based on elemental analysis, FTIR spectroscopy and thermal (TG/DTA) analysis followed by computational analysis of noncovalent interactions and quantum chemical calculations of interaction energies. In 1, two crystallographically different Co(II) atoms adopt a deformed octahedral geometry, while bridging mell acts as a tetrakis monodentate ligand allowing the development of wavy-like anionic chains running along [100] direction. The 3D supramolecular network of 1 is composed of alternating supramolecular and water layers connected by hydrogen bonds. The supramolecular layer is formed of ionic interactions between complex cations and polymeric complex anions, established mainly through O-H...O hydrogen bonds, as well as stacking interactions between bipy ligands, while the water layers are comprised of hydrogen bonded lattice water molecules. Upon heating up to 1200 degrees C in nitrogen and air atmosphere, complex 1 showed multiple-step degradation that resulted in the formation of Co and Co3O4, respectively. Computed Hirshfeld surfaces and 2D fingerprint plots indicated that O-H...O hydrogen bonds are the most dominant in the crystal structure, while the shape index and curvedness mapped on the Hirshfeld surfaces of 1 revealed that stacking interactions have an important role in the stabilization of the crystal packing. Quantum chemical calculations showed that, aside from ionic hydrogen-bonded interaction between cation and anionic polymer, the important role in the stability of supramolecular structure of 1 is played by hydrogen bonds of cation and anionic polymer with lattice water, as well as by stacking interactions between bipy ligands.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Structure",
title = "Crystallographic, spectroscopic, thermal and computational studies of polymeric cobalt(II)-mellitate complex with 2,2 '-bipyridine",
pages = "132202",
volume = "1252",
doi = "10.1016/j.molstruc.2021.132202"
}

Radovanović, L., Malenov, D. P., Rodić, M. V., Kremenović, A.,& Rogan, J.. (2022). Crystallographic, spectroscopic, thermal and computational studies of polymeric cobalt(II)-mellitate complex with 2,2 '-bipyridine. in Journal of Molecular Structure
Elsevier B.V.., 1252, 132202.
https://doi.org/10.1016/j.molstruc.2021.132202

Radovanović L, Malenov DP, Rodić MV, Kremenović A, Rogan J. Crystallographic, spectroscopic, thermal and computational studies of polymeric cobalt(II)-mellitate complex with 2,2 '-bipyridine. in Journal of Molecular Structure. 2022;1252:132202.
doi:10.1016/j.molstruc.2021.132202 .

Radovanović, Lidija, Malenov, Dušan P., Rodić, Marko, V, Kremenović, Aleksandar, Rogan, Jelena, "Crystallographic, spectroscopic, thermal and computational studies of polymeric cobalt(II)-mellitate complex with 2,2 '-bipyridine" in Journal of Molecular Structure, 1252 (2022):132202,
https://doi.org/10.1016/j.molstruc.2021.132202 . .

TY  - JOUR
AU  - Ristić, Predrag
AU  - Filipović, Nenad
AU  - Blagojević, Vladimir
AU  - Ćirković, Jovana
AU  - Barta Hollo, Berta
AU  - Đokić, Veljko
AU  - Donnard, Morgan
AU  - Gulea, Mihaela
AU  - Marjanović, Ivana
AU  - Klisurić, Olivera R.
AU  - Todorović, Tamara R.
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4924
AB  - Four silver-based coordination polymers, {[Ag(L1)(2)]NO3}(infinity) (1), {[Ag(L1)(2)]ClO4}(infinity) (2), {[Ag(L2)(2)]NO3 center dot H2O}(infinity) (3) and {[Ag(L2)(2)]ClO4}(infinity) (4), were synthesized using the thiomorpholine-4-carbonitrile (L1) and piperazine-1,4-dicarbonitrile (L2) ligands. Compounds 1 and 2 are two-dimensional, while 3 and 4 are three-dimensional. L1 and L2 are 1,4-bis-monodentate ligands in all compounds, while Ag(i) ions are four-coordinated in a slightly distorted tetrahedral geometry. Topological analysis in standard representations suggests that underlying nets in 1 and 2 have an sql topology, while 3 and 4 exhibit a dia topology. Thermal analysis shows that 3 loses crystalline water at room temperature, while other compounds show good thermal stability. All compounds show good photocatalytic activity for photocatalytic degradation of the mordant blue 9 dye, with reaction rates in the range 0.029 to 0.061 min(-1). The best result was obtained for compound 4, which can be correlated to its largest lattice volume.
T2  - CrystEngComm
T1  - 2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior
EP  - 4815
IS  - 27
SP  - 4799
VL  - 23
DO  - 10.1039/d1ce00394a
ER  - 

@article{
author = "Ristić, Predrag and Filipović, Nenad and Blagojević, Vladimir and Ćirković, Jovana and Barta Hollo, Berta and Đokić, Veljko and Donnard, Morgan and Gulea, Mihaela and Marjanović, Ivana and Klisurić, Olivera R. and Todorović, Tamara R.",
year = "2021",
abstract = "Four silver-based coordination polymers, {[Ag(L1)(2)]NO3}(infinity) (1), {[Ag(L1)(2)]ClO4}(infinity) (2), {[Ag(L2)(2)]NO3 center dot H2O}(infinity) (3) and {[Ag(L2)(2)]ClO4}(infinity) (4), were synthesized using the thiomorpholine-4-carbonitrile (L1) and piperazine-1,4-dicarbonitrile (L2) ligands. Compounds 1 and 2 are two-dimensional, while 3 and 4 are three-dimensional. L1 and L2 are 1,4-bis-monodentate ligands in all compounds, while Ag(i) ions are four-coordinated in a slightly distorted tetrahedral geometry. Topological analysis in standard representations suggests that underlying nets in 1 and 2 have an sql topology, while 3 and 4 exhibit a dia topology. Thermal analysis shows that 3 loses crystalline water at room temperature, while other compounds show good thermal stability. All compounds show good photocatalytic activity for photocatalytic degradation of the mordant blue 9 dye, with reaction rates in the range 0.029 to 0.061 min(-1). The best result was obtained for compound 4, which can be correlated to its largest lattice volume.",
journal = "CrystEngComm",
title = "2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior",
pages = "4815-4799",
number = "27",
volume = "23",
doi = "10.1039/d1ce00394a"
}

Ristić, P., Filipović, N., Blagojević, V., Ćirković, J., Barta Hollo, B., Đokić, V., Donnard, M., Gulea, M., Marjanović, I., Klisurić, O. R.,& Todorović, T. R.. (2021). 2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior. in CrystEngComm, 23(27), 4799-4815.
https://doi.org/10.1039/d1ce00394a

Ristić P, Filipović N, Blagojević V, Ćirković J, Barta Hollo B, Đokić V, Donnard M, Gulea M, Marjanović I, Klisurić OR, Todorović TR. 2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior. in CrystEngComm. 2021;23(27):4799-4815.
doi:10.1039/d1ce00394a .

Ristić, Predrag, Filipović, Nenad, Blagojević, Vladimir, Ćirković, Jovana, Barta Hollo, Berta, Đokić, Veljko, Donnard, Morgan, Gulea, Mihaela, Marjanović, Ivana, Klisurić, Olivera R., Todorović, Tamara R., "2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior" in CrystEngComm, 23, no. 27 (2021):4799-4815,
https://doi.org/10.1039/d1ce00394a . .

TY  - JOUR
AU  - Apostolov, Suzana
AU  - Mijin, Dušan
AU  - Petrović, Slobodan
AU  - Vastag, Gyongyi
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/9
AB  - The selected diphenylacetamide derivatives were subjected to chromatographic and in silico approach in order to obtain significant information about their structure-activity relationships. As an early step in the assessment of their biological profile, drug-likeness and lead-likeness rules were performed, as well as determination of the bioactivity scores. The relationships between the obtained chromatographic parameters and the relevant software lipophilicity/pharmacokinetic/toxicity predictors of the studied derivatives were examined by linear regression and multivariate methods. Beside the satisfactory linear relationships obtained for each applied system, the multivariate methods gave more concrete relations between the analyzed parameters of biological activity. Higher similarity between the chromatographic parameters (R (M) (0), C (0)), standard measure of lipophilicity and pharmacokinetic predictors was confirmed, while the chromatographic parameter m obtained in the same conditions exhibits better agreement with the bioactivity scores and toxicity parameters. Also, it was observed that the values of diphenylacetamide's biological activity parameters are in the greatest extent conditioned by the polarity of the substituent presented in its molecule.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - In silico approach in the assessment of chromatographic parameters as descriptors of diphenylacetamides' biological/pharmacological profile
EP  - 862
IS  - 19-20
SP  - 852
VL  - 43
DO  - 10.1080/10826076.2020.1835672
ER  - 

@article{
author = "Apostolov, Suzana and Mijin, Dušan and Petrović, Slobodan and Vastag, Gyongyi",
year = "2020",
abstract = "The selected diphenylacetamide derivatives were subjected to chromatographic and in silico approach in order to obtain significant information about their structure-activity relationships. As an early step in the assessment of their biological profile, drug-likeness and lead-likeness rules were performed, as well as determination of the bioactivity scores. The relationships between the obtained chromatographic parameters and the relevant software lipophilicity/pharmacokinetic/toxicity predictors of the studied derivatives were examined by linear regression and multivariate methods. Beside the satisfactory linear relationships obtained for each applied system, the multivariate methods gave more concrete relations between the analyzed parameters of biological activity. Higher similarity between the chromatographic parameters (R (M) (0), C (0)), standard measure of lipophilicity and pharmacokinetic predictors was confirmed, while the chromatographic parameter m obtained in the same conditions exhibits better agreement with the bioactivity scores and toxicity parameters. Also, it was observed that the values of diphenylacetamide's biological activity parameters are in the greatest extent conditioned by the polarity of the substituent presented in its molecule.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "In silico approach in the assessment of chromatographic parameters as descriptors of diphenylacetamides' biological/pharmacological profile",
pages = "862-852",
number = "19-20",
volume = "43",
doi = "10.1080/10826076.2020.1835672"
}

Apostolov, S., Mijin, D., Petrović, S.,& Vastag, G.. (2020). In silico approach in the assessment of chromatographic parameters as descriptors of diphenylacetamides' biological/pharmacological profile. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 43(19-20), 852-862.
https://doi.org/10.1080/10826076.2020.1835672

Apostolov S, Mijin D, Petrović S, Vastag G. In silico approach in the assessment of chromatographic parameters as descriptors of diphenylacetamides' biological/pharmacological profile. in Journal of Liquid Chromatography & Related Technologies. 2020;43(19-20):852-862.
doi:10.1080/10826076.2020.1835672 .

Apostolov, Suzana, Mijin, Dušan, Petrović, Slobodan, Vastag, Gyongyi, "In silico approach in the assessment of chromatographic parameters as descriptors of diphenylacetamides' biological/pharmacological profile" in Journal of Liquid Chromatography & Related Technologies, 43, no. 19-20 (2020):852-862,
https://doi.org/10.1080/10826076.2020.1835672 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Šekuljica, Sanja
AU  - Guzsvány, Valéria
AU  - Nagy, László
AU  - Kónya, Zoltán
AU  - Avramov-Ivić, Milka
AU  - Mijin, Dušan
AU  - Petrović, Slobodan
AU  - Anojčić, Jasmina
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4726
AB  - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH  gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.
PB  - Elsevier B.V.
T2  - Journal of Electroanalytical Chemistry
T1  - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
VL  - 873
DO  - 10.1016/j.jelechem.2020.114324
ER  - 

@article{
author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov-Ivić, Milka and Mijin, Dušan and Petrović, Slobodan and Anojčić, Jasmina",
year = "2020",
abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH  gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.",
publisher = "Elsevier B.V.",
journal = "Journal of Electroanalytical Chemistry",
title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations",
volume = "873",
doi = "10.1016/j.jelechem.2020.114324"
}

Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov-Ivić, M., Mijin, D., Petrović, S.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry
Elsevier B.V.., 873.
https://doi.org/10.1016/j.jelechem.2020.114324

Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov-Ivić M, Mijin D, Petrović S, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873.
doi:10.1016/j.jelechem.2020.114324 .

Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov-Ivić, Milka, Mijin, Dušan, Petrović, Slobodan, Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020),
https://doi.org/10.1016/j.jelechem.2020.114324 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Šekuljica, Sanja
AU  - Guzsvány, Valéria
AU  - Nagy, László
AU  - Kónya, Zoltán
AU  - Avramov-Ivić, Milka
AU  - Mijin, Dušan
AU  - Petrović, Slobodan
AU  - Anojčić, Jasmina
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4392
AB  - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH  gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.
PB  - Elsevier B.V.
T2  - Journal of Electroanalytical Chemistry
T1  - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
SP  - 114324
VL  - 873
DO  - 10.1016/j.jelechem.2020.114324
ER  - 

@article{
author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov-Ivić, Milka and Mijin, Dušan and Petrović, Slobodan and Anojčić, Jasmina",
year = "2020",
abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH  gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.",
publisher = "Elsevier B.V.",
journal = "Journal of Electroanalytical Chemistry",
title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations",
pages = "114324",
volume = "873",
doi = "10.1016/j.jelechem.2020.114324"
}

Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov-Ivić, M., Mijin, D., Petrović, S.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry
Elsevier B.V.., 873, 114324.
https://doi.org/10.1016/j.jelechem.2020.114324

Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov-Ivić M, Mijin D, Petrović S, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873:114324.
doi:10.1016/j.jelechem.2020.114324 .

Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov-Ivić, Milka, Mijin, Dušan, Petrović, Slobodan, Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020):114324,
https://doi.org/10.1016/j.jelechem.2020.114324 . .

TY  - JOUR
AU  - Tot, Kristina
AU  - Lazić, Anita
AU  - Đaković-Sekulić, Tatjana
PY  - 2020
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6
AB  - In this study, lipophilicity of 21 cycloalkylspiro-5-hidantoins was assessed. The overall goal of lipophilicity evaluation is preliminary investigation which should result in a decrease of the traditionally high attrition rates for compounds entering clinical trials. Lipophilicity assessment was done by reversed-phase thin-layer chromatography and in silico methods. Chromatographic analyses were performed on C-18 modified thin-layer of silica gel with a two-component mobile phase consisting of water and organic solvent (acetonitrile, acetone, dioxane, or tetrahydrofuran) in different ratios. The chromatographic lipophilicities (R (M) (0)) were discussed and compared with computational log Ps calculated with various algorithms as well as in silico ADMET descriptors using linear regression and multivariate approach (hierarchical cluster analysis and principal component analysis). A high correlation was obtained between R (M) (0) values and calculated log P indicating a strong relationship between the variables. Multivariate data analysis enabled the comparison of the chemical structures, lipophilicity, pharmacokinetic predictors and toxicity of the investigated compounds.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - A comparative study of chromatographic lipophilicity and bioactivity parameters of selected spirohydantoins
EP  - 933
IS  - 19-20
SP  - 925
VL  - 43
DO  - 10.1080/10826076.2020.1856137
ER  - 

@article{
author = "Tot, Kristina and Lazić, Anita and Đaković-Sekulić, Tatjana",
year = "2020, 2020",
abstract = "In this study, lipophilicity of 21 cycloalkylspiro-5-hidantoins was assessed. The overall goal of lipophilicity evaluation is preliminary investigation which should result in a decrease of the traditionally high attrition rates for compounds entering clinical trials. Lipophilicity assessment was done by reversed-phase thin-layer chromatography and in silico methods. Chromatographic analyses were performed on C-18 modified thin-layer of silica gel with a two-component mobile phase consisting of water and organic solvent (acetonitrile, acetone, dioxane, or tetrahydrofuran) in different ratios. The chromatographic lipophilicities (R (M) (0)) were discussed and compared with computational log Ps calculated with various algorithms as well as in silico ADMET descriptors using linear regression and multivariate approach (hierarchical cluster analysis and principal component analysis). A high correlation was obtained between R (M) (0) values and calculated log P indicating a strong relationship between the variables. Multivariate data analysis enabled the comparison of the chemical structures, lipophilicity, pharmacokinetic predictors and toxicity of the investigated compounds.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "A comparative study of chromatographic lipophilicity and bioactivity parameters of selected spirohydantoins",
pages = "933-925",
number = "19-20",
volume = "43",
doi = "10.1080/10826076.2020.1856137"
}

Tot, K., Lazić, A.,& Đaković-Sekulić, T.. (2020). A comparative study of chromatographic lipophilicity and bioactivity parameters of selected spirohydantoins. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 43(19-20), 925-933.
https://doi.org/10.1080/10826076.2020.1856137

Tot K, Lazić A, Đaković-Sekulić T. A comparative study of chromatographic lipophilicity and bioactivity parameters of selected spirohydantoins. in Journal of Liquid Chromatography & Related Technologies. 2020;43(19-20):925-933.
doi:10.1080/10826076.2020.1856137 .

Tot, Kristina, Lazić, Anita, Đaković-Sekulić, Tatjana, "A comparative study of chromatographic lipophilicity and bioactivity parameters of selected spirohydantoins" in Journal of Liquid Chromatography & Related Technologies, 43, no. 19-20 (2020):925-933,
https://doi.org/10.1080/10826076.2020.1856137 . .