TY  - JOUR
AU  - Jovašević, Jovana S.
AU  - Mićić, Maja M.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
AU  - Dimitrijević, Suzana
AU  - Tomić, Simonida
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1624
AB  - New hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver salt. FTIR spectroscopy has confirmed binding of silver particles in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive bacteria S. aureus, where the reduction of cells was about 70% after two hours of exposure, for the sample with the highest PVP content. The least susceptible to the antimicrobial activity of hydrogels examined was the Gram-negative bacteria E. coli, where the percent of cell reduction was below 20%. Bearing in mind the influence of the time of exposure of microbes to the Ag/ /P(HEMA/IA)/PVP hybrid hydrogels, it was observed that the reduction of the number of cells depends on time, microbial culture and type of hybrid hydrogel sample. Due to their swelling and antimicrobial properties, silver/poly(2-hydroxyethyl methacrylate/itaconic acid)/poly(vinylpyrrolidone) hybrid hydrogles show potential to use in the field of biomedicine, especially for treatment of skin and burns in dermocosmetics.
AB  - U radu je prikazana sinteza niza hibridnih hidrogelova na bazi 2-hidroksietil metakrilata, itakonske kiseline i poli(vinilpirolidona) u koje su ugrađene čestice srebra, s ciljem primene ovih sistema u biomedicinske svrhe. Određene su strukturne karakteristike hidrogelova. Bubrenja gelova je izvedeno u in vitro uslovima i pokazana je zavisnost stepena bubrenja od temperature i udela PVP. Ispitivanje antimikrobne aktivnosti hidrogelova je izvedeno korišćenjem mikrobnih kultura E. coli, S. aureus i C. albicans. Najveću osetljivost nakon izlaganja uzorcima pokazuje patogeni kvasac C. albicans, a najmanju bakterija E. coli. Može se izvesti zaključak da su svi sintetisani hibridni hidrogelovi pokazali povoljna difuziona svojstva u in vitro uslovima, kao i da antimikrobna aktivnost zavisi od vrste hidrogela i soja mikroba, i vremena izlaganja hidrogelova testiranim mikrobima.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Antimicrobial activity of hybrid hydrogels based on poly(vinylpyrrolidone) containing silver
T1  - Antimikrobna aktivnost hibridnih hidrogelova na bazi poli(vinilpirolidona) koji sadrže srebro
EP  - 214
IS  - 3
SP  - 209
VL  - 64
DO  - 10.2298/HEMIND091221030J
ER  - 

@article{
author = "Jovašević, Jovana S. and Mićić, Maja M. and Suljovrujić, Edin H. and Filipović, Jovanka M. and Dimitrijević, Suzana and Tomić, Simonida",
year = "2010",
abstract = "New hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver salt. FTIR spectroscopy has confirmed binding of silver particles in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive bacteria S. aureus, where the reduction of cells was about 70% after two hours of exposure, for the sample with the highest PVP content. The least susceptible to the antimicrobial activity of hydrogels examined was the Gram-negative bacteria E. coli, where the percent of cell reduction was below 20%. Bearing in mind the influence of the time of exposure of microbes to the Ag/ /P(HEMA/IA)/PVP hybrid hydrogels, it was observed that the reduction of the number of cells depends on time, microbial culture and type of hybrid hydrogel sample. Due to their swelling and antimicrobial properties, silver/poly(2-hydroxyethyl methacrylate/itaconic acid)/poly(vinylpyrrolidone) hybrid hydrogles show potential to use in the field of biomedicine, especially for treatment of skin and burns in dermocosmetics., U radu je prikazana sinteza niza hibridnih hidrogelova na bazi 2-hidroksietil metakrilata, itakonske kiseline i poli(vinilpirolidona) u koje su ugrađene čestice srebra, s ciljem primene ovih sistema u biomedicinske svrhe. Određene su strukturne karakteristike hidrogelova. Bubrenja gelova je izvedeno u in vitro uslovima i pokazana je zavisnost stepena bubrenja od temperature i udela PVP. Ispitivanje antimikrobne aktivnosti hidrogelova je izvedeno korišćenjem mikrobnih kultura E. coli, S. aureus i C. albicans. Najveću osetljivost nakon izlaganja uzorcima pokazuje patogeni kvasac C. albicans, a najmanju bakterija E. coli. Može se izvesti zaključak da su svi sintetisani hibridni hidrogelovi pokazali povoljna difuziona svojstva u in vitro uslovima, kao i da antimikrobna aktivnost zavisi od vrste hidrogela i soja mikroba, i vremena izlaganja hidrogelova testiranim mikrobima.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Antimicrobial activity of hybrid hydrogels based on poly(vinylpyrrolidone) containing silver, Antimikrobna aktivnost hibridnih hidrogelova na bazi poli(vinilpirolidona) koji sadrže srebro",
pages = "214-209",
number = "3",
volume = "64",
doi = "10.2298/HEMIND091221030J"
}

Jovašević, J. S., Mićić, M. M., Suljovrujić, E. H., Filipović, J. M., Dimitrijević, S.,& Tomić, S.. (2010). Antimicrobial activity of hybrid hydrogels based on poly(vinylpyrrolidone) containing silver. in Hemijska industrija
Association of Chemical Engineers of Serbia., 64(3), 209-214.
https://doi.org/10.2298/HEMIND091221030J

Jovašević JS, Mićić MM, Suljovrujić EH, Filipović JM, Dimitrijević S, Tomić S. Antimicrobial activity of hybrid hydrogels based on poly(vinylpyrrolidone) containing silver. in Hemijska industrija. 2010;64(3):209-214.
doi:10.2298/HEMIND091221030J .

Jovašević, Jovana S., Mićić, Maja M., Suljovrujić, Edin H., Filipović, Jovanka M., Dimitrijević, Suzana, Tomić, Simonida, "Antimicrobial activity of hybrid hydrogels based on poly(vinylpyrrolidone) containing silver" in Hemijska industrija, 64, no. 3 (2010):209-214,
https://doi.org/10.2298/HEMIND091221030J . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Mićić, Maja M.
AU  - Dobić, Sava N.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1707
AB  - pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Radiation Physics and Chemistry
T1  - Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application
EP  - 649
IS  - 5
SP  - 643
VL  - 79
DO  - 10.1016/j.radphyschem.2009.11.015
ER  - 

@article{
author = "Tomić, Simonida and Mićić, Maja M. and Dobić, Sava N. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2010",
abstract = "pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Radiation Physics and Chemistry",
title = "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application",
pages = "649-643",
number = "5",
volume = "79",
doi = "10.1016/j.radphyschem.2009.11.015"
}

Tomić, S., Mićić, M. M., Dobić, S. N., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry
Pergamon-Elsevier Science Ltd, Oxford., 79(5), 643-649.
https://doi.org/10.1016/j.radphyschem.2009.11.015

Tomić S, Mićić MM, Dobić SN, Filipović JM, Suljovrujić EH. Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry. 2010;79(5):643-649.
doi:10.1016/j.radphyschem.2009.11.015 .

Tomić, Simonida, Mićić, Maja M., Dobić, Sava N., Filipović, Jovanka M., Suljovrujić, Edin H., "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application" in Radiation Physics and Chemistry, 79, no. 5 (2010):643-649,
https://doi.org/10.1016/j.radphyschem.2009.11.015 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1620
AB  - In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels' properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems.
PB  - Elsevier Science Sa, Lausanne
T2  - Chemical Engineering Journal
T1  - Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels
EP  - 809
IS  - 2
SP  - 801
VL  - 160
DO  - 10.1016/j.cej.2010.03.089
ER  - 

@article{
author = "Tomić, Simonida and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2010",
abstract = "In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels' properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Chemical Engineering Journal",
title = "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels",
pages = "809-801",
number = "2",
volume = "160",
doi = "10.1016/j.cej.2010.03.089"
}

Tomić, S., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal
Elsevier Science Sa, Lausanne., 160(2), 801-809.
https://doi.org/10.1016/j.cej.2010.03.089

Tomić S, Mićić MM, Filipović JM, Suljovrujić EH. Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal. 2010;160(2):801-809.
doi:10.1016/j.cej.2010.03.089 .

Tomić, Simonida, Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels" in Chemical Engineering Journal, 160, no. 2 (2010):801-809,
https://doi.org/10.1016/j.cej.2010.03.089 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Mićić, Maja M.
AU  - Krezović, Bojana D.
AU  - Dobić, Sava N.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1400
AB  - pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
AB  - pH i temperaturno osetljivi hidrogelovi na bazi kopolimera 2-hidroksietilmetakrilata (HEMA) i itakonske kiseline (IK) sintetisani su upotrebom gama zračenja i karakterisani s ciljem ispitivanja njihove potencijalne primene kao biomaterijala. Ispitivan je uticaj odnosa komonomera u ovim inteligentnim polimernim biomaterijalima na morfologiju, mehanička svojstva, biokompatibilnost i penetraciju mikroba. Mehanička svojstva kopolimera su ispitivana dinamičko-mehaničkom analizom (DMA), dok je morfologija karakterisana skenirajućom elektronskom mikroskopijom (SEM). Pokazalo se da su morfologija i mehanička svojstva ovih hidrogelova odgovarajući za većinu biomedicinskih primena. In vitro analizom biokompatibilnosti P(HEMA/IK) hidrogelova potvrđeno je da nisu toksični za ćelije niti izazivaju značajnu hemolitičku aktivnost. Takođe, test mikrobne penetracije pokazao je da ni Staphylococcus aureus ni Escherichia coli ne prolaze kroz hidrogelne obloge; stoga se P(HEMA/IK) obloge mogu smatrati dobrom barijerom protiv mikroba, a radi održavanja sterilnosti okolne sredine. Svi rezultati pokazuju da P(HEMA/IK) hidrogelovi imaju veliku mogućnost primene u biomedicini, posebno kod tretmana kože i kao obloge za opekotine.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Smart hydrogels based on itaconic acid for biomedical application
T1  - Inteligentni hidrogelovi na bazi itakonske kiseline za biomedicinsku primenu
EP  - 610
IS  - 6
SP  - 603
VL  - 63
DO  - 10.2298/HEMIND0906603T
ER  - 

@article{
author = "Tomić, Simonida and Mićić, Maja M. and Krezović, Bojana D. and Dobić, Sava N. and Suljovrujić, Edin H. and Filipović, Jovanka M.",
year = "2009",
abstract = "pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings., pH i temperaturno osetljivi hidrogelovi na bazi kopolimera 2-hidroksietilmetakrilata (HEMA) i itakonske kiseline (IK) sintetisani su upotrebom gama zračenja i karakterisani s ciljem ispitivanja njihove potencijalne primene kao biomaterijala. Ispitivan je uticaj odnosa komonomera u ovim inteligentnim polimernim biomaterijalima na morfologiju, mehanička svojstva, biokompatibilnost i penetraciju mikroba. Mehanička svojstva kopolimera su ispitivana dinamičko-mehaničkom analizom (DMA), dok je morfologija karakterisana skenirajućom elektronskom mikroskopijom (SEM). Pokazalo se da su morfologija i mehanička svojstva ovih hidrogelova odgovarajući za većinu biomedicinskih primena. In vitro analizom biokompatibilnosti P(HEMA/IK) hidrogelova potvrđeno je da nisu toksični za ćelije niti izazivaju značajnu hemolitičku aktivnost. Takođe, test mikrobne penetracije pokazao je da ni Staphylococcus aureus ni Escherichia coli ne prolaze kroz hidrogelne obloge; stoga se P(HEMA/IK) obloge mogu smatrati dobrom barijerom protiv mikroba, a radi održavanja sterilnosti okolne sredine. Svi rezultati pokazuju da P(HEMA/IK) hidrogelovi imaju veliku mogućnost primene u biomedicini, posebno kod tretmana kože i kao obloge za opekotine.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Smart hydrogels based on itaconic acid for biomedical application, Inteligentni hidrogelovi na bazi itakonske kiseline za biomedicinsku primenu",
pages = "610-603",
number = "6",
volume = "63",
doi = "10.2298/HEMIND0906603T"
}

Tomić, S., Mićić, M. M., Krezović, B. D., Dobić, S. N., Suljovrujić, E. H.,& Filipović, J. M.. (2009). Smart hydrogels based on itaconic acid for biomedical application. in Hemijska industrija
Association of Chemical Engineers of Serbia., 63(6), 603-610.
https://doi.org/10.2298/HEMIND0906603T

Tomić S, Mićić MM, Krezović BD, Dobić SN, Suljovrujić EH, Filipović JM. Smart hydrogels based on itaconic acid for biomedical application. in Hemijska industrija. 2009;63(6):603-610.
doi:10.2298/HEMIND0906603T .

Tomić, Simonida, Mićić, Maja M., Krezović, Bojana D., Dobić, Sava N., Suljovrujić, Edin H., Filipović, Jovanka M., "Smart hydrogels based on itaconic acid for biomedical application" in Hemijska industrija, 63, no. 6 (2009):603-610,
https://doi.org/10.2298/HEMIND0906603T . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Mićić, Maja M.
AU  - Dokić, D.
AU  - Vasiljević-Radović, Dana
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1527
AB  - Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Materials and Manufacturing Processes
T1  - Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application
EP  - 1201
IS  - 10-11
SP  - 1197
VL  - 24
DO  - 10.1080/10426910903022247
ER  - 

@article{
author = "Tomić, Simonida and Mićić, Maja M. and Dokić, D. and Vasiljević-Radović, Dana and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2009",
abstract = "Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Materials and Manufacturing Processes",
title = "Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application",
pages = "1201-1197",
number = "10-11",
volume = "24",
doi = "10.1080/10426910903022247"
}

Tomić, S., Mićić, M. M., Dokić, D., Vasiljević-Radović, D., Filipović, J. M.,& Suljovrujić, E. H.. (2009). Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application. in Materials and Manufacturing Processes
Taylor & Francis Inc, Philadelphia., 24(10-11), 1197-1201.
https://doi.org/10.1080/10426910903022247

Tomić S, Mićić MM, Dokić D, Vasiljević-Radović D, Filipović JM, Suljovrujić EH. Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application. in Materials and Manufacturing Processes. 2009;24(10-11):1197-1201.
doi:10.1080/10426910903022247 .

Tomić, Simonida, Mićić, Maja M., Dokić, D., Vasiljević-Radović, Dana, Filipović, Jovanka M., Suljovrujić, Edin H., "Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application" in Materials and Manufacturing Processes, 24, no. 10-11 (2009):1197-1201,
https://doi.org/10.1080/10426910903022247 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Dimitrijević, Suzana
AU  - Marinković, Aleksandar
AU  - Najman, Stevo
AU  - Filipović, Jovanka M.
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1465
AB  - In the present study poly(2-hydroxyethyl methacrylate-co-itaconic acid) (P(HEMA/IA)) hydrogels were synthesized by free-radical copolymerization of 2-hydroxyethyl methacrylate and itaconic acid in order to evaluate as controlled release drug delivery system. All polymerizations were performed in a mixture of water/ethanol with ethylene glycol dimethacrylate, as crosslinking agent, potassium persulfate, as initiator, and N, N, N', N'-tetramethylethylene diamine, as activator. The samples were characterized by FTIR and SEM. Swelling kinetics and antibiotic release studies were performed using gravimetry and UV spectrophotometry, respectively. The antibacterial activity studies were performed bearing in mind that infections are the most common cause of biomaterial implant failure and represent a constant menace to the application of medical implants. The hemocompatibility testing was performed as imperative for medical devices intended for direct or indirect blood exposure. In accordance with the results of antibacterial assessment on gels loaded with antibiotics and hemolytic activity testing these gels exerted good bacterial growth inhibition and favorable hemolytic activity. The release profiles of antibiotics, evaluated in vitro conditions, were correspondent for antibacterial therapeutics. Therefore, it was concluded that (P(HEMA/IA)) gels could be propound for the potential application as drug delivery systems for the controlled release of antibiotics.
PB  - Springer, New York
T2  - Polymer Bulletin
T1  - Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels
EP  - 851
IS  - 6
SP  - 837
VL  - 63
DO  - 10.1007/s00289-009-0123-2
ER  - 

@article{
author = "Tomić, Simonida and Dimitrijević, Suzana and Marinković, Aleksandar and Najman, Stevo and Filipović, Jovanka M.",
year = "2009",
abstract = "In the present study poly(2-hydroxyethyl methacrylate-co-itaconic acid) (P(HEMA/IA)) hydrogels were synthesized by free-radical copolymerization of 2-hydroxyethyl methacrylate and itaconic acid in order to evaluate as controlled release drug delivery system. All polymerizations were performed in a mixture of water/ethanol with ethylene glycol dimethacrylate, as crosslinking agent, potassium persulfate, as initiator, and N, N, N', N'-tetramethylethylene diamine, as activator. The samples were characterized by FTIR and SEM. Swelling kinetics and antibiotic release studies were performed using gravimetry and UV spectrophotometry, respectively. The antibacterial activity studies were performed bearing in mind that infections are the most common cause of biomaterial implant failure and represent a constant menace to the application of medical implants. The hemocompatibility testing was performed as imperative for medical devices intended for direct or indirect blood exposure. In accordance with the results of antibacterial assessment on gels loaded with antibiotics and hemolytic activity testing these gels exerted good bacterial growth inhibition and favorable hemolytic activity. The release profiles of antibiotics, evaluated in vitro conditions, were correspondent for antibacterial therapeutics. Therefore, it was concluded that (P(HEMA/IA)) gels could be propound for the potential application as drug delivery systems for the controlled release of antibiotics.",
publisher = "Springer, New York",
journal = "Polymer Bulletin",
title = "Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels",
pages = "851-837",
number = "6",
volume = "63",
doi = "10.1007/s00289-009-0123-2"
}

Tomić, S., Dimitrijević, S., Marinković, A., Najman, S.,& Filipović, J. M.. (2009). Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels. in Polymer Bulletin
Springer, New York., 63(6), 837-851.
https://doi.org/10.1007/s00289-009-0123-2

Tomić S, Dimitrijević S, Marinković A, Najman S, Filipović JM. Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels. in Polymer Bulletin. 2009;63(6):837-851.
doi:10.1007/s00289-009-0123-2 .

Tomić, Simonida, Dimitrijević, Suzana, Marinković, Aleksandar, Najman, Stevo, Filipović, Jovanka M., "Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels" in Polymer Bulletin, 63, no. 6 (2009):837-851,
https://doi.org/10.1007/s00289-009-0123-2 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1156
AB  - The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization. Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2, 3.5 and 5 mol%) were studied in a wide pH and temperature range. Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior. Special attention was devoted to temperature investigations around physiological temperature (37 degrees C), where small changes in temperature significantly influence swelling and drug release of these hydrogels. Due to maximum swelling of hydrogels around 40 degrees C, the P(HEMA/IA) hydrogel containing 5mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25-42 degrees C, in order to evaluate their potential for medical applications.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Radiation Physics and Chemistry
T1  - Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation
EP  - 1394
IS  - 8-9
SP  - 1390
VL  - 76
DO  - 10.1016/j.radphyschem.2007.02.038
ER  - 

@article{
author = "Tomić, Simonida and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization. Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2, 3.5 and 5 mol%) were studied in a wide pH and temperature range. Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior. Special attention was devoted to temperature investigations around physiological temperature (37 degrees C), where small changes in temperature significantly influence swelling and drug release of these hydrogels. Due to maximum swelling of hydrogels around 40 degrees C, the P(HEMA/IA) hydrogel containing 5mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25-42 degrees C, in order to evaluate their potential for medical applications.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Radiation Physics and Chemistry",
title = "Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation",
pages = "1394-1390",
number = "8-9",
volume = "76",
doi = "10.1016/j.radphyschem.2007.02.038"
}

Tomić, S., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation. in Radiation Physics and Chemistry
Pergamon-Elsevier Science Ltd, Oxford., 76(8-9), 1390-1394.
https://doi.org/10.1016/j.radphyschem.2007.02.038

Tomić S, Mićić MM, Filipović JM, Suljovrujić EH. Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation. in Radiation Physics and Chemistry. 2007;76(8-9):1390-1394.
doi:10.1016/j.radphyschem.2007.02.038 .

Tomić, Simonida, Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation" in Radiation Physics and Chemistry, 76, no. 8-9 (2007):1390-1394,
https://doi.org/10.1016/j.radphyschem.2007.02.038 . .

TY  - JOUR
AU  - Mićić, Maja M.
AU  - Tomić, Simonida
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1019
AB  - Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.
PB  - 8th Conference of the Yugoslav Materials Research Society
T2  - Materials Science Forum
T1  - Release and diffusion studies of hydrogels based on itaconic acid
EP  - 446
SP  - 441
VL  - 555
DO  - 10.4028/0-87849-441-3.441
ER  - 

@article{
author = "Mićić, Maja M. and Tomić, Simonida and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.",
publisher = "8th Conference of the Yugoslav Materials Research Society",
journal = "Materials Science Forum",
title = "Release and diffusion studies of hydrogels based on itaconic acid",
pages = "446-441",
volume = "555",
doi = "10.4028/0-87849-441-3.441"
}

Mićić, M. M., Tomić, S., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum
8th Conference of the Yugoslav Materials Research Society., 555, 441-446.
https://doi.org/10.4028/0-87849-441-3.441

Mićić MM, Tomić S, Filipović JM, Suljovrujić EH. Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum. 2007;555:441-446.
doi:10.4028/0-87849-441-3.441 .

Mićić, Maja M., Tomić, Simonida, Filipović, Jovanka M., Suljovrujić, Edin H., "Release and diffusion studies of hydrogels based on itaconic acid" in Materials Science Forum, 555 (2007):441-446,
https://doi.org/10.4028/0-87849-441-3.441 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1085
AB  - The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were prepared by gamma irradiation, in order to examine the potential use of these hydrogels in controlled drug release systems. The influence of IA content in the gel on the swelling characteristics and the releasing behavior of hydrogels, and the effect of different drugs, theophylline (TPH) and fenethylline hydrochloride (FE), on the releasing behavior of P(HEMA/IA) matrix were investigated in vitro. The diffusion exponents for swelling and drug release indicate that the mechanisms of buffer uptake and drug release are governed by Fickian diffusion. The swelling kinetics and, therefore, the release rate depends on the matrix swelling degree. The drug release was faster for copolymeric hydrogels with a higher content of itaconic acid. Furthermore, the drug release for TPH as model drug was faster due to a smaller molecular size and a weaker interaction of the TPH molecules with(in) the P(HEMA/IA) copolymeric networks.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Radiation Physics and Chemistry
T1  - Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation
EP  - 810
IS  - 5
SP  - 801
VL  - 76
DO  - 10.1016/j.radphyschem.2006.05.013
ER  - 

@article{
author = "Tomić, Simonida and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were prepared by gamma irradiation, in order to examine the potential use of these hydrogels in controlled drug release systems. The influence of IA content in the gel on the swelling characteristics and the releasing behavior of hydrogels, and the effect of different drugs, theophylline (TPH) and fenethylline hydrochloride (FE), on the releasing behavior of P(HEMA/IA) matrix were investigated in vitro. The diffusion exponents for swelling and drug release indicate that the mechanisms of buffer uptake and drug release are governed by Fickian diffusion. The swelling kinetics and, therefore, the release rate depends on the matrix swelling degree. The drug release was faster for copolymeric hydrogels with a higher content of itaconic acid. Furthermore, the drug release for TPH as model drug was faster due to a smaller molecular size and a weaker interaction of the TPH molecules with(in) the P(HEMA/IA) copolymeric networks.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Radiation Physics and Chemistry",
title = "Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation",
pages = "810-801",
number = "5",
volume = "76",
doi = "10.1016/j.radphyschem.2006.05.013"
}

Tomić, S., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation. in Radiation Physics and Chemistry
Pergamon-Elsevier Science Ltd, Oxford., 76(5), 801-810.
https://doi.org/10.1016/j.radphyschem.2006.05.013

Tomić S, Mićić MM, Filipović JM, Suljovrujić EH. Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation. in Radiation Physics and Chemistry. 2007;76(5):801-810.
doi:10.1016/j.radphyschem.2006.05.013 .

Tomić, Simonida, Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation" in Radiation Physics and Chemistry, 76, no. 5 (2007):801-810,
https://doi.org/10.1016/j.radphyschem.2006.05.013 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
PY  - 2006
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/961
AB  - Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.
PB  - Springer, New York
T2  - Polymer Bulletin
T1  - Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
EP  - 702
IS  - 5
SP  - 691
VL  - 57
DO  - 10.1007/s00289-006-0606-3
ER  - 

@article{
author = "Tomić, Simonida and Suljovrujić, Edin H. and Filipović, Jovanka M.",
year = "2006",
abstract = "Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.",
publisher = "Springer, New York",
journal = "Polymer Bulletin",
title = "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid",
pages = "702-691",
number = "5",
volume = "57",
doi = "10.1007/s00289-006-0606-3"
}

Tomić, S., Suljovrujić, E. H.,& Filipović, J. M.. (2006). Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Polymer Bulletin
Springer, New York., 57(5), 691-702.
https://doi.org/10.1007/s00289-006-0606-3

Tomić S, Suljovrujić EH, Filipović JM. Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Polymer Bulletin. 2006;57(5):691-702.
doi:10.1007/s00289-006-0606-3 .

Tomić, Simonida, Suljovrujić, Edin H., Filipović, Jovanka M., "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid" in Polymer Bulletin, 57, no. 5 (2006):691-702,
https://doi.org/10.1007/s00289-006-0606-3 . .