Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels
Authorized Users Only
2013
Authors
Mićić, Maja M.Milić-Vukašinović, Tanja
Mitrić, Miodrag
Jokić, Bojan M.
Suljovrujić, Edin H.
Article (Published version)
Metadata
Show full item recordAbstract
Silver nanoparticles were fabricated via in situ reduction of silver nitrate embedded in swollen P(HEMA/IA) hydrogel, using gamma radiolysis method. Copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), previously synthesised by gamma radiation for wound dressing application, were used as a carrier and a stabilising agent, while ethyl alcohol was used as a free radical scavenger. The influence of different P(HEMA/IA) hydrogels and silver salt concentrations on the size and distribution of nanoparticles was investigated. The Ag/P(HEMA/IA) nanocomposites were characterised by high resolution scanning electron microscopy, energy dispersive spectroscopy, wide-angle X-ray diffraction, UV-Vis spectroscopy and swelling measurements. Escherichia coli (Gram-negative bacterium), Staphylococcus aureus (Gram-positive bacterium) and Candida albicans (fungus) were used to prove the antimicrobial properties of Ag/P(HEMA/IA) nanocomposites. The inhibition kinetics o...f bacteria growth was investigated by measuring the colony-forming unit. The antimicrobial effectiveness of the Ag/P(HEMA/IA) hydrogel nanocomposite was demonstrated even at small silver concentrations. P(HEMA/IA) hydrogels containing nanosilver particles was found suitable to be used as wound dressing.
Keywords:
Ag nanoparticles (AgNPs) / Gamma radiation / P(HEMA/IA) hydrogel / Antimicrobial activitySource:
Polymer Bulletin, 2013, 70, 12, 3347-3357Funding / projects:
- Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.1007/s00289-013-1026-9
ISSN: 0170-0839; 1436-2449
WoS: 000325774400008
Scopus: 2-s2.0-84886085710
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Mićić, Maja M. AU - Milić-Vukašinović, Tanja AU - Mitrić, Miodrag AU - Jokić, Bojan M. AU - Suljovrujić, Edin H. PY - 2013 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5713 AB - Silver nanoparticles were fabricated via in situ reduction of silver nitrate embedded in swollen P(HEMA/IA) hydrogel, using gamma radiolysis method. Copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), previously synthesised by gamma radiation for wound dressing application, were used as a carrier and a stabilising agent, while ethyl alcohol was used as a free radical scavenger. The influence of different P(HEMA/IA) hydrogels and silver salt concentrations on the size and distribution of nanoparticles was investigated. The Ag/P(HEMA/IA) nanocomposites were characterised by high resolution scanning electron microscopy, energy dispersive spectroscopy, wide-angle X-ray diffraction, UV-Vis spectroscopy and swelling measurements. Escherichia coli (Gram-negative bacterium), Staphylococcus aureus (Gram-positive bacterium) and Candida albicans (fungus) were used to prove the antimicrobial properties of Ag/P(HEMA/IA) nanocomposites. The inhibition kinetics of bacteria growth was investigated by measuring the colony-forming unit. The antimicrobial effectiveness of the Ag/P(HEMA/IA) hydrogel nanocomposite was demonstrated even at small silver concentrations. P(HEMA/IA) hydrogels containing nanosilver particles was found suitable to be used as wound dressing. T2 - Polymer Bulletin T1 - Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels EP - 3357 IS - 12 SP - 3347 VL - 70 DO - 10.1007/s00289-013-1026-9 ER -
@article{ author = "Mićić, Maja M. and Milić-Vukašinović, Tanja and Mitrić, Miodrag and Jokić, Bojan M. and Suljovrujić, Edin H.", year = "2013", abstract = "Silver nanoparticles were fabricated via in situ reduction of silver nitrate embedded in swollen P(HEMA/IA) hydrogel, using gamma radiolysis method. Copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), previously synthesised by gamma radiation for wound dressing application, were used as a carrier and a stabilising agent, while ethyl alcohol was used as a free radical scavenger. The influence of different P(HEMA/IA) hydrogels and silver salt concentrations on the size and distribution of nanoparticles was investigated. The Ag/P(HEMA/IA) nanocomposites were characterised by high resolution scanning electron microscopy, energy dispersive spectroscopy, wide-angle X-ray diffraction, UV-Vis spectroscopy and swelling measurements. Escherichia coli (Gram-negative bacterium), Staphylococcus aureus (Gram-positive bacterium) and Candida albicans (fungus) were used to prove the antimicrobial properties of Ag/P(HEMA/IA) nanocomposites. The inhibition kinetics of bacteria growth was investigated by measuring the colony-forming unit. The antimicrobial effectiveness of the Ag/P(HEMA/IA) hydrogel nanocomposite was demonstrated even at small silver concentrations. P(HEMA/IA) hydrogels containing nanosilver particles was found suitable to be used as wound dressing.", journal = "Polymer Bulletin", title = "Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels", pages = "3357-3347", number = "12", volume = "70", doi = "10.1007/s00289-013-1026-9" }
Mićić, M. M., Milić-Vukašinović, T., Mitrić, M., Jokić, B. M.,& Suljovrujić, E. H.. (2013). Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels. in Polymer Bulletin, 70(12), 3347-3357. https://doi.org/10.1007/s00289-013-1026-9
Mićić MM, Milić-Vukašinović T, Mitrić M, Jokić BM, Suljovrujić EH. Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels. in Polymer Bulletin. 2013;70(12):3347-3357. doi:10.1007/s00289-013-1026-9 .
Mićić, Maja M., Milić-Vukašinović, Tanja, Mitrić, Miodrag, Jokić, Bojan M., Suljovrujić, Edin H., "Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels" in Polymer Bulletin, 70, no. 12 (2013):3347-3357, https://doi.org/10.1007/s00289-013-1026-9 . .