Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom
Synthesis and characterization of novel triphenyltin(IV) compound with 3-(4-methyl-2-oxoquinolinyl)propanoic acid
Authors
Kasalović, Marijana P.Lađarević, Jelena
Božić, Bojan
Jevtić, Verica V.
Pantelić, Nebojša Đ.
Conference object (Published version)
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U poslednjoj deceniji jedinjenja organokalaja(IV) privukla su veliku pažnju istraživača zbog svoje izvanredne citotoksične aktivnosti protiv raznih oblika tumora. Ovde je prikazana sinteza 3-(4-metil-2-oksohinolinil)propanske kiseline i njenog kompleksa trifenilkalaja(IV). Ligand je dobijen u dva koraka. U prvom koraku, u reakciji između 4-metil-hinolin-2-ona i metil-3-bromopropionata sintetisan je odgovarajući metil-estar, čijom hidrolizom, u drugom koraku, je dobijen ligand. U reakciji liganda, koji je deprotonovan LiOH, i ekvimolarne količine Ph3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Naredna istraživanja sintetisanih jedinjenja biće usmerena ka in vitro ispitivanju citotoksične aktivnosti prema raznim ćelijskim linijama karcinoma, kao i na ispitivanje mehanizma njihovog delovanja.
Organotin(IV) compounds have greatly attracted researchers' attention in the last decade for their outstanding cytotoxic activity against different tumor cells. Herein, the synthesis of 3-(4-methyl-2-oxoquinolinyl)propanoic acid and its triphenyltin(IV) complex has been performed. The ligand precursor has been synthesized in two steps. In the first step, reaction between 4-methylquinoline-2-on and methyl 3-bromopropionate afforded corresponding methyl ester, whose hydrolysis, in the second step, produced targeted ligand. In the reaction of ligand precursor, which was deprotonated with LiOH, with equimolar amount of Ph3SnCl, the expected complex was obtained as white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of synthesized compounds will be focused on in vitro cytotoxic activity against various cancer cell lines, as well as investigation of mechanism of their action.
Source:
Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021, 2021, 62-Publisher:
- Beograd : Srpsko hemijsko društvo
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200122 (University of Kragujevac, Faculty of Science) (RS-MESTD-inst-2020-200122)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200178 (University of Belgrade, Faculty of Biology) (RS-MESTD-inst-2020-200178)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200116 (University of Belgrade, Faculty of Agriculture) (RS-MESTD-inst-2020-200116)
Institution/Community
Tehnološko-metalurški fakultetTY - CONF AU - Kasalović, Marijana P. AU - Lađarević, Jelena AU - Božić, Bojan AU - Jevtić, Verica V. AU - Pantelić, Nebojša Đ. PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6781 AB - U poslednjoj deceniji jedinjenja organokalaja(IV) privukla su veliku pažnju istraživača zbog svoje izvanredne citotoksične aktivnosti protiv raznih oblika tumora. Ovde je prikazana sinteza 3-(4-metil-2-oksohinolinil)propanske kiseline i njenog kompleksa trifenilkalaja(IV). Ligand je dobijen u dva koraka. U prvom koraku, u reakciji između 4-metil-hinolin-2-ona i metil-3-bromopropionata sintetisan je odgovarajući metil-estar, čijom hidrolizom, u drugom koraku, je dobijen ligand. U reakciji liganda, koji je deprotonovan LiOH, i ekvimolarne količine Ph3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Naredna istraživanja sintetisanih jedinjenja biće usmerena ka in vitro ispitivanju citotoksične aktivnosti prema raznim ćelijskim linijama karcinoma, kao i na ispitivanje mehanizma njihovog delovanja. AB - Organotin(IV) compounds have greatly attracted researchers' attention in the last decade for their outstanding cytotoxic activity against different tumor cells. Herein, the synthesis of 3-(4-methyl-2-oxoquinolinyl)propanoic acid and its triphenyltin(IV) complex has been performed. The ligand precursor has been synthesized in two steps. In the first step, reaction between 4-methylquinoline-2-on and methyl 3-bromopropionate afforded corresponding methyl ester, whose hydrolysis, in the second step, produced targeted ligand. In the reaction of ligand precursor, which was deprotonated with LiOH, with equimolar amount of Ph3SnCl, the expected complex was obtained as white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of synthesized compounds will be focused on in vitro cytotoxic activity against various cancer cell lines, as well as investigation of mechanism of their action. PB - Beograd : Srpsko hemijsko društvo C3 - Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021 T1 - Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom T1 - Synthesis and characterization of novel triphenyltin(IV) compound with 3-(4-methyl-2-oxoquinolinyl)propanoic acid SP - 62 UR - https://hdl.handle.net/21.15107/rcub_technorep_6781 ER -
@conference{ author = "Kasalović, Marijana P. and Lađarević, Jelena and Božić, Bojan and Jevtić, Verica V. and Pantelić, Nebojša Đ.", year = "2021", abstract = "U poslednjoj deceniji jedinjenja organokalaja(IV) privukla su veliku pažnju istraživača zbog svoje izvanredne citotoksične aktivnosti protiv raznih oblika tumora. Ovde je prikazana sinteza 3-(4-metil-2-oksohinolinil)propanske kiseline i njenog kompleksa trifenilkalaja(IV). Ligand je dobijen u dva koraka. U prvom koraku, u reakciji između 4-metil-hinolin-2-ona i metil-3-bromopropionata sintetisan je odgovarajući metil-estar, čijom hidrolizom, u drugom koraku, je dobijen ligand. U reakciji liganda, koji je deprotonovan LiOH, i ekvimolarne količine Ph3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Naredna istraživanja sintetisanih jedinjenja biće usmerena ka in vitro ispitivanju citotoksične aktivnosti prema raznim ćelijskim linijama karcinoma, kao i na ispitivanje mehanizma njihovog delovanja., Organotin(IV) compounds have greatly attracted researchers' attention in the last decade for their outstanding cytotoxic activity against different tumor cells. Herein, the synthesis of 3-(4-methyl-2-oxoquinolinyl)propanoic acid and its triphenyltin(IV) complex has been performed. The ligand precursor has been synthesized in two steps. In the first step, reaction between 4-methylquinoline-2-on and methyl 3-bromopropionate afforded corresponding methyl ester, whose hydrolysis, in the second step, produced targeted ligand. In the reaction of ligand precursor, which was deprotonated with LiOH, with equimolar amount of Ph3SnCl, the expected complex was obtained as white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of synthesized compounds will be focused on in vitro cytotoxic activity against various cancer cell lines, as well as investigation of mechanism of their action.", publisher = "Beograd : Srpsko hemijsko društvo", journal = "Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021", title = "Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom, Synthesis and characterization of novel triphenyltin(IV) compound with 3-(4-methyl-2-oxoquinolinyl)propanoic acid", pages = "62", url = "https://hdl.handle.net/21.15107/rcub_technorep_6781" }
Kasalović, M. P., Lađarević, J., Božić, B., Jevtić, V. V.,& Pantelić, N. Đ.. (2021). Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom. in Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021 Beograd : Srpsko hemijsko društvo., 62. https://hdl.handle.net/21.15107/rcub_technorep_6781
Kasalović MP, Lađarević J, Božić B, Jevtić VV, Pantelić NĐ. Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom. in Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021. 2021;:62. https://hdl.handle.net/21.15107/rcub_technorep_6781 .
Kasalović, Marijana P., Lađarević, Jelena, Božić, Bojan, Jevtić, Verica V., Pantelić, Nebojša Đ., "Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom" in Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021 (2021):62, https://hdl.handle.net/21.15107/rcub_technorep_6781 .