dc.creator | Marković, Maja D. | |
dc.creator | Seslija, Sanja I. | |
dc.creator | Panić, Vesna V. | |
dc.creator | Pjanović, Rada V. | |
dc.date.accessioned | 2022-04-20T18:15:43Z | |
dc.date.available | 2022-04-20T18:15:43Z | |
dc.date.issued | 2019 | |
dc.identifier.isbn | 978-86-7132-076-4 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5074 | |
dc.description.abstract | Three dimensional polymer networks, hydrogels, have shown a great potential in
controlled release and targeted delivery of active substances. pH sensitive hydrogels
based on poly(methacrylic acid) have attracted significant attention due to their
biocompatibility, non-toxicity and the possession of the huge number of ionogenic
carboxylic groups. On the other hand, the usage of these hydrogels for controlled release
and targeted delivery of poorly water-soluble drugs is limited by their highly hydrophilic
nature. We overcame this limitation by modifying PMAA with amphiphilic substance -
casein. The addition of this natural protein enabled the encapsulation, targeted delivery
and controlled release of poorly water-soluble model drug - caffeine. Three carriers with
different neutralization degree of methacrylic acid were synthesized via free radical
polymerization. The FTIR spectra revealed that two types of interactions were
established between casein and caffeine: hydrophobic interactions and hydrogen bonds.
The SEM micrographs showed that the structure of the carriers depended on the change
of neutralization degree of the methacrylic acid. The swelling of synthesized carriers and
the caffeine in vitro release were monitored in two environments at 37°C: 0.1M HCl
pH=1.2 (simulation of environment in human stomach) and phosphate buffer pH=6.8
(simulation of environment in human intestines). The synthesized carriers had higher
swelling degree and the higher release rate of caffeine in the phosphate buffer pH=6.8
than in 0.1M HCl. The increase in neutralization degree of methacrylic acid caused the
increase in swelling degree of the carriers and the increase in release rate of caffeine.
Presented results showed that synthesized carriers are promising candidates for targeted
delivery of poorly water-soluble drugs. | sr |
dc.language.iso | en | sr |
dc.publisher | Serbian Chemical Society and Serbian Young Chemists Club Karnegijeva 4/III, 11000 Belgrade, Serbia | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Conference of the Young Chemists of Serbia | sr |
dc.title | Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs | sr |
dc.type | conferenceObject | sr |
dc.rights.license | ARR | sr |
dc.citation.spage | 134 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_technorep_5074 | |
dc.type.version | publishedVersion | sr |