dc.creator | Cvijetić, Ilija N. | |
dc.creator | Herlah, Barbara | |
dc.creator | Marinković, Aleksandar | |
dc.creator | Perdih, Andrej | |
dc.creator | Bjelogrlić, Snežana K. | |
dc.date.accessioned | 2023-05-11T13:55:52Z | |
dc.date.available | 2023-05-11T13:55:52Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1424-8247 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6361 | |
dc.description.abstract | Phenotypic screening of α-substituted thiocarbohydrazones revealed promising activity of 1,5-bis(salicylidene)thiocarbohydrazide against leukemia and breast cancer cells. Supplementary cell-based studies indicated an impairment of DNA replication via the ROS-independent pathway. The structural similarity of α-substituted thiocarbohydrazone to previously published thiosemicarbazone catalytic inhibitors targeting the ATP-binding site of human DNA topoisomerase IIα prompted us to investigate the inhibition activity on this target. Thiocarbohydrazone acted as a catalytic inhibitor and did not intercalate the DNA molecule, which validated their engagement with this cancer target. A comprehensive computational assessment of molecular recognition for a selected thiosemicarbazone and thiocarbohydrazone provided useful information for further optimization of this discovered lead compound for chemotherapeutic anticancer drug discovery. | sr |
dc.language.iso | en | sr |
dc.publisher | MDPI | sr |
dc.relation | The Slovenian Research Agency with research project J1-4402 (A.P.) and research program P1-0012 (A.P.) as well as by a young researcher grant (B.H.). | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Pharmaceuticals | sr |
dc.subject | cancer research | sr |
dc.subject | catalytic inhibitors | sr |
dc.subject | dynophores | sr |
dc.subject | human DNA topoisomerase IIα | sr |
dc.subject | molecular dynamics | sr |
dc.subject | phenotypic screening | sr |
dc.subject | thiocarbohydrazones | sr |
dc.title | Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.citation.issue | 3 | |
dc.citation.rank | M21~ | |
dc.citation.spage | 341 | |
dc.citation.volume | 16 | |
dc.identifier.doi | 10.3390/ph16030341 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/17023/Phenotypic_Discovery_pub_2023.pdf | |
dc.identifier.scopus | 2-s2.0-85152402533 | |
dc.type.version | publishedVersion | sr |