TY  - JOUR
AU  - Spasojević, Pavle
AU  - Adnađević, Borivoj
AU  - Veličković, Sava
AU  - Jovanović, Jelena
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1926
AB  - The effects of heating mode (conventional isothermal heating (CIH) and microwave isothermal heating (MWIH) on the kinetics of polymerization and the properties important for the application (residual monomer, hardness, and water absorption) of three commercial poly(methyl methacrylate) (PMMA) base dental materials were investigated. The degree of monomer conversion was determined by infrared spectrometry. The hardness of the polymerized samples was measured by shore D method, whereas the water absorption was measured gravimetrically. Kinetics models for polymerizations using different heating modes were determined by model fitting method. The rate of the MWIH polymerization was eight times higher compared with the CIH polymerization. The CIH polymerization is found to be the phase-boundary controlled reaction for which the rate of contracting volume is the rate limiting step, whereas MWIH polymerization is found to be the first-order reaction and the monomer concentration in the polymerization mixture is the rate limiting step. The samples of PMMA base dental materials synthesized by MWIH polymerization exhibit better application properties (hardness and water absorption).
PB  - Wiley, Hoboken
T2  - Journal of Applied Polymer Science
T1  - Influence of Microwave Heating on the Polymerization Kinetics and Application Properties of the PMMA Dental Materials
EP  - 3606
IS  - 6
SP  - 3598
VL  - 119
DO  - 10.1002/app.33041
ER  - 

@article{
author = "Spasojević, Pavle and Adnađević, Borivoj and Veličković, Sava and Jovanović, Jelena",
year = "2011",
abstract = "The effects of heating mode (conventional isothermal heating (CIH) and microwave isothermal heating (MWIH) on the kinetics of polymerization and the properties important for the application (residual monomer, hardness, and water absorption) of three commercial poly(methyl methacrylate) (PMMA) base dental materials were investigated. The degree of monomer conversion was determined by infrared spectrometry. The hardness of the polymerized samples was measured by shore D method, whereas the water absorption was measured gravimetrically. Kinetics models for polymerizations using different heating modes were determined by model fitting method. The rate of the MWIH polymerization was eight times higher compared with the CIH polymerization. The CIH polymerization is found to be the phase-boundary controlled reaction for which the rate of contracting volume is the rate limiting step, whereas MWIH polymerization is found to be the first-order reaction and the monomer concentration in the polymerization mixture is the rate limiting step. The samples of PMMA base dental materials synthesized by MWIH polymerization exhibit better application properties (hardness and water absorption).",
publisher = "Wiley, Hoboken",
journal = "Journal of Applied Polymer Science",
title = "Influence of Microwave Heating on the Polymerization Kinetics and Application Properties of the PMMA Dental Materials",
pages = "3606-3598",
number = "6",
volume = "119",
doi = "10.1002/app.33041"
}

Spasojević, P., Adnađević, B., Veličković, S.,& Jovanović, J.. (2011). Influence of Microwave Heating on the Polymerization Kinetics and Application Properties of the PMMA Dental Materials. in Journal of Applied Polymer Science
Wiley, Hoboken., 119(6), 3598-3606.
https://doi.org/10.1002/app.33041

Spasojević P, Adnađević B, Veličković S, Jovanović J. Influence of Microwave Heating on the Polymerization Kinetics and Application Properties of the PMMA Dental Materials. in Journal of Applied Polymer Science. 2011;119(6):3598-3606.
doi:10.1002/app.33041 .

Spasojević, Pavle, Adnađević, Borivoj, Veličković, Sava, Jovanović, Jelena, "Influence of Microwave Heating on the Polymerization Kinetics and Application Properties of the PMMA Dental Materials" in Journal of Applied Polymer Science, 119, no. 6 (2011):3598-3606,
https://doi.org/10.1002/app.33041 . .

TY  - JOUR
AU  - Milosavljević, Nedeljko
AU  - Milašinović, Nikola
AU  - Popović, Ivanka
AU  - Filipović, Jovanka M.
AU  - Kalagasidis Krušić, Melina
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1908
AB  - Novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid were prepared in two steps. Chitosan was first ionically crosslinked with itaconic acid, after which a free radical polymerization and crosslinking of the chitosan/itaconic acid network was performed by adding methacrylic acid and a crosslinker in order to achieve better mechanical properties and tunable swelling. The samples were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, X-ray diffraction, dynamic mechanical analysis and the swelling ratios of the hydrogels at various pH values (2.0-8.0). The hydrogel composition is found to have a great impact on the hydrogel structure, mechanical and thermal properties, morphology and swelling kinetics. The highly porous morphology of the gels is probably connected with the bulky chitosan/itaconic acid network which reduces the degree of crosslinking in the second step of the synthesis due to steric hindrances. The gels demonstrate substantial change in buffer absorbency with change of pH, low for acid buffers and the higher for pH values above 6 where the swelling is considerably slow, thus suggesting their strong candidature for use as oral drug-delivery systems in the lower parts of the gastrointestinal tract and for drugs that require longer release times.
PB  - Wiley-Blackwell, Hoboken
T2  - Polymer International
T1  - Preparation and characterization of pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid
EP  - 452
IS  - 3
SP  - 443
VL  - 60
DO  - 10.1002/pi.2967
ER  - 

@article{
author = "Milosavljević, Nedeljko and Milašinović, Nikola and Popović, Ivanka and Filipović, Jovanka M. and Kalagasidis Krušić, Melina",
year = "2011",
abstract = "Novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid were prepared in two steps. Chitosan was first ionically crosslinked with itaconic acid, after which a free radical polymerization and crosslinking of the chitosan/itaconic acid network was performed by adding methacrylic acid and a crosslinker in order to achieve better mechanical properties and tunable swelling. The samples were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, X-ray diffraction, dynamic mechanical analysis and the swelling ratios of the hydrogels at various pH values (2.0-8.0). The hydrogel composition is found to have a great impact on the hydrogel structure, mechanical and thermal properties, morphology and swelling kinetics. The highly porous morphology of the gels is probably connected with the bulky chitosan/itaconic acid network which reduces the degree of crosslinking in the second step of the synthesis due to steric hindrances. The gels demonstrate substantial change in buffer absorbency with change of pH, low for acid buffers and the higher for pH values above 6 where the swelling is considerably slow, thus suggesting their strong candidature for use as oral drug-delivery systems in the lower parts of the gastrointestinal tract and for drugs that require longer release times.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Polymer International",
title = "Preparation and characterization of pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid",
pages = "452-443",
number = "3",
volume = "60",
doi = "10.1002/pi.2967"
}

Milosavljević, N., Milašinović, N., Popović, I., Filipović, J. M.,& Kalagasidis Krušić, M.. (2011). Preparation and characterization of pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid. in Polymer International
Wiley-Blackwell, Hoboken., 60(3), 443-452.
https://doi.org/10.1002/pi.2967

Milosavljević N, Milašinović N, Popović I, Filipović JM, Kalagasidis Krušić M. Preparation and characterization of pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid. in Polymer International. 2011;60(3):443-452.
doi:10.1002/pi.2967 .

Milosavljević, Nedeljko, Milašinović, Nikola, Popović, Ivanka, Filipović, Jovanka M., Kalagasidis Krušić, Melina, "Preparation and characterization of pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid" in Polymer International, 60, no. 3 (2011):443-452,
https://doi.org/10.1002/pi.2967 . .

TY  - JOUR
AU  - Pergal, Marija
AU  - Antić, Vesna
AU  - Govedarica, Milutin
AU  - Gođevac, Dejan
AU  - Ostojić, Sanja
AU  - Đonlagić, Jasna
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5658
AB  - Novel polyurethane copolymers derived from 4,4'-methylenediphenyl diisocyanate (MDI), 1,4-butanediol (BD) and alpha, omega-dihydroxy-[poly(caprolactone)-poly (dimethylsiloxane)-poly(caprolactone)] (a, x-dihydroxy( PCL-PDMS-PCL); (M) over bar (n) 6100 g mol(-1)) were synthesized by a two-step polyaddition reaction in solution. In the synthesis of the polyurethanes, the PCL blocks served as a compatibilizer between the nonpolar PDMS blocks and the polar comonomers, MDI and BD. The synthesis of thermoplastic polyurethanes (TPU) with high soft segment contents was optimized in terms of the concentrations of the reactants, the molar ratio of the NCO/OH groups, and the time and temperature of the polyaddition reaction. The structure, composition, and hard MDI/BD segment length of the synthesized polyurethane copolymers were determined by H-1, C-13-NMR, and two-dimensional correlation (COSY, HSQC, and HMBC) spectroscopy, while the hydrogen bonding interactions in the copolymers were analyzed by FT-IR spectroscopy. The influence of the reaction conditions on the structure, molecular weight, thermal, and some physical properties was studied at constant composition of the reaction mixture. A change in the molar ratio of the NCO/OH groups and the reaction conditions modified not only the molecular weight of the synthesized polyurethanes, but also the microstructure and therefore the thermal and physical properties of the copolymers. It was demonstrated that only PCL segments with high soft segment contents crystallize, thereby showing spherulitic morphology.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Applied Polymer Science
T1  - Synthesis and Characterization of Novel Urethane-Siloxane Copolymers with a High Content of PCL-PDMS-PCL Segments
EP  - 2730
IS  - 4
SP  - 2715
VL  - 122
DO  - 10.1002/app.33926
ER  - 

@article{
author = "Pergal, Marija and Antić, Vesna and Govedarica, Milutin and Gođevac, Dejan and Ostojić, Sanja and Đonlagić, Jasna",
year = "2011",
abstract = "Novel polyurethane copolymers derived from 4,4'-methylenediphenyl diisocyanate (MDI), 1,4-butanediol (BD) and alpha, omega-dihydroxy-[poly(caprolactone)-poly (dimethylsiloxane)-poly(caprolactone)] (a, x-dihydroxy( PCL-PDMS-PCL); (M) over bar (n) 6100 g mol(-1)) were synthesized by a two-step polyaddition reaction in solution. In the synthesis of the polyurethanes, the PCL blocks served as a compatibilizer between the nonpolar PDMS blocks and the polar comonomers, MDI and BD. The synthesis of thermoplastic polyurethanes (TPU) with high soft segment contents was optimized in terms of the concentrations of the reactants, the molar ratio of the NCO/OH groups, and the time and temperature of the polyaddition reaction. The structure, composition, and hard MDI/BD segment length of the synthesized polyurethane copolymers were determined by H-1, C-13-NMR, and two-dimensional correlation (COSY, HSQC, and HMBC) spectroscopy, while the hydrogen bonding interactions in the copolymers were analyzed by FT-IR spectroscopy. The influence of the reaction conditions on the structure, molecular weight, thermal, and some physical properties was studied at constant composition of the reaction mixture. A change in the molar ratio of the NCO/OH groups and the reaction conditions modified not only the molecular weight of the synthesized polyurethanes, but also the microstructure and therefore the thermal and physical properties of the copolymers. It was demonstrated that only PCL segments with high soft segment contents crystallize, thereby showing spherulitic morphology.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Applied Polymer Science",
title = "Synthesis and Characterization of Novel Urethane-Siloxane Copolymers with a High Content of PCL-PDMS-PCL Segments",
pages = "2730-2715",
number = "4",
volume = "122",
doi = "10.1002/app.33926"
}

Pergal, M., Antić, V., Govedarica, M., Gođevac, D., Ostojić, S.,& Đonlagić, J.. (2011). Synthesis and Characterization of Novel Urethane-Siloxane Copolymers with a High Content of PCL-PDMS-PCL Segments. in Journal of Applied Polymer Science
Wiley-Blackwell, Malden., 122(4), 2715-2730.
https://doi.org/10.1002/app.33926

Pergal M, Antić V, Govedarica M, Gođevac D, Ostojić S, Đonlagić J. Synthesis and Characterization of Novel Urethane-Siloxane Copolymers with a High Content of PCL-PDMS-PCL Segments. in Journal of Applied Polymer Science. 2011;122(4):2715-2730.
doi:10.1002/app.33926 .

Pergal, Marija, Antić, Vesna, Govedarica, Milutin, Gođevac, Dejan, Ostojić, Sanja, Đonlagić, Jasna, "Synthesis and Characterization of Novel Urethane-Siloxane Copolymers with a High Content of PCL-PDMS-PCL Segments" in Journal of Applied Polymer Science, 122, no. 4 (2011):2715-2730,
https://doi.org/10.1002/app.33926 . .

TY  - JOUR
AU  - Popov-Pergal, Katarina M.
AU  - Poleti, Dejan
AU  - Rancic, Milica P.
AU  - Meden, Antun
AU  - Pergal, Marija
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5616
AB  - The derivatives of 5-substituted-2,4-thiazolidinedione have a broad spectrum of biological activities. In this article, new 5-(arylidene)-3-(4-methylbenzoyl)thiayolidine-2,4-diones 3a-k, with arylidene groups such as 4-phenylbenzylidene 3a, 3,4-dimethoxybenzylidene 3b, 2-hydroxybenzylidene 3c, 4-ethoxybenzylidene 3d, 5-methyl-2-furfurylidene 3e, 4-dimethylaminobenzylidene 3f, 1-naphthylidene 3g, 3,4-methylenedioxybenzylidene 3h, 4-benzyloxybenzylidene 3i, benzylidene 3j, and 4-methoxybenzylidene 3k, were synthesized by direct acylation of alkali metal salts of 5-arylidene-2,4-thiazolidinediones with 4-methylbenzoylchloride. Their structures were confirmed by elemental analysis, IR, (1)H NMR and MS spectroscopy. In addition, crystal structure of the compound 3d was determined using single-crystal X-ray diffraction data.
PB  - Wiley-Blackwell Publishing, Inc, Malden
T2  - Journal of Heterocyclic Chemistry
T1  - Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones
EP  - 228
IS  - 1
SP  - 224
VL  - 47
DO  - 10.1002/jhet.288
ER  - 

@article{
author = "Popov-Pergal, Katarina M. and Poleti, Dejan and Rancic, Milica P. and Meden, Antun and Pergal, Marija",
year = "2010",
abstract = "The derivatives of 5-substituted-2,4-thiazolidinedione have a broad spectrum of biological activities. In this article, new 5-(arylidene)-3-(4-methylbenzoyl)thiayolidine-2,4-diones 3a-k, with arylidene groups such as 4-phenylbenzylidene 3a, 3,4-dimethoxybenzylidene 3b, 2-hydroxybenzylidene 3c, 4-ethoxybenzylidene 3d, 5-methyl-2-furfurylidene 3e, 4-dimethylaminobenzylidene 3f, 1-naphthylidene 3g, 3,4-methylenedioxybenzylidene 3h, 4-benzyloxybenzylidene 3i, benzylidene 3j, and 4-methoxybenzylidene 3k, were synthesized by direct acylation of alkali metal salts of 5-arylidene-2,4-thiazolidinediones with 4-methylbenzoylchloride. Their structures were confirmed by elemental analysis, IR, (1)H NMR and MS spectroscopy. In addition, crystal structure of the compound 3d was determined using single-crystal X-ray diffraction data.",
publisher = "Wiley-Blackwell Publishing, Inc, Malden",
journal = "Journal of Heterocyclic Chemistry",
title = "Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones",
pages = "228-224",
number = "1",
volume = "47",
doi = "10.1002/jhet.288"
}

Popov-Pergal, K. M., Poleti, D., Rancic, M. P., Meden, A.,& Pergal, M.. (2010). Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones. in Journal of Heterocyclic Chemistry
Wiley-Blackwell Publishing, Inc, Malden., 47(1), 224-228.
https://doi.org/10.1002/jhet.288

Popov-Pergal KM, Poleti D, Rancic MP, Meden A, Pergal M. Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones. in Journal of Heterocyclic Chemistry. 2010;47(1):224-228.
doi:10.1002/jhet.288 .

Popov-Pergal, Katarina M., Poleti, Dejan, Rancic, Milica P., Meden, Antun, Pergal, Marija, "Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones" in Journal of Heterocyclic Chemistry, 47, no. 1 (2010):224-228,
https://doi.org/10.1002/jhet.288 . .

TY  - JOUR
AU  - Panić, Vesna
AU  - Adnađević, Borivoj
AU  - Veličković, Sava
AU  - Jovanović, Jelena
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1688
AB  - Poly(methacrylic acid) hydrogels were synthesized. The effects of the synthesis parameters: the neutralization degree of methacrylic acid and the concentrations of monomer, crosslinker and initiator on the xerogels structural properties: the xerogel density (rho(xg)), the number average molar mass between the network crosslinks (M-c), the crosslink degree (rho
PB  - Elsevier Science Sa, Lausanne
T2  - Chemical Engineering Journal
T1  - The effects of the synthesis parameters on the xerogels structures and on the swelling parameters of the poly(methacrylic acid) hydrogels
EP  - 214
IS  - 1
SP  - 206
VL  - 156
DO  - 10.1016/j.cej.2009.10.040
ER  - 

@article{
author = "Panić, Vesna and Adnađević, Borivoj and Veličković, Sava and Jovanović, Jelena",
year = "2010",
abstract = "Poly(methacrylic acid) hydrogels were synthesized. The effects of the synthesis parameters: the neutralization degree of methacrylic acid and the concentrations of monomer, crosslinker and initiator on the xerogels structural properties: the xerogel density (rho(xg)), the number average molar mass between the network crosslinks (M-c), the crosslink degree (rho",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Chemical Engineering Journal",
title = "The effects of the synthesis parameters on the xerogels structures and on the swelling parameters of the poly(methacrylic acid) hydrogels",
pages = "214-206",
number = "1",
volume = "156",
doi = "10.1016/j.cej.2009.10.040"
}

Panić, V., Adnađević, B., Veličković, S.,& Jovanović, J.. (2010). The effects of the synthesis parameters on the xerogels structures and on the swelling parameters of the poly(methacrylic acid) hydrogels. in Chemical Engineering Journal
Elsevier Science Sa, Lausanne., 156(1), 206-214.
https://doi.org/10.1016/j.cej.2009.10.040

Panić V, Adnađević B, Veličković S, Jovanović J. The effects of the synthesis parameters on the xerogels structures and on the swelling parameters of the poly(methacrylic acid) hydrogels. in Chemical Engineering Journal. 2010;156(1):206-214.
doi:10.1016/j.cej.2009.10.040 .

Panić, Vesna, Adnađević, Borivoj, Veličković, Sava, Jovanović, Jelena, "The effects of the synthesis parameters on the xerogels structures and on the swelling parameters of the poly(methacrylic acid) hydrogels" in Chemical Engineering Journal, 156, no. 1 (2010):206-214,
https://doi.org/10.1016/j.cej.2009.10.040 . .

TY  - JOUR
AU  - Pepić, Dragana
AU  - Anđelković, Darinka R.
AU  - Nikolić, Marija
AU  - Grujić, Svetlana
AU  - Đonlagić, Jasna
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1656
AB  - Poly (ε-caprolactone), PCL, is an aliphatic polyester suitable for controlled drug release due to its biodegradability, biocompatibility, non-toxicity and high permeability to many therapeutic drugs. This study investigates the effect of the preparation parameters on the size and the morphology of the PCL microspheres and on the release profile of carbamazepine from these microspheres. The PCL microspheres were prepared using oil-in-water (o/w) emulsion solvent evaporation method with the poly(vinyl alcohol), PVA, as the emulsion stabilizer. The influence of the stirring rate applied during the emulsion formation, the homogenization time and the emulsifier concentration on diameter and size distribution of the microspheres was analyzed by scanning electron microscope (SEM). The initial emulsion was formed applying high stirring rates of 10000, 18000 and 23000 rpm, for homogenization times: 5, 10 and 15 min. The diameter was strongly influenced by the stirring rate, and the average particle size decreased from 9.2 to 2.8 ìm with the increase of the stirring rate. Increasing the amount of PVA in the water phase from 0.2 to 1 mass% improved stabilization of the oil droplets and led to a slight decrease of the average particle diameter. Drug-loaded microspheres were prepared by the same technique using different amounts of carbamazepine (10 and 15 mass%), under given conditions (1.0 mass% PVA, stirring rate of 18000 rpm for a period of 5 min of emulsion formation). Additionally, microspheres were prepared by applying low stirring rate of 1000 rpm with 10 and 15 mass% of the drug. The SEM analysis showed that microspheres created with 18000 rpm stirring rate, had average diameters of 3-4 ìm, and the microspheres prepared with 1000 rpm stirring rate were larger than 100 ìm. It was also observed that, in the case of the large microspheres, carbamazepine was deposited on their surfaces, while the small microspheres had smooth surfaces without observable drug crystals. The encapsulation efficiency and the release behaviour of the carbamazepine were examined using high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV). The drug encapsulation efficiencies were in the range from 69 to 81%, and were increasing with the increase of the amount of carbamazepine in both series. In vitro release experiments were carried out in the phosphate buffer solution (pH 7) at 37°C. The release rate was influenced by the microspheres size and morphology. The larger microspheres released more carbamazepine (85-95%) compared to the small ones (50-65%) for the same period. This behavior was attributed to the different drug distribution in the PCL matrix. Different mathematical models were used to describe drug release kinetics. It was concluded that the mechanism of the carbamazepine release from the microspheres was diffusion-controlled, independent on the type of microspheres. The kinetic parameters showed that the release of carbamazepine was slower from the smaller microspheres, probably as a result of more even distribution of the drug in the polymer matrix.
AB  - Cilj ovog rada je ispitivanje uticaja uslova dobijanja mikrosfera biodegradabilnog poli(ε-kaprolaktona) tehnikom otparavanja rastvarača iz emulzije, na veličinu i raspodelu veličina mikrosfera. Polazne emulzije rastvora polimera u vodi formirane su pri velikim brzinama mešanja tokom formiranja emulzije u opsegu od 10000 do 23000 o min-1, radi dobijanja mikrosfera malih prečnika. Varirana je brzina mešanja prilikom formiranja emulzije, dužina trajanja emulgovanja velikim brzinama mešanja i udeo stabilizatora emulzije, poli(vinil alkohola). Veličina i raspodela veličina polimernih mikrosfera određivana je skenirajućom elektronskom mikroskopijom. U polimerne mikrosfere inkapsuliran je lek karbamazepin iz grupe antiepileptika i određivana je efikasnost inkapsulacije, kao i profil otpuštanja leka u puferskom rastvoru metodom tečne hromatografije sa UV spektroskopijom. Takođe je izučavana kinetika otpuštanja karbamazepina korišćenjem različitih modela s ciljem ispitivanja mehanizma otpuštanja leka iz mikrosfera dobijenih pri različitim uslovima.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Optimization of preparation conditions of poly(ε-caprolactone) microspheres for controlled release of carbamazepine
T1  - Optimizacija uslova dobijanja mikrosfera na bazi biodegradabilnog poli(ε-kaprolaktona) za kontrolisano otpuštanje karbamazepina
EP  - 502
IS  - 6
SP  - 491
VL  - 64
DO  - 10.2298/HEMIND101117073P
ER  - 

@article{
author = "Pepić, Dragana and Anđelković, Darinka R. and Nikolić, Marija and Grujić, Svetlana and Đonlagić, Jasna",
year = "2010",
abstract = "Poly (ε-caprolactone), PCL, is an aliphatic polyester suitable for controlled drug release due to its biodegradability, biocompatibility, non-toxicity and high permeability to many therapeutic drugs. This study investigates the effect of the preparation parameters on the size and the morphology of the PCL microspheres and on the release profile of carbamazepine from these microspheres. The PCL microspheres were prepared using oil-in-water (o/w) emulsion solvent evaporation method with the poly(vinyl alcohol), PVA, as the emulsion stabilizer. The influence of the stirring rate applied during the emulsion formation, the homogenization time and the emulsifier concentration on diameter and size distribution of the microspheres was analyzed by scanning electron microscope (SEM). The initial emulsion was formed applying high stirring rates of 10000, 18000 and 23000 rpm, for homogenization times: 5, 10 and 15 min. The diameter was strongly influenced by the stirring rate, and the average particle size decreased from 9.2 to 2.8 ìm with the increase of the stirring rate. Increasing the amount of PVA in the water phase from 0.2 to 1 mass% improved stabilization of the oil droplets and led to a slight decrease of the average particle diameter. Drug-loaded microspheres were prepared by the same technique using different amounts of carbamazepine (10 and 15 mass%), under given conditions (1.0 mass% PVA, stirring rate of 18000 rpm for a period of 5 min of emulsion formation). Additionally, microspheres were prepared by applying low stirring rate of 1000 rpm with 10 and 15 mass% of the drug. The SEM analysis showed that microspheres created with 18000 rpm stirring rate, had average diameters of 3-4 ìm, and the microspheres prepared with 1000 rpm stirring rate were larger than 100 ìm. It was also observed that, in the case of the large microspheres, carbamazepine was deposited on their surfaces, while the small microspheres had smooth surfaces without observable drug crystals. The encapsulation efficiency and the release behaviour of the carbamazepine were examined using high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV). The drug encapsulation efficiencies were in the range from 69 to 81%, and were increasing with the increase of the amount of carbamazepine in both series. In vitro release experiments were carried out in the phosphate buffer solution (pH 7) at 37°C. The release rate was influenced by the microspheres size and morphology. The larger microspheres released more carbamazepine (85-95%) compared to the small ones (50-65%) for the same period. This behavior was attributed to the different drug distribution in the PCL matrix. Different mathematical models were used to describe drug release kinetics. It was concluded that the mechanism of the carbamazepine release from the microspheres was diffusion-controlled, independent on the type of microspheres. The kinetic parameters showed that the release of carbamazepine was slower from the smaller microspheres, probably as a result of more even distribution of the drug in the polymer matrix., Cilj ovog rada je ispitivanje uticaja uslova dobijanja mikrosfera biodegradabilnog poli(ε-kaprolaktona) tehnikom otparavanja rastvarača iz emulzije, na veličinu i raspodelu veličina mikrosfera. Polazne emulzije rastvora polimera u vodi formirane su pri velikim brzinama mešanja tokom formiranja emulzije u opsegu od 10000 do 23000 o min-1, radi dobijanja mikrosfera malih prečnika. Varirana je brzina mešanja prilikom formiranja emulzije, dužina trajanja emulgovanja velikim brzinama mešanja i udeo stabilizatora emulzije, poli(vinil alkohola). Veličina i raspodela veličina polimernih mikrosfera određivana je skenirajućom elektronskom mikroskopijom. U polimerne mikrosfere inkapsuliran je lek karbamazepin iz grupe antiepileptika i određivana je efikasnost inkapsulacije, kao i profil otpuštanja leka u puferskom rastvoru metodom tečne hromatografije sa UV spektroskopijom. Takođe je izučavana kinetika otpuštanja karbamazepina korišćenjem različitih modela s ciljem ispitivanja mehanizma otpuštanja leka iz mikrosfera dobijenih pri različitim uslovima.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Optimization of preparation conditions of poly(ε-caprolactone) microspheres for controlled release of carbamazepine, Optimizacija uslova dobijanja mikrosfera na bazi biodegradabilnog poli(ε-kaprolaktona) za kontrolisano otpuštanje karbamazepina",
pages = "502-491",
number = "6",
volume = "64",
doi = "10.2298/HEMIND101117073P"
}

Pepić, D., Anđelković, D. R., Nikolić, M., Grujić, S.,& Đonlagić, J.. (2010). Optimization of preparation conditions of poly(ε-caprolactone) microspheres for controlled release of carbamazepine. in Hemijska industrija
Association of Chemical Engineers of Serbia., 64(6), 491-502.
https://doi.org/10.2298/HEMIND101117073P

Pepić D, Anđelković DR, Nikolić M, Grujić S, Đonlagić J. Optimization of preparation conditions of poly(ε-caprolactone) microspheres for controlled release of carbamazepine. in Hemijska industrija. 2010;64(6):491-502.
doi:10.2298/HEMIND101117073P .

Pepić, Dragana, Anđelković, Darinka R., Nikolić, Marija, Grujić, Svetlana, Đonlagić, Jasna, "Optimization of preparation conditions of poly(ε-caprolactone) microspheres for controlled release of carbamazepine" in Hemijska industrija, 64, no. 6 (2010):491-502,
https://doi.org/10.2298/HEMIND101117073P . .

TY  - JOUR
AU  - Milosavljević, Nedeljko
AU  - Milašinović, Nikola
AU  - Filipović, Jovanka M.
AU  - Kalagasidis Krušić, Melina
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1642
AB  - Semi-interpenetrating networks (semi-IPNs) based on chitosan and poly(N-vinyl-2-pyrrolidone) were prepared in order to achieve better mechanical properties. The samples were characterized by FTIR, SEM, DMA analysis and the swelling behavior at different pHs (2.0-8.0). The semi- -IPNs composition was found to have a great impact on the hydrogel structure, mechanical properties, morphology and swelling kinetics. The gels demonstrated substantial change in buffer absorbency with the change of pH, high for acid buffers and lower for pH values above 6 where the swelling was considerably slow. Incorporation of PVP led to better mechanical strength of semi-IPNs while keeping a satisfactory degree of swelling, which makes them suitable for various applications.
AB  - U ovom radu je prikazana sinteza i karakterizacija semi-IPM hitozana sa poli(N-vinil-2-pirolidonom) različitog sastava i stepena umreženja. FTIR analizom je utvrđeno da interakcije između hitozana i PVP-a potiču od amino grupa hitozana i karbonilnih grupa PVP. Utvrđeno je da semi-IPM imaju poroznu strukturu i da bubrenje zavisi od pH okolnog rastvora, koncentracije umreživača i sadržaja PVP-a. Dodatak PVP-a poboljšava mehanička svojstva, ali istovremeno zadržava zadovoljavajući stepen bubrenja što sintetisane semi-IPM čini pogodnim za primenu u raznim oblastima.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Synthesis and characterization of semi-interpenetrating networks of chitosan and poly(N-vinyl-2-pyrrolidone)
T1  - Sinteza i karakterizacija semi-interpenetrirajućih mreža hitozana i poli(N-vinil-2-pirolidona)
EP  - 517
IS  - 6
SP  - 511
VL  - 64
DO  - 10.2298/HEMIND100827057M
ER  - 

@article{
author = "Milosavljević, Nedeljko and Milašinović, Nikola and Filipović, Jovanka M. and Kalagasidis Krušić, Melina",
year = "2010",
abstract = "Semi-interpenetrating networks (semi-IPNs) based on chitosan and poly(N-vinyl-2-pyrrolidone) were prepared in order to achieve better mechanical properties. The samples were characterized by FTIR, SEM, DMA analysis and the swelling behavior at different pHs (2.0-8.0). The semi- -IPNs composition was found to have a great impact on the hydrogel structure, mechanical properties, morphology and swelling kinetics. The gels demonstrated substantial change in buffer absorbency with the change of pH, high for acid buffers and lower for pH values above 6 where the swelling was considerably slow. Incorporation of PVP led to better mechanical strength of semi-IPNs while keeping a satisfactory degree of swelling, which makes them suitable for various applications., U ovom radu je prikazana sinteza i karakterizacija semi-IPM hitozana sa poli(N-vinil-2-pirolidonom) različitog sastava i stepena umreženja. FTIR analizom je utvrđeno da interakcije između hitozana i PVP-a potiču od amino grupa hitozana i karbonilnih grupa PVP. Utvrđeno je da semi-IPM imaju poroznu strukturu i da bubrenje zavisi od pH okolnog rastvora, koncentracije umreživača i sadržaja PVP-a. Dodatak PVP-a poboljšava mehanička svojstva, ali istovremeno zadržava zadovoljavajući stepen bubrenja što sintetisane semi-IPM čini pogodnim za primenu u raznim oblastima.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Synthesis and characterization of semi-interpenetrating networks of chitosan and poly(N-vinyl-2-pyrrolidone), Sinteza i karakterizacija semi-interpenetrirajućih mreža hitozana i poli(N-vinil-2-pirolidona)",
pages = "517-511",
number = "6",
volume = "64",
doi = "10.2298/HEMIND100827057M"
}

Milosavljević, N., Milašinović, N., Filipović, J. M.,& Kalagasidis Krušić, M.. (2010). Synthesis and characterization of semi-interpenetrating networks of chitosan and poly(N-vinyl-2-pyrrolidone). in Hemijska industrija
Association of Chemical Engineers of Serbia., 64(6), 511-517.
https://doi.org/10.2298/HEMIND100827057M

Milosavljević N, Milašinović N, Filipović JM, Kalagasidis Krušić M. Synthesis and characterization of semi-interpenetrating networks of chitosan and poly(N-vinyl-2-pyrrolidone). in Hemijska industrija. 2010;64(6):511-517.
doi:10.2298/HEMIND100827057M .

Milosavljević, Nedeljko, Milašinović, Nikola, Filipović, Jovanka M., Kalagasidis Krušić, Melina, "Synthesis and characterization of semi-interpenetrating networks of chitosan and poly(N-vinyl-2-pyrrolidone)" in Hemijska industrija, 64, no. 6 (2010):511-517,
https://doi.org/10.2298/HEMIND100827057M . .

TY  - JOUR
AU  - Milašinović, Nikola
AU  - Kalagasidis Krušić, Melina
AU  - Knežević-Jugović, Zorica
AU  - Filipović, Jovanka
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1593
AB  - Temperature- and pH-sensitive hydrogels, based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA), were synthesized by free radical crosslinking copolymerization in the presence of lipase from Candida rugosa. The samples were characterized for their sensitivity to the changes of external conditions and the ability to control the release of a hydrophilic model protein, lipase. These hydrogels were highly responsive to temperature and pH, at constant ionic strength. Parameters, such as the crosslinking degree and non-ionic/ionic (NiPAAm/IA) ratio, were found to impact the hydrogel structure, mechanical properties, morphology and swelling kinetics at different pH and temperatures. The hydrogels demonstrated protein loading efficiency as high as 95 wt%. Release studies of a hydrophilic model protein at a physiological temperature of 37 degrees C were performed at different pH values. High dependence of lipase release kinetics on hydrogel structure and the environmental pH was found, showing generally low release rates, lower in acidic media (pH 2.20) and higher at higher pHs (6.80). Lipase activity was retained even after treatment conditions that would provoke denaturation of the enzyme if it was not protected in the gel. The obtained hydrogels were found suitable for releasing therapeutic proteins in a controlled manner at specific sites in gastrointestinal tract.
PB  - Elsevier Science Bv, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Hydrogels of N-isopropylacrylamide copolymers with controlled release of a model protein
EP  - 61
IS  - 1-2
SP  - 53
VL  - 383
DO  - 10.1016/j.ijpharm.2009.09.001
ER  - 

@article{
author = "Milašinović, Nikola and Kalagasidis Krušić, Melina and Knežević-Jugović, Zorica and Filipović, Jovanka",
year = "2010",
abstract = "Temperature- and pH-sensitive hydrogels, based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA), were synthesized by free radical crosslinking copolymerization in the presence of lipase from Candida rugosa. The samples were characterized for their sensitivity to the changes of external conditions and the ability to control the release of a hydrophilic model protein, lipase. These hydrogels were highly responsive to temperature and pH, at constant ionic strength. Parameters, such as the crosslinking degree and non-ionic/ionic (NiPAAm/IA) ratio, were found to impact the hydrogel structure, mechanical properties, morphology and swelling kinetics at different pH and temperatures. The hydrogels demonstrated protein loading efficiency as high as 95 wt%. Release studies of a hydrophilic model protein at a physiological temperature of 37 degrees C were performed at different pH values. High dependence of lipase release kinetics on hydrogel structure and the environmental pH was found, showing generally low release rates, lower in acidic media (pH 2.20) and higher at higher pHs (6.80). Lipase activity was retained even after treatment conditions that would provoke denaturation of the enzyme if it was not protected in the gel. The obtained hydrogels were found suitable for releasing therapeutic proteins in a controlled manner at specific sites in gastrointestinal tract.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Hydrogels of N-isopropylacrylamide copolymers with controlled release of a model protein",
pages = "61-53",
number = "1-2",
volume = "383",
doi = "10.1016/j.ijpharm.2009.09.001"
}

Milašinović, N., Kalagasidis Krušić, M., Knežević-Jugović, Z.,& Filipović, J.. (2010). Hydrogels of N-isopropylacrylamide copolymers with controlled release of a model protein. in International Journal of Pharmaceutics
Elsevier Science Bv, Amsterdam., 383(1-2), 53-61.
https://doi.org/10.1016/j.ijpharm.2009.09.001

Milašinović N, Kalagasidis Krušić M, Knežević-Jugović Z, Filipović J. Hydrogels of N-isopropylacrylamide copolymers with controlled release of a model protein. in International Journal of Pharmaceutics. 2010;383(1-2):53-61.
doi:10.1016/j.ijpharm.2009.09.001 .

Milašinović, Nikola, Kalagasidis Krušić, Melina, Knežević-Jugović, Zorica, Filipović, Jovanka, "Hydrogels of N-isopropylacrylamide copolymers with controlled release of a model protein" in International Journal of Pharmaceutics, 383, no. 1-2 (2010):53-61,
https://doi.org/10.1016/j.ijpharm.2009.09.001 . .

TY  - JOUR
AU  - Milašinović, Nikola
AU  - Milosavljević, Nedeljko
AU  - Filipović, Jovanka
AU  - Knežević-Jugović, Zorica
AU  - Kalagasidis Krušić, Melina
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1586
AB  - Temperature- and pH-sensitive hydrogels based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA) were applied for immobilization of lipase from Candida rugosa (CRL). The hydrogels were synthesized by free radical crosslinking copolymerization in the presence of lipase. Characterization of samples by swelling studies, at pH 2.20 and 6.80 at a temperature of 37 degrees C, scanning electron microscopy (SEM) and Fourier transform infrared analysis (FT-IR) confirmed that the degree of crosslinking, the nonionic/ionic (NiPAAm/IA) ratio and the enzyme content had impacts on the hydrogel structure, mechanical properties, morphology and swelling kinetics. All hydrogels demonstrated protein loading efficiencies as high as 95 wt.%. A specific activity of the immobilized lipase of around 38 IU/g was attained for an enzyme loading of 20.0 wt.%. As a result, improved pH and temperature optima values were obtained for the immobilized systems in relation to those for the free lipase.
PB  - Elsevier Science Bv, Amsterdam
T2  - Reactive & Functional Polymers
T1  - Synthesis, characterization and application of poly(N-isopropylacrylamide-co-itaconic acid) hydrogels as supports for lipase immobilization
EP  - 814
IS  - 10
SP  - 807
VL  - 70
DO  - 10.1016/j.reactfunctpolym.2010.07.017
ER  - 

@article{
author = "Milašinović, Nikola and Milosavljević, Nedeljko and Filipović, Jovanka and Knežević-Jugović, Zorica and Kalagasidis Krušić, Melina",
year = "2010",
abstract = "Temperature- and pH-sensitive hydrogels based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA) were applied for immobilization of lipase from Candida rugosa (CRL). The hydrogels were synthesized by free radical crosslinking copolymerization in the presence of lipase. Characterization of samples by swelling studies, at pH 2.20 and 6.80 at a temperature of 37 degrees C, scanning electron microscopy (SEM) and Fourier transform infrared analysis (FT-IR) confirmed that the degree of crosslinking, the nonionic/ionic (NiPAAm/IA) ratio and the enzyme content had impacts on the hydrogel structure, mechanical properties, morphology and swelling kinetics. All hydrogels demonstrated protein loading efficiencies as high as 95 wt.%. A specific activity of the immobilized lipase of around 38 IU/g was attained for an enzyme loading of 20.0 wt.%. As a result, improved pH and temperature optima values were obtained for the immobilized systems in relation to those for the free lipase.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Reactive & Functional Polymers",
title = "Synthesis, characterization and application of poly(N-isopropylacrylamide-co-itaconic acid) hydrogels as supports for lipase immobilization",
pages = "814-807",
number = "10",
volume = "70",
doi = "10.1016/j.reactfunctpolym.2010.07.017"
}

Milašinović, N., Milosavljević, N., Filipović, J., Knežević-Jugović, Z.,& Kalagasidis Krušić, M.. (2010). Synthesis, characterization and application of poly(N-isopropylacrylamide-co-itaconic acid) hydrogels as supports for lipase immobilization. in Reactive & Functional Polymers
Elsevier Science Bv, Amsterdam., 70(10), 807-814.
https://doi.org/10.1016/j.reactfunctpolym.2010.07.017

Milašinović N, Milosavljević N, Filipović J, Knežević-Jugović Z, Kalagasidis Krušić M. Synthesis, characterization and application of poly(N-isopropylacrylamide-co-itaconic acid) hydrogels as supports for lipase immobilization. in Reactive & Functional Polymers. 2010;70(10):807-814.
doi:10.1016/j.reactfunctpolym.2010.07.017 .

Milašinović, Nikola, Milosavljević, Nedeljko, Filipović, Jovanka, Knežević-Jugović, Zorica, Kalagasidis Krušić, Melina, "Synthesis, characterization and application of poly(N-isopropylacrylamide-co-itaconic acid) hydrogels as supports for lipase immobilization" in Reactive & Functional Polymers, 70, no. 10 (2010):807-814,
https://doi.org/10.1016/j.reactfunctpolym.2010.07.017 . .

TY  - JOUR
AU  - Milosavljević, Nedeljko
AU  - Ristić, Mirjana
AU  - Perić-Grujić, Aleksandra
AU  - Filipović, Jovanka M.
AU  - Štrbac, Svetlana
AU  - Rakočević, Zlatko Lj.
AU  - Kalagasidis Krušić, Melina
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1716
AB  - A hydrogel has been synthesized by ionic crosslinking of chitosan (Ch) with itaconic acid (IA), followed by a free radical polymerization and crosslinking of Ch/IA network by adding methacrylic acid and the crosslinker. The resulting material (Ch/IA/MAA hydrogel) was characterized by spectral (Fourier transform infrared (FTIR)), thermal (thermogravimetric analysis (TGA)) and structural (SEM/EDX and atomic force microscopy (AFM)) analyses. The prepared hydrogel was investigated as potential adsorbent for removal of Cd2+ ions from aqueous solution. The effect of various physico-chemical parameters such as pH, adsorbent dosage, adsorbate concentration and contact time was studied in batch experiments. The results of spectral analyses of Cd-loaded hydrogel have shown that active functional groups are -NH2, -OH and -COOH. SEM/EDX analysis and AFM surface topography and phase images indicated that apart from the adsorption on the surface of the hydrogel, sorption takes place in the bulk, as well. The experimental kinetic and equilibrium data were better fitted by pseudo-second order kinetic model and Langmuir adsorption isotherm. The parameters obtained in thermodynamic studies showed that the adsorption of Cd2+ on Ch/IA/MAA hydrogel was spontaneous and exothermic in nature. Desorption studies were carried out using acid leaching (HNO3) and it has been shown that the regenerated hydrogel can be reused three times without any loss of adsorption capacity. The maximum adsorption of 285.7 mg/g has been obtained at pH 5.5 and the results of adsorption/desorption experiments implies that the Ch/IA/MAA hydrogel may be used as efficient sorbent for removal of Cd2+ ions from aqueous solution.
PB  - Elsevier Science Sa, Lausanne
T2  - Chemical Engineering Journal
T1  - Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution
EP  - 562
IS  - 2
SP  - 554
VL  - 165
DO  - 10.1016/j.cej.2010.09.072
ER  - 

@article{
author = "Milosavljević, Nedeljko and Ristić, Mirjana and Perić-Grujić, Aleksandra and Filipović, Jovanka M. and Štrbac, Svetlana and Rakočević, Zlatko Lj. and Kalagasidis Krušić, Melina",
year = "2010",
abstract = "A hydrogel has been synthesized by ionic crosslinking of chitosan (Ch) with itaconic acid (IA), followed by a free radical polymerization and crosslinking of Ch/IA network by adding methacrylic acid and the crosslinker. The resulting material (Ch/IA/MAA hydrogel) was characterized by spectral (Fourier transform infrared (FTIR)), thermal (thermogravimetric analysis (TGA)) and structural (SEM/EDX and atomic force microscopy (AFM)) analyses. The prepared hydrogel was investigated as potential adsorbent for removal of Cd2+ ions from aqueous solution. The effect of various physico-chemical parameters such as pH, adsorbent dosage, adsorbate concentration and contact time was studied in batch experiments. The results of spectral analyses of Cd-loaded hydrogel have shown that active functional groups are -NH2, -OH and -COOH. SEM/EDX analysis and AFM surface topography and phase images indicated that apart from the adsorption on the surface of the hydrogel, sorption takes place in the bulk, as well. The experimental kinetic and equilibrium data were better fitted by pseudo-second order kinetic model and Langmuir adsorption isotherm. The parameters obtained in thermodynamic studies showed that the adsorption of Cd2+ on Ch/IA/MAA hydrogel was spontaneous and exothermic in nature. Desorption studies were carried out using acid leaching (HNO3) and it has been shown that the regenerated hydrogel can be reused three times without any loss of adsorption capacity. The maximum adsorption of 285.7 mg/g has been obtained at pH 5.5 and the results of adsorption/desorption experiments implies that the Ch/IA/MAA hydrogel may be used as efficient sorbent for removal of Cd2+ ions from aqueous solution.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Chemical Engineering Journal",
title = "Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution",
pages = "562-554",
number = "2",
volume = "165",
doi = "10.1016/j.cej.2010.09.072"
}

Milosavljević, N., Ristić, M., Perić-Grujić, A., Filipović, J. M., Štrbac, S., Rakočević, Z. Lj.,& Kalagasidis Krušić, M.. (2010). Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution. in Chemical Engineering Journal
Elsevier Science Sa, Lausanne., 165(2), 554-562.
https://doi.org/10.1016/j.cej.2010.09.072

Milosavljević N, Ristić M, Perić-Grujić A, Filipović JM, Štrbac S, Rakočević ZL, Kalagasidis Krušić M. Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution. in Chemical Engineering Journal. 2010;165(2):554-562.
doi:10.1016/j.cej.2010.09.072 .

Milosavljević, Nedeljko, Ristić, Mirjana, Perić-Grujić, Aleksandra, Filipović, Jovanka M., Štrbac, Svetlana, Rakočević, Zlatko Lj., Kalagasidis Krušić, Melina, "Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution" in Chemical Engineering Journal, 165, no. 2 (2010):554-562,
https://doi.org/10.1016/j.cej.2010.09.072 . .

TY  - JOUR
AU  - Milosavljević, Nedeljko
AU  - Kljajević, Ljiljana M.
AU  - Popović, Ivanka
AU  - Filipović, Jovanka M.
AU  - Kalagasidis Krušić, Melina
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1696
AB  - Chitosan is a biodegradable, non-toxic, biocompatible polymer convenient for use in drug delivery. In this study, hybrid polymeric networks (HPNs) based on chitosan, itaconic acid and poly(vinyl alcohol) (PVA) were prepared and characterized. Chitosan was dissolved in itaconic acid in order to obtain ionic crosslinking with the dicarboxylic acid. In the second step, this chitosan/itaconic acid network was mixed with PVA and chemically crosslinked with glutaraldehyde. The chitosan/itaconic acid ratio was kept constant, while the concentrations of PVA and glutaraldehyde were varied. All samples were characterized using swelling studies, dynamic mechanical analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction and scanning electron microscopy. The equilibrium degrees of swelling obtained for the HPNs were higher than most of the values reported for chitosan hydrogels obtained by dissolving chitosan in acetic acid or HCI aqueous solutions. This method of synthesis also resulted in hydrogels with better mechanical properties and thermal stability. By changing the PVA content and the degree of crosslinking, it is possible to finely tune the properties of the HPNs, which could make them suitable as potential matrices in controlled drug delivery.
PB  - Wiley, Hoboken
T2  - Polymer International
T1  - Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength
EP  - 694
IS  - 5
SP  - 686
VL  - 59
DO  - 10.1002/pi.2756
ER  - 

@article{
author = "Milosavljević, Nedeljko and Kljajević, Ljiljana M. and Popović, Ivanka and Filipović, Jovanka M. and Kalagasidis Krušić, Melina",
year = "2010",
abstract = "Chitosan is a biodegradable, non-toxic, biocompatible polymer convenient for use in drug delivery. In this study, hybrid polymeric networks (HPNs) based on chitosan, itaconic acid and poly(vinyl alcohol) (PVA) were prepared and characterized. Chitosan was dissolved in itaconic acid in order to obtain ionic crosslinking with the dicarboxylic acid. In the second step, this chitosan/itaconic acid network was mixed with PVA and chemically crosslinked with glutaraldehyde. The chitosan/itaconic acid ratio was kept constant, while the concentrations of PVA and glutaraldehyde were varied. All samples were characterized using swelling studies, dynamic mechanical analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction and scanning electron microscopy. The equilibrium degrees of swelling obtained for the HPNs were higher than most of the values reported for chitosan hydrogels obtained by dissolving chitosan in acetic acid or HCI aqueous solutions. This method of synthesis also resulted in hydrogels with better mechanical properties and thermal stability. By changing the PVA content and the degree of crosslinking, it is possible to finely tune the properties of the HPNs, which could make them suitable as potential matrices in controlled drug delivery.",
publisher = "Wiley, Hoboken",
journal = "Polymer International",
title = "Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength",
pages = "694-686",
number = "5",
volume = "59",
doi = "10.1002/pi.2756"
}

Milosavljević, N., Kljajević, L. M., Popović, I., Filipović, J. M.,& Kalagasidis Krušić, M.. (2010). Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength. in Polymer International
Wiley, Hoboken., 59(5), 686-694.
https://doi.org/10.1002/pi.2756

Milosavljević N, Kljajević LM, Popović I, Filipović JM, Kalagasidis Krušić M. Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength. in Polymer International. 2010;59(5):686-694.
doi:10.1002/pi.2756 .

Milosavljević, Nedeljko, Kljajević, Ljiljana M., Popović, Ivanka, Filipović, Jovanka M., Kalagasidis Krušić, Melina, "Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength" in Polymer International, 59, no. 5 (2010):686-694,
https://doi.org/10.1002/pi.2756 . .

TY  - JOUR
AU  - Kalagasidis Krušić, Melina
AU  - Veličković, Sava
AU  - Griffiths, Peter C.
AU  - Filipović, Jovanka
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1682
AB  - The aim of the work reported here was to investigate temperature- and pH-sensitive hydrogels of N-isopropylacrylamide (NIPAM) and itaconic acid (IA) and their semi-interpenetrating polymer networks (semi-IPNs) with varying contents of poly(ethylene glycol) (PEG). The stimuli responsiveness, swelling behaviour and mechanical properties of the hydrogels and semi-IPNs were studied in order to investigate the effect of various amounts of PEG. Pulsed-gradient spin-echo NMR experiments were carried out to investigate the diffusion process. The pH sensitivity increased with an increasing amount of PEG in the semi-IPNs, while the overall rate of water uptake was diffusion-controlled (n  lt  0.5). For certain PEG contents (5 and 10 wt%), the semi-IPNs exhibited better mechanical properties than the poly(NIPAM-co-IA) copolymer. The calculated values of the self-diffusion coefficients of water indicated facilitated diffusion of water through the system with increased amounts of PEG, while the self-diffusion coefficients of a model compound, metoprolol tartrate, showed no significant dependence on the amount of PEG. According to the results obtained and compared to results reported in the literature, the investigated semi-IPNs may have potential applications in the controlled release of macromolecular active agents such as proteins and peptides.
PB  - Wiley, Hoboken
T2  - Polymer International
T1  - Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol)
EP  - 262
IS  - 2
SP  - 256
VL  - 59
DO  - 10.1002/pi.2717
ER  - 

@article{
author = "Kalagasidis Krušić, Melina and Veličković, Sava and Griffiths, Peter C. and Filipović, Jovanka",
year = "2010",
abstract = "The aim of the work reported here was to investigate temperature- and pH-sensitive hydrogels of N-isopropylacrylamide (NIPAM) and itaconic acid (IA) and their semi-interpenetrating polymer networks (semi-IPNs) with varying contents of poly(ethylene glycol) (PEG). The stimuli responsiveness, swelling behaviour and mechanical properties of the hydrogels and semi-IPNs were studied in order to investigate the effect of various amounts of PEG. Pulsed-gradient spin-echo NMR experiments were carried out to investigate the diffusion process. The pH sensitivity increased with an increasing amount of PEG in the semi-IPNs, while the overall rate of water uptake was diffusion-controlled (n  lt  0.5). For certain PEG contents (5 and 10 wt%), the semi-IPNs exhibited better mechanical properties than the poly(NIPAM-co-IA) copolymer. The calculated values of the self-diffusion coefficients of water indicated facilitated diffusion of water through the system with increased amounts of PEG, while the self-diffusion coefficients of a model compound, metoprolol tartrate, showed no significant dependence on the amount of PEG. According to the results obtained and compared to results reported in the literature, the investigated semi-IPNs may have potential applications in the controlled release of macromolecular active agents such as proteins and peptides.",
publisher = "Wiley, Hoboken",
journal = "Polymer International",
title = "Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol)",
pages = "262-256",
number = "2",
volume = "59",
doi = "10.1002/pi.2717"
}

Kalagasidis Krušić, M., Veličković, S., Griffiths, P. C.,& Filipović, J.. (2010). Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol). in Polymer International
Wiley, Hoboken., 59(2), 256-262.
https://doi.org/10.1002/pi.2717

Kalagasidis Krušić M, Veličković S, Griffiths PC, Filipović J. Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol). in Polymer International. 2010;59(2):256-262.
doi:10.1002/pi.2717 .

Kalagasidis Krušić, Melina, Veličković, Sava, Griffiths, Peter C., Filipović, Jovanka, "Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol)" in Polymer International, 59, no. 2 (2010):256-262,
https://doi.org/10.1002/pi.2717 . .

TY  - JOUR
AU  - Vučković, Marija V.
AU  - Antić, Vesna
AU  - Govedarica, Milutin
AU  - Đonlagić, Jasna
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5615
AB  - A series of thermoplastic elastomers based on ethylene oxide- poly(dimethylsiloxane)-ethylene oxide (EO-PDMS-EO), as the soft segment, and poly(butylene terephthalate) (PBT), as the hard segment, were synthesized by catalyzed two-step, melt transesterification reaction of dimethyl terephthalate (DMT) with 1, 4-butanediol (BD) and α, ω-dihydroxy-(EO-PDMS-EO). Copolymers with a content of hard PBT segments between 40 and 90 mass % and a constant length of the soft EO-PDMS-EO segments were prepared. The siloxane prepolymer with hydrophilic terminal EO units was used to improve the miscibility between the polar comonomers, DMT and BD, and the nonpolar PDMS. The molecular structure and composition of the copolymers were determined by 1HNMR spectroscopy, whereas the effectiveness of the incorporation of α, ω-dihydroxy-(EO-PDMS-EO) into the copolymer chains was verified by chloroform extraction. The effects of the structure and composition of the copolymers on the melting temperatures and the degree of crystallinity, as well as on the thermal degradation stability and some rheological properties, were studied. It was demonstrated that the degree of crystallinity, the melting and crystallization temperatures of the copolymers increased with increasing mass fraction of the PBT segments. The thermal stability of the copolymers was lower than that of PBT homopolymer, because of the presence of thermoliable ether bonds in the soft segments.
PB  - Wiley
T2  - Journal of Applied Polymer Science
T1  - Synthesis and characterization of copolymers based on poly(butylene terephthalate) and ethylene oxide-poly(dimethylsiloxane)-ethylene oxide
EP  - 3216
IS  - 6
SP  - 3205
VL  - 115
DO  - 10.1002/app.31416
ER  - 

@article{
author = "Vučković, Marija V. and Antić, Vesna and Govedarica, Milutin and Đonlagić, Jasna",
year = "2010",
abstract = "A series of thermoplastic elastomers based on ethylene oxide- poly(dimethylsiloxane)-ethylene oxide (EO-PDMS-EO), as the soft segment, and poly(butylene terephthalate) (PBT), as the hard segment, were synthesized by catalyzed two-step, melt transesterification reaction of dimethyl terephthalate (DMT) with 1, 4-butanediol (BD) and α, ω-dihydroxy-(EO-PDMS-EO). Copolymers with a content of hard PBT segments between 40 and 90 mass % and a constant length of the soft EO-PDMS-EO segments were prepared. The siloxane prepolymer with hydrophilic terminal EO units was used to improve the miscibility between the polar comonomers, DMT and BD, and the nonpolar PDMS. The molecular structure and composition of the copolymers were determined by 1HNMR spectroscopy, whereas the effectiveness of the incorporation of α, ω-dihydroxy-(EO-PDMS-EO) into the copolymer chains was verified by chloroform extraction. The effects of the structure and composition of the copolymers on the melting temperatures and the degree of crystallinity, as well as on the thermal degradation stability and some rheological properties, were studied. It was demonstrated that the degree of crystallinity, the melting and crystallization temperatures of the copolymers increased with increasing mass fraction of the PBT segments. The thermal stability of the copolymers was lower than that of PBT homopolymer, because of the presence of thermoliable ether bonds in the soft segments.",
publisher = "Wiley",
journal = "Journal of Applied Polymer Science",
title = "Synthesis and characterization of copolymers based on poly(butylene terephthalate) and ethylene oxide-poly(dimethylsiloxane)-ethylene oxide",
pages = "3216-3205",
number = "6",
volume = "115",
doi = "10.1002/app.31416"
}

Vučković, M. V., Antić, V., Govedarica, M.,& Đonlagić, J.. (2010). Synthesis and characterization of copolymers based on poly(butylene terephthalate) and ethylene oxide-poly(dimethylsiloxane)-ethylene oxide. in Journal of Applied Polymer Science
Wiley., 115(6), 3205-3216.
https://doi.org/10.1002/app.31416

Vučković MV, Antić V, Govedarica M, Đonlagić J. Synthesis and characterization of copolymers based on poly(butylene terephthalate) and ethylene oxide-poly(dimethylsiloxane)-ethylene oxide. in Journal of Applied Polymer Science. 2010;115(6):3205-3216.
doi:10.1002/app.31416 .

Vučković, Marija V., Antić, Vesna, Govedarica, Milutin, Đonlagić, Jasna, "Synthesis and characterization of copolymers based on poly(butylene terephthalate) and ethylene oxide-poly(dimethylsiloxane)-ethylene oxide" in Journal of Applied Polymer Science, 115, no. 6 (2010):3205-3216,
https://doi.org/10.1002/app.31416 . .

TY  - JOUR
AU  - Antić, Vesna
AU  - Pergal, Marija
AU  - Antić, Mališa
AU  - Đonlagić, Jasna
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5613
AB  - Two series of thermoplastic elastomers (TPES), based on poly(dimethylsiloxane) (PDMS) as the soft segment and poly(butylene terephthalate) (PBT) as the hard segment, were analyzed by dynamic mechanical spectroscopy. In the first TPES series the lengths of both hard and soft segments were varied while the mass ratio of the hard to soft segments was nearly constant (about 60 mass%). In the second series, the mass ratio of hard and soft segments was varied in the range from 60/40 to 40/60, with a constant length of soft PDMS segments. The influence of the structure and composition of TPESs on the rheological properties, such as complex dynamic viscosity, μ*, the storage, G', and loss, G', shear modulus as well as the microphase separation transition temperature, TMST, was examined. The obtained results showed that the storage modulus of the TPESs increased in a rubbery plateau region with increase in degree of crystallinity. The rheological measurements of TPESs also showed that a microphase reorganization occurred during the melting process. The microphase separation transition temperatures were in the range from 220 to 234°C. In the isotropic molten state, the complex dynamic viscosity increased with increasing both the content and length of hard PBT segments.
AB  - Dve serije termoplastičnih elastomera (TPES) na bazi poli(dimetilsiloksana) kao mekog segmenta i poli(butilentereftalata) kao tvrdog segmenta su analizirane dinamičko-mehaničkom spektroskopijom. U prvoj TPES seriji varirane su dužine tvrdih i mekih segmenata dok je njihov maseni odnos bio skoro konstantan (oko 60 mas%). U drugoj seriji, odnos tvrdih i mekih segmenata je variran u opsegu od 60/40 do 40/60, dok je dužina mekih PDMS segmenata bila konstantna. Ispitan je uticaj strukture i sastava TPES kopolimera na reološka svojstva, kao što su kompleksni dinamički viskozitet, μ*, moduli sačuvane, G', i izgubljene energije, G', i temperatura mikrofaznog razdvajanja, TMST. Dobijeni rezultati su pokazali da su uzorci sa većim stepenom kristaliničnosti imali i veće module sačuvane energije u gumolikom platou. Reološka merenja su takođe pokazala da svi TPES uzorci ispoljavaju mikrofaznu reorganizaciju u procesu topljenja. Temperature mikrofaznog razdvajanja su bile u opsegu od 220 do 234°C. U izotropskom rastopu, kompleksni dinamički viskoziteti su rasli sa povećanjem sadržaja i dužine PBT segmenata.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Rheological behaviour of thermoplastic poly(ester-siloxane)s
T1  - Reološko ponašanje termoplastičnih poli(estar-siloksana)
EP  - 545
IS  - 6
SP  - 537
VL  - 64
DO  - 10.2298/HEMIND101015067A
ER  - 

@article{
author = "Antić, Vesna and Pergal, Marija and Antić, Mališa and Đonlagić, Jasna",
year = "2010",
abstract = "Two series of thermoplastic elastomers (TPES), based on poly(dimethylsiloxane) (PDMS) as the soft segment and poly(butylene terephthalate) (PBT) as the hard segment, were analyzed by dynamic mechanical spectroscopy. In the first TPES series the lengths of both hard and soft segments were varied while the mass ratio of the hard to soft segments was nearly constant (about 60 mass%). In the second series, the mass ratio of hard and soft segments was varied in the range from 60/40 to 40/60, with a constant length of soft PDMS segments. The influence of the structure and composition of TPESs on the rheological properties, such as complex dynamic viscosity, μ*, the storage, G', and loss, G', shear modulus as well as the microphase separation transition temperature, TMST, was examined. The obtained results showed that the storage modulus of the TPESs increased in a rubbery plateau region with increase in degree of crystallinity. The rheological measurements of TPESs also showed that a microphase reorganization occurred during the melting process. The microphase separation transition temperatures were in the range from 220 to 234°C. In the isotropic molten state, the complex dynamic viscosity increased with increasing both the content and length of hard PBT segments., Dve serije termoplastičnih elastomera (TPES) na bazi poli(dimetilsiloksana) kao mekog segmenta i poli(butilentereftalata) kao tvrdog segmenta su analizirane dinamičko-mehaničkom spektroskopijom. U prvoj TPES seriji varirane su dužine tvrdih i mekih segmenata dok je njihov maseni odnos bio skoro konstantan (oko 60 mas%). U drugoj seriji, odnos tvrdih i mekih segmenata je variran u opsegu od 60/40 do 40/60, dok je dužina mekih PDMS segmenata bila konstantna. Ispitan je uticaj strukture i sastava TPES kopolimera na reološka svojstva, kao što su kompleksni dinamički viskozitet, μ*, moduli sačuvane, G', i izgubljene energije, G', i temperatura mikrofaznog razdvajanja, TMST. Dobijeni rezultati su pokazali da su uzorci sa većim stepenom kristaliničnosti imali i veće module sačuvane energije u gumolikom platou. Reološka merenja su takođe pokazala da svi TPES uzorci ispoljavaju mikrofaznu reorganizaciju u procesu topljenja. Temperature mikrofaznog razdvajanja su bile u opsegu od 220 do 234°C. U izotropskom rastopu, kompleksni dinamički viskoziteti su rasli sa povećanjem sadržaja i dužine PBT segmenata.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Rheological behaviour of thermoplastic poly(ester-siloxane)s, Reološko ponašanje termoplastičnih poli(estar-siloksana)",
pages = "545-537",
number = "6",
volume = "64",
doi = "10.2298/HEMIND101015067A"
}

Antić, V., Pergal, M., Antić, M.,& Đonlagić, J.. (2010). Rheological behaviour of thermoplastic poly(ester-siloxane)s. in Hemijska industrija
Association of Chemical Engineers of Serbia., 64(6), 537-545.
https://doi.org/10.2298/HEMIND101015067A

Antić V, Pergal M, Antić M, Đonlagić J. Rheological behaviour of thermoplastic poly(ester-siloxane)s. in Hemijska industrija. 2010;64(6):537-545.
doi:10.2298/HEMIND101015067A .

Antić, Vesna, Pergal, Marija, Antić, Mališa, Đonlagić, Jasna, "Rheological behaviour of thermoplastic poly(ester-siloxane)s" in Hemijska industrija, 64, no. 6 (2010):537-545,
https://doi.org/10.2298/HEMIND101015067A . .

TY  - JOUR
AU  - Milovanović, Miloš B.
AU  - Avramović, Milena
AU  - Katsikas, Lynne
AU  - Popović, Ivanka
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1594
AB  - The general literature procedure for the preparation of the reversible addition-fragmentation chain transfer (RAFT) agent 2-(2-cyanopropyl)-dithiobenzoate (CPDB) was modified by omitting the recrystallisation of the intermediate di(thiobenzoyl)disulphide. The yield of the CPDB in the simplified synthesis was increased four times compared to the standard one. The behaviour of the CPDB obtained by the modified procedure and by the standard one in the polymerisation of methyl methacrylate was investigated. The CPDB synthesized by the simplified procedure showed itself to be a good RAFT agent, giving excellent control over the polymerisation of methyl methacrylate and it behaved in the same manner as the CPDB prepared by the literature method. The obtained poly(methyl methacrylate) had a narrow molecular weight distibution (PD = 1.1).
AB  - Standardni postupak sinteze 2-(2-cijanopropil)-ditiobenzoata (CPDB) agensa iz literature za RAFT polimerizaciju, odnosno za reverzibilnu adiciono-fragmentacionu transfer polimerizaciju, je modifikovan izostavljanjem prekristalizacije međuproizvoda bis-(tiobenzoil)disulfida. Prinos CPDB-a sintetisanog pojednostavljenim postupkom je četiri puta veći u odnosu na prinos CPDB-a sintetisanog standardnim postupkom. Ispitano je ponašanje CPDB-a dobijenog modifikovanim i onog dobijenog standardnim postupkom u polimerizaciji metil metakrilata. CPDB dobijen pojednostavljenim postupkom pokazao se kao dobar RAFT agens koji uspostavlja odličnu kontrolu polimerizacije metil metakrilata i koji se ponaša na isti način kao CPDB sintetisan standardnim postupkom. Dobijeni poli(metil metakrilat) ima usku širinu raspodele molskih masa (PD = 1.1).
PB  - Serbian Chemical Society, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Simplification of the synthesis of the reversible addition-fragmentation chain transfer agent 2-(2-cyanopropyl)-dithiobenzoate
T1  - Pojednostavljenje postupka sinteze raft agensa 2-(2-cijanopropil)-ditiobenzoata
EP  - 1719
IS  - 12
SP  - 1711
VL  - 75
UR  - https://hdl.handle.net/21.15107/rcub_technorep_1594
ER  - 

@article{
author = "Milovanović, Miloš B. and Avramović, Milena and Katsikas, Lynne and Popović, Ivanka",
year = "2010",
abstract = "The general literature procedure for the preparation of the reversible addition-fragmentation chain transfer (RAFT) agent 2-(2-cyanopropyl)-dithiobenzoate (CPDB) was modified by omitting the recrystallisation of the intermediate di(thiobenzoyl)disulphide. The yield of the CPDB in the simplified synthesis was increased four times compared to the standard one. The behaviour of the CPDB obtained by the modified procedure and by the standard one in the polymerisation of methyl methacrylate was investigated. The CPDB synthesized by the simplified procedure showed itself to be a good RAFT agent, giving excellent control over the polymerisation of methyl methacrylate and it behaved in the same manner as the CPDB prepared by the literature method. The obtained poly(methyl methacrylate) had a narrow molecular weight distibution (PD = 1.1)., Standardni postupak sinteze 2-(2-cijanopropil)-ditiobenzoata (CPDB) agensa iz literature za RAFT polimerizaciju, odnosno za reverzibilnu adiciono-fragmentacionu transfer polimerizaciju, je modifikovan izostavljanjem prekristalizacije međuproizvoda bis-(tiobenzoil)disulfida. Prinos CPDB-a sintetisanog pojednostavljenim postupkom je četiri puta veći u odnosu na prinos CPDB-a sintetisanog standardnim postupkom. Ispitano je ponašanje CPDB-a dobijenog modifikovanim i onog dobijenog standardnim postupkom u polimerizaciji metil metakrilata. CPDB dobijen pojednostavljenim postupkom pokazao se kao dobar RAFT agens koji uspostavlja odličnu kontrolu polimerizacije metil metakrilata i koji se ponaša na isti način kao CPDB sintetisan standardnim postupkom. Dobijeni poli(metil metakrilat) ima usku širinu raspodele molskih masa (PD = 1.1).",
publisher = "Serbian Chemical Society, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Simplification of the synthesis of the reversible addition-fragmentation chain transfer agent 2-(2-cyanopropyl)-dithiobenzoate, Pojednostavljenje postupka sinteze raft agensa 2-(2-cijanopropil)-ditiobenzoata",
pages = "1719-1711",
number = "12",
volume = "75",
url = "https://hdl.handle.net/21.15107/rcub_technorep_1594"
}

Milovanović, M. B., Avramović, M., Katsikas, L.,& Popović, I.. (2010). Simplification of the synthesis of the reversible addition-fragmentation chain transfer agent 2-(2-cyanopropyl)-dithiobenzoate. in Journal of the Serbian Chemical Society
Serbian Chemical Society, Belgrade., 75(12), 1711-1719.
https://hdl.handle.net/21.15107/rcub_technorep_1594

Milovanović MB, Avramović M, Katsikas L, Popović I. Simplification of the synthesis of the reversible addition-fragmentation chain transfer agent 2-(2-cyanopropyl)-dithiobenzoate. in Journal of the Serbian Chemical Society. 2010;75(12):1711-1719.
https://hdl.handle.net/21.15107/rcub_technorep_1594 .

Milovanović, Miloš B., Avramović, Milena, Katsikas, Lynne, Popović, Ivanka, "Simplification of the synthesis of the reversible addition-fragmentation chain transfer agent 2-(2-cyanopropyl)-dithiobenzoate" in Journal of the Serbian Chemical Society, 75, no. 12 (2010):1711-1719,
https://hdl.handle.net/21.15107/rcub_technorep_1594 .

TY  - JOUR
AU  - Džunuzović, Enis
AU  - Marinović-Cincović, Milena
AU  - Džunuzović, Jasna
AU  - Jeremić, Katarina B.
AU  - Nedeljković, Jovan
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1668
AB  - Incorporation of inorganic nanoparticles can significantly affect the properties of the polymer matrix. The properties of polymer nanocomposites depend on the type of incorporated nanoparticles, their size and shape, their concentration, and interactions with the polymer matrix. Homogeneity of polymer nanocomposites is influenced very much by the preparation method. In this study, TiO2 nanoparticles surface modified with 6-palmitate ascorbic acid (6-PAA) were encapsulated in poly(methyl methacrylate) (PMMA) by in situ radical polymerization of methyl methacrylate initiated by 2,2'-azobisisobutyronitrile (AIBN). The surface modification of the TiO2 nanoparticles was achieved by the formation of a charge transfer complex between TiO2 nanoparticles and 6-palmitate ascorbic acid. The radical polymerization of MMA in the presence of TiO2-PAA nanoparticles was conducted in solution (PMMA/TiO2-PAA-R), in bulk (PMMA/TiO2-PAA-M) or in suspension (PMMA/TiO2-PAA-S). The main purpose of this study was to investigate the influence of the preparation method on the molar masses and thermal properties of PMMA/TiO2-PAA nanocomposite. It was obtained that molar masses of PMMA extracted from the composites had smaller values compared to molar masses of pure PMMA synthesized in the same manner, which indicated that TiO2-PAA nanoparticles affected the reaction of termination. Thermal properties were investigated by DSC and TGA. The values of glass transition temperature, Tg, were influenced by the way the radical polymerization was conducted, even in the case of the pure PMMA. The Tg of composite samples was always smaller than the value of the corresponding PMMA sample and the smallest value was obtained for PMMA/TiO2-PAA-M since they contained the largest amount of low molar mass residue. The TGA results showed that thermal and thermooxidative stability of polymer composites obtained in solution and in suspension was better than for the pure PMMA obtained in the same way.
AB  - Predmet ovog rada je dobijanje i karakterizacija nanokompozita kod kojih polimernu matricu čini poli(metil metakrilat) (PMMA), a kao neorgansko punilo nanočestice titan-dioksida. Svi uzorci nanokompozita dobijeni su in situ polimerizacijom preko slobodnih radikala metil metakrilata (MMA) u prisustvu čestica punila. Površinska modifikacija korišćenih nanočestica titan-dioksida izvršena je palmitatom askorbinske kiseline. Uzorci nanokompozita su pripremljeni polimerizacijom metil metakrilata u rastvoru, u masi i suspenzionom polimerizacijom. Određene su vrednosti molarne mase PMMA ekstrahovanog iz kompozitnih uzoraka i dobijeno je da su one manje od vrednosti molarne mase čistog PMMA dobijenog na isti način, na osnovu čega se može zaključiti da nanočestice TiO2-PAA prisutne u toku polimerizacije u sva tri slučaja utiču na reakcije terminacije i dovode do smanjenja molarne mase PMMA matrice. Diferencijalnom skenirajućom kalorimetrijom i termogravimetrijskom analizom utvrđeno je i da način sinteze polimerne matrice i koncentracija čestica punila utiču na termička svojstva dobijenih polimernih nanokompozita.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Influence of the way of synthesis of poly(methyl methacrylate) in the presence of surface modified TiO2 nanoparticles on the properties of obtained nanocomposites
T1  - Uticaj načina sinteze poli(metil metakrilata) u prisustvu površinski modifikovanih TiO2 nanočestica na svojstva dobijenih nanokompozita
EP  - 489
IS  - 6
SP  - 473
VL  - 64
DO  - 10.2298/HEMIND100923059D
ER  - 

@article{
author = "Džunuzović, Enis and Marinović-Cincović, Milena and Džunuzović, Jasna and Jeremić, Katarina B. and Nedeljković, Jovan",
year = "2010",
abstract = "Incorporation of inorganic nanoparticles can significantly affect the properties of the polymer matrix. The properties of polymer nanocomposites depend on the type of incorporated nanoparticles, their size and shape, their concentration, and interactions with the polymer matrix. Homogeneity of polymer nanocomposites is influenced very much by the preparation method. In this study, TiO2 nanoparticles surface modified with 6-palmitate ascorbic acid (6-PAA) were encapsulated in poly(methyl methacrylate) (PMMA) by in situ radical polymerization of methyl methacrylate initiated by 2,2'-azobisisobutyronitrile (AIBN). The surface modification of the TiO2 nanoparticles was achieved by the formation of a charge transfer complex between TiO2 nanoparticles and 6-palmitate ascorbic acid. The radical polymerization of MMA in the presence of TiO2-PAA nanoparticles was conducted in solution (PMMA/TiO2-PAA-R), in bulk (PMMA/TiO2-PAA-M) or in suspension (PMMA/TiO2-PAA-S). The main purpose of this study was to investigate the influence of the preparation method on the molar masses and thermal properties of PMMA/TiO2-PAA nanocomposite. It was obtained that molar masses of PMMA extracted from the composites had smaller values compared to molar masses of pure PMMA synthesized in the same manner, which indicated that TiO2-PAA nanoparticles affected the reaction of termination. Thermal properties were investigated by DSC and TGA. The values of glass transition temperature, Tg, were influenced by the way the radical polymerization was conducted, even in the case of the pure PMMA. The Tg of composite samples was always smaller than the value of the corresponding PMMA sample and the smallest value was obtained for PMMA/TiO2-PAA-M since they contained the largest amount of low molar mass residue. The TGA results showed that thermal and thermooxidative stability of polymer composites obtained in solution and in suspension was better than for the pure PMMA obtained in the same way., Predmet ovog rada je dobijanje i karakterizacija nanokompozita kod kojih polimernu matricu čini poli(metil metakrilat) (PMMA), a kao neorgansko punilo nanočestice titan-dioksida. Svi uzorci nanokompozita dobijeni su in situ polimerizacijom preko slobodnih radikala metil metakrilata (MMA) u prisustvu čestica punila. Površinska modifikacija korišćenih nanočestica titan-dioksida izvršena je palmitatom askorbinske kiseline. Uzorci nanokompozita su pripremljeni polimerizacijom metil metakrilata u rastvoru, u masi i suspenzionom polimerizacijom. Određene su vrednosti molarne mase PMMA ekstrahovanog iz kompozitnih uzoraka i dobijeno je da su one manje od vrednosti molarne mase čistog PMMA dobijenog na isti način, na osnovu čega se može zaključiti da nanočestice TiO2-PAA prisutne u toku polimerizacije u sva tri slučaja utiču na reakcije terminacije i dovode do smanjenja molarne mase PMMA matrice. Diferencijalnom skenirajućom kalorimetrijom i termogravimetrijskom analizom utvrđeno je i da način sinteze polimerne matrice i koncentracija čestica punila utiču na termička svojstva dobijenih polimernih nanokompozita.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Influence of the way of synthesis of poly(methyl methacrylate) in the presence of surface modified TiO2 nanoparticles on the properties of obtained nanocomposites, Uticaj načina sinteze poli(metil metakrilata) u prisustvu površinski modifikovanih TiO2 nanočestica na svojstva dobijenih nanokompozita",
pages = "489-473",
number = "6",
volume = "64",
doi = "10.2298/HEMIND100923059D"
}

Džunuzović, E., Marinović-Cincović, M., Džunuzović, J., Jeremić, K. B.,& Nedeljković, J.. (2010). Influence of the way of synthesis of poly(methyl methacrylate) in the presence of surface modified TiO2 nanoparticles on the properties of obtained nanocomposites. in Hemijska industrija
Association of Chemical Engineers of Serbia., 64(6), 473-489.
https://doi.org/10.2298/HEMIND100923059D

Džunuzović E, Marinović-Cincović M, Džunuzović J, Jeremić KB, Nedeljković J. Influence of the way of synthesis of poly(methyl methacrylate) in the presence of surface modified TiO2 nanoparticles on the properties of obtained nanocomposites. in Hemijska industrija. 2010;64(6):473-489.
doi:10.2298/HEMIND100923059D .

Džunuzović, Enis, Marinović-Cincović, Milena, Džunuzović, Jasna, Jeremić, Katarina B., Nedeljković, Jovan, "Influence of the way of synthesis of poly(methyl methacrylate) in the presence of surface modified TiO2 nanoparticles on the properties of obtained nanocomposites" in Hemijska industrija, 64, no. 6 (2010):473-489,
https://doi.org/10.2298/HEMIND100923059D . .

TY  - JOUR
AU  - Marinović, Sanja
AU  - Popović, Ivanka
AU  - Dunjić, Branko
AU  - Tasić, S.
AU  - Božić, B.
AU  - Jovanović, Dušan M.
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1583
AB  - The aim of this study was to investigate the influence of different components of interpenetrating polymer networks (IPNs) on their behavior in dual curing automotive applications. Dual curing is one of possible ways to obtain fast curing, scratch resistant coatings for use in OEM and car refinish applications. Dual curing systems, upon hardening, represent interpenetrating networks (IPNs) [1]. IPN's were obtained using novel acrylate-terminated hyperbranched polyester with high functionality and compared to classical 2-pack polyurethane clear coat. In our previous manuscript [1] we investigated the influence of the acrylated hyperbranched polyester (HBP(A)) content in dual curing systems. In this article we studied the influence of the reactive diluent on dual curing compositions. To this end, we have chosen IPN with 50/50 weigth ratio of polyurethane (PU) and polyacrylic (PA) component. In order to determine more clearly the role of the HBP(A) in one IPN HBP(A) was changed with hexane diol diacrylate (HDDA), keeping the same ratio with EHA. The IPNs were characterized by dynamic-mechanical analysis (DMA), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The mechanical properties of the IPNs were also investigated. The IPN with HDDA as reactive diluent, had the best performance. IPN with H BP(A) had the highest glass transition temperature Tg and the highest crosslink density, but it did not have the highest hardness.
PB  - Elsevier Science Sa, Lausanne
T2  - Progress in Organic Coatings
T1  - The influence of different components on interpenetrating polymer network's (IPN's) characteristics as automotive top coats
EP  - 298
IS  - 4
SP  - 293
VL  - 68
DO  - 10.1016/j.porgcoat.2010.03.010
ER  - 

@article{
author = "Marinović, Sanja and Popović, Ivanka and Dunjić, Branko and Tasić, S. and Božić, B. and Jovanović, Dušan M.",
year = "2010",
abstract = "The aim of this study was to investigate the influence of different components of interpenetrating polymer networks (IPNs) on their behavior in dual curing automotive applications. Dual curing is one of possible ways to obtain fast curing, scratch resistant coatings for use in OEM and car refinish applications. Dual curing systems, upon hardening, represent interpenetrating networks (IPNs) [1]. IPN's were obtained using novel acrylate-terminated hyperbranched polyester with high functionality and compared to classical 2-pack polyurethane clear coat. In our previous manuscript [1] we investigated the influence of the acrylated hyperbranched polyester (HBP(A)) content in dual curing systems. In this article we studied the influence of the reactive diluent on dual curing compositions. To this end, we have chosen IPN with 50/50 weigth ratio of polyurethane (PU) and polyacrylic (PA) component. In order to determine more clearly the role of the HBP(A) in one IPN HBP(A) was changed with hexane diol diacrylate (HDDA), keeping the same ratio with EHA. The IPNs were characterized by dynamic-mechanical analysis (DMA), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The mechanical properties of the IPNs were also investigated. The IPN with HDDA as reactive diluent, had the best performance. IPN with H BP(A) had the highest glass transition temperature Tg and the highest crosslink density, but it did not have the highest hardness.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Progress in Organic Coatings",
title = "The influence of different components on interpenetrating polymer network's (IPN's) characteristics as automotive top coats",
pages = "298-293",
number = "4",
volume = "68",
doi = "10.1016/j.porgcoat.2010.03.010"
}

Marinović, S., Popović, I., Dunjić, B., Tasić, S., Božić, B.,& Jovanović, D. M.. (2010). The influence of different components on interpenetrating polymer network's (IPN's) characteristics as automotive top coats. in Progress in Organic Coatings
Elsevier Science Sa, Lausanne., 68(4), 293-298.
https://doi.org/10.1016/j.porgcoat.2010.03.010

Marinović S, Popović I, Dunjić B, Tasić S, Božić B, Jovanović DM. The influence of different components on interpenetrating polymer network's (IPN's) characteristics as automotive top coats. in Progress in Organic Coatings. 2010;68(4):293-298.
doi:10.1016/j.porgcoat.2010.03.010 .

Marinović, Sanja, Popović, Ivanka, Dunjić, Branko, Tasić, S., Božić, B., Jovanović, Dušan M., "The influence of different components on interpenetrating polymer network's (IPN's) characteristics as automotive top coats" in Progress in Organic Coatings, 68, no. 4 (2010):293-298,
https://doi.org/10.1016/j.porgcoat.2010.03.010 . .

TY  - JOUR
AU  - Stojanović, Željko
AU  - Jeremić, Katarina
AU  - Jovanović, Slobodan
AU  - Nierling, Wolfgang
AU  - Lechner, Manfred Dieter
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5622
AB  - Uzorci karboksimetil skroba pripremljeni su reakcijom eterifikacije u heterogenom
medijumu. Tri uzorka su pripremljena iz kukuruznog skroba a tri iz skroba iz krompira. Stepen supstitucije sintetisanih uzoraka je iznosio od 0,40 do 1,10. Uzorci su
ispitivani metodama statičkog i dinamičkog rasipanja svetlosti i viskozimetrijom razblaženih rastvora u 0,10 M rastvoru NaCl kao rastvaraču na 25 °C. Određene su
vrednosti molarnih masa, MW, poluprečnika rotacije, Rg, hidrodinamičkog poluprečnika, Rh, i graničnog viskozitetnog broja, [η]. Utvrđeno je da su uzorci bez obzira na
tip skroba i stepen supstitucije međusobno slični. Fraktalne dimenzije, df, iznose 2,380
(Rg – MW) i 2,406 (Rη – MW), dok parametar ρ iznosi 1,195. Vrednost fraktalne dimenzije i parametra ρ karakteristične su vrednosti za ponašanje razgranatih klastera u
termodinamički dobrim rastvaračima.
AB  - Carboxymethyl starch samples were prepared by etherification in heterogeneous media. Three samples were prepared from corn starch and three samples from potato starch. Degree of substitution of prepared samples ranged from 0.40 to 1.10. The samples were investigated by static and dynamic light scattering and viscosity of diluted solution in 0.10 M NaCl as solvent at 25 °C. The values of molar mass, MW, radius of gyration, Rg, hydrodynamic radius, Rh, and limited viscosity number, [η] were determined. It was found that the samples are similar to each other regardless of the type of starch and the degree of substitution. Fractal dimension, d f, was equal to 2.380 (Rg - MW) and 2.406 (Rη - MW), while parameter ρ was 1.195. The values of fractal dimension and parameter ρ are characteristic values for the behavior of branched clusters in thermodynamically good solvents.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Oblik i veličina makromolekula karboksimetil skroba u razblaženim rastvorima
T1  - The shape and size of macromolecules of carboxymethyl starch in diluted solutions
EP  - 602
IS  - 6
SP  - 593
VL  - 63
DO  - 10.2298/HEMIND0906593S
ER  - 

@article{
author = "Stojanović, Željko and Jeremić, Katarina and Jovanović, Slobodan and Nierling, Wolfgang and Lechner, Manfred Dieter",
year = "2009",
abstract = "Uzorci karboksimetil skroba pripremljeni su reakcijom eterifikacije u heterogenom
medijumu. Tri uzorka su pripremljena iz kukuruznog skroba a tri iz skroba iz krompira. Stepen supstitucije sintetisanih uzoraka je iznosio od 0,40 do 1,10. Uzorci su
ispitivani metodama statičkog i dinamičkog rasipanja svetlosti i viskozimetrijom razblaženih rastvora u 0,10 M rastvoru NaCl kao rastvaraču na 25 °C. Određene su
vrednosti molarnih masa, MW, poluprečnika rotacije, Rg, hidrodinamičkog poluprečnika, Rh, i graničnog viskozitetnog broja, [η]. Utvrđeno je da su uzorci bez obzira na
tip skroba i stepen supstitucije međusobno slični. Fraktalne dimenzije, df, iznose 2,380
(Rg – MW) i 2,406 (Rη – MW), dok parametar ρ iznosi 1,195. Vrednost fraktalne dimenzije i parametra ρ karakteristične su vrednosti za ponašanje razgranatih klastera u
termodinamički dobrim rastvaračima., Carboxymethyl starch samples were prepared by etherification in heterogeneous media. Three samples were prepared from corn starch and three samples from potato starch. Degree of substitution of prepared samples ranged from 0.40 to 1.10. The samples were investigated by static and dynamic light scattering and viscosity of diluted solution in 0.10 M NaCl as solvent at 25 °C. The values of molar mass, MW, radius of gyration, Rg, hydrodynamic radius, Rh, and limited viscosity number, [η] were determined. It was found that the samples are similar to each other regardless of the type of starch and the degree of substitution. Fractal dimension, d f, was equal to 2.380 (Rg - MW) and 2.406 (Rη - MW), while parameter ρ was 1.195. The values of fractal dimension and parameter ρ are characteristic values for the behavior of branched clusters in thermodynamically good solvents.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Oblik i veličina makromolekula karboksimetil skroba u razblaženim rastvorima, The shape and size of macromolecules of carboxymethyl starch in diluted solutions",
pages = "602-593",
number = "6",
volume = "63",
doi = "10.2298/HEMIND0906593S"
}

Stojanović, Ž., Jeremić, K., Jovanović, S., Nierling, W.,& Lechner, M. D.. (2009). Oblik i veličina makromolekula karboksimetil skroba u razblaženim rastvorima. in Hemijska industrija
Association of Chemical Engineers of Serbia., 63(6), 593-602.
https://doi.org/10.2298/HEMIND0906593S

Stojanović Ž, Jeremić K, Jovanović S, Nierling W, Lechner MD. Oblik i veličina makromolekula karboksimetil skroba u razblaženim rastvorima. in Hemijska industrija. 2009;63(6):593-602.
doi:10.2298/HEMIND0906593S .

Stojanović, Željko, Jeremić, Katarina, Jovanović, Slobodan, Nierling, Wolfgang, Lechner, Manfred Dieter, "Oblik i veličina makromolekula karboksimetil skroba u razblaženim rastvorima" in Hemijska industrija, 63, no. 6 (2009):593-602,
https://doi.org/10.2298/HEMIND0906593S . .

TY  - JOUR
AU  - Panić, Vesna
AU  - Jovanović, J.
AU  - Adnađević, Borivoj
AU  - Veličković, Jovan S.
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1441
AB  - Hydrogels based on crosslinked polymethacrylic acid were synthesized via free-radical polymerization in aqueous solution, using N,N'-methylene bisacrylamide as a crosslinking agent and 2,2'-azobis-[2-(2-imidazolin-2-yl)propane] dihydrochloride as an initiator. The influence of the reaction parameters (the neutralization degree of methacrylic acid and the initial monomer concentration) on the equilibrium swelling degree, the swelling kinetic parameters and the basic structural properties of xerogels was investigated. The change of synthesis parameters leads to the change of the basic structural parameters of xerogel, as well as the equilibrium swelling degree and the initial swelling rate of the hydrogels. It is found that there are power form relationships between the equilibrium swelling degree, the initial swelling rate and the structural xerogel's properties and the change of the neutralization degree of monomer, i.e. the monomer concentration. The examined correlations proved that the crosslinking density is the crucial parameter which determines all the other investigated structural and swelling parameters.
PB  - Maik Nauka/Interperiodica/Springer, New York
T2  - Russian Journal of Physical Chemistry A
T1  - Effect of synthesis parameters on polymethacrylic acid xerogel structures and equilibrium swelling
EP  - 1562
IS  - 9
SP  - 1558
VL  - 83
DO  - 10.1134/S003602440909026X
ER  - 

@article{
author = "Panić, Vesna and Jovanović, J. and Adnađević, Borivoj and Veličković, Jovan S.",
year = "2009",
abstract = "Hydrogels based on crosslinked polymethacrylic acid were synthesized via free-radical polymerization in aqueous solution, using N,N'-methylene bisacrylamide as a crosslinking agent and 2,2'-azobis-[2-(2-imidazolin-2-yl)propane] dihydrochloride as an initiator. The influence of the reaction parameters (the neutralization degree of methacrylic acid and the initial monomer concentration) on the equilibrium swelling degree, the swelling kinetic parameters and the basic structural properties of xerogels was investigated. The change of synthesis parameters leads to the change of the basic structural parameters of xerogel, as well as the equilibrium swelling degree and the initial swelling rate of the hydrogels. It is found that there are power form relationships between the equilibrium swelling degree, the initial swelling rate and the structural xerogel's properties and the change of the neutralization degree of monomer, i.e. the monomer concentration. The examined correlations proved that the crosslinking density is the crucial parameter which determines all the other investigated structural and swelling parameters.",
publisher = "Maik Nauka/Interperiodica/Springer, New York",
journal = "Russian Journal of Physical Chemistry A",
title = "Effect of synthesis parameters on polymethacrylic acid xerogel structures and equilibrium swelling",
pages = "1562-1558",
number = "9",
volume = "83",
doi = "10.1134/S003602440909026X"
}

Panić, V., Jovanović, J., Adnađević, B.,& Veličković, J. S.. (2009). Effect of synthesis parameters on polymethacrylic acid xerogel structures and equilibrium swelling. in Russian Journal of Physical Chemistry A
Maik Nauka/Interperiodica/Springer, New York., 83(9), 1558-1562.
https://doi.org/10.1134/S003602440909026X

Panić V, Jovanović J, Adnađević B, Veličković JS. Effect of synthesis parameters on polymethacrylic acid xerogel structures and equilibrium swelling. in Russian Journal of Physical Chemistry A. 2009;83(9):1558-1562.
doi:10.1134/S003602440909026X .

Panić, Vesna, Jovanović, J., Adnađević, Borivoj, Veličković, Jovan S., "Effect of synthesis parameters on polymethacrylic acid xerogel structures and equilibrium swelling" in Russian Journal of Physical Chemistry A, 83, no. 9 (2009):1558-1562,
https://doi.org/10.1134/S003602440909026X . .

TY  - JOUR
AU  - Žugić, Dragana
AU  - Spasojević, Pavle
AU  - Petrović, Zoran
AU  - Đonlagić, Jasna
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1513
AB  - Three series of novel semi-interpenetrating polymer networks, based on crosslinked poly(N-isopropylacrylamide), PNIPA, and different amounts of the linear poly(N-vinylpyrrolidone), PVP, were synthesized to improve the mechanical properties and thermal response of PNIPA gels. The effect of the incorporation of the linear PVP into the temperature responsive networks on the temperature-induced transition, swelling/deswelling behavior, and mechanical properties Was Studied. Polymer networks with four different crosslinking densities were prepared with varying molar ratios (25/1 to 100/1) of the monomer (N-isopropylacrylamide) to the crosslinker (N,N'-methylenebisacrylamide). The hydrogels were characterized by determination of the equilibrium degree of swelling, the dynamic shear modulus and the effective crosslinking density, as well as tensile strength and elongation at break. Furthermore, the deswelling kinetics of the hydrogels was studied by measuring their water retention capacity. The inclusion of the linear hydrophilic PVP in the PNIPA networks increased the equilibrium degree of swelling. The tensile strength of the semi-interpenetrating networks (SIPNs) reinforced with linear PVP was higher than that of the PNIPA networks. The elongation at break of these SIPNs varied between 22%, and 55%, which are 22 - 41% larger than those for pure PNIPA networks.
PB  - Wiley, Hoboken
T2  - Journal of Applied Polymer Science
T1  - Semi-Interpenetrating Networks Based on Poly(N-isopropyl acrylamide) and Poly(N-vinylpyrrolidone)
EP  - 1603
IS  - 3
SP  - 1593
VL  - 113
DO  - 10.1002/app.30075
ER  - 

@article{
author = "Žugić, Dragana and Spasojević, Pavle and Petrović, Zoran and Đonlagić, Jasna",
year = "2009",
abstract = "Three series of novel semi-interpenetrating polymer networks, based on crosslinked poly(N-isopropylacrylamide), PNIPA, and different amounts of the linear poly(N-vinylpyrrolidone), PVP, were synthesized to improve the mechanical properties and thermal response of PNIPA gels. The effect of the incorporation of the linear PVP into the temperature responsive networks on the temperature-induced transition, swelling/deswelling behavior, and mechanical properties Was Studied. Polymer networks with four different crosslinking densities were prepared with varying molar ratios (25/1 to 100/1) of the monomer (N-isopropylacrylamide) to the crosslinker (N,N'-methylenebisacrylamide). The hydrogels were characterized by determination of the equilibrium degree of swelling, the dynamic shear modulus and the effective crosslinking density, as well as tensile strength and elongation at break. Furthermore, the deswelling kinetics of the hydrogels was studied by measuring their water retention capacity. The inclusion of the linear hydrophilic PVP in the PNIPA networks increased the equilibrium degree of swelling. The tensile strength of the semi-interpenetrating networks (SIPNs) reinforced with linear PVP was higher than that of the PNIPA networks. The elongation at break of these SIPNs varied between 22%, and 55%, which are 22 - 41% larger than those for pure PNIPA networks.",
publisher = "Wiley, Hoboken",
journal = "Journal of Applied Polymer Science",
title = "Semi-Interpenetrating Networks Based on Poly(N-isopropyl acrylamide) and Poly(N-vinylpyrrolidone)",
pages = "1603-1593",
number = "3",
volume = "113",
doi = "10.1002/app.30075"
}

Žugić, D., Spasojević, P., Petrović, Z.,& Đonlagić, J.. (2009). Semi-Interpenetrating Networks Based on Poly(N-isopropyl acrylamide) and Poly(N-vinylpyrrolidone). in Journal of Applied Polymer Science
Wiley, Hoboken., 113(3), 1593-1603.
https://doi.org/10.1002/app.30075

Žugić D, Spasojević P, Petrović Z, Đonlagić J. Semi-Interpenetrating Networks Based on Poly(N-isopropyl acrylamide) and Poly(N-vinylpyrrolidone). in Journal of Applied Polymer Science. 2009;113(3):1593-1603.
doi:10.1002/app.30075 .

Žugić, Dragana, Spasojević, Pavle, Petrović, Zoran, Đonlagić, Jasna, "Semi-Interpenetrating Networks Based on Poly(N-isopropyl acrylamide) and Poly(N-vinylpyrrolidone)" in Journal of Applied Polymer Science, 113, no. 3 (2009):1593-1603,
https://doi.org/10.1002/app.30075 . .

TY  - JOUR
AU  - Kalagasidis Krušić, Melina
AU  - Ilić, Marija
AU  - Filipović, Jovanka
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1506
AB  - Copolymer hydrogels of N-isopropylacrylamide and itaconic acid (IA), crosslinked with N,N'-methylenebisacrylamide, were prepared by radical copolymerization. These hydrogels were investigated with regard to their composition to find materials with satisfactory swelling and drug release properties. A paracetamol is used as a model drug to investigate drug release profile of the hydrogels. It was found that the investigated hydrogels exhibited pH- and temperature-dependent swelling behaviour with restricted swelling and lower equilibrium degree of swelling at lower pH values and temperatures above the LCST value of PNIPAM (around 34 A degrees C). The diffusion exponent for paracetamol release indicate that the mechanism of paracetamol release are governed by Fickian diffusion, while in all release media initial diffusion coefficient was lower than late time diffusion coefficient. Furthermore, the paracetamol release rate depends on the hydrogel degree of swelling and it increased in the first stage of diffusion process, whereas was no significant difference thereafter. The presence of the IA moieties incorporated into the network weakened the shear resistance of the hydrogels. In order to calculate the pore size the characteristic ratio for PNIPAM, C (n) = 11.7, was calculated. Based on the pore size, the investigated hydrogels can be regarded as microporous. According to the obtained results swelling behaviour, mechanical properties, drug-loading capacity and the drug release rate could be controlled by hydrogel composition and crosslinking density, which is important for application of the investigated hydrogels as drug delivery systems.
PB  - Springer, New York
T2  - Polymer Bulletin
T1  - Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels
EP  - 211
IS  - 2
SP  - 197
VL  - 63
DO  - 10.1007/s00289-009-0086-3
ER  - 

@article{
author = "Kalagasidis Krušić, Melina and Ilić, Marija and Filipović, Jovanka",
year = "2009",
abstract = "Copolymer hydrogels of N-isopropylacrylamide and itaconic acid (IA), crosslinked with N,N'-methylenebisacrylamide, were prepared by radical copolymerization. These hydrogels were investigated with regard to their composition to find materials with satisfactory swelling and drug release properties. A paracetamol is used as a model drug to investigate drug release profile of the hydrogels. It was found that the investigated hydrogels exhibited pH- and temperature-dependent swelling behaviour with restricted swelling and lower equilibrium degree of swelling at lower pH values and temperatures above the LCST value of PNIPAM (around 34 A degrees C). The diffusion exponent for paracetamol release indicate that the mechanism of paracetamol release are governed by Fickian diffusion, while in all release media initial diffusion coefficient was lower than late time diffusion coefficient. Furthermore, the paracetamol release rate depends on the hydrogel degree of swelling and it increased in the first stage of diffusion process, whereas was no significant difference thereafter. The presence of the IA moieties incorporated into the network weakened the shear resistance of the hydrogels. In order to calculate the pore size the characteristic ratio for PNIPAM, C (n) = 11.7, was calculated. Based on the pore size, the investigated hydrogels can be regarded as microporous. According to the obtained results swelling behaviour, mechanical properties, drug-loading capacity and the drug release rate could be controlled by hydrogel composition and crosslinking density, which is important for application of the investigated hydrogels as drug delivery systems.",
publisher = "Springer, New York",
journal = "Polymer Bulletin",
title = "Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels",
pages = "211-197",
number = "2",
volume = "63",
doi = "10.1007/s00289-009-0086-3"
}

Kalagasidis Krušić, M., Ilić, M.,& Filipović, J.. (2009). Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels. in Polymer Bulletin
Springer, New York., 63(2), 197-211.
https://doi.org/10.1007/s00289-009-0086-3

Kalagasidis Krušić M, Ilić M, Filipović J. Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels. in Polymer Bulletin. 2009;63(2):197-211.
doi:10.1007/s00289-009-0086-3 .

Kalagasidis Krušić, Melina, Ilić, Marija, Filipović, Jovanka, "Swelling behaviour and paracetamol release from poly(N-isopropylacrylamide-itaconic acid) hydrogels" in Polymer Bulletin, 63, no. 2 (2009):197-211,
https://doi.org/10.1007/s00289-009-0086-3 . .

TY  - JOUR
AU  - Džunuzović, Enis
AU  - Vodnik, Vesna
AU  - Jeremić, Katarina B.
AU  - Nedeljković, Jovan
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1477
AB  - TiO2 nanoparticles. surface modified with 6-palmitate ascorbic acid, were incorporated in polystyrene (PS) by in situ bulk radical polymerization of styrene using 2,2'-azobisisobutyronitrile as initiator. The molar mass and polydispersity of synthesized samples were estimated by gel permeation chromatography. The influence of surface modified TiO2 nanoparticles on the thermal properties of PS matrix was examined using thermogravimetry and differential scanning calorimetry. Molar mass and polydispersity of PS were not influenced by the presence of the TiO2 nanoparticles. On the other hand, PS/TiO2 nanocomposites have higher glass transition temperature and better thermal and thermooxidative stability than the pure PS.
PB  - Elsevier Science Bv, Amsterdam
T2  - Materials Letters
T1  - Thermal properties of PS/TiO2 nanocomposites obtained by in situ bulk radical polymerization of styrene
EP  - 910
IS  - 11
SP  - 908
VL  - 63
DO  - 10.1016/j.matlet.2009.01.039
ER  - 

@article{
author = "Džunuzović, Enis and Vodnik, Vesna and Jeremić, Katarina B. and Nedeljković, Jovan",
year = "2009",
abstract = "TiO2 nanoparticles. surface modified with 6-palmitate ascorbic acid, were incorporated in polystyrene (PS) by in situ bulk radical polymerization of styrene using 2,2'-azobisisobutyronitrile as initiator. The molar mass and polydispersity of synthesized samples were estimated by gel permeation chromatography. The influence of surface modified TiO2 nanoparticles on the thermal properties of PS matrix was examined using thermogravimetry and differential scanning calorimetry. Molar mass and polydispersity of PS were not influenced by the presence of the TiO2 nanoparticles. On the other hand, PS/TiO2 nanocomposites have higher glass transition temperature and better thermal and thermooxidative stability than the pure PS.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Materials Letters",
title = "Thermal properties of PS/TiO2 nanocomposites obtained by in situ bulk radical polymerization of styrene",
pages = "910-908",
number = "11",
volume = "63",
doi = "10.1016/j.matlet.2009.01.039"
}

Džunuzović, E., Vodnik, V., Jeremić, K. B.,& Nedeljković, J.. (2009). Thermal properties of PS/TiO2 nanocomposites obtained by in situ bulk radical polymerization of styrene. in Materials Letters
Elsevier Science Bv, Amsterdam., 63(11), 908-910.
https://doi.org/10.1016/j.matlet.2009.01.039

Džunuzović E, Vodnik V, Jeremić KB, Nedeljković J. Thermal properties of PS/TiO2 nanocomposites obtained by in situ bulk radical polymerization of styrene. in Materials Letters. 2009;63(11):908-910.
doi:10.1016/j.matlet.2009.01.039 .

Džunuzović, Enis, Vodnik, Vesna, Jeremić, Katarina B., Nedeljković, Jovan, "Thermal properties of PS/TiO2 nanocomposites obtained by in situ bulk radical polymerization of styrene" in Materials Letters, 63, no. 11 (2009):908-910,
https://doi.org/10.1016/j.matlet.2009.01.039 . .

TY  - JOUR
AU  - Džunuzović, Enis
AU  - Marinović-Cincović, Milena
AU  - Jeremić, Katarina B.
AU  - Nedeljković, Jovan
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1521
AB  - Poly(methyl methacrylate)/alpha-Fe2O3 Composites were prepared by in situ bulk radical polymerization of methyl methacrylate in the presence of the cubic alpha-Fe2O3 particles using 2,2'-azobisisobutyronitrile as initiator. The cubic a alpha-Fe2O3 particles were synthesized by forced hydrolysis of FeCl3 and characterized by X-ray diffraction analysis and transmission electron microscopy. The molar masses and molar mass distribution of synthesized PMMA samples were determined by gel permeation chromatography. The influence of alpha-Fe2O3 filler particles on the thermal properties of the PMMA matrix was investigated using thermogravimetry and differential scanning calorimetry. The molar mass and polydispersity of PMMA extracted from composite samples were not influenced by cubic alpha-Fe2O3 particles. The obtained composites have better thermal and thermooxiclative stability than pure PMMA. On the other hand, the values of the glass transition temperature of composite samples were identical to the glass transition temperature of pure PMMA.
PB  - Elsevier Sci Ltd, Oxford
T2  - Polymer Degradation and Stability
T1  - Influence of cubic alpha-Fe2O3 particles on the thermal stability of poly(methyl methacrylate) synthesized by in situ bulk polymerization
EP  - 704
IS  - 4
SP  - 701
VL  - 94
DO  - 10.1016/j.polymdegradstab.2008.12.018
ER  - 

@article{
author = "Džunuzović, Enis and Marinović-Cincović, Milena and Jeremić, Katarina B. and Nedeljković, Jovan",
year = "2009",
abstract = "Poly(methyl methacrylate)/alpha-Fe2O3 Composites were prepared by in situ bulk radical polymerization of methyl methacrylate in the presence of the cubic alpha-Fe2O3 particles using 2,2'-azobisisobutyronitrile as initiator. The cubic a alpha-Fe2O3 particles were synthesized by forced hydrolysis of FeCl3 and characterized by X-ray diffraction analysis and transmission electron microscopy. The molar masses and molar mass distribution of synthesized PMMA samples were determined by gel permeation chromatography. The influence of alpha-Fe2O3 filler particles on the thermal properties of the PMMA matrix was investigated using thermogravimetry and differential scanning calorimetry. The molar mass and polydispersity of PMMA extracted from composite samples were not influenced by cubic alpha-Fe2O3 particles. The obtained composites have better thermal and thermooxiclative stability than pure PMMA. On the other hand, the values of the glass transition temperature of composite samples were identical to the glass transition temperature of pure PMMA.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Polymer Degradation and Stability",
title = "Influence of cubic alpha-Fe2O3 particles on the thermal stability of poly(methyl methacrylate) synthesized by in situ bulk polymerization",
pages = "704-701",
number = "4",
volume = "94",
doi = "10.1016/j.polymdegradstab.2008.12.018"
}

Džunuzović, E., Marinović-Cincović, M., Jeremić, K. B.,& Nedeljković, J.. (2009). Influence of cubic alpha-Fe2O3 particles on the thermal stability of poly(methyl methacrylate) synthesized by in situ bulk polymerization. in Polymer Degradation and Stability
Elsevier Sci Ltd, Oxford., 94(4), 701-704.
https://doi.org/10.1016/j.polymdegradstab.2008.12.018

Džunuzović E, Marinović-Cincović M, Jeremić KB, Nedeljković J. Influence of cubic alpha-Fe2O3 particles on the thermal stability of poly(methyl methacrylate) synthesized by in situ bulk polymerization. in Polymer Degradation and Stability. 2009;94(4):701-704.
doi:10.1016/j.polymdegradstab.2008.12.018 .

Džunuzović, Enis, Marinović-Cincović, Milena, Jeremić, Katarina B., Nedeljković, Jovan, "Influence of cubic alpha-Fe2O3 particles on the thermal stability of poly(methyl methacrylate) synthesized by in situ bulk polymerization" in Polymer Degradation and Stability, 94, no. 4 (2009):701-704,
https://doi.org/10.1016/j.polymdegradstab.2008.12.018 . .

TY  - JOUR
AU  - Džunuzović, Enis
AU  - Marinović-Cincović, Milena
AU  - Vuković, J.
AU  - Jeremić, Katarina B.
AU  - Nedeljković, Jovan
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1524
AB  - The surface of anatase TiO2 nanoparticles, obtained by the controlled hydrolysis of titanium tetrachloride, was modified by 6-palmitate ascorbic acid. The surface modified TiO2 nanoparticles were dispersed in methyl methacrylate and mixed with a appropriate amount of poly(methyl methacrylate) to obtain a syrup. The nano-composite sheets were made by bulk polymerization of the syrup in a glass sandwich cell using 2,2'-azobisisobutyronitrile as initiator. The molar masses and molar mass distributions of synthesized poly(methyl methacrylate) samples were determined by gel permeation chromatography. The content of unreacted double bonds in synthesized samples was determined by H-1 NMR spectroscopy. The influence of TiO2 nanoparticles on the thermal stability of the poly(methyl methacrylate) matrix was investigated using thermogravimetric analysis and differential scanning calorimetry. The synthesized samples of poly(methyl methacrylate) have different molar mass and polydispersity depending on the content of the surface modified TiO2 nanoparticles. The values of glass transition temperature of so prepared nanocomposite samples were lower than for pure poly(methyl methacrylate), while the glass transition temperature of samples preheated in inert atmosphere was very similar to the glass transition temperature of pure poly(methyl methacrylate). The thermal stability of nanocomposite samples in nitrogen and air was different from thermal stability of pure poly(methyl methacrylate). POLYM. COMPOS., 30:737-742, 2009.
PB  - Wiley-Blackwell, Malden
T2  - Polymer Composites
T1  - Thermal Properties of PMMA/TiO2 Nanocomposites Prepared by In-Situ Bulk Polymerization
EP  - 742
IS  - 6
SP  - 737
VL  - 30
DO  - 10.1002/pc.20606
ER  - 

@article{
author = "Džunuzović, Enis and Marinović-Cincović, Milena and Vuković, J. and Jeremić, Katarina B. and Nedeljković, Jovan",
year = "2009",
abstract = "The surface of anatase TiO2 nanoparticles, obtained by the controlled hydrolysis of titanium tetrachloride, was modified by 6-palmitate ascorbic acid. The surface modified TiO2 nanoparticles were dispersed in methyl methacrylate and mixed with a appropriate amount of poly(methyl methacrylate) to obtain a syrup. The nano-composite sheets were made by bulk polymerization of the syrup in a glass sandwich cell using 2,2'-azobisisobutyronitrile as initiator. The molar masses and molar mass distributions of synthesized poly(methyl methacrylate) samples were determined by gel permeation chromatography. The content of unreacted double bonds in synthesized samples was determined by H-1 NMR spectroscopy. The influence of TiO2 nanoparticles on the thermal stability of the poly(methyl methacrylate) matrix was investigated using thermogravimetric analysis and differential scanning calorimetry. The synthesized samples of poly(methyl methacrylate) have different molar mass and polydispersity depending on the content of the surface modified TiO2 nanoparticles. The values of glass transition temperature of so prepared nanocomposite samples were lower than for pure poly(methyl methacrylate), while the glass transition temperature of samples preheated in inert atmosphere was very similar to the glass transition temperature of pure poly(methyl methacrylate). The thermal stability of nanocomposite samples in nitrogen and air was different from thermal stability of pure poly(methyl methacrylate). POLYM. COMPOS., 30:737-742, 2009.",
publisher = "Wiley-Blackwell, Malden",
journal = "Polymer Composites",
title = "Thermal Properties of PMMA/TiO2 Nanocomposites Prepared by In-Situ Bulk Polymerization",
pages = "742-737",
number = "6",
volume = "30",
doi = "10.1002/pc.20606"
}

Džunuzović, E., Marinović-Cincović, M., Vuković, J., Jeremić, K. B.,& Nedeljković, J.. (2009). Thermal Properties of PMMA/TiO2 Nanocomposites Prepared by In-Situ Bulk Polymerization. in Polymer Composites
Wiley-Blackwell, Malden., 30(6), 737-742.
https://doi.org/10.1002/pc.20606

Džunuzović E, Marinović-Cincović M, Vuković J, Jeremić KB, Nedeljković J. Thermal Properties of PMMA/TiO2 Nanocomposites Prepared by In-Situ Bulk Polymerization. in Polymer Composites. 2009;30(6):737-742.
doi:10.1002/pc.20606 .

Džunuzović, Enis, Marinović-Cincović, Milena, Vuković, J., Jeremić, Katarina B., Nedeljković, Jovan, "Thermal Properties of PMMA/TiO2 Nanocomposites Prepared by In-Situ Bulk Polymerization" in Polymer Composites, 30, no. 6 (2009):737-742,
https://doi.org/10.1002/pc.20606 . .

TY  - JOUR
AU  - Milašinović, Nikola
AU  - Kalagasidis Krušić, Melina
AU  - Knežević-Jugović, Zorica
AU  - Filipović, Jovanka M.
PY  - 2008
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1330
AB  - The application of lipases as catalysts in chemical reactions has been deterred by the high cost of isolation and purification of enzymes, the instability of their structure when they are isolated from their natural environment, contamination of products with residual protein, their sensitivity to process conditions, etc. These problems could be overcome using immobilized lipases. Immobilization is achieved by fixing enzymes to or within solid supports and as a result a heterogeneous system is obtained. The present paper reports on the immobilization of Candida rugosa lipase in hydrogels based on N-isopropylacrylamide and itaconic acid. Immobilization of lipase is carried out by two different methods. In the first method, lipase is added to the reaction mixture before polymerization and crosslinking (in situ polymerization), while in the second method the synthetized hydrogels are immersed in lipase solution and left to rich the equilibrium swelling. The specific activities of the immobilized lipase were determined in both cases and compared. The amount of the immobilized lipase is higher if the immobilization is carried out by immersing hydrogel in lipase solution. It was observed that in both cases lipase activity increases with an increase of the itaconic acid content up to 10 wt% and thereafter decreases. From the measurements of shear storage moduli (G') it was concluded that the increase of the itaconic acid content decreases the mechanical properties of the hydrogels. SEM analysis confirmed the highly porous structure of hydrogels. It was found that greater pores were achieved when the enzyme was immobilized by in situ polymerization. When the enzyme was immobilized by in situ polymerization the itaconic acid content had not great effect on the mass of the immobilized enzyme, except for the 100/0 sample. On the contrary, for the samples where the enzyme was immobilized by swelling, the increase of the itaconic acid content increases the mass of the immobilized enzyme. Concerning the activity of the immobilized lipase, the swelling degree and mechanical properties of the investigated hydrogels, the best results were performed by the 95/5 hydrogel sample.
AB  - U radu je ispitana imobilizacija lipaze iz Candida rugosa u pH- i temperaturno-osetljive hidrogelove N-izopropilakrilamida i itakonske kiseline različitog sastava i pod različitim uslovima. Aktivnost imobilisanog enzima je ispitana standardnom metodom na emulziji maslinovog ulja. Praćena je kinetika otpuštanja enzima iz hidrogelova. Utvrđeno je da na aktivnost imobilisane lipaze utiče način imobilizacije i sastav hidrogelova. Značajan uticaj ima i temperatura na kojoj se izvodi imobilizacija, tako da se sa promenom temperature menja i masa imobilisane lipaze kao i njena specifična aktivnost. Ispitana su mehanička svojstva i morfologija sintetisanih hidrogelova.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - The influence of composition of poly(n-isopropylacrylamide-co-itaconic acid) hydrogel on immobilized Candida rugosa lipase activity
T1  - Uticaj sastava poli(n-izopropilakrilamida-ko-itakonska kiselina) hidrogela na aktivnost imobilisane lipaze iz Candida rugosa
EP  - 344
IS  - 6
SP  - 339
VL  - 62
DO  - 10.2298/HEMIND0806339M
ER  - 

@article{
author = "Milašinović, Nikola and Kalagasidis Krušić, Melina and Knežević-Jugović, Zorica and Filipović, Jovanka M.",
year = "2008",
abstract = "The application of lipases as catalysts in chemical reactions has been deterred by the high cost of isolation and purification of enzymes, the instability of their structure when they are isolated from their natural environment, contamination of products with residual protein, their sensitivity to process conditions, etc. These problems could be overcome using immobilized lipases. Immobilization is achieved by fixing enzymes to or within solid supports and as a result a heterogeneous system is obtained. The present paper reports on the immobilization of Candida rugosa lipase in hydrogels based on N-isopropylacrylamide and itaconic acid. Immobilization of lipase is carried out by two different methods. In the first method, lipase is added to the reaction mixture before polymerization and crosslinking (in situ polymerization), while in the second method the synthetized hydrogels are immersed in lipase solution and left to rich the equilibrium swelling. The specific activities of the immobilized lipase were determined in both cases and compared. The amount of the immobilized lipase is higher if the immobilization is carried out by immersing hydrogel in lipase solution. It was observed that in both cases lipase activity increases with an increase of the itaconic acid content up to 10 wt% and thereafter decreases. From the measurements of shear storage moduli (G') it was concluded that the increase of the itaconic acid content decreases the mechanical properties of the hydrogels. SEM analysis confirmed the highly porous structure of hydrogels. It was found that greater pores were achieved when the enzyme was immobilized by in situ polymerization. When the enzyme was immobilized by in situ polymerization the itaconic acid content had not great effect on the mass of the immobilized enzyme, except for the 100/0 sample. On the contrary, for the samples where the enzyme was immobilized by swelling, the increase of the itaconic acid content increases the mass of the immobilized enzyme. Concerning the activity of the immobilized lipase, the swelling degree and mechanical properties of the investigated hydrogels, the best results were performed by the 95/5 hydrogel sample., U radu je ispitana imobilizacija lipaze iz Candida rugosa u pH- i temperaturno-osetljive hidrogelove N-izopropilakrilamida i itakonske kiseline različitog sastava i pod različitim uslovima. Aktivnost imobilisanog enzima je ispitana standardnom metodom na emulziji maslinovog ulja. Praćena je kinetika otpuštanja enzima iz hidrogelova. Utvrđeno je da na aktivnost imobilisane lipaze utiče način imobilizacije i sastav hidrogelova. Značajan uticaj ima i temperatura na kojoj se izvodi imobilizacija, tako da se sa promenom temperature menja i masa imobilisane lipaze kao i njena specifična aktivnost. Ispitana su mehanička svojstva i morfologija sintetisanih hidrogelova.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "The influence of composition of poly(n-isopropylacrylamide-co-itaconic acid) hydrogel on immobilized Candida rugosa lipase activity, Uticaj sastava poli(n-izopropilakrilamida-ko-itakonska kiselina) hidrogela na aktivnost imobilisane lipaze iz Candida rugosa",
pages = "344-339",
number = "6",
volume = "62",
doi = "10.2298/HEMIND0806339M"
}

Milašinović, N., Kalagasidis Krušić, M., Knežević-Jugović, Z.,& Filipović, J. M.. (2008). The influence of composition of poly(n-isopropylacrylamide-co-itaconic acid) hydrogel on immobilized Candida rugosa lipase activity. in Hemijska industrija
Association of Chemical Engineers of Serbia., 62(6), 339-344.
https://doi.org/10.2298/HEMIND0806339M

Milašinović N, Kalagasidis Krušić M, Knežević-Jugović Z, Filipović JM. The influence of composition of poly(n-isopropylacrylamide-co-itaconic acid) hydrogel on immobilized Candida rugosa lipase activity. in Hemijska industrija. 2008;62(6):339-344.
doi:10.2298/HEMIND0806339M .

Milašinović, Nikola, Kalagasidis Krušić, Melina, Knežević-Jugović, Zorica, Filipović, Jovanka M., "The influence of composition of poly(n-isopropylacrylamide-co-itaconic acid) hydrogel on immobilized Candida rugosa lipase activity" in Hemijska industrija, 62, no. 6 (2008):339-344,
https://doi.org/10.2298/HEMIND0806339M . .